This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Gly-Pro-Arg-Pro
catalog :
G1895
citations: 42
Reference
Lopatko Fagerström I, Ståhl A, Mossberg M, Tati R, Kristoffersson A, Kahn R, et al. Blockade of the kallikrein-kinin system reduces endothelial complement activation in vascular inflammation. EBioMedicine. 2019;47:319-328 pubmed publisher
Justo Sanz R, Monzón Manzano E, Fernández Bello I, Teresa Álvarez Román M, Martin Salces M, Rivas Pollmar M, et al. Platelet Apoptosis and PAI-1 are Involved in the Pro-Coagulant State of Immune Thrombocytopaenia Patients Treated with Thrombopoietin Receptor Agonists. Thromb Haemost. 2019;119:645-659 pubmed publisher
Neubauer K, Boeckelmann D, Koehler U, Kracht J, Kirschner J, Pendziwiat M, et al. Hereditary neuralgic amyotrophy in childhood caused by duplication within the SEPT9 gene: A family study. Cytoskeleton (Hoboken). 2019;76:131-136 pubmed publisher
Frelinger A, Gerrits A, Neculaes V, Gremmel T, Torres A, Caiafa A, et al. Tunable activation of therapeutic platelet-rich plasma by pulse electric field: Differential effects on clot formation, growth factor release, and platelet morphology. PLoS ONE. 2018;13:e0203557 pubmed publisher
Blanco Abad V, Noia M, Valle A, Fontenla F, Folgueira I, de Felipe A, et al. The coagulation system helps control infection caused by the ciliate parasite Philasterides dicentrarchi in the turbot Scophthalmus maximus (L.). Dev Comp Immunol. 2018;87:147-156 pubmed publisher
Pasalic L, Wing Lun E, Lau J, Campbell H, Pennings G, Lau E, et al. Novel assay demonstrates that coronary artery disease patients have heightened procoagulant platelet response. J Thromb Haemost. 2018;16:1198-1210 pubmed publisher
Fernández Bello I, Jimenez Yuste V, de Paz R, Martin Salces M, Justo Sanz R, Monzón Manzano E, et al. Factors Involved in Maintaining Haemostasis in Patients with Myelodysplastic Syndrome. Thromb Haemost. 2018;118:734-744 pubmed publisher
Reddy E, Wang H, Bang K, Packham M, Rand M. Young steady-state rabbit platelets do not have an enhanced capacity to expose procoagulant phosphatidylserine. Platelets. 2018;29:27-33 pubmed publisher
Miao D, Li D, Chen M, Zhao M. Platelets are activated in ANCA-associated vasculitis via thrombin-PARs pathway and can activate the alternative complement pathway. Arthritis Res Ther. 2017;19:252 pubmed publisher
Zuev Y, Litvinov R, Sitnitsky A, Idiyatullin B, Bakirova D, Galanakis D, et al. Conformational Flexibility and Self-Association of Fibrinogen in Concentrated Solutions. J Phys Chem B. 2017;121:7833-7843 pubmed publisher
Vinholt P, Nielsen C, Söderström A, Brandes A, Nybo M. Dabigatran reduces thrombin-induced platelet aggregation and activation in a dose-dependent manner. J Thromb Thrombolysis. 2017;44:216-222 pubmed publisher
Holt R, Luo D, Gruver N, Khismatullin D. Quasi-static acoustic tweezing thromboelastometry. J Thromb Haemost. 2017;15:1453-1462 pubmed publisher
Frelinger A, Grace R, Gerrits A, Berny Lang M, Brown T, Carmichael S, et al. Platelet function tests, independent of platelet count, are associated with bleeding severity in ITP. Blood. 2015;126:873-9 pubmed publisher
Jones C, Tucker K, Sasikumar P, Sage T, Kaiser W, Moore C, et al. Integrin-linked kinase regulates the rate of platelet activation and is essential for the formation of stable thrombi. J Thromb Haemost. 2014;12:1342-52 pubmed publisher
Abaeva A, Canault M, Kotova Y, Obydennyy S, Yakimenko A, Podoplelova N, et al. Procoagulant platelets form an ?-granule protein-covered "cap" on their surface that promotes their attachment to aggregates. J Biol Chem. 2013;288:29621-32 pubmed publisher
Brzoska T, Suzuki Y, Mogami H, Sano H, Urano T. Binding of thrombin-activated platelets to a fibrin scaffold through ?(IIb)?? evokes phosphatidylserine exposure on their cell surface. PLoS ONE. 2013;8:e55466 pubmed publisher
Ramapanicker R, Sun X, Viljanen J, Baltzer L. Powerful binders for the D-dimer by conjugation of the GPRP peptide to polypeptides from a designed set--illustrating a general route to new binders for proteins. Bioconjug Chem. 2013;24:17-25 pubmed publisher
Colace T, Muthard R, Diamond S. Thrombus growth and embolism on tissue factor-bearing collagen surfaces under flow: role of thrombin with and without fibrin. Arterioscler Thromb Vasc Biol. 2012;32:1466-76 pubmed publisher
Park R, Ping L, Song J, Hong S, Choi T, Choi J, et al. Fibrinogen residue ?Ala341 is necessary for calcium binding and 'A-a' interactions. Thromb Haemost. 2012;107:875-83 pubmed publisher
Bowley S, Merenbloom B, Okumura N, Betts L, Heroux A, Gorkun O, et al. Polymerization-defective fibrinogen variant gammaD364A binds knob "A" peptide mimic. Biochemistry. 2008;47:8607-13 pubmed publisher
Okumura N, Terasawa F, Haneishi A, Fujihara N, Hirota Kawadobora M, Yamauchi K, et al. B:b interactions are essential for polymerization of variant fibrinogens with impaired holes 'a'. J Thromb Haemost. 2007;5:2352-9 pubmed
Weisel J. Which knobs fit into which holes in fibrin polymerization?. J Thromb Haemost. 2007;5:2340-3 pubmed
Geer C, Tripathy A, Schoenfisch M, Lord S, Gorkun O. Role of 'B-b' knob-hole interactions in fibrin binding to adsorbed fibrinogen. J Thromb Haemost. 2007;5:2344-51 pubmed
Litvinov R, Gorkun O, Galanakis D, Yakovlev S, Medved L, Shuman H, et al. Polymerization of fibrin: Direct observation and quantification of individual B:b knob-hole interactions. Blood. 2007;109:130-8 pubmed
Gallistl S, Muntean W, Zenz W. Gly-pro-arg-pro (GPRP) enhances free thrombin. Thromb Res. 1995;78:547-50 pubmed
Niemann S, Spehr N, Van Aken H, Morgenstern E, Peters G, Herrmann M, et al. Soluble fibrin is the main mediator of Staphylococcus aureus adhesion to platelets. Circulation. 2004;110:193-200 pubmed
Lugovskoy E, Gritsenko P, Kolesnikova I, Zolotarova E, Chernishov V, Nieuwenhuizen W, et al. Two monoclonal antibodies to D-dimer-specific inhibitors of fibrin polymerization. Thromb Res. 2004;113:251-9 pubmed
Kostelansky M, Betts L, Gorkun O, Lord S. 2.8 A crystal structures of recombinant fibrinogen fragment D with and without two peptide ligands: GHRP binding to the "b" site disrupts its nearby calcium-binding site. Biochemistry. 2002;41:12124-32 pubmed
Li N, Hallden G, Hjemdahl P. A whole-blood flow cytometric assay for leukocyte CD11b expression using fluorescence signal triggering. Eur J Haematol. 2000;65:57-65 pubmed
Shenkman B, Rubinstein E, Tamarin I, Dardik R, Savion N, Varon D. Staphylococcus aureus adherence to thrombin-treated endothelial cells is mediated by fibrinogen but not by platelets. J Lab Clin Med. 2000;135:43-51 pubmed
De Cristofaro R, Landolfi R. Measurement of plasma fibrinogen concentration by the prothrombin-time-derived method: applicability and limitations. Blood Coagul Fibrinolysis. 1998;9:251-9 pubmed
Lorand L, Parameswaran K, Murthy S. A double-headed Gly-Pro-Arg-Pro ligand mimics the functions of the E domain of fibrin for promoting the end-to-end crosslinking of gamma chains by factor XIIIa. Proc Natl Acad Sci U S A. 1998;95:537-41 pubmed
Pratt K, Côté H, Chung D, Stenkamp R, Davie E. The primary fibrin polymerization pocket: three-dimensional structure of a 30-kDa C-terminal gamma chain fragment complexed with the peptide Gly-Pro-Arg-Pro. Proc Natl Acad Sci U S A. 1997;94:7176-81 pubmed
Nakatsuji T. Acceleration of thrombosis and hemolysis by fibrinolysis inhibiting factor and suppression by Ia antigen expressed on T cells in partially hepatectomized Lewis rats. Int J Hematol. 1996;64:181-8 pubmed
Chen X, Hua Z, Zhu D. A low molecular weight urokinase derivative with enhanced fibrin affinity. Biochem Mol Biol Int. 1996;39:797-803 pubmed
Chen X, Hua Z, Zhu D. Chemical conjugation of Gly-Pro-Arg-Pro. Tetrapeptide to low molecular weight urokinase. Biochem Mol Biol Int. 1996;39:455-60 pubmed
Haddeland U, Sletten K, Bennick A, Nieuwenhuizen W, Brosstad F. Aggregated, conformationally changed fibrinogen exposes the stimulating sites for t-PA-catalysed plasminogen activation. Thromb Haemost. 1996;75:326-31 pubmed
Hua Z, Chen X, Dong C, Zhu D. Characterization of a recombinant chimeric plasminogen activator composed of Gly-Pro-Arg-Pro tetrapeptide and truncated urokinase-type plasminogen activator expressed in Escherichia coli. Biochem Biophys Res Commun. 1996;222:576-83 pubmed
Colman R, Scott C. When and where is factor XI activated by thrombin?. Blood. 1996;87:2089 pubmed
Wu J, Diamond S. Fluorogenic fibrinogen and fibrin facilitate macromolecular assembly and dynamic assay of picomolar levels of plasminogen activators under well mixed conditions. Thromb Haemost. 1995;74:711-7 pubmed
Laudano A, Doolittle R. Studies on synthetic peptides that bind to fibrinogen and prevent fibrin polymerization. Structural requirements, number of binding sites, and species differences. Biochemistry. 1980;19:1013-9 pubmed
Yamazumi K, Doolittle R. The synthetic peptide Gly-Pro-Arg-Pro-amide limits the plasmic digestion of fibrinogen in the same fashion as calcium ion. Protein Sci. 1992;1:1719-20 pubmed
product information
Catalog Number :
G1895
Product Name :
Gly-Pro-Arg-Pro
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
≥97% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA