This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
protein
product name :
Epoxomicin
catalog :
E3652
citations: 24
Reference
Bernatik O, Paclíková P, Sri Ganji R, Bryja V. Activity of Smurf2 Ubiquitin Ligase Is Regulated by the Wnt Pathway Protein Dishevelled. Cells. 2020;9: pubmed publisher
Kon E, Calvo Jiménez E, Cossard A, Na Y, Cooper J, Jossin Y. N-cadherin-regulated FGFR ubiquitination and degradation control mammalian neocortical projection neuron migration. elife. 2019;8: pubmed publisher
Zmuda F, Sastry L, Shepherd S, Jones D, Scott A, Craggs P, et al. Identification of Novel Trypanosoma cruzi Proteasome Inhibitors Using a Luminescence-Based High-Throughput Screening Assay. Antimicrob Agents Chemother. 2019;63: pubmed publisher
Chiramel A, Meyerson N, McNally K, Broeckel R, Montoya V, Méndez Solís O, et al. TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation. Cell Rep. 2019;27:3269-3283.e6 pubmed publisher
Fujimaki M, Furuya N, Saiki S, Amo T, Imamichi Y, Hattori N. Iron supply via NCOA4-mediated ferritin degradation maintains mitochondrial functions. Mol Cell Biol. 2019;: pubmed publisher
Beauvarlet J, Bensadoun P, Darbo E, Labrunie G, Rousseau B, Richard E, et al. Modulation of the ATM/autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells. Nucleic Acids Res. 2019;47:2739-2756 pubmed publisher
Schultz M, Krus K, Kaushik S, Dang D, Chopra R, Qi L, et al. Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD. Nat Commun. 2018;9:3671 pubmed publisher
Li C, Zhang Y, Cheng X, Yuan H, Zhu S, Liu J, et al. PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism. Dev Cell. 2018;46:441-455.e8 pubmed publisher
Nath S, Yu Z, Gipson T, Marsh G, Yoshidome E, Robins D, et al. Androgen receptor polyglutamine expansion drives age-dependent quality control defects and muscle dysfunction. J Clin Invest. 2018;128:3630-3641 pubmed publisher
Carnemolla A, Michelazzi S, Agostoni E. PIN1 Modulates Huntingtin Levels and Aggregate Accumulation: An In vitro Model. Front Cell Neurosci. 2017;11:121 pubmed publisher
Pomatto L, Wong S, Carney C, Shen B, Tower J, Davies K. The age- and sex-specific decline of the 20s proteasome and the Nrf2/CncC signal transduction pathway in adaption and resistance to oxidative stress in Drosophila melanogaster. Aging (Albany NY). 2017;9:1153-1185 pubmed publisher
Kitagawa M, Shiozaki A, Ichikawa D, Nakashima S, Kosuga T, Konishi H, et al. Tumor necrosis factor-α-induced apoptosis of gastric cancer MKN28 cells: accelerated degradation of the inhibitor of apoptosis family members. Arch Biochem Biophys. 2015;566:43-8 pubmed publisher
De Rasmo D, Signorile A, Santeramo A, Larizza M, Lattanzio P, Capitanio G, et al. Intramitochondrial adenylyl cyclase controls the turnover of nuclear-encoded subunits and activity of mammalian complex I of the respiratory chain. Biochim Biophys Acta. 2015;1853:183-91 pubmed publisher
Ito M, Hayashi K, Adachi E, Minamisawa T, Homma S, Koido S, et al. Combinatorial contextualization of peptidic epitopes for enhanced cellular immunity. PLoS ONE. 2014;9:e110425 pubmed publisher
Smuder A, Nelson W, Hudson M, Kavazis A, Powers S. Inhibition of the ubiquitin-proteasome pathway does not protect against ventilator-induced accelerated proteolysis or atrophy in the diaphragm. Anesthesiology. 2014;121:115-26 pubmed publisher
Hofmeister Brix A, Lenzen S, Baltrusch S. The ubiquitin-proteasome system regulates the stability and activity of the glucose sensor glucokinase in pancreatic β-cells. Biochem J. 2013;456:173-84 pubmed publisher
Kim K, Crews C. From epoxomicin to carfilzomib: chemistry, biology, and medical outcomes. Nat Prod Rep. 2013;30:600-4 pubmed publisher
Yu X, Ajayi A, Boga N, Strom A. Differential degradation of full-length and cleaved ataxin-7 fragments in a novel stable inducible SCA7 model. J Mol Neurosci. 2012;47:219-33 pubmed publisher
Mandriota S, Buser R, Lesne L, Stouder C, Favaudon V, Maechler P, et al. Ataxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cells. J Biol Chem. 2010;285:13092-106 pubmed publisher
Czesny B, Goshu S, Cook J, Williamson K. The proteasome inhibitor epoxomicin has potent Plasmodium falciparum gametocytocidal activity. Antimicrob Agents Chemother. 2009;53:4080-5 pubmed publisher
Percherancier Y, Germain Desprez D, Galisson F, Mascle X, Dianoux L, Estephan P, et al. Role of SUMO in RNF4-mediated promyelocytic leukemia protein (PML) degradation: sumoylation of PML and phospho-switch control of its SUMO binding domain dissected in living cells. J Biol Chem. 2009;284:16595-608 pubmed publisher
Princiotta M, Schubert U, Chen W, Bennink J, Myung J, Crews C, et al. Cells adapted to the proteasome inhibitor 4-hydroxy- 5-iodo-3-nitrophenylacetyl-Leu-Leu-leucinal-vinyl sulfone require enzymatically active proteasomes for continued survival. Proc Natl Acad Sci U S A. 2001;98:513-8 pubmed
Schwarz K, de Giuli R, Schmidtke G, Kostka S, van Den Broek M, Kim K, et al. The selective proteasome inhibitors lactacystin and epoxomicin can be used to either up- or down-regulate antigen presentation at nontoxic doses. J Immunol. 2000;164:6147-57 pubmed
Meng L, Mohan R, Kwok B, Elofsson M, Sin N, Crews C. Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity. Proc Natl Acad Sci U S A. 1999;96:10403-8 pubmed
product information
Catalog Number :
E3652
Product Name :
Epoxomicin
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
≥95% (HPLC), solid
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA