This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Erastin
catalog :
E7781
citations: 96
Reference
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Nagase H, Katagiri Y, Oh hashi K, Geller H, Hirata Y. Reduced Sulfation Enhanced Oxytosis and Ferroptosis in Mouse Hippocampal HT22 Cells. Biomolecules. 2020;10: pubmed publisher
Lovatt M, Adnan K, Kocaba V, Dirisamer M, Peh G, Mehta J. Peroxiredoxin-1 regulates lipid peroxidation in corneal endothelial cells. Redox Biol. 2020;30:101417 pubmed publisher
Li Y, Yan H, Xu X, Liu H, Wu C, Zhao L. Erastin/sorafenib induces cisplatin-resistant non-small cell lung cancer cell ferroptosis through inhibition of the Nrf2/xCT pathway. Oncol Lett. 2020;19:323-333 pubmed publisher
Liu N, Lin X, Huang C. Activation of the reverse transsulfuration pathway through NRF2/CBS confers erastin-induced ferroptosis resistance. Br J Cancer. 2020;122:279-292 pubmed publisher
Dai E, Meng L, Kang R, Wang X, Tang D. ESCRT-III-dependent membrane repair blocks ferroptosis. Biochem Biophys Res Commun. 2020;522:415-421 pubmed publisher
Wei S, Qiu T, Yao X, Wang N, Jiang L, Jia X, et al. Arsenic induces pancreatic dysfunction and ferroptosis via mitochondrial ROS-autophagy-lysosomal pathway. J Hazard Mater. 2020;384:121390 pubmed publisher
Gai C, Yu M, Li Z, Wang Y, Ding D, Zheng J, et al. Acetaminophen sensitizing erastin-induced ferroptosis via modulation of Nrf2/heme oxygenase-1 signaling pathway in non-small-cell lung cancer. J Cell Physiol. 2020;235:3329-3339 pubmed publisher
Gao X, Guo N, Xu H, Pan T, Lei H, Yan A, et al. Ibuprofen induces ferroptosis of glioblastoma cells via downregulation of nuclear factor erythroid 2-related factor 2 signaling pathway. Anticancer Drugs. 2020;31:27-34 pubmed publisher
Wang L, Liu Y, Du T, Yang H, Lei L, Guo M, et al. ATF3 promotes erastin-induced ferroptosis by suppressing system Xc. Cell Death Differ. 2020;27:662-675 pubmed publisher
Dächert J, Ehrenfeld V, Habermann K, Dolgikh N, Fulda S. Targeting ferroptosis in rhabdomyosarcoma cells. Int J Cancer. 2020;146:510-520 pubmed publisher
Oh B, Lee S, Park G, Hwang Y, Lim J, Park E, et al. Erastin Inhibits Septic Shock and Inflammatory Gene Expression via Suppression of the NF-κB Pathway. J Clin Med. 2019;8: pubmed publisher
Zivanović J, Kouroussis E, Kohl J, Adhikari B, Bursać B, Schott Roux S, et al. Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration. Cell Metab. 2019;30:1152-1170.e13 pubmed publisher
Qi W, Li Z, Xia L, Dai J, Zhang Q, Wu C, et al. LncRNA GABPB1-AS1 and GABPB1 regulate oxidative stress during erastin-induced ferroptosis in HepG2 hepatocellular carcinoma cells. Sci Rep. 2019;9:16185 pubmed publisher
Su L, Jiang X, Yang C, Zhang J, Chen B, Li Y, et al. Pannexin 1 mediates ferroptosis that contributes to renal ischemia/reperfusion injury. J Biol Chem. 2019;294:19395-19404 pubmed publisher
Park E, Chung S. ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation. Cell Death Dis. 2019;10:822 pubmed publisher
Wang T, Liang J, Zhang C, Xiong Y, Guan K, Yuan H. The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis. Cell Death Dis. 2019;10:755 pubmed publisher
Wang N, Zeng G, Yin J, Bian Z. Artesunate activates the ATF4-CHOP-CHAC1 pathway and affects ferroptosis in Burkitt's Lymphoma. Biochem Biophys Res Commun. 2019;519:533-539 pubmed publisher
Bi J, Yang S, Li L, Dai Q, Borcherding N, Wagner B, et al. Metadherin enhances vulnerability of cancer cells to ferroptosis. Cell Death Dis. 2019;10:682 pubmed publisher
Yang W, Ding C, Sun T, Rupprecht G, Lin C, Hsu D, et al. The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma. Cell Rep. 2019;28:2501-2508.e4 pubmed publisher
Homma T, Kobayashi S, Sato H, Fujii J. Edaravone, a free radical scavenger, protects against ferroptotic cell death in vitro. Exp Cell Res. 2019;384:111592 pubmed publisher
Vartanian S, Lee J, Klijn C, Gnad F, Bagniewska M, Schaefer G, et al. ERBB3 and IGF1R Signaling Are Required for Nrf2-Dependent Growth in KEAP1-Mutant Lung Cancer. Cancer Res. 2019;79:4828-4839 pubmed publisher
Nagpal A, Redvers R, Ling X, Ayton S, Fuentes M, Tavancheh E, et al. Neoadjuvant neratinib promotes ferroptosis and inhibits brain metastasis in a novel syngeneic model of spontaneous HER2+ve breast cancer metastasis. Breast Cancer Res. 2019;21:94 pubmed publisher
Van Acker Z, Van Raemdonck G, Logie E, Van Acker S, Baggerman G, Vanden Berghe W, et al. Connecting the Dots in the Neuroglobin-Protein Interaction Network of an Unstressed and Ferroptotic Cell Death Neuroblastoma Model. Cells. 2019;8: pubmed publisher
Chen Y, Zhu G, Liu Y, Wu Q, Zhang X, Bian Z, et al. O-GlcNAcylated c-Jun antagonizes ferroptosis via inhibiting GSH synthesis in liver cancer. Cell Signal. 2019;63:109384 pubmed publisher
Wu J, Minikes A, Gao M, Bian H, Li Y, Stockwell B, et al. Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signalling. Nature. 2019;572:402-406 pubmed publisher
Daher B, Parks S, Durivault J, Cormerais Y, Baidarjad H, Tambutte E, et al. Genetic ablation of the cystine transporter xCT in PDAC cells inhibits mTORC1, growth, survival and tumor formation via nutrient and oxidative stresses. Cancer Res. 2019;: pubmed publisher
Gong Y, Wang N, Liu N, Dong H. Lipid Peroxidation and GPX4 Inhibition Are Common Causes for Myofibroblast Differentiation and Ferroptosis. DNA Cell Biol. 2019;38:725-733 pubmed publisher
Chen G, Benthani F, Wu J, Liang D, Bian Z, Jiang X. Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis. Cell Death Differ. 2019;: pubmed publisher
Zhang X, Du L, Qiao Y, Zhang X, Zheng W, Wu Q, et al. Ferroptosis is governed by differential regulation of transcription in liver cancer. Redox Biol. 2019;24:101211 pubmed publisher
Ye F, Chai W, Xie M, Yang M, Yu Y, Cao L, et al. HMGB1 regulates erastin-induced ferroptosis via RAS-JNK/p38 signaling in HL-60/NRASQ61L cells. Am J Cancer Res. 2019;9:730-739 pubmed
Kain H, Glennon E, Vijayan K, Arang N, Douglass A, Fortin C, et al. Liver stage malaria infection is controlled by host regulators of lipid peroxidation. Cell Death Differ. 2019;: pubmed publisher
Alim I, Caulfield J, Chen Y, Swarup V, Geschwind D, Ivanova E, et al. Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke. Cell. 2019;177:1262-1279.e25 pubmed publisher
Wang W, Green M, Choi J, Gijon M, Kennedy P, Johnson J, et al. CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy. Nature. 2019;569:270-274 pubmed publisher
Martinez A, Mirkovic J, Stanisz Z, Patwari F, Yang W. NSC-34 motor neuron-like cells are sensitized to ferroptosis upon differentiation. FEBS Open Bio. 2019;9:582-593 pubmed publisher
Wang Z, Jin D, Ma D, Ji C, Wu W, Xu L, et al. Ferroptosis suppressed the growth of melanoma that may be related to DNA damage. Dermatol Ther. 2019;32:e12921 pubmed publisher
Zhang Y, Koppula P, Gan B. Regulation of H2A ubiquitination and SLC7A11 expression by BAP1 and PRC1. Cell Cycle. 2019;18:773-783 pubmed publisher
Pan X, Lin Z, Jiang D, Yu Y, Yang D, Zhou H, et al. Erastin decreases radioresistance of NSCLC cells partially by inducing GPX4-mediated ferroptosis. Oncol Lett. 2019;17:3001-3008 pubmed publisher
Hirata Y, Iwasaki T, Makimura Y, Okajima S, Oh hashi K, Takemori H. Inhibition of double-stranded RNA-dependent protein kinase prevents oxytosis and ferroptosis in mouse hippocampal HT22 cells. Toxicology. 2019;418:1-10 pubmed publisher
Garcia Bermudez J, Baudrier L, Bayraktar E, Shen Y, La K, Guarecuco R, et al. Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death. Nature. 2019;567:118-122 pubmed publisher
Lee B, Jun H, Kim J, Kim J. Astrocytic cystine/glutamate antiporter is a key regulator of erythropoietin expression in the ischemic retina. FASEB J. 2019;33:6045-6054 pubmed publisher
Liu T, Jiang L, Tavana O, Gu W. The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11. Cancer Res. 2019;79:1913-1924 pubmed publisher
Wen Q, Liu J, Kang R, Zhou B, Tang D. The release and activity of HMGB1 in ferroptosis. Biochem Biophys Res Commun. 2019;510:278-283 pubmed publisher
Cotticelli M, Xia S, Lin D, Lee T, Terrab L, Wipf P, et al. Ferroptosis as a Novel Therapeutic Target for Friedreich's Ataxia. J Pharmacol Exp Ther. 2019;369:47-54 pubmed publisher
Dangol S, Chen Y, Hwang B, Jwa N. Iron- and Reactive Oxygen Species-Dependent Ferroptotic Cell Death in Rice-Magnaporthe oryzae Interactions. Plant Cell. 2019;31:189-209 pubmed publisher
Lôrincz T, Holczer M, Kapuy O, Szarka A. The Interrelationship of Pharmacologic Ascorbate Induced Cell Death and Ferroptosis. Pathol Oncol Res. 2019;25:669-679 pubmed publisher
Nagakannan P, Islam M, Karimi Abdolrezaee S, Eftekharpour E. Inhibition of VDAC1 Protects Against Glutamate-Induced Oxytosis and Mitochondrial Fragmentation in Hippocampal HT22 Cells. Cell Mol Neurobiol. 2019;39:73-85 pubmed publisher
Hirayama T, Miki A, Nagasawa H. Organelle-specific analysis of labile Fe(ii) during ferroptosis by using a cocktail of various colour organelle-targeted fluorescent probes. Metallomics. 2019;11:111-117 pubmed publisher
Moerke C, Jaco I, Dewitz C, Müller T, Jacobsen A, Gautheron J, et al. The anticonvulsive Phenhydan® suppresses extrinsic cell death. Cell Death Differ. 2018;: pubmed publisher
Zhang Y, Shi J, Liu X, Feng L, Gong Z, Koppula P, et al. BAP1 links metabolic regulation of ferroptosis to tumour suppression. Nat Cell Biol. 2018;20:1181-1192 pubmed publisher
Wang D, Xie N, Gao W, Kang R, Tang D. The ferroptosis inducer erastin promotes proliferation and differentiation in human peripheral blood mononuclear cells. Biochem Biophys Res Commun. 2018;503:1689-1695 pubmed publisher
Zhang K, Wu L, Zhang P, Luo M, Du J, Gao T, et al. miR-9 regulates ferroptosis by targeting glutamic-oxaloacetic transaminase GOT1 in melanoma. Mol Carcinog. 2018;57:1566-1576 pubmed publisher
Gao H, Bai Y, Jia Y, Zhao Y, Kang R, Tang D, et al. Ferroptosis is a lysosomal cell death process. Biochem Biophys Res Commun. 2018;503:1550-1556 pubmed publisher
Sui M, Jiang X, Chen J, Yang H, Zhu Y. Magnesium isoglycyrrhizinate ameliorates liver fibrosis and hepatic stellate cell activation by regulating ferroptosis signaling pathway. Biomed Pharmacother. 2018;106:125-133 pubmed publisher
Hassannia B, Wiernicki B, Ingold I, Qu F, Van Herck S, Tyurina Y, et al. Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma. J Clin Invest. 2018;128:3341-3355 pubmed publisher
Miess H, Dankworth B, Gouw A, Rosenfeldt M, Schmitz W, Jiang M, et al. The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma. Oncogene. 2018;37:5435-5450 pubmed publisher
Bruni A, Pepper A, Pawlick R, Gala López B, Gamble A, Kin T, et al. Ferroptosis-inducing agents compromise in vitro human islet viability and function. Cell Death Dis. 2018;9:595 pubmed publisher
Sheng X, Cui C, Shan C, Li Y, Sheng D, Sun B, et al. O-Phenylenediamine: a privileged pharmacophore of ferrostatins for radical-trapping reactivity in blocking ferroptosis. Org Biomol Chem. 2018;16:3952-3960 pubmed publisher
Gaschler M, Andia A, Liu H, Csuka J, Hurlocker B, Vaiana C, et al. FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation. Nat Chem Biol. 2018;14:507-515 pubmed publisher
Bai Y, Chang R, Wang H, Xiao F, Ge R, Wang L. ENPP2 protects cardiomyocytes from erastin-induced ferroptosis. Biochem Biophys Res Commun. 2018;499:44-51 pubmed publisher
Luo M, Wu L, Zhang K, Wang H, Zhang T, Gutierrez L, et al. miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma. Cell Death Differ. 2018;25:1457-1472 pubmed publisher
Sato M, Kusumi R, Hamashima S, Kobayashi S, Sasaki S, Komiyama Y, et al. The ferroptosis inducer erastin irreversibly inhibits system xc- and synergizes with cisplatin to increase cisplatin's cytotoxicity in cancer cells. Sci Rep. 2018;8:968 pubmed publisher
Ingold I, Berndt C, Schmitt S, Doll S, Poschmann G, Buday K, et al. Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis. Cell. 2018;172:409-422.e21 pubmed publisher
Baba Y, Higa J, Shimada B, Horiuchi K, Suhara T, Kobayashi M, et al. Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2018;314:H659-H668 pubmed publisher
Beatty A, Fink L, Singh T, Strigun A, Peter E, Ferrer C, et al. Metabolite Profiling Reveals the Glutathione Biosynthetic Pathway as a Therapeutic Target in Triple-Negative Breast Cancer. Mol Cancer Ther. 2018;17:264-275 pubmed publisher
Hong S, Lee D, Lee Y, Jo M, Jeong Y, Kwon W, et al. Molecular crosstalk between ferroptosis and apoptosis: emerging role of ER stress-induced p53-independent PUMA expression. Oncotarget. 2017;8:115164-115178 pubmed publisher
Raggi C, Gammella E, Correnti M, Buratti P, Forti E, Andersen J, et al. Dysregulation of Iron Metabolism in Cholangiocarcinoma Stem-like Cells. Sci Rep. 2017;7:17667 pubmed publisher
Trumbach D, Pfeiffer S, Poppe M, Scherb H, Doll S, Wurst W, et al. ENCoRE: an efficient software for CRISPR screens identifies new players in extrinsic apoptosis. BMC Genomics. 2017;18:905 pubmed publisher
Yotsumoto S, Muroi Y, Chiba T, Ohmura R, Yoneyama M, Magarisawa M, et al. Hyperoxidation of ether-linked phospholipids accelerates neutrophil extracellular trap formation. Sci Rep. 2017;7:16026 pubmed publisher
Hangauer M, Viswanathan V, Ryan M, Bole D, Eaton J, Matov A, et al. Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition. Nature. 2017;551:247-250 pubmed publisher
Dehart D, Lemasters J, Maldonado E. Erastin-Like Anti-Warburg Agents Prevent Mitochondrial Depolarization Induced by Free Tubulin and Decrease Lactate Formation in Cancer Cells. SLAS Discov. 2017;:2472555217731556 pubmed publisher
Brown C, Amante J, Goel H, Mercurio A. The α6β4 integrin promotes resistance to ferroptosis. J Cell Biol. 2017;216:4287-4297 pubmed publisher
Romero R, Sayin V, Davidson S, Bauer M, Singh S, LeBoeuf S, et al. Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis. Nat Med. 2017;23:1362-1368 pubmed publisher
Hattori K, Ishikawa H, Sakauchi C, Takayanagi S, Naguro I, Ichijo H. Cold stress-induced ferroptosis involves the ASK1-p38 pathway. EMBO Rep. 2017;18:2067-2078 pubmed publisher
Xie Y, Zhu S, Zhong M, Yang M, Sun X, Liu J, et al. Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma. Gastroenterology. 2017;153:1429-1443.e5 pubmed publisher
Adedoyin O, Boddu R, Traylor A, Lever J, Bolisetty S, George J, et al. Heme Oxygenase-1 Mitigates Ferroptosis in Renal Proximal Tubule Cells. Am J Physiol Renal Physiol. 2017;:ajprenal.00044.2017 pubmed publisher
Shin C, Mishra P, Watrous J, Carelli V, D Aurelio M, Jain M, et al. The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility. Nat Commun. 2017;8:15074 pubmed publisher
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Basuli D, Tesfay L, Deng Z, Paul B, Yamamoto Y, Ning G, et al. Iron addiction: a novel therapeutic target in ovarian cancer. Oncogene. 2017;36:4089-4099 pubmed publisher
Zhu S, Zhang Q, Sun X, Zeh H, Lotze M, Kang R, et al. HSPA5 Regulates Ferroptotic Cell Death in Cancer Cells. Cancer Res. 2017;77:2064-2077 pubmed publisher
Wang D, Peng Y, Xie Y, Zhou B, Sun X, Kang R, et al. Antiferroptotic activity of non-oxidative dopamine. Biochem Biophys Res Commun. 2016;480:602-607 pubmed publisher
Song X, Xie Y, Kang R, Hou W, Sun X, Epperly M, et al. FANCD2 protects against bone marrow injury from ferroptosis. Biochem Biophys Res Commun. 2016;480:443-449 pubmed publisher
Haß C, Belz K, Schoeneberger H, Fulda S. Sensitization of acute lymphoblastic leukemia cells for LCL161-induced cell death by targeting redox homeostasis. Biochem Pharmacol. 2016;105:14-22 pubmed publisher
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Sun X, Ou Z, Chen R, Niu X, Chen D, Kang R, et al. Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells. Hepatology. 2016;63:173-84 pubmed publisher
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Sun X, Ou Z, Xie M, Kang R, Fan Y, Niu X, et al. HSPB1 as a novel regulator of ferroptotic cancer cell death. Oncogene. 2015;34:5617-25 pubmed publisher
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product information
Catalog Number :
E7781
Product Name :
Erastin
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA