This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Disialoganglioside-GD 2 from bovine brain
catalog :
G0776
citations: 36
Reference
Görges M, West N, Deyell R, Winton P, Cheung W, Lauder G. Dexmedetomidine and hydromorphone: a novel pain management strategy for the oncology ward setting during anti-GD2 immunotherapy for high-risk neuroblastoma in children. Pediatr Blood Cancer. 2015;62:29-34 pubmed publisher
Cheng M, Ahmed M, Xu H, Cheung N. Structural design of disialoganglioside GD2 and CD3-bispecific antibodies to redirect T cells for tumor therapy. Int J Cancer. 2015;136:476-86 pubmed publisher
Hong S, Ostaszewski B, Yang T, O Malley T, Jin M, Yanagisawa K, et al. Soluble A? oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes. Neuron. 2014;82:308-19 pubmed publisher
Cheung N, Cheung I, Kramer K, Modak S, Kuk D, Pandit Taskar N, et al. Key role for myeloid cells: phase II results of anti-G(D2) antibody 3F8 plus granulocyte-macrophage colony-stimulating factor for chemoresistant osteomedullary neuroblastoma. Int J Cancer. 2014;135:2199-205 pubmed publisher
Matarrese P, Garofalo T, Manganelli V, Gambardella L, Marconi M, Grasso M, et al. Evidence for the involvement of GD3 ganglioside in autophagosome formation and maturation. Autophagy. 2014;10:750-65 pubmed publisher
Ahmed M, Cheung N. Engineering anti-GD2 monoclonal antibodies for cancer immunotherapy. FEBS Lett. 2014;588:288-97 pubmed publisher
Siebert N, Seidel D, Eger C, Brackrock D, Reker D, Schmidt M, et al. Validated detection of anti-GD2 antibody ch14.18/CHO in serum of neuroblastoma patients using anti-idiotype antibody ganglidiomab. J Immunol Methods. 2013;398-399:51-9 pubmed publisher
Kroesen M, Nierkens S, Ansems M, Wassink M, Orentas R, Boon L, et al. A transplantable TH-MYCN transgenic tumor model in C57Bl/6 mice for preclinical immunological studies in neuroblastoma. Int J Cancer. 2014;134:1335-45 pubmed publisher
Horwacik I, Durbas M, Boratyn E, Wegrzyn P, Rokita H. Targeting GD2 ganglioside and aurora A kinase as a dual strategy leading to cell death in cultures of human neuroblastoma cells. Cancer Lett. 2013;341:248-64 pubmed publisher
Druĭ A, Tsaur G, Popov A, Tuponogov S, Shorikov E, Tsvirenko S, et al. [The TH, ELAVL4 and GD2 gene expression as diagnostic markers of bone marrow lesions in patients with neuroblastoma]. Vopr Onkol. 2012;58:514-20 pubmed
Lode H, Schmidt M, Seidel D, Huebener N, Brackrock D, Bleeke M, et al. Vaccination with anti-idiotype antibody ganglidiomab mediates a GD(2)-specific anti-neuroblastoma immune response. Cancer Immunol Immunother. 2013;62:999-1010 pubmed publisher
Cochonneau D, Terme M, Michaud A, Dorvillius M, Gautier N, Frikeche J, et al. Cell cycle arrest and apoptosis induced by O-acetyl-GD2-specific monoclonal antibody 8B6 inhibits tumor growth in vitro and in vivo. Cancer Lett. 2013;333:194-204 pubmed publisher
Vincent M, Bessard A, Cochonneau D, Teppaz G, Solé V, Maillasson M, et al. Tumor targeting of the IL-15 superagonist RLI by an anti-GD2 antibody strongly enhances its antitumor potency. Int J Cancer. 2013;133:757-65 pubmed publisher
Sakai D, Nakamura Y, Nakai T, Mishima T, Kato S, Grad S, et al. Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc. Nat Commun. 2012;3:1264 pubmed publisher
Alderson K, Luangrath M, Elsenheimer M, Gillies S, Navid F, Rakhmilevich A, et al. Enhancement of the anti-melanoma response of Hu14.18K322A by ?CD40 + CpG. Cancer Immunol Immunother. 2013;62:665-75 pubmed publisher
Ruf P, Schäfer B, Eissler N, Mocikat R, Hess J, Plöscher M, et al. Ganglioside GD2-specific trifunctional surrogate antibody Surek demonstrates therapeutic activity in a mouse melanoma model. J Transl Med. 2012;10:219 pubmed publisher
Shibina A, Seidel D, Somanchi S, Lee D, Stermann A, Maurer B, et al. Fenretinide sensitizes multidrug-resistant human neuroblastoma cells to antibody-independent and ch14.18-mediated NK cell cytotoxicity. J Mol Med (Berl). 2013;91:459-72 pubmed publisher
Tong W, Sprules T, Gehring K, Saragovi H. Rational design of peptide ligands against a glycolipid by NMR studies. Methods Mol Biol. 2012;928:39-52 pubmed publisher
Tarek N, Le Luduec J, Gallagher M, Zheng J, Venstrom J, Chamberlain E, et al. Unlicensed NK cells target neuroblastoma following anti-GD2 antibody treatment. J Clin Invest. 2012;122:3260-70 pubmed publisher
Shen M, Gong F, Pang P, Zhu K, Meng X, Wu C, et al. An MRI-visible non-viral vector for targeted Bcl-2 siRNA delivery to neuroblastoma. Int J Nanomedicine. 2012;7:3319-32 pubmed publisher
Eissler N, Ruf P, Mysliwietz J, Lindhofer H, Mocikat R. Trifunctional bispecific antibodies induce tumor-specific T cells and elicit a vaccination effect. Cancer Res. 2012;72:3958-66 pubmed publisher
Yankelevich M, Kondadasula S, Thakur A, Buck S, Cheung N, Lum L. Anti-CD3?×?anti-GD2 bispecific antibody redirects T-cell cytolytic activity to neuroblastoma targets. Pediatr Blood Cancer. 2012;59:1198-205 pubmed publisher
Tivnan A, Orr W, Gubala V, Nooney R, Williams D, McDonagh C, et al. Inhibition of neuroblastoma tumor growth by targeted delivery of microRNA-34a using anti-disialoganglioside GD2 coated nanoparticles. PLoS ONE. 2012;7:e38129 pubmed publisher
Shibuya H, Hamamura K, Hotta H, Matsumoto Y, Nishida Y, Hattori H, et al. Enhancement of malignant properties of human osteosarcoma cells with disialyl gangliosides GD2/GD3. Cancer Sci. 2012;103:1656-64 pubmed publisher
Mast C. [Nursing care for a child with recurrent neuroblastoma treated with immunotherapy]. Kinderkrankenschwester. 2012;31:142-4 pubmed
Matthay K, George R, Yu A. Promising therapeutic targets in neuroblastoma. Clin Cancer Res. 2012;18:2740-53 pubmed publisher
Battula V, Shi Y, Evans K, Wang R, Spaeth E, Jacamo R, et al. Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis. J Clin Invest. 2012;122:2066-78 pubmed publisher
Ziebarth A, Felder M, Harter J, Connor J. Uterine leiomyosarcoma diffusely express disialoganglioside GD2 and bind the therapeutic immunocytokine 14.18-IL2: implications for immunotherapy. Cancer Immunol Immunother. 2012;61:1149-53 pubmed publisher
Kailayangiri S, Altvater B, Meltzer J, Pscherer S, Luecke A, Dierkes C, et al. The ganglioside antigen G(D2) is surface-expressed in Ewing sarcoma and allows for MHC-independent immune targeting. Br J Cancer. 2012;106:1123-33 pubmed publisher
Cazet A, Bobowski M, Rombouts Y, Lefebvre J, Steenackers A, Popa I, et al. The ganglioside G(D2) induces the constitutive activation of c-Met in MDA-MB-231 breast cancer cells expressing the G(D3) synthase. Glycobiology. 2012;22:806-16 pubmed publisher
Louis C, Savoldo B, Dotti G, Pule M, Yvon E, Myers G, et al. Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma. Blood. 2011;118:6050-6 pubmed publisher
Alvarez Rueda N, Desselle A, Cochonneau D, Chaumette T, Clémenceau B, Leprieur S, et al. A monoclonal antibody to O-acetyl-GD2 ganglioside and not to GD2 shows potent anti-tumor activity without peripheral nervous system cross-reactivity. PLoS ONE. 2011;6:e25220 pubmed publisher
Heimburg Molinaro J, Lum M, Vijay G, Jain M, Almogren A, Rittenhouse Olson K. Cancer vaccines and carbohydrate epitopes. Vaccine. 2011;29:8802-26 pubmed publisher
Acosta S, Mayol G, Rodriguez E, Lavarino C, De Preter K, Kumps C, et al. Identification of tumoral glial precursor cells in neuroblastoma. Cancer Lett. 2011;312:73-81 pubmed publisher
Soman G, Yang X, Jiang H, Giardina S, Mitra G. Comparison of GD2 binding capture ELISA assays for anti-GD2-antibodies using GD2-coated plates and a GD2-expressing cell-based ELISA. J Immunol Methods. 2011;373:181-91 pubmed publisher
Pichla S, Murali R, Burnett R. The crystal structure of a Fab fragment to the melanoma-associated GD2 ganglioside. J Struct Biol. 1997;119:6-16 pubmed
product information
Catalog Number :
G0776
Product Name :
Disialoganglioside-GD 2 from bovine brain
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
~95%, lyophilized powder, semisynthetic
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA