This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Etomidate
catalog :
E6530
citations: 72
Reference
Liu H, Zhu D, Wang C, Guan H, Li S, Hu C, et al. Effects of Etomidate on the Steroidogenesis of Rat Immature Leydig Cells. PLoS ONE. 2015;10:e0139311 pubmed publisher
Song J, Lu Z, Jiao Y, Yang B, Gao H, Zhang J, et al. Etomidate Anesthesia during ERCP Caused More Stable Haemodynamic Responses Compared with Propofol: A Randomized Clinical Trial. Int J Med Sci. 2015;12:559-65 pubmed publisher
Skyschally A, Gent S, Amanakis G, Schulte C, Kleinbongard P, Heusch G. Across-Species Transfer of Protection by Remote Ischemic Preconditioning With Species-Specific Myocardial Signal Transduction by Reperfusion Injury Salvage Kinase and Survival Activating Factor Enhancement Pathways. Circ Res. 2015;117:279-88 pubmed publisher
Cabral Teixeira J, Martinez Fernandez A, Cai W, Terzic A, Mercola M, Willems E. Cholesterol-derived glucocorticoids control early fate specification in embryonic stem cells. Stem Cell Res. 2015;15:88-95 pubmed publisher
Zarnowska E, Rodgers F, Oh I, Rau V, Lor C, Laha K, et al. Etomidate blocks LTP and impairs learning but does not enhance tonic inhibition in mice carrying the N265M point mutation in the beta3 subunit of the GABA(A) receptor. Neuropharmacology. 2015;93:171-178 pubmed publisher
Kakazu C, Lippmann M. Playing with fire: debate about propofol-induced hypotension. Br J Anaesth. 2015;114:164-5 pubmed publisher
Green D. Cardiac output decrease and propofol: what is the mechanism?. Br J Anaesth. 2015;114:163-4 pubmed publisher
Bakala N Goma J, Le Moigne V, Soismier N, Laencina L, Le Chevalier F, Roux A, et al. Mycobacterium abscessus phospholipase C expression is induced during coculture within amoebae and enhances M. abscessus virulence in mice. Infect Immun. 2015;83:780-91 pubmed publisher
Møller Helgestad O, Poulsen C, Christiansen E, Lassen J, Ravn H. Support with intra-aortic balloon pump vs. Impella2.5® and blood flow to the heart, brain and kidneys - an experimental porcine model of ischaemic heart failure. Int J Cardiol. 2015;178:153-8 pubmed publisher
Krueger M, Bechmann I, Immig K, Reichenbach A, Härtig W, Michalski D. Blood-brain barrier breakdown involves four distinct stages of vascular damage in various models of experimental focal cerebral ischemia. J Cereb Blood Flow Metab. 2015;35:292-303 pubmed publisher
Wang X, Jin A, An M, Ding Y, Tuo Y, Qiu Y. Etomidate deteriorates the toxicity of advanced glycation end products to human endothelial Eahy926 cells. J Toxicol Sci. 2014;39:887-96 pubmed
Joung K, Jo J, Kim W, Choi D, Chin J, Lee E, et al. Association of preoperative uric acid and acute kidney injury following cardiovascular surgery. J Cardiothorac Vasc Anesth. 2014;28:1440-7 pubmed publisher
Campagna J, Pojasek K, Grayzel D, Randle J, Raines D. Advancing novel anesthetics: pharmacodynamic and pharmacokinetic studies of cyclopropyl-methoxycarbonyl metomidate in dogs. Anesthesiology. 2014;121:1203-16 pubmed publisher
Kragh K, Alhede M, Jensen P, Moser C, Scheike T, Jacobsen C, et al. Polymorphonuclear leukocytes restrict growth of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients. Infect Immun. 2014;82:4477-86 pubmed publisher
Zhang Y, Li R, Zhu J, Wang Z, Lv S, Xiong J. Etomidate increases mortality in septic rats through inhibition of nuclear factor kappa-B rather than by causing adrenal insufficiency. J Surg Res. 2015;193:399-406 pubmed publisher
Guo Z, Pang L, Jia X, Wang X, Su X, Li P, et al. Intraoperative target-controlled infusion anesthesia application using remifentanil hydrochloride with etomidate in patients with severe burn as monitored using Narcotrend. Burns. 2015;41:100-5 pubmed publisher
Vega Zelaya L, Torres C, Garnes Camarena O, Ortega G, García Navarrete E, Navas M, et al. Electrocorticographic evidence and surgical implications of different physiopathologic subtypes of temporal epilepsy. Clin Neurophysiol. 2014;125:2349-57 pubmed publisher
Smahel M, Duskova M, Polakova I, Musil J. Enhancement of DNA vaccine potency against legumain. J Immunother. 2014;37:293-303 pubmed publisher
Polakova I, Duskova M, Smahel M. Antitumor DNA vaccination against the Sox2 transcription factor. Int J Oncol. 2014;45:139-46 pubmed publisher
Pejo E, Santer P, Jeffrey S, Gallin H, Husain S, Raines D. Analogues of etomidate: modifications around etomidate's chiral carbon and the impact on in vitro and in vivo pharmacology. Anesthesiology. 2014;121:290-301 pubmed publisher
Sah N, Sikdar S. Tonic current through GABAA receptors and hyperpolarization-activated cyclic nucleotide-gated channels modulate resonance properties of rat subicular pyramidal neurons. Eur J Neurosci. 2014;40:2241-54 pubmed publisher
Baars T, Skyschally A, Klein Hitpass L, Cario E, Erbel R, Heusch G, et al. microRNA expression and its potential role in cardioprotection by ischemic postconditioning in pigs. Pflugers Arch. 2014;466:1953-61 pubmed publisher
Kakazu C, Lippmann M. Bispectral index monitors, non-invasive cardiac output monitors, and haemodynamics of induction agents. Br J Anaesth. 2014;112:169 pubmed publisher
Komatsu R, You J, Mascha E, Sessler D, Kasuya Y, Turan A. Anesthetic induction with etomidate, rather than propofol, is associated with increased 30-day mortality and cardiovascular morbidity after noncardiac surgery. Anesth Analg. 2013;117:1329-37 pubmed publisher
Legrand M, Plaud B. Etomidate and general anesthesia: the butterfly effect?. Anesth Analg. 2013;117:1267-9 pubmed publisher
Johnston P, Sen M, Hua Y, Camarco D, Shun T, Lazo J, et al. High-content pSTAT3/1 imaging assays to screen for selective inhibitors of STAT3 pathway activation in head and neck cancer cell lines. Assay Drug Dev Technol. 2014;12:55-79 pubmed publisher
Stewart D, Hotta M, Li G, Desai R, Chiara D, Olsen R, et al. Cysteine substitutions define etomidate binding and gating linkages in the α-M1 domain of γ-aminobutyric acid type A (GABAA) receptors. J Biol Chem. 2013;288:30373-86 pubmed publisher
Dominguez E, Rivera Del Alamo M, Novellas R, Espada Y, Santos L, Garcia F, et al. Doppler evaluation of the effects of propofol, etomidate and alphaxalone on fetoplacental circulation hemodynamics in the pregnant ewe. Placenta. 2013;34:738-44 pubmed publisher
van den Heuvel I, Wurmb T, Böttiger B, Bernhard M. Pros and cons of etomidate--more discussion than evidence?. Curr Opin Anaesthesiol. 2013;26:404-8 pubmed publisher
Chan C, Shorr A, Mitchell A. The authors reply. Crit Care Med. 2013;41:e96 pubmed publisher
Sterling S, Puskarich M, Jones A. The effect of etomidate on mortality in sepsis remains unclear. Crit Care Med. 2013;41:e95 pubmed publisher
Kretschmannova K, Hines R, Revilla Sanchez R, Terunuma M, Tretter V, Jurd R, et al. Enhanced tonic inhibition influences the hypnotic and amnestic actions of the intravenous anesthetics etomidate and propofol. J Neurosci. 2013;33:7264-73 pubmed publisher
Yates A, Wolfson A, Shum L, Kehrl T. A descriptive study of myoclonus associated with etomidate procedural sedation in the ED. Am J Emerg Med. 2013;31:852-4 pubmed publisher
Gunderson E, Lukasik V, Ashton M, Merideth R, Madsen R. Effects of anesthetic induction with midazolam-propofol and midazolam-etomidate on selected ocular and cardiorespiratory variables in clinically normal dogs. Am J Vet Res. 2013;74:629-35 pubmed publisher
Stewart D, Hotta M, Desai R, Forman S. State-dependent etomidate occupancy of its allosteric agonist sites measured in a cysteine-substituted GABAA receptor. Mol Pharmacol. 2013;83:1200-8 pubmed publisher
Shanmugasundararaj S, Zhou X, Neunzig J, Bernhardt R, Cotten J, Ge R, et al. Carboetomidate: an analog of etomidate that interacts weakly with 11β-hydroxylase. Anesth Analg. 2013;116:1249-56 pubmed publisher
Hahner S, Kreissl M, Fassnacht M, Haenscheid H, Bock S, Verburg F, et al. Functional characterization of adrenal lesions using [123I]IMTO-SPECT/CT. J Clin Endocrinol Metab. 2013;98:1508-18 pubmed publisher
Coursin D, Fish J, Joffe A. Etomidate-trusted alternative time to trust alternatives?. Crit Care Med. 2013;41:917-9 pubmed publisher
Li P, Eaton M, Steinbach J, Akk G. The benzodiazepine diazepam potentiates responses of ?1?2?2L ?-aminobutyric acid type A receptors activated by either ?-aminobutyric acid or allosteric agonists. Anesthesiology. 2013;118:1417-25 pubmed publisher
Desai R, Miller K, Raines D. The pyrrole etomidate analog carboetomidate potently inhibits human 5-HT3A receptor function: comparisons with etomidate and potential implications for emetogenesis. Anesth Analg. 2013;116:573-9 pubmed publisher
Janouschek H, Nickl Jockschat T, Haeck M, Gillmann B, Grozinger M. Comparison of methohexital and etomidate as anesthetic agents for electroconvulsive therapy in affective and psychotic disorders. J Psychiatr Res. 2013;47:686-93 pubmed publisher
Křišťan J, Stara A, Turek J, Policar T, Velisek J. Comparison of the effects of four anaesthetics on haematological and blood biochemical profiles in pikeperch (Sander lucioperca L.). Neuro Endocrinol Lett. 2012;33 Suppl 3:66-71 pubmed
Berger M, Hammerschmidt F, Qian R, Hahner S, Schirbel A, Stichelberger M, et al. [(3)H]metyrapol and 4-[(131)i]iodometomidate label overlapping, but not identical, binding sites on rat adrenal membranes. Mol Pharm. 2013;10:1119-30 pubmed publisher
McPhee L, Badawi O, Fraser G, Lerwick P, Riker R, Zuckerman I, et al. Single-dose etomidate is not associated with increased mortality in ICU patients with sepsis: analysis of a large electronic ICU database. Crit Care Med. 2013;41:774-83 pubmed publisher
Möller Petrun A, Kamenik M. Bispectral index-guided induction of general anaesthesia in patients undergoing major abdominal surgery using propofol or etomidate: a double-blind, randomized, clinical trial. Br J Anaesth. 2013;110:388-96 pubmed publisher
Xie Z, McMillan K, Pike C, Cahill A, Herring B, Wang Q, et al. Interaction of anesthetics with neurotransmitter release machinery proteins. J Neurophysiol. 2013;109:758-67 pubmed publisher
Budde A, Mets B. Pro: etomidate is the ideal induction agent for a cardiac anesthetic. J Cardiothorac Vasc Anesth. 2013;27:180-3 pubmed publisher
Malhotra A. Con: etomidate--the ideal induction agent for a cardiac anesthetic?. J Cardiothorac Vasc Anesth. 2013;27:178-9 pubmed publisher
Lauzier F, Turgeon A. Etomidate: buy now, pay later?*. Crit Care Med. 2012;40:3086-7 pubmed publisher
Payen J. Etomidate for critically ill patients: let us clarify the debate. Eur J Anaesthesiol. 2012;29:504-5 pubmed publisher
Hempel K, Haenscheid H, Biko J, Hategan M, Kaiser F, Kreissl M, et al. Frequency of transferrin receptor positive reticulocytes (TF-Ret) in blood as an indicator of total-body radiation exposure: a pilot study in nuclear medicine patients. Radiat Res. 2012;178:481-8 pubmed publisher
Wu J, Yao S, Wu Z, Wu Z, Chu S, Xia G, et al. A comparison of anesthetic regimens using etomidate and propofol in patients undergoing first-trimester abortions: double-blind, randomized clinical trial of safety and efficacy. Contraception. 2013;87:55-62 pubmed publisher
Erdur B, Degirmenci E, Kortunay S, Yuksel A, Seyit M, Ergin A. Effects of pretreatment with etomidate, ketamine, phenytoin, and phenytoin/midazolam on acute, lethal cocaine toxicity. Neurol Res. 2012;34:952-6 pubmed publisher
Chan C, Mitchell A, Shorr A. Etomidate is associated with mortality and adrenal insufficiency in sepsis: a meta-analysis*. Crit Care Med. 2012;40:2945-53 pubmed publisher
Archambault P, Dionne C, Lortie G, Leblanc F, Rioux A, Larouche G. Adrenal inhibition following a single dose of etomidate in intubated traumatic brain injury victims. CJEM. 2012;14:270-82 pubmed
de la Grandville B, Arroyo D, Walder B. Etomidate for critically ill patients. Con: do you really want to weaken the frail?. Eur J Anaesthesiol. 2012;29:511-4 pubmed publisher
Ray D, McKeown D. Etomidate for critically ill patients. Pro: yes we can use it. Eur J Anaesthesiol. 2012;29:506-10 pubmed publisher
Sneyd J. Novel etomidate derivatives. Curr Pharm Des. 2012;18:6253-6 pubmed
Forman S. Monod-Wyman-Changeux allosteric mechanisms of action and the pharmacology of etomidate. Curr Opin Anaesthesiol. 2012;25:411-8 pubmed publisher
Preda V, Sen J, Karavitaki N, Grossman A. Etomidate in the management of hypercortisolaemia in Cushing's syndrome: a review. Eur J Endocrinol. 2012;167:137-43 pubmed publisher
Cherfan A, Arabi Y, Al Dorzi H, Kenny L. Advantages and disadvantages of etomidate use for intubation of patients with sepsis. Pharmacotherapy. 2012;32:475-82 pubmed publisher
Toft P, Jensen A. [Etomidate can not be recommended to patients with septic shock]. Ugeskr Laeger. 2011;173:1421-3 pubmed
Heyn J, Geiger C, Hinske C, Briegel J, Weis F. Medical suppression of hypercortisolemia in Cushing's syndrome with particular consideration of etomidate. Pituitary. 2012;15:117-25 pubmed publisher
Albert S, Ariyan S, Rather A. The effect of etomidate on adrenal function in critical illness: a systematic review. Intensive Care Med. 2011;37:901-10 pubmed publisher
Forman S. Clinical and molecular pharmacology of etomidate. Anesthesiology. 2011;114:695-707 pubmed publisher
Edwin S, Walker P. Controversies surrounding the use of etomidate for rapid sequence intubation in patients with suspected sepsis. Ann Pharmacother. 2010;44:1307-13 pubmed publisher
Creagh O, Torres H, Rodríguez N, Gatica S. Alpha-2B adrenergic receptor mediated hemodynamic profile of etomidate. P R Health Sci J. 2010;29:91-5 pubmed
Hohl C, Kelly Smith C, Yeung T, Sweet D, Doyle Waters M, Schulzer M. The effect of a bolus dose of etomidate on cortisol levels, mortality, and health services utilization: a systematic review. Ann Emerg Med. 2010;56:105-13.e5 pubmed publisher
Van Deuren B, Van Ammel K, Somers Y, Cools F, Straetemans R, van der Linde H, et al. The fentanyl/etomidate-anaesthetised beagle (FEAB) dog: a versatile in vivo model in cardiovascular safety research. J Pharmacol Toxicol Methods. 2009;60:11-23 pubmed publisher
Ching K, Baum C. Newer agents for rapid sequence intubation: etomidate and rocuronium. Pediatr Emerg Care. 2009;25:200-7; quiz 208-10 pubmed publisher
Nestor N, Burton J. ED use of etomidate for rapid sequence induction. Am J Emerg Med. 2008;26:946-50 pubmed publisher
Vanlersberghe C, Camu F. Etomidate and other non-barbiturates. Handb Exp Pharmacol. 2008;:267-82 pubmed publisher
product information
Catalog Number :
E6530
Product Name :
Etomidate
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
>98% (HPLC), powder
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA