This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
N-Formyl-Met-Leu-Phe
catalog :
F3506
citations: 117
Reference
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Wang J, Li J, Zhao Y, Yi W, Bian J, Wan X, et al. Up-regulation of programmed cell death 1 ligand 1 on neutrophils may be involved in sepsis-induced immunosuppression: an animal study and a prospective case-control study. Anesthesiology. 2015;122:852-63 pubmed publisher
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Wang W, Li T, Wang X, Yuan W, Cheng Y, Zhang H, et al. FAM19A4 is a novel cytokine ligand of formyl peptide receptor 1 (FPR1) and is able to promote the migration and phagocytosis of macrophages. Cell Mol Immunol. 2015;12:615-24 pubmed publisher
Santos A, Douiri A, Becares N, Wu S, Stephens A, Radulovic S, et al. Basophil activation test discriminates between allergy and tolerance in peanut-sensitized children. J Allergy Clin Immunol. 2014;134:645-52 pubmed publisher
Stark J, Varbiro S, Sipos M, Tulassay Z, Sara L, Adler I, et al. Antioxidant effect of the active metabolites of tibolone. Gynecol Endocrinol. 2015;31:31-5 pubmed publisher
Campillo Gimenez L, Casulli S, Dudoit Y, Seang S, Carcelain G, Lambert Niclot S, et al. Neutrophils in antiretroviral therapy-controlled HIV demonstrate hyperactivation associated with a specific IL-17/IL-22 environment. J Allergy Clin Immunol. 2014;134:1142-52.e5 pubmed publisher
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Ezeamuzie C, El Hashim A, Renno W, Edafiogho I. Antiallergic and antiasthmatic effects of a novel enhydrazinone ester (CEE-1): inhibition of activation of both mast cells and eosinophils. J Pharmacol Exp Ther. 2014;350:444-54 pubmed publisher
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Lee H, Kim H, Lee S, Jung Y, Kim S, Bae Y. A membrane-tethering pepducin that inhibits formyl peptide receptor 2-induced signaling. Pharmazie. 2014;69:293-6 pubmed
Estevão Silva C, Kummer R, Fachini Queiroz F, Grespan R, Nogueira de Melo G, Baroni S, et al. Anethole and eugenol reduce in vitro and in vivo leukocyte migration induced by fMLP, LTB4, and carrageenan. J Nat Med. 2014;68:567-75 pubmed publisher
Bednar F, Song C, Bardi G, Cornwell W, Rogers T. Cross-desensitization of CCR1, but not CCR2, following activation of the formyl peptide receptor FPR1. J Immunol. 2014;192:5305-13 pubmed publisher
Morshed M, Hlushchuk R, Simon D, Walls A, Obata Ninomiya K, Karasuyama H, et al. NADPH oxidase-independent formation of extracellular DNA traps by basophils. J Immunol. 2014;192:5314-23 pubmed publisher
Pergola C, Gerstmeier J, Mönch B, Caliskan B, Luderer S, Weinigel C, et al. The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP). Br J Pharmacol. 2014;171:3051-64 pubmed publisher
Wood M, Cole A, Eade C, Chen L, Chai K, Cole A. The HIV-1 gp41 ectodomain is cleaved by matriptase to produce a chemotactic peptide that acts through FPR2. Immunology. 2014;142:474-83 pubmed publisher
Taylor A, Tang W, Bruscia E, Zhang P, Lin A, Gaines P, et al. SRF is required for neutrophil migration in response to inflammation. Blood. 2014;123:3027-36 pubmed publisher
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Polesskaya O, Wong C, Lebron L, Chamberlain J, Gelbard H, Goodfellow V, et al. MLK3 regulates fMLP-stimulated neutrophil motility. Mol Immunol. 2014;58:214-22 pubmed publisher
Sumagin R, Robin A, Nusrat A, Parkos C. Transmigrated neutrophils in the intestinal lumen engage ICAM-1 to regulate the epithelial barrier and neutrophil recruitment. Mucosal Immunol. 2014;7:905-15 pubmed publisher
Lysak D, Vlas T, Holubova M, Miklikova M, Jindra P. In vitro testing of immunosupressive effects of mesenchymal stromal cells on lymphocytes stimulated with alloantigens. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015;159:215-9 pubmed publisher
Xu S, Zhou X, Yuan D, Xu Y, He P. Caveolin-1 scaffolding domain promotes leukocyte adhesion by reduced basal endothelial nitric oxide-mediated ICAM-1 phosphorylation in rat mesenteric venules. Am J Physiol Heart Circ Physiol. 2013;305:H1484-93 pubmed publisher
Lin M, Chen B, Huang C, Dai C, Hwang T, Sheu J. Eunicellin-based diterpenoids from the Formosan soft coral Klyxum molle with inhibitory activity on superoxide generation and elastase release by neutrophils. J Nat Prod. 2013;76:1661-7 pubmed publisher
van den Broek L, Kroeze K, Waaijman T, Breetveld M, Sampat Sardjoepersad S, Niessen F, et al. Differential response of human adipose tissue-derived mesenchymal stem cells, dermal fibroblasts, and keratinocytes to burn wound exudates: potential role of skin-specific chemokine CCL27. Tissue Eng Part A. 2014;20:197-209 pubmed publisher
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Maaty W, Lord C, Gripentrog J, Riesselman M, Keren Aviram G, Liu T, et al. Identification of C-terminal phosphorylation sites of N-formyl peptide receptor-1 (FPR1) in human blood neutrophils. J Biol Chem. 2013;288:27042-58 pubmed publisher
Zhang L, Xia X, Zhang M, Wang Y, Xing G, Yin X, et al. Integrated analysis of genomics and proteomics reveals that CKIP-1 is a novel macrophage migration regulator. Biochem Biophys Res Commun. 2013;436:382-7 pubmed publisher
Babin K, Antoine F, Goncalves D, Girard D. TiO2, CeO2 and ZnO nanoparticles and modulation of the degranulation process in human neutrophils. Toxicol Lett. 2013;221:57-63 pubmed publisher
Sekonyela R, Palmer J, Bok J, Jain S, Berthier E, Forseth R, et al. RsmA regulates Aspergillus fumigatus gliotoxin cluster metabolites including cyclo(L-Phe-L-Ser), a potential new diagnostic marker for invasive aspergillosis. PLoS ONE. 2013;8:e62591 pubmed publisher
Carlo T, Kalwa H, Levy B. 15-Epi-lipoxin A4 inhibits human neutrophil superoxide anion generation by regulating polyisoprenyl diphosphate phosphatase 1. FASEB J. 2013;27:2733-41 pubmed publisher
Fumagalli L, Campa C, Germena G, Lowell C, Hirsch E, Berton G. Class I phosphoinositide-3-kinases and SRC kinases play a nonredundant role in regulation of adhesion-independent and -dependent neutrophil reactive oxygen species generation. J Immunol. 2013;190:3648-60 pubmed publisher
Tong H, Tian D, He Z, Liu Y, Chu X, Sun X. Polysaccharides from Bupleurum chinense impact the recruitment and migration of neutrophils by blocking fMLP chemoattractant receptor-mediated functions. Carbohydr Polym. 2013;92:1071-7 pubmed publisher
Zhou C, Zhou Y, Wang J, Feng Y, Wang H, Xue J, et al. V101L of human formyl peptide receptor 1 (FPR1) increases receptor affinity and augments the antagonism mediated by cyclosporins. Biochem J. 2013;451:245-55 pubmed publisher
Tsai Y, Huang L, Lin H, Hung Y, Lee M, Kuo S, et al. Inhibition of formyl peptide-stimulated superoxide anion generation by Fal-002-2 occurs mainly through the blockade of the p21-activated kinase and protein kinase C signaling pathways in ratneutrophils. Eur J Pharmacol. 2013;701:114-23 pubmed publisher
Tsai Y, Wang Y, Lee M, Hsu M, Wang J. p38 Mitogen-activated protein kinase and extracellular signal-regulated kinase signaling pathways are not essential regulators of formyl peptide-stimulated p47(phox) activation in neutrophils. Eur J Pharmacol. 2013;701:96-105 pubmed publisher
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Mithu V, Bakthavatsalam S, Madhu P. (13)C-(13)c homonuclear recoupling in solid-state nuclear magnetic resonance at a moderately high magic-angle-spinning frequency. PLoS ONE. 2013;8:e50504 pubmed publisher
Edelman J, Fung Y, Pennings G, Reddel C, Bannon P, Bayfield M, et al. Off-pump coronary artery bypass surgery induces prolonged alterations to host neutrophil physiology. Shock. 2013;39:149-54 pubmed publisher
Wu S, Smith D. Impact of intestinal PepT1 on the kinetics and dynamics of N-formyl-methionyl-leucyl-phenylalanine, a bacterially-produced chemotactic peptide. Mol Pharm. 2013;10:677-84 pubmed publisher
Cai C, Tang S, Wang X, Cai S, Meng X, Zou W, et al. Requirement for both receptor-operated and store-operated calcium entry in N-formyl-methionine-leucine-phenylalanine-induced neutrophil polarization. Biochem Biophys Res Commun. 2013;430:816-21 pubmed publisher
Yuan S, Ghoshdastider U, Trzaskowski B, Latek D, Debinski A, Pulawski W, et al. The role of water in activation mechanism of human N-formyl peptide receptor 1 (FPR1) based on molecular dynamics simulations. PLoS ONE. 2012;7:e47114 pubmed publisher
Gemperle C, Schmid M, Herova M, Marti Jaun J, Wuest S, Loretz C, et al. Regulation of the formyl peptide receptor 1 (FPR1) gene in primary human macrophages. PLoS ONE. 2012;7:e50195 pubmed publisher
Alkayed F, Kashimata M, Koyama N, Hayashi T, Tamura Y, Azuma Y. P2Y11 purinoceptor mediates the ATP-enhanced chemotactic response of rat neutrophils. J Pharmacol Sci. 2012;120:288-95 pubmed
Parks K, Davis J. Epinephrine, cortisol, endotoxin, nutrition, and the neutrophil. Surg Infect (Larchmt). 2012;13:300-6 pubmed publisher
He H, Liao D, Wang Z, Wang Z, Zhou H, Wang M, et al. Functional characterization of three mouse formyl peptide receptors. Mol Pharmacol. 2013;83:389-98 pubmed publisher
Wang J, Shiratori I, Uehori J, Ikawa M, Arase H. Neutrophil infiltration during inflammation is regulated by PILR? via modulation of integrin activation. Nat Immunol. 2013;14:34-40 pubmed publisher
Filaferro M, Novi C, Ruggieri V, Genedani S, Alboni S, Malagoli D, et al. Neuropeptide S stimulates human monocyte chemotaxis via NPS receptor activation. Peptides. 2013;39:16-20 pubmed publisher
Majewska E, Wittek N, Rysz J, Baj Z. The influence of uremic high cystatin C concentration on neutrophil apoptosis and selected neutrophil functions isolated from healthy subjects. Med Sci Monit. 2012;18:CR667-73 pubmed
Sato T, Hongu T, Sakamoto M, Funakoshi Y, Kanaho Y. Molecular mechanisms of N-formyl-methionyl-leucyl-phenylalanine-induced superoxide generation and degranulation in mouse neutrophils: phospholipase D is dispensable. Mol Cell Biol. 2013;33:136-45 pubmed publisher
Liu L, Aerbajinai W, Ahmed S, Rodgers G, Angers S, Parent C. Radil controls neutrophil adhesion and motility through ?2-integrin activation. Mol Biol Cell. 2012;23:4751-65 pubmed publisher
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Kanaho Y, Sato T, Hongu T, Funakoshi Y. Molecular mechanisms of fMLP-induced superoxide generation and degranulation in mouse neutrophils. Adv Biol Regul. 2013;53:128-34 pubmed publisher
Capsoni F, Ongari A, Reali E, Bosè F, Altomare G. The protein kinase C inhibitor AEB071 (sotrastaurin) modulates migration and superoxide anion production by human neutrophils in vitro. Int J Immunopathol Pharmacol. 2012;25:617-26 pubmed
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product information
Catalog Number :
F3506
Product Name :
N-Formyl-Met-Leu-Phe
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
≥97% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA