This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Gly-Pro-Arg-Pro
catalog :
G1895
citations: 42
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Justo Sanz R, Monzón Manzano E, Fernández Bello I, Teresa Álvarez Román M, Martin Salces M, Rivas Pollmar M, et al. Platelet Apoptosis and PAI-1 are Involved in the Pro-Coagulant State of Immune Thrombocytopaenia Patients Treated with Thrombopoietin Receptor Agonists. Thromb Haemost. 2019;119:645-659 pubmed publisher
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Okumura N, Terasawa F, Haneishi A, Fujihara N, Hirota Kawadobora M, Yamauchi K, et al. B:b interactions are essential for polymerization of variant fibrinogens with impaired holes 'a'. J Thromb Haemost. 2007;5:2352-9 pubmed
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Weisel J. Which knobs fit into which holes in fibrin polymerization?. J Thromb Haemost. 2007;5:2340-3 pubmed
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Geer C, Tripathy A, Schoenfisch M, Lord S, Gorkun O. Role of 'B-b' knob-hole interactions in fibrin binding to adsorbed fibrinogen. J Thromb Haemost. 2007;5:2344-51 pubmed
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Litvinov R, Gorkun O, Galanakis D, Yakovlev S, Medved L, Shuman H, et al. Polymerization of fibrin: Direct observation and quantification of individual B:b knob-hole interactions. Blood. 2007;109:130-8 pubmed
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Gallistl S, Muntean W, Zenz W. Gly-pro-arg-pro (GPRP) enhances free thrombin. Thromb Res. 1995;78:547-50 pubmed
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Niemann S, Spehr N, Van Aken H, Morgenstern E, Peters G, Herrmann M, et al. Soluble fibrin is the main mediator of Staphylococcus aureus adhesion to platelets. Circulation. 2004;110:193-200 pubmed
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Lugovskoy E, Gritsenko P, Kolesnikova I, Zolotarova E, Chernishov V, Nieuwenhuizen W, et al. Two monoclonal antibodies to D-dimer-specific inhibitors of fibrin polymerization. Thromb Res. 2004;113:251-9 pubmed
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Kostelansky M, Betts L, Gorkun O, Lord S. 2.8 A crystal structures of recombinant fibrinogen fragment D with and without two peptide ligands: GHRP binding to the "b" site disrupts its nearby calcium-binding site. Biochemistry. 2002;41:12124-32 pubmed
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Li N, Hallden G, Hjemdahl P. A whole-blood flow cytometric assay for leukocyte CD11b expression using fluorescence signal triggering. Eur J Haematol. 2000;65:57-65 pubmed
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Shenkman B, Rubinstein E, Tamarin I, Dardik R, Savion N, Varon D. Staphylococcus aureus adherence to thrombin-treated endothelial cells is mediated by fibrinogen but not by platelets. J Lab Clin Med. 2000;135:43-51 pubmed
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De Cristofaro R, Landolfi R. Measurement of plasma fibrinogen concentration by the prothrombin-time-derived method: applicability and limitations. Blood Coagul Fibrinolysis. 1998;9:251-9 pubmed
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Lorand L, Parameswaran K, Murthy S. A double-headed Gly-Pro-Arg-Pro ligand mimics the functions of the E domain of fibrin for promoting the end-to-end crosslinking of gamma chains by factor XIIIa. Proc Natl Acad Sci U S A. 1998;95:537-41 pubmed
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Pratt K, Côté H, Chung D, Stenkamp R, Davie E. The primary fibrin polymerization pocket: three-dimensional structure of a 30-kDa C-terminal gamma chain fragment complexed with the peptide Gly-Pro-Arg-Pro. Proc Natl Acad Sci U S A. 1997;94:7176-81 pubmed
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Nakatsuji T. Acceleration of thrombosis and hemolysis by fibrinolysis inhibiting factor and suppression by Ia antigen expressed on T cells in partially hepatectomized Lewis rats. Int J Hematol. 1996;64:181-8 pubmed
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Chen X, Hua Z, Zhu D. A low molecular weight urokinase derivative with enhanced fibrin affinity. Biochem Mol Biol Int. 1996;39:797-803 pubmed
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Chen X, Hua Z, Zhu D. Chemical conjugation of Gly-Pro-Arg-Pro. Tetrapeptide to low molecular weight urokinase. Biochem Mol Biol Int. 1996;39:455-60 pubmed
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Haddeland U, Sletten K, Bennick A, Nieuwenhuizen W, Brosstad F. Aggregated, conformationally changed fibrinogen exposes the stimulating sites for t-PA-catalysed plasminogen activation. Thromb Haemost. 1996;75:326-31 pubmed
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Hua Z, Chen X, Dong C, Zhu D. Characterization of a recombinant chimeric plasminogen activator composed of Gly-Pro-Arg-Pro tetrapeptide and truncated urokinase-type plasminogen activator expressed in Escherichia coli. Biochem Biophys Res Commun. 1996;222:576-83 pubmed
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Colman R, Scott C. When and where is factor XI activated by thrombin?. Blood. 1996;87:2089 pubmed
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Wu J, Diamond S. Fluorogenic fibrinogen and fibrin facilitate macromolecular assembly and dynamic assay of picomolar levels of plasminogen activators under well mixed conditions. Thromb Haemost. 1995;74:711-7 pubmed
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Laudano A, Doolittle R. Studies on synthetic peptides that bind to fibrinogen and prevent fibrin polymerization. Structural requirements, number of binding sites, and species differences. Biochemistry. 1980;19:1013-9 pubmed
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Yamazumi K, Doolittle R. The synthetic peptide Gly-Pro-Arg-Pro-amide limits the plasmic digestion of fibrinogen in the same fashion as calcium ion. Protein Sci. 1992;1:1719-20 pubmed
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product information
Catalog Number :
G1895
Product Name :
Gly-Pro-Arg-Pro
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
≥97% (HPLC)
company information

MilliporeSigma
questions and comments
