This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
β-Estradiol 3-(β-D-glucuronide) sodium salt
catalog :
E2127
citations: 25
Reference
Shrestha S, Casey F, Hakk H, Smith D, Padmanabhan G. Fate and transformation of an estrogen conjugate and its metabolites in agricultural soils. Environ Sci Technol. 2012;46:11047-53 pubmed publisher
Sato Y, Nagata M, Kawamura A, Miyashita A, Usui T. Protein quantification of UDP-glucuronosyltransferases 1A1 and 2B7 in human liver microsomes by LC-MS/MS and correlation with glucuronidation activities. Xenobiotica. 2012;42:823-9 pubmed publisher
Megaraj V, Zhao T, Paumi C, Gerk P, Kim R, Vore M. Functional analysis of nonsynonymous single nucleotide polymorphisms of multidrug resistance-associated protein 2 (ABCC2). Pharmacogenet Genomics. 2011;21:506-15 pubmed publisher
Zhou J, Tracy T, Remmel R. Correlation between bilirubin glucuronidation and estradiol-3-gluronidation in the presence of model UDP-glucuronosyltransferase 1A1 substrates/inhibitors. Drug Metab Dispos. 2011;39:322-9 pubmed publisher
Mohamed M, Tseng T, Frye R. Inhibitory effects of commonly used herbal extracts on UGT1A1 enzyme activity. Xenobiotica. 2010;40:663-9 pubmed publisher
Kobayashi K, Ito K, Takada T, Sugiyama Y, Suzuki H. Functional analysis of nonsynonymous single nucleotide polymorphism type ATP-binding cassette transmembrane transporter subfamily C member 3. Pharmacogenet Genomics. 2008;18:823-33 pubmed publisher
Antonilli L, Brusadin V, Milella M, Sobrero F, Badiani A, Nencini P. In vivo chronic exposure to heroin or naltrexone selectively inhibits liver microsome formation of estradiol-3-glucuronide in the rat. Biochem Pharmacol. 2008;76:672-9 pubmed publisher
O Connor K, Brindle E, Shofer J, Miller R, Klein N, Soules M, et al. Statistical correction for non-parallelism in a urinary enzyme immunoassay. J Immunoassay Immunochem. 2004;25:259-78 pubmed
Gerk P, Li W, Vore M. Estradiol 3-glucuronide is transported by the multidrug resistance-associated protein 2 but does not activate the allosteric site bound by estradiol 17-glucuronide. Drug Metab Dispos. 2004;32:1139-45 pubmed
Tohyama O, Imura A, Iwano A, Freund J, Henrissat B, Fujimori T, et al. Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides. J Biol Chem. 2004;279:9777-84 pubmed
Mottino A, Veggi L, Wood M, Román J, Vore M. Biliary secretion of glutathione in estradiol 17beta-D-glucuronide-induced cholestasis. J Pharmacol Exp Ther. 2003;307:306-13 pubmed
O Connor K, Brindle E, Holman D, Klein N, Soules M, Campbell K, et al. Urinary estrone conjugate and pregnanediol 3-glucuronide enzyme immunoassays for population research. Clin Chem. 2003;49:1139-48 pubmed
Soars M, Ring B, Wrighton S. The effect of incubation conditions on the enzyme kinetics of udp-glucuronosyltransferases. Drug Metab Dispos. 2003;31:762-7 pubmed
Tabas L, Dantzig A. A high-throughput assay for measurement of multidrug resistance protein-mediated transport of leukotriene C4 into membrane vesicles. Anal Biochem. 2002;310:61-6 pubmed
Fisher M, VandenBranden M, Findlay K, Burchell B, Thummel K, Hall S, et al. Tissue distribution and interindividual variation in human UDP-glucuronosyltransferase activity: relationship between UGT1A1 promoter genotype and variability in a liver bank. Pharmacogenetics. 2000;10:727-39 pubmed
Panter G, Thompson R, Beresford N, Sumpter J. Transformation of a non-oestrogenic steroid metabolite to an oestrogenically active substance by minimal bacterial activity. Chemosphere. 1999;38:3579-96 pubmed
Freundl G, Bonnar J, Flynn A, Frank Herrmann P, Kirkmann R, Snowden R. [Contraception per computer. Hormone system persona--results of studies in Germany]. Fortschr Med. 1998;116:47-8 pubmed
Kanai N, Lu R, Bao Y, Wolkoff A, Vore M, Schuster V. Estradiol 17 beta-D-glucuronide is a high-affinity substrate for oatp organic anion transporter. Am J Physiol. 1996;270:F326-31 pubmed
Zhu B, Evaristus E, Antoniak S, Sarabia S, Ricci M, Liehr J. Metabolic deglucuronidation and demethylation of estrogen conjugates as a source of parent estrogens and catecholestrogen metabolites in Syrian hamster kidney, a target organ of estrogen-induced tumorigenesis. Toxicol Appl Pharmacol. 1996;136:186-93 pubmed
Ruoff W, Dziuk P. Absorption and metabolism of estrogens from the stomach and duodenum of pigs. Domest Anim Endocrinol. 1994;11:197-208 pubmed
Connors S, Vore M. Coregulation of C3-hydroxyl versus C17-hydroxyl glucuronidation of beta-estradiol in pregnancy and after treatment with phenobarbital or ethinyl-estradiol. J Pharmacol Exp Ther. 1988;246:54-9 pubmed
Rae M, Mole P, Paterson C. Evaluation of urinary oestrogen assays after the menopause and their potential for screening. Clin Chim Acta. 1988;176:71-81 pubmed
Kan K, Monte M, Parslow R, Coleman R. Oestradiol 17 beta-glucuronide increases tight-junctional permeability in rat liver. Biochem J. 1989;261:297-300 pubmed
Changchit A, Durham S, Vore M. Characterization of [3H]estradiol-17 beta-(beta-D-glucuronide) binding sites in basolateral and canalicular liver plasma membranes. Biochem Pharmacol. 1990;40:1219-25 pubmed
Abernathy C, Zimmerman H, Ishak K, Utili R, Gillespie J. Drug-induced cholestasis in the perfused rat liver and its reversal by tauroursodeoxycholate: an ultrastructural study. Proc Soc Exp Biol Med. 1992;199:54-8 pubmed
product information
Catalog Number :
E2127
Product Name :
β-Estradiol 3-(β-D-glucuronide) sodium salt
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA