This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
protein
product name :
Elastase from porcine pancreas
catalog :
E0258
citations: 72
Reference
Komaravolu R, Waltmann M, Konaniah E, Jaeschke A, Hui D. ApoER2 (Apolipoprotein E Receptor-2) Deficiency Accelerates Smooth Muscle Cell Senescence via Cytokinesis Impairment and Promotes Fibrotic Neointima After Vascular Injury. Arterioscler Thromb Vasc Biol. 2019;39:2132-2144 pubmed publisher
Zhang Z, Tremblay J, Raelson J, Sofer T, Du L, Fang Q, et al. EPHA4 regulates vascular smooth muscle cell contractility and is a sex-specific hypertension risk gene in individuals with type 2 diabetes. J Hypertens. 2019;37:775-789 pubmed publisher
Matsuyama S, Shirato K, Kawase M, Terada Y, Kawachi K, Fukushi S, et al. Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not Activated Directly by Cellular Furin during Viral Entry into Target Cells. J Virol. 2018;92: pubmed publisher
Cui X, Luan J, Dong K, Chen S, Wang Y, Watford W, et al. RGC-32 (Response Gene to Complement 32) Deficiency Protects Endothelial Cells From Inflammation and Attenuates Atherosclerosis. Arterioscler Thromb Vasc Biol. 2018;38:e36-e47 pubmed publisher
Lall N, Kishore N, Fibrich B, Lambrechts I. In vitro and In vivo Activity of Myrsine africana on Elastase Inhibition and Anti-wrinkle Activity. Pharmacogn Mag. 2017;13:583-589 pubmed publisher
Spoof L, Błaszczyk A, Meriluoto J, Cegłowska M, Mazur Marzec H. Structures and Activity of New Anabaenopeptins Produced by Baltic Sea Cyanobacteria. Mar Drugs. 2015;14:8 pubmed publisher
Varbanets L, Matseliukh O, Avdiiuk K, Hudzenko O, Nidialkova N, Romanovs ka V, et al. [Hydrolytic activity of microorganisms of the Dead Sea coastal ecosystems]. Mikrobiol Z. 2014;76:16-20 pubmed
Weber H, Jonas L, Wakileh M, Krüger B. Beneficial effect of the bioflavonoid quercetin on cholecystokinin-induced mitochondrial dysfunction in isolated rat pancreatic acinar cells. Can J Physiol Pharmacol. 2014;92:215-25 pubmed publisher
Shang T, Liu Z, Liu C. Antioxidant Vitamin C attenuates experimental abdominal aortic aneurysm development in an elastase-induced rat model. J Surg Res. 2014;188:316-25 pubmed publisher
Shang T, Ran F, Qiao Q, Liu Z, Liu C. Tanshinone IIA attenuates elastase-induced AAA in rats via inhibition of MyD88-dependent TLR-4 signaling. Vasa. 2014;43:39-46 pubmed publisher
Szabo A, Radisky E, Sahin Toth M. Zymogen activation confers thermodynamic stability on a key peptide bond and protects human cationic trypsin from degradation. J Biol Chem. 2014;289:4753-61 pubmed publisher
Nguyen P, Lewis J, Sneyd J, Lee R, Torpy D, Shorten P. Development of a formula for estimating plasma free cortisol concentration from a measured total cortisol concentration when elastase-cleaved and intact corticosteroid binding globulin coexist. J Steroid Biochem Mol Biol. 2014;141:16-25 pubmed publisher
Tada Y, Wada K, Shimada K, Makino H, Liang E, Murakami S, et al. Roles of hypertension in the rupture of intracranial aneurysms. Stroke. 2014;45:579-86 pubmed publisher
Zhang J, Jiang R, Wang W, Takayama H, Tanaka Y. Apoptosis are induced in J774 macrophages upon phagocytosis and killing of Pseudomonas aeruginosa. Cell Immunol. 2013;286:11-5 pubmed publisher
Bian Y, Wang L, Chen C, Lu J, Fan J, Chen S, et al. Quantification of pancreatic exocrine function of chronic pancreatitis with secretin-enhanced MRCP. World J Gastroenterol. 2013;19:7177-82 pubmed publisher
Zhou H, Yan H, Bertram P, Hu Y, Springer L, Thompson R, et al. Fibrinogen-specific antibody induces abdominal aortic aneurysm in mice through complement lectin pathway activation. Proc Natl Acad Sci U S A. 2013;110:E4335-44 pubmed publisher
Du X, Chen N, Wong A, Craik C, Bromme D. Elastin degradation by cathepsin V requires two exosites. J Biol Chem. 2013;288:34871-81 pubmed publisher
Reina E, Ramos F, Castellanos L, Aragón M, Ospina L. Anti-inflammatory R-prostaglandins from Caribbean Colombian soft coral Plexaura homomalla. J Pharm Pharmacol. 2013;65:1643-52 pubmed publisher
Takai S, Jin D, Yamamoto D, Li Z, Otsuki Y, Miyazaki M. Significance of matrix metalloproteinase-9 inhibition by imidapril for prevention of abdominal aortic aneurysms in angiotensin II type 1 receptor-knockout mice. J Pharmacol Sci. 2013;123:185-94 pubmed
Jha S, Sanyal I, Amla D. Single amino acid substitutions in recombinant plant-derived human α1-proteinase inhibitor confer enhanced stability and functional efficacy. Biochim Biophys Acta. 2014;1840:416-27 pubmed publisher
Ruffell B, Affara N, Cottone L, Junankar S, Johansson M, DeNardo D, et al. Cathepsin C is a tissue-specific regulator of squamous carcinogenesis. Genes Dev. 2013;27:2086-98 pubmed publisher
Shin H, Kim J, Park J, Yoon D. Can we predict postoperative pancreatic leakage after pancreaticoduodenectomy using preoperative fecal elastase-1 level?. J Clin Lab Anal. 2013;27:379-83 pubmed publisher
Shirato K, Kawase M, Matsuyama S. Middle East respiratory syndrome coronavirus infection mediated by the transmembrane serine protease TMPRSS2. J Virol. 2013;87:12552-61 pubmed publisher
Lin M, Chen B, Huang C, Dai C, Hwang T, Sheu J. Eunicellin-based diterpenoids from the Formosan soft coral Klyxum molle with inhibitory activity on superoxide generation and elastase release by neutrophils. J Nat Prod. 2013;76:1661-7 pubmed publisher
Hou H, Cheng S, Liu H, Yang F, Wang H, Yu C. Elastase induced lung epithelial cell apoptosis and emphysema through placenta growth factor. Cell Death Dis. 2013;4:e793 pubmed publisher
Tan S, Chua S, Chen Y, Rice S, Kjelleberg S, Nielsen T, et al. Identification of five structurally unrelated quorum-sensing inhibitors of Pseudomonas aeruginosa from a natural-derivative database. Antimicrob Agents Chemother. 2013;57:5629-41 pubmed publisher
Qasim M, Wang L, Qasim S, Lu S, Lu W, Wynn R, et al. Additivity-based design of the strongest possible turkey ovomucoid third domain inhibitors for porcine pancreatic elastase (PPE) and Streptomyces griseus protease B (SGPB). FEBS Lett. 2013;587:3021-6 pubmed publisher
Lee C, Hwang T, He W, Tsai Y, Yen C, Yen H, et al. Anti-neutrophilic inflammatory steroidal glycosides from Solanum torvum. Phytochemistry. 2013;95:315-21 pubmed publisher
Deckert V, Kretz B, Habbout A, Raghay K, Labbé J, Abello N, et al. Development of abdominal aortic aneurysm is decreased in mice with plasma phospholipid transfer protein deficiency. Am J Pathol. 2013;183:975-86 pubmed publisher
Kobayashi S, Fujinawa R, Ota F, Kobayashi S, Angata T, Ueno M, et al. A single dose of lipopolysaccharide into mice with emphysema mimics human chronic obstructive pulmonary disease exacerbation as assessed by micro-computed tomography. Am J Respir Cell Mol Biol. 2013;49:971-7 pubmed publisher
Nordin S, Jovic S, Kurut A, Andersson C, Gela A, Bjartell A, et al. High expression of midkine in the airways of patients with cystic fibrosis. Am J Respir Cell Mol Biol. 2013;49:935-42 pubmed publisher
Vallejo M, Niemeyer G, Vaglenov A, Hock T, Urie B, Christopherson P, et al. Decreased hematopoietic progenitor cell mobilization in pearl mice. Exp Hematol. 2013;41:848-57 pubmed publisher
Yoshida T, Matsuwaki Y, Asaka D, Hama T, Otori N, Moriyama H. The expression of protease-activated receptors in chronic rhinosinusitis. Int Arch Allergy Immunol. 2013;161 Suppl 2:138-46 pubmed publisher
Dogru D, Pekcan S, Yalcin E, Ozcelik U, Kiper N, Gurcan N, et al. The role of serum Pseudomonas aeruginosa antibodies in the diagnosis and follow-up of cystic fibrosis. Turk J Pediatr. 2013;55:50-7 pubmed
Zhou H, Yan H, Cannon J, Springer L, Green J, Pham C. CD43-mediated IFN-? production by CD8+ T cells promotes abdominal aortic aneurysm in mice. J Immunol. 2013;190:5078-85 pubmed publisher
Urazovskaia E, Mikashinovich Z. [The blood biochemical indicators as possible markers of destruction of kerato-hyaline tissue of nails in patients with onycholysis]. Klin Lab Diagn. 2012;:8-10 pubmed
Batra J, Szabo A, Caulfield T, Soares A, Sahin Toth M, Radisky E. Long-range electrostatic complementarity governs substrate recognition by human chymotrypsin C, a key regulator of digestive enzyme activation. J Biol Chem. 2013;288:9848-59 pubmed publisher
Titarenko O, D iakova M, Esmedliaeva D, Pavlova M, El kin A, Alekseeva N, et al. [Peculiarities of the circulating phagocytes functional activity in patients with different forms of drug-resistant pulmonary tuberculosis]. Biomed Khim. 2012;58:467-74 pubmed
Matseliukh O, Nidialkova N, Varbanets L. [Purification and physicochemical properties of Bacillus thuringiensis IMB B-7324 peptidase with elastolytic and fibrinolytic activity]. Ukr Biokhim Zh (1999). 2012;84:25-36 pubmed
Esther C, Olsen B, Lin F, Fine J, Boucher R. Exhaled breath condensate adenosine tracks lung function changes in cystic fibrosis. Am J Physiol Lung Cell Mol Physiol. 2013;304:L504-9 pubmed publisher
Salvador L, Taori K, Biggs J, Jakoncic J, Ostrov D, Paul V, et al. Potent elastase inhibitors from cyanobacteria: structural basis and mechanisms mediating cytoprotective and anti-inflammatory effects in bronchial epithelial cells. J Med Chem. 2013;56:1276-90 pubmed publisher
Kuo P, Yang M, Hwang T, Lai Y, Li Y, Thang T, et al. Anti-inflammatory diterpenoids from Croton tonkinensis. J Nat Prod. 2013;76:230-6 pubmed publisher
Kurimoto E, Miyahara N, Kanehiro A, Waseda K, Taniguchi A, Ikeda G, et al. IL-17A is essential to the development of elastase-induced pulmonary inflammation and emphysema in mice. Respir Res. 2013;14:5 pubmed publisher
Wan H, Lee K, Kim B, Zou F, Yoon H, Je Y, et al. A spider-derived Kunitz-type serine protease inhibitor that acts as a plasmin inhibitor and an elastase inhibitor. PLoS ONE. 2013;8:e53343 pubmed publisher
Engels G, Gu Y, van Oeveren W, Rakhorst G, Mariani M, Erasmus M. The utility of lung epithelium specific biomarkers in cardiac surgery: a comparison of biomarker profiles in on- and off-pump coronary bypass surgery. J Cardiothorac Surg. 2013;8:4 pubmed publisher
Thornton P, Reduwan Billah S, Cameron N. Enzyme-degradable self-assembled hydrogels from polyalanine-modified poly(ethylene glycol) star polymers. Macromol Rapid Commun. 2013;34:257-62 pubmed publisher
Iida Y, Xu B, Xuan H, Glover K, Tanaka H, Hu X, et al. Peptide inhibitor of CXCL4-CCL5 heterodimer formation, MKEY, inhibits experimental aortic aneurysm initiation and progression. Arterioscler Thromb Vasc Biol. 2013;33:718-26 pubmed publisher
Johnston W, Salmon M, Su G, Lu G, Stone M, Zhao Y, et al. Genetic and pharmacologic disruption of interleukin-1β signaling inhibits experimental aortic aneurysm formation. Arterioscler Thromb Vasc Biol. 2013;33:294-304 pubmed publisher
Bi Y, Zhong H, Xu K, Ni Y, Qi X, Zhang Z, et al. Performance of a modified rabbit model of abdominal aortic aneurysm induced by topical application of porcine elastase: 5-month follow-up study. Eur J Vasc Endovasc Surg. 2013;45:145-52 pubmed publisher
Cockerill G. Commentary on 'Performance of a modified rabbit model of abdominal aortic aneurysm induced by topical application of porcine elastase: 5-month follow-up study'. Eur J Vasc Endovasc Surg. 2013;45:153 pubmed publisher
Lopes F, Toledo A, Olivo C, Prado C, Leick E, Medeiros M, et al. A comparative study of extracellular matrix remodeling in two murine models of emphysema. Histol Histopathol. 2013;28:269-76 pubmed publisher
Chi H, Chen H, He K, Wu L, Yang B, Sun R, et al. pNovo+: de novo peptide sequencing using complementary HCD and ETD tandem mass spectra. J Proteome Res. 2013;12:615-25 pubmed publisher
O Sullivan B, Baker D, Leung K, Reed G, Baker S, Borowitz D. Evolution of pancreatic function during the first year in infants with cystic fibrosis. J Pediatr. 2013;162:808-812.e1 pubmed publisher
Chicooree N, Griffiths J, Connolly Y, Tan C, Malliri A, Eyers C, et al. A novel approach to the analysis of SUMOylation with the independent use of trypsin and elastase digestion followed by database searching utilising consecutive residue addition to lysine. Rapid Commun Mass Spectrom. 2013;27:127-34 pubmed publisher
Parlee S, McNeil J, Muruganandan S, Sinal C, Goralski K. Elastase and tryptase govern TNF?-mediated production of active chemerin by adipocytes. PLoS ONE. 2012;7:e51072 pubmed publisher
Terryn C, Sellami M, Fichel C, Diebold M, Gangloff S, Le Naour R, et al. Rapid method of quantification of tight-junction organization using image analysis. Cytometry A. 2013;83:235-41 pubmed publisher
Barros S, Martins J, Marcos J, Cavaco Paulo A. Influence of secretory leukocyte protease inhibitor-based peptides on elastase activity and their incorporation in hyaluronic acid hydrogels for chronic wound therapy. Biopolymers. 2012;98:576-90 pubmed publisher
Bagchi S, Ghosh S. Partial Purification and Characterization of an Elastase-inhibitory Lipid Derivative from a Cyanobacterium, Microcystis Ku2. Indian J Microbiol. 2011;51:496-500 pubmed
Belouzard S, MADU I, Whittaker G. Elastase-mediated activation of the severe acute respiratory syndrome coronavirus spike protein at discrete sites within the S2 domain. J Biol Chem. 2010;285:22758-63 pubmed publisher
Michalek A, Buckley M, Bonassar L, COHEN I, Iatridis J. Measurement of local strains in intervertebral disc anulus fibrosus tissue under dynamic shear: contributions of matrix fiber orientation and elastin content. J Biomech. 2009;42:2279-85 pubmed publisher
Hanczko R, Fernandez D, Doherty E, Qian Y, Vas G, Niland B, et al. Prevention of hepatocarcinogenesis and increased susceptibility to acetaminophen-induced liver failure in transaldolase-deficient mice by N-acetylcysteine. J Clin Invest. 2009;119:1546-57 pubmed publisher
Nichol J, Khan A, Birbach M, Gaynor J, Gooch K. Hemodynamics and axial strain additively increase matrix remodeling and MMP-9, but not MMP-2, expression in arteries engineered by directed remodeling. Tissue Eng Part A. 2009;15:1281-90 pubmed publisher
Cesar L, Miskolczi L, Lieber B, Sadasivan C, Gounis M, Wakhloo A. Neurological deficits associated with the elastase-induced aneurysm model in rabbits. Neurol Res. 2009;31:414-9 pubmed publisher
Johns D, Wong M, Athanasiou K. Clinically relevant cell sources for TMJ disc engineering. J Dent Res. 2008;87:548-52 pubmed
Tomomura A, Tomomura M, Fukushige T, Akiyama M, Kubota N, Kumaki K, et al. Molecular cloning and expression of serum calcium-decreasing factor (caldecrin). J Biol Chem. 1995;270:30315-21 pubmed
Bolognesi M, Djinovic Carugo K, Ascenzi P. Molecular bases for human leucocyte elastase inhibition. Monaldi Arch Chest Dis. 1994;49:144-9 pubmed
Rugani N, Carriere F, Thim L, Borgstrom B, Sarda L. Lipid binding and activating properties of porcine pancreatic colipase split at the Ile79-Thr80 bond. Biochim Biophys Acta. 1995;1247:185-94 pubmed
Harper J, Cook R, Roberts C, Mclaughlin B, Powers J. Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II. Bovine chymotrypsin A alpha, and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester su. Biochemistry. 1984;23:2995-3002 pubmed
Kawashima I, Tani T, Shimoda K, Takiguchi Y. Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas. DNA. 1987;6:163-72 pubmed
Davies K, Lin S, Pacifici R. Protein damage and degradation by oxygen radicals. IV. Degradation of denatured protein. J Biol Chem. 1987;262:9914-20 pubmed
Bieth J, Dirrig S, Jung M, Boudier C, Papamichael E, Sakarellos C, et al. Investigation of the active center of rat pancreatic elastase. Biochim Biophys Acta. 1989;994:64-74 pubmed
Bode W, Meyer E, Powers J. Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors. Biochemistry. 1989;28:1951-63 pubmed
product information
Catalog Number :
E0258
Product Name :
Elastase from porcine pancreas
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
Type IV, Protein 50-90 %, lyophilized powder, ?4.0 units/mg protein (biuret)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA