This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
protein
product name :
[D-Pen 2,5 ]-Enkephalin hydrate
catalog :
E3888
citations: 41
Reference
Wang Z, Jiang C, He Q, Matsuda M, Han Q, Wang K, et al. Anti-PD-1 treatment impairs opioid antinociception in rodents and nonhuman primates. Sci Transl Med. 2020;12: pubmed publisher
Kuo A, Magiera J, Rethwan N, Andersson A, Leen Lam A, Wyse B, et al. In vitro profiling of opioid ligands using the cAMP formation inhibition assay and the β-arrestin2 recruitment assay: No two ligands have the same profile. Eur J Pharmacol. 2020;872:172947 pubmed publisher
Birdsong W, Jongbloets B, Engeln K, Wang D, Scherrer G, Mao T. Synapse-specific opioid modulation of thalamo-cortico-striatal circuits. elife. 2019;8: pubmed publisher
Patton M, Padgett K, McKeon P, Lu S, Abrams T, Mathur B. An Aplysia-like synaptic switch for rapid protection against ethanol-induced synaptic inhibition in a mammalian habit circuit. Neuropharmacology. 2019;144:1-8 pubmed publisher
Wang Y, Chai J, Xu X, Ye R, Zan G, Liu G, et al. Pharmacological Characterization of Dezocine, a Potent Analgesic Acting as a κ Partial Agonist and μ Partial Agonist. Sci Rep. 2018;8:14087 pubmed publisher
Thompson A, Feeney C, Kristal M. Amniotic-fluid ingestion enhances central δ-opioid-induced hypoalgesia in rats in the cold-water tail-flick assay in a repeated-measures design. Brain Res. 2018;1697:53-58 pubmed publisher
Dunn A, Reed B, Guariglia C, Dunn A, Hillman J, Kreek M. Structurally Related Kappa Opioid Receptor Agonists with Substantial Differential Signaling Bias: Neuroendocrine and Behavioral Effects in C57BL6 Mice. Int J Neuropsychopharmacol. 2018;21:847-857 pubmed publisher
Jacobs B, Pando M, Jennings E, Chavera T, Clarke W, Berg K. Allosterism within δ Opioid-κ Opioid Receptor Heteromers in Peripheral Sensory Neurons: Regulation of κ Opioid Agonist Efficacy. Mol Pharmacol. 2018;93:376-386 pubmed publisher
Perkovska S, Mejean C, Ayoub M, Li J, Hemery F, Corbani M, et al. V1b vasopressin receptor trafficking and signaling : role of arrestins, G proteins and Src kinase. Traffic. 2017;: pubmed publisher
Asahi H, Inoue S, Niikura M, Kunigo K, Suzuki Y, Kobayashi F, et al. Profiling molecular factors associated with pyknosis and developmental arrest induced by an opioid receptor antagonist and dihydroartemisinin in Plasmodium falciparum. PLoS ONE. 2017;12:e0184874 pubmed publisher
Bull F, Baptista Hon D, Lambert J, Walwyn W, Hales T. Morphine activation of mu opioid receptors causes disinhibition of neurons in the ventral tegmental area mediated by β-arrestin2 and c-Src. Sci Rep. 2017;7:9969 pubmed publisher
Zádor F, Király K, Váradi A, Balogh M, Fehér Ã, Kocsis D, et al. New opioid receptor antagonist: Naltrexone-14-O-sulfate synthesis and pharmacology. Eur J Pharmacol. 2017;809:111-121 pubmed publisher
Panahi Y, Saboory E, Rassouli A, Sadeghi Hashjin G, Roshan Milani S, Derafshpour L, et al. The effect of selective opioid receptor agonists and antagonists on epileptiform activity in morphine-dependent infant mice hippocampal slices. Int J Dev Neurosci. 2017;60:56-62 pubmed publisher
Floettmann E, Bui K, Sostek M, Payza K, Eldon M. Pharmacologic Profile of Naloxegol, a Peripherally Acting µ-Opioid Receptor Antagonist, for the Treatment of Opioid-Induced Constipation. J Pharmacol Exp Ther. 2017;361:280-291 pubmed publisher
Cerlesi M, Ding H, Bird M, Kiguchi N, Ferrari F, Malfacini D, et al. Pharmacological studies on the NOP and opioid receptor agonist PWT2-[Dmt1]N/OFQ(1-13). Eur J Pharmacol. 2017;794:115-126 pubmed publisher
Robertson D, Sleno R, Nagi K, Pétrin D, Hébert T, Pineyro G. Design and construction of conformational biosensors to monitor ion channel activation: A prototype FlAsH/BRET-approach to Kir3 channels. Methods. 2016;92:19-35 pubmed publisher
Gadetskaya A, Taráwneh A, Zhusupova G, Gemejiyeva N, Cantrell C, Cutler S, et al. Sulfated phenolic compounds from Limonium caspium: Isolation, structural elucidation, and biological evaluation. Fitoterapia. 2015;104:80-5 pubmed publisher
Bird M, Vardanyan R, Hruby V, Calo G, Guerrini R, Salvadori S, et al. Development and characterisation of novel fentanyl-delta opioid receptor antagonist based bivalent ligands. Br J Anaesth. 2015;114:646-56 pubmed publisher
Chajra H, Amstutz B, Schweikert K, Auriol D, Redziniak G, Lefèvre F. Opioid receptor delta as a global modulator of skin differentiation and barrier function repair. Int J Cosmet Sci. 2015;37:386-94 pubmed publisher
Zádor F, Lénárt N, Csibrány B, Sántha M, Molnár M, Tuka B, et al. Low dosage of rimonabant leads to anxiolytic-like behavior via inhibiting expression levels and G-protein activity of kappa opioid receptors in a cannabinoid receptor independent manner. Neuropharmacology. 2015;89:298-307 pubmed
Mika J, Popiolek Barczyk K, Rojewska E, Makuch W, Starowicz K, Przewlocka B. Delta-opioid receptor analgesia is independent of microglial activation in a rat model of neuropathic pain. PLoS ONE. 2014;9:e104420 pubmed publisher
Gassaway M, Rives M, Kruegel A, Javitch J, Sames D. The atypical antidepressant and neurorestorative agent tianeptine is a μ-opioid receptor agonist. Transl Psychiatry. 2014;4:e411 pubmed publisher
Kuo A, Wyse B, Meutermans W, Smith M. In vivo profiling of seven common opioids for antinociception, constipation and respiratory depression: no two opioids have the same profile. Br J Pharmacol. 2015;172:532-48 pubmed publisher
Andersen S, Baar C, Fladvad T, Laugsand E, Skorpen F. The N-terminally truncated µ3 and µ3-like opioid receptors are transcribed from a novel promoter upstream of exon 2 in the human OPRM1 gene. PLoS ONE. 2013;8:e71024 pubmed publisher
Nockemann D, Rouault M, Labuz D, Hublitz P, McKnelly K, Reis F, et al. The K(+) channel GIRK2 is both necessary and sufficient for peripheral opioid-mediated analgesia. EMBO Mol Med. 2013;5:1263-77 pubmed publisher
Morse M, Sun H, Tran E, Levenson R, Fang Y. Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family. BMC Pharmacol Toxicol. 2013;14:17 pubmed publisher
Charbaji N, Schäfer Korting M, Küchler S. Morphine stimulates cell migration of oral epithelial cells by delta-opioid receptor activation. PLoS ONE. 2012;7:e42616 pubmed publisher
Morse M, Tran E, Sun H, Levenson R, Fang Y. Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target. PLoS ONE. 2011;6:e25643 pubmed publisher
Cheng Y, Tao Y, Sun J, Wang Y, Xu X, Chen J, et al. Adenosine A(1) receptor agonist N(6)-cyclohexyl-adenosine induced phosphorylation of delta opioid receptor and desensitization of its signaling. Acta Pharmacol Sin. 2010;31:784-90 pubmed publisher
Archer Lahlou E, Audet N, Amraei M, Huard K, Paquin Gobeil M, Pineyro G. Src promotes delta opioid receptor (DOR) desensitization by interfering with receptor recycling. J Cell Mol Med. 2009;13:147-63 pubmed publisher
Parenty G, Appelbe S, Milligan G. CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2-DOP receptor heterodimer. Biochem J. 2008;412:245-56 pubmed publisher
Ankö M, Panula P. Functional modulation of human delta opioid receptor by neuropeptide FF. BMC Neurosci. 2005;6:21 pubmed
Gharagozlou P, Demirci H, Clark J, Lameh J. Activation profiles of opioid ligands in HEK cells expressing delta opioid receptors. BMC Neurosci. 2002;3:19 pubmed
Witt K, Huber J, Egleton R, Roberts M, Bentley M, Guo L, et al. Pharmacodynamic and pharmacokinetic characterization of poly(ethylene glycol) conjugation to met-enkephalin analog [D-Pen2, D-Pen5]-enkephalin (DPDPE). J Pharmacol Exp Ther. 2001;298:848-56 pubmed
Gao B, Hagenbuch B, Kullak Ublick G, Benke D, Aguzzi A, Meier P. Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier. J Pharmacol Exp Ther. 2000;294:73-9 pubmed
Piros E, Charles R, Song L, Evans C, Hales T. Cloned delta-opioid receptors in GH(3) cells inhibit spontaneous Ca(2+) oscillations and prolactin release through K(IR) channel activation. J Neurophysiol. 2000;83:2691-8 pubmed
Allouche S, Hasbi A, Ferey V, Sola B, Jauzac P, Polastron J. Pharmacological delta1- and delta2-opioid receptor subtypes in the human neuroblastoma cell line SK-N-BE: no evidence for distinct molecular entities. Biochem Pharmacol. 2000;59:915-25 pubmed
Jewett D, Mosberg H, Woods J. Discriminative stimulus effects of a centrally administered, delta-opioid peptide (D-Pen2-D-Pen5-enkephalin) in pigeons. Psychopharmacology (Berl). 1996;127:225-30 pubmed
Devine D, Wise R. Self-administration of morphine, DAMGO, and DPDPE into the ventral tegmental area of rats. J Neurosci. 1994;14:1978-84 pubmed
Akiyama K, Gee K, Mosberg H, Hruby V, Yamamura H. Characterization of [3H][2-D-penicillamine, 5-D-penicillamine]-enkephalin binding to delta opiate receptors in the rat brain and neuroblastoma--glioma hybrid cell line (NG 108-15). Proc Natl Acad Sci U S A. 1985;82:2543-7 pubmed
Portoghese P, Sultana M, Takemori A. Naltrindole 5'-isothiocyanate: a nonequilibrium, highly selective delta opioid receptor antagonist. J Med Chem. 1990;33:1547-8 pubmed
product information
Catalog Number :
E3888
Product Name :
[D-Pen 2,5 ]-Enkephalin hydrate
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
≥95% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA