This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Paraoxon-ethyl
catalog :
D9286
citations: 80
Reference
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Motovali Bashi M, Sedaghat S, Dehghanian F. Association between Serum Paraoxonase 1 Activities (PONase/AREase) and L55M Polymorphism in Risk of Female Infertility. Avicenna J Med Biotechnol. 2015;7:173-8 pubmed
Black L, Srivastava R, Schoeb T, Moore R, Barnes S, KABAROWSKI J. Cholesterol-Independent Suppression of Lymphocyte Activation, Autoimmunity, and Glomerulonephritis by Apolipoprotein A-I in Normocholesterolemic Lupus-Prone Mice. J Immunol. 2015;195:4685-98 pubmed publisher
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Ciumărnean L, Dronca E, Vesa Å, Sâmpelean D, Buzoianu A, AchimaÅŸ Cadariu A. Paraoxonase 1 genotype-phenotype correlation in patients with metabolic syndrome. Rom J Morphol Embryol. 2015;56:387-92 pubmed
Angelini D, Moyer R, Cole S, Willis K, Oyler J, Dorsey R, et al. The Pesticide Metabolites Paraoxon and Malaoxon Induce Cellular Death by Different Mechanisms in Cultured Human Pulmonary Cells. Int J Toxicol. 2015;34:433-41 pubmed publisher
Yin L, Meng X, Zhou X, Zhang T, Sun H, Yang Z, et al. Simultaneous determination of carboprost methylate and its active metabolite carboprost in dog plasma by liquid chromatography-tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application to a pharmacokine. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;998-999:8-14 pubmed publisher
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Zunec S, Radic B, Kuca K, Musilek K, Lucić Vrdoljak A. Comparative determination of the efficacy of bispyridinium oximes in paraoxon poisoning. Arh Hig Rada Toksikol. 2015;66:129-34 pubmed publisher
Tokudome Y, Katayanagi M, Hashimoto F. Esterase Activity and Intracellular Localization in Reconstructed Human Epidermal Cultured Skin Models. Ann Dermatol. 2015;27:269-74 pubmed publisher
Scherrer D, Zago V, Parra E, Avansini S, Panzoldo N, Alexandre F, et al. Asymptomatic individuals with high HDL-C levels overexpress ABCA1 and ABCG1 and present miR-33a dysregulation in peripheral blood mononuclear cells. Gene. 2015;570:50-6 pubmed publisher
Azab H, Khairy G, Kamel R. Time-resolved fluorescence sensing of pesticides chlorpyrifos, crotoxyphos and endosulfan by the luminescent Eu(III)-8-allyl-3-carboxycoumarin probe. Spectrochim Acta A Mol Biomol Spectrosc. 2015;148:114-24 pubmed publisher
Tiniakou I, Drakos E, Sinatkas V, Van Eck M, Zannis V, Boumpas D, et al. High-density lipoprotein attenuates Th1 and th17 autoimmune responses by modulating dendritic cell maturation and function. J Immunol. 2015;194:4676-87 pubmed publisher
Gugliucci A, Caccavello R, Nassar H, Abu Ahmad W, Sinnreich R, Kark J. Low protective PON1 lactonase activity in an Arab population with high rates of coronary heart disease and diabetes. Clin Chim Acta. 2015;445:41-7 pubmed publisher
Berríos V, Boukli N, Rodriguez J, Negraes P, Schwindt T, Trujillo C, et al. Paraoxon and Pyridostigmine Interfere with Neural Stem Cell Differentiation. Neurochem Res. 2015;40:2091-101 pubmed publisher
Demirtas S, Karahan O, Yazıcı S, Guclu O, Calıskan A, Tezcan O, et al. Investigation of possible prophylactic, renoprotective, and cardioprotective effects of thromboprophylactic drugs against ischemia-reperfusion injury. Kaohsiung J Med Sci. 2015;31:115-22 pubmed publisher
Zúñiga Venegas L, Aquea G, Taborda M, Bernal G, Pancetti F. Determination of the genotype and phenotype of serum paraoxonase 1 (PON1) status in a group of agricultural and nonagricultural workers in the Coquimbo Region, Chile. J Toxicol Environ Health A. 2015;78:357-68 pubmed publisher
Van den Eede N, Erratico C, Exarchou V, Maho W, Neels H, Covaci A. In vitro biotransformation of tris(2-butoxyethyl) phosphate (TBOEP) in human liver and serum. Toxicol Appl Pharmacol. 2015;284:246-53 pubmed publisher
Lőrincz H, Harangi M, Oláh A, Szabó G, Fülöp P, Somodi S, et al. Altered lipid subfraction profile and impaired antioxidant defense of high-density lipoprotein in Smith-Lemli-Opitz syndrome. Pediatr Res. 2015;77:703-9 pubmed publisher
Ruban A, Biton I, Markovich A, Mirelman D. MRS of brain metabolite levels demonstrates the ability of scavenging of excess brain glutamate to protect against nerve agent induced seizures. Int J Mol Sci. 2015;16:3226-36 pubmed publisher
Atasoy H, Güleç Yilmaz S, Ergen A, Görmüş U, Küçükhüseyin Ã, Dalan B, et al. Paraoxonase1 192 (PON1 192) gene polymorphism and serum paraoxonase activity in panic disorder patients. In Vivo. 2015;29:51-4 pubmed
Falahati Pour S, Lotfi A, Ahmadian G, Baghizadeh A. Covalent immobilization of recombinant organophosphorus hydrolase on spores of Bacillus subtilis. J Appl Microbiol. 2015;118:976-88 pubmed publisher
Salminen A, Åström P, Metso J, Soliymani R, Salo T, Jauhiainen M, et al. Matrix metalloproteinase 8 degrades apolipoprotein A-I and reduces its cholesterol efflux capacity. FASEB J. 2015;29:1435-45 pubmed publisher
Kumari R, Patel D, Panchal S, Jha R, Satyanarayana G, Asati A, et al. Fast agitated directly suspended droplet microextraction technique for the rapid analysis of eighteen organophosphorus pesticides in human blood. J Chromatogr A. 2015;1377:27-34 pubmed publisher
Türkeş C, Soyut H, Beydemir S. Human serum paraoxonase-1 (hPON1): in vitro inhibition effects of moxifloxacin hydrochloride, levofloxacin hemihidrate, cefepime hydrochloride, cefotaxime sodium and ceftizoxime sodium. J Enzyme Inhib Med Chem. 2015;30:622-8 pubmed publisher
Cervellati C, Romani A, Bergamini C, Bosi C, Sanz J, Passaro A, et al. PON-1 and ferroxidase activities in older patients with mild cognitive impairment, late onset Alzheimer's disease or vascular dementia. Clin Chem Lab Med. 2015;53:1049-56 pubmed publisher
Parra E, Panzoldo N, Zago V, Scherrer D, Alexandre F, Bakkarat J, et al. HDL size is more accurate than HDL cholesterol to predict carotid subclinical atherosclerosis in individuals classified as low cardiovascular risk. PLoS ONE. 2014;9:e114212 pubmed publisher
El Banna H, Jiman Fatani A. Anti-cyclic citrullinated peptide antibodies and paraoxonase-1 polymorphism in rheumatoid arthritis. BMC Musculoskelet Disord. 2014;15:379 pubmed publisher
Bar Klein G, Swissa E, Kamintsky L, Shekh Ahmad T, Saar Ashkenazy R, Hubary Y, et al. sec-Butyl-propylacetamide (SPD) and two of its stereoisomers rapidly terminate paraoxon-induced status epilepticus in rats. Epilepsia. 2014;55:1953-8 pubmed publisher
Thomsen R, Nielsen L, Holm N, Rasmussen H, Linnet K. Synthetic cannabimimetic agents metabolized by carboxylesterases. Drug Test Anal. 2015;7:565-76 pubmed publisher
Deshpande L, Phillips K, Huang B, Delorenzo R. Chronic behavioral and cognitive deficits in a rat survival model of paraoxon toxicity. Neurotoxicology. 2014;44:352-7 pubmed publisher
Hua X, Yin W, Shi H, Li M, Wang Y, Wang H, et al. Development of phage immuno-loop-mediated isothermal amplification assays for organophosphorus pesticides in agro-products. Anal Chem. 2014;86:8441-7 pubmed publisher
Bajaj P, Aggarwal G, Tripathy R, Pande A. Interplay between amino acid residues at positions 192 and 115 in modulating hydrolytic activities of human paraoxonase 1. Biochimie. 2014;105:202-10 pubmed publisher
Cohen E, Aviram M, Khatib S, Artoul F, Rabin A, Mannheim D, et al. Human carotid plaque phosphatidylcholine specifically interacts with paraoxonase 1, increases its activity, and enhances its uptake by macrophage at the expense of its binding to HDL. Free Radic Biol Med. 2014;76:14-24 pubmed publisher
Abe K, Yoshida S, Suzuki Y, Mori J, Doi Y, Takahashi S, et al. Haloalkylphosphorus hydrolases purified from Sphingomonas sp. strain TDK1 and Sphingobium sp. strain TCM1. Appl Environ Microbiol. 2014;80:5866-73 pubmed publisher
McDaniel C, Dail M, Wills R, Chambers H, Chambers J. Paraoxonase 1 polymorphisms within a Mississippi USA population as possible biomarkers of enzyme activities associated with disease susceptibility. Biochem Genet. 2014;52:509-23 pubmed publisher
Jasna J, Anandbabu K, Bharathi S, Angayarkanni N. Paraoxonase enzyme protects retinal pigment epithelium from chlorpyrifos insult. PLoS ONE. 2014;9:e101380 pubmed publisher
Liu T, Zhang X, Zhang J, Liang Z, Cai W, Huang M, et al. Association between PON1 rs662 polymorphism and coronary artery disease. Eur J Clin Nutr. 2014;68:1029-35 pubmed publisher
Shrot S, Ramaty E, Biala Y, Bar Klein G, Daninos M, Kamintsky L, et al. Prevention of organophosphate-induced chronic epilepsy by early benzodiazepine treatment. Toxicology. 2014;323:19-25 pubmed publisher
Sakai K, Igarashi M, Yamamuro D, Ohshiro T, Nagashima S, Takahashi M, et al. Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages. J Lipid Res. 2014;55:2033-40 pubmed publisher
Deshpande L, Carter D, Phillips K, Blair R, Delorenzo R. Development of status epilepticus, sustained calcium elevations and neuronal injury in a rat survival model of lethal paraoxon intoxication. Neurotoxicology. 2014;44:17-26 pubmed publisher
Campanha H, Carvalho F, Schlosser P. Active and peripheral anionic sites of acetylcholinesterase have differential modulation effects on cell proliferation, adhesion and neuritogenesis in the NG108-15 cell line. Toxicol Lett. 2014;230:122-31 pubmed publisher
Sayin M, Guler O. Purification of bovine serum paraoxonase and its immobilization on Eupergit C 250 L by covalent attachment. J Enzyme Inhib Med Chem. 2015;30:69-74 pubmed publisher
Durmaz T, Keles T, Ayhan H, Cay N, Bayram N, Bilen E, et al. Diminished serum paraoxonase activity in patients with coronary artery calcification. Kardiol Pol. 2014;72:831-8 pubmed publisher
Ondracek K, Bandouchova H, Damkova V, Hilscherova K, Kral J, Osickova J, et al. Risk of combined exposure of birds to cyanobacterial biomass containing microcystins, acetylcholinesterase inhibitor and anticoagulant. Neuro Endocrinol Lett. 2012;33 Suppl 3:155-60 pubmed
Dou D, Park J, Rana S, Madden B, Jiang H, Pang Y. Novel selective and irreversible mosquito acetylcholinesterase inhibitors for controlling malaria and other mosquito-borne diseases. Sci Rep. 2013;3:1068 pubmed publisher
Abramochkin D, Borodinova A, Rosenshtraukh L, Nikolsky E. Both neuronal and non-neuronal acetylcholine take part in non-quantal acetylcholine release in the rat atrium. Life Sci. 2012;91:1023-6 pubmed
Cavalieri F, Micheli L, Kaliappan S, Teo B, Zhou M, Palleschi G, et al. Antimicrobial and biosensing ultrasound-responsive lysozyme-shelled microbubbles. ACS Appl Mater Interfaces. 2013;5:464-71 pubmed publisher
Guo Y, Guo T. A dual-template imprinted capsule with remarkably enhanced catalytic activity for pesticide degradation and elimination simultaneously. Chem Commun (Camb). 2013;49:1073-5 pubmed publisher
Atanasov V, Petrova I, Dishovsky C. In vitro investigation of efficacy of new reactivators on OPC inhibited rat brain acetylcholinesterase. Chem Biol Interact. 2013;203:139-43 pubmed publisher
Radic Z, Dale T, Kovarik Z, Berend S, Garcia E, Zhang L, et al. Catalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with non-pyridinium oximes. Biochem J. 2013;450:231-42 pubmed publisher
Tokuriki N, Jackson C, Afriat Jurnou L, Wyganowski K, Tang R, Tawfik D. Diminishing returns and tradeoffs constrain the laboratory optimization of an enzyme. Nat Commun. 2012;3:1257 pubmed publisher
Estevez J, Mangas I, Sogorb M, Vilanova E. Interactions of neuropathy inducers and potentiators/promoters with soluble esterases. Chem Biol Interact. 2013;203:245-50 pubmed publisher
Fu G, Chen W, Yue X, Jiang X. Highly sensitive colorimetric detection of organophosphate pesticides using copper catalyzed click chemistry. Talanta. 2013;103:110-5 pubmed publisher
ROSENBERG Y, Laube B, Mao L, Jiang X, Hernandez Abanto S, Lee K, et al. Pulmonary delivery of an aerosolized recombinant human butyrylcholinesterase pretreatment protects against aerosolized paraoxon in macaques. Chem Biol Interact. 2013;203:167-71 pubmed publisher
Porzio E, Di Gennaro S, Palma A, Manco G. Mn2+ modulates the kinetic properties of an archaeal member of the PLL family. Chem Biol Interact. 2013;203:251-6 pubmed publisher
Kirby S, Norris J, Richard Smith J, Bahnson B, Cerasoli D. Human paraoxonase double mutants hydrolyze V and G class organophosphorus nerve agents. Chem Biol Interact. 2013;203:181-5 pubmed publisher
Hiblot J, Gotthard G, Chabriere E, Elias M. Characterisation of the organophosphate hydrolase catalytic activity of SsoPox. Sci Rep. 2012;2:779 pubmed publisher
Petrov K, Malomouzh A, Kovyazina I, Krejci E, Nikitashina A, Proskurina S, et al. Regulation of acetylcholinesterase activity by nitric oxide in rat neuromuscular junction via N-methyl-D-aspartate receptor activation. Eur J Neurosci. 2013;37:181-9 pubmed publisher
Scognamiglio V, Pezzotti I, Pezzotti G, Cano J, Manfredonia I, Buonasera K, et al. Towards an integrated biosensor array for simultaneous and rapid multi-analysis of endocrine disrupting chemicals. Anal Chim Acta. 2012;751:161-70 pubmed publisher
Yozzo K, McGee S, Volz D. Adverse outcome pathways during zebrafish embryogenesis: a case study with paraoxon. Aquat Toxicol. 2013;126:346-54 pubmed publisher
Otto T, Scott J, Kauffman M, Hodgins S, diTargiani R, Hughes J, et al. Identification and characterization of novel catalytic bioscavengers of organophosphorus nerve agents. Chem Biol Interact. 2013;203:186-90 pubmed publisher
Jafari M, Salehi M, Asgari A, Ahmadi S, Abbasnezhad M, Hajihoosani R, et al. Effects of paraoxon on serum biochemical parameters and oxidative stress induction in various tissues of Wistar and Norway rats. Environ Toxicol Pharmacol. 2012;34:876-87 pubmed publisher
Radic Z, Sit R, Garcia E, Zhang L, Berend S, Kovarik Z, et al. Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates. Chem Biol Interact. 2013;203:67-71 pubmed publisher
Erzengin M, Basaran I, Cakir U, Aybey A, Sinan S. In vitro inhibition effect of some dihydroxy coumarin compounds on purified human serum paraoxonase 1 (PON1). Appl Biochem Biotechnol. 2012;168:1540-8 pubmed publisher
Crow J, Bittles V, Borazjani A, Potter P, Ross M. Covalent inhibition of recombinant human carboxylesterase 1 and 2 and monoacylglycerol lipase by the carbamates JZL184 and URB597. Biochem Pharmacol. 2012;84:1215-22 pubmed publisher
Mishra R, Istamboulie G, Bhand S, Marty J. Detoxification of organophosphate residues using phosphotriesterase and their evaluation using flow based biosensor. Anal Chim Acta. 2012;745:64-9 pubmed publisher
Nurulain S, Petroianu G, Shafiullah M, Kalasz H, Oz M, Saeed T, et al. Sub-chronic exposure to paraoxon neither induces nor exacerbates diabetes mellitus in Wistar rat. J Appl Toxicol. 2013;33:1036-43 pubmed publisher
Chen D, Wang J, Xu Y, Zhang L. A thin film electro-acoustic enzyme biosensor allowing the detection of trace organophosphorus pesticides. Anal Biochem. 2012;429:42-4 pubmed publisher
López Canut V, Ruiz Pernía J, Castillo R, Moliner V, Tuñón I. Hydrolysis of phosphotriesters: a theoretical analysis of the enzymatic and solution mechanisms. Chemistry. 2012;18:9612-21 pubmed publisher
Petroianu G, Nurulain S, Shafiullah M, Hasan M, Kuca K, Lorke D. Usefulness of administration of non-organophosphate cholinesterase inhibitors before acute exposure to organophosphates: assessment using paraoxon. J Appl Toxicol. 2013;33:894-900 pubmed publisher
Tadin Strapps M, Peterson L, Cumiskey A, Rosa R, Mendoza V, Castro Perez J, et al. siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids. J Lipid Res. 2011;52:1084-97 pubmed publisher
Deshpande L, Carter D, Blair R, Delorenzo R. Development of a prolonged calcium plateau in hippocampal neurons in rats surviving status epilepticus induced by the organophosphate diisopropylfluorophosphate. Toxicol Sci. 2010;116:623-31 pubmed publisher
Lorke D, Petroianu G. Minireview: does in-vitro testing of oximes help predict their in-vivo action after paraoxon exposure?. J Appl Toxicol. 2009;29:459-69 pubmed publisher
Ece A, Gurkan F, Celik F, Bosnak M, Yel S, Balik H, et al. Paraoxonase, total antioxidant activity and peroxide levels in marasmic children: relationships with leptin. Clin Biochem. 2007;40:634-9 pubmed
Shiri Sverdlov R, Wouters K, van Gorp P, Gijbels M, Noel B, Buffat L, et al. Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibrates. J Hepatol. 2006;44:732-41 pubmed
Kural B, Orem C, Uydu H, Alver A, Orem A. The effects of lipid-lowering therapy on paraoxonase activities and their relationships with the oxidant-antioxidant system in patients with dyslipidemia. Coron Artery Dis. 2004;15:277-83 pubmed
Raiszadeh F, Solati M, Etemadi A, Azizi F. Serum paraoxonase activity before and after treatment of thyrotoxicosis. Clin Endocrinol (Oxf). 2004;60:75-80 pubmed
Azizi F, Rahmani M, Raiszadeh F, Solati M, Navab M. Association of lipids, lipoproteins, apolipoproteins and paraoxonase enzyme activity with premature coronary artery disease. Coron Artery Dis. 2002;13:9-16 pubmed
product information
Catalog Number :
D9286
Product Name :
Paraoxon-ethyl
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
≥90%, oil
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA