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product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Diclofenac sodium salt
catalog :
D6899
citations: 202
Reference
Li X, Huang H, Zhang S, Liu Q, Wang Y. Label-free quantitative proteomics positions the effects and mechanisms of Herba Lysimachiae on synovial diseases based on biolabel-led research pattern. J Chromatogr B Analyt Technol Biomed Life Sci. 2020;1138:121969 pubmed publisher
Michailidis E, Vercauteren K, Mancio Silva L, Andrus L, Jahan C, Ricardo Lax I, et al. Expansion, in vivo-ex vivo cycling, and genetic manipulation of primary human hepatocytes. Proc Natl Acad Sci U S A. 2020;117:1678-1688 pubmed publisher
Duval A, Troquier L, De Souza Silva O, Demartines N, Dormond O. Diclofenac Potentiates Sorafenib-Based Treatments of Hepatocellular Carcinoma by Enhancing Oxidative Stress. Cancers (Basel). 2019;11: pubmed publisher
McAleer C, Long C, Elbrecht D, Sasserath T, Bridges L, Rumsey J, et al. Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics. Sci Transl Med. 2019;11: pubmed publisher
Van Sebille Y, Gibson R, Wardill H, Carney T, Bowen J. Use of zebrafish to model chemotherapy and targeted therapy gastrointestinal toxicity. Exp Biol Med (Maywood). 2019;244:1178-1185 pubmed publisher
Freitas R, Coppola F, Costa S, Manzini C, Intorre L, Meucci V, et al. Does salinity modulates the response of Mytilus galloprovincialis exposed to triclosan and diclofenac?. Environ Pollut. 2019;251:756-765 pubmed publisher
Yi J, Kim Y, Lee Y, Bang O, Kim N. Effect of an ethanol extract of Descurainia sophia seeds on Phase I and II drug metabolizing enzymes and P-glycoprotein activity in vitro. BMC Complement Altern Med. 2015;15:441 pubmed publisher
Ribeiro A, Pedrosa M, Moreira N, Pereira M, Silva A. Environmental friendly method for urban wastewater monitoring of micropollutants defined in the Directive 2013/39/EU and Decision 2015/495/EU. J Chromatogr A. 2015;1418:140-9 pubmed publisher
Elsaftawy H, Ahmed M, Saif M, Mousa R. Sequential Intracorneal Ring Segment Implantation and Corneal Transepithelial Collagen Cross-Linking in Keratoconus. Cornea. 2015;34:1420-6 pubmed publisher
Enayatifard R, Mahjoob A, Ebrahimi P, Ebrahimnejad P. Evaluation of the effect of physical variables on in vitro release of diclofenac pellets using Box-Behnken design. Iran J Basic Med Sci. 2015;18:710-4 pubmed
Whitted C, Palau V, Torrenegra R, Harirforoosh S. Development of reversed-phase high performance liquid chromatography methods for quantification of two isomeric flavones and the application of the methods to pharmacokinetic studies in rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;1001:150-5 pubmed publisher
Lu R, Liu S, Wang Q, Li X. Nanoemulsions as novel oral carriers of stiripentol: insights into the protective effect and absorption enhancement. Int J Nanomedicine. 2015;10:4937-46 pubmed publisher
Bomba F, Wandji B, Piegang B, Awouafack M, Sriram D, Yogeeswari P, et al. Antinociceptive properties of the aqueous and methanol extracts of the stem bark of Petersianthus macrocarpus (P. Beauv.) Liben (Lecythidaceae) in mice. J Ethnopharmacol. 2015;174:66-73 pubmed publisher
Pandurangan K, Krishnappan V, Subramanian V, Subramanyan R. Anti-inflammatory effect of certain dimethoxy flavones. Inflammopharmacology. 2015;23:307-17 pubmed publisher
Nowrotek M, Sochacki A, Felis E, Miksch K. Removal of diclofenac and sulfamethoxazole from synthetic municipal waste water in microcosm downflow constructed wetlands: Start-up results. Int J Phytoremediation. 2016;18:157-63 pubmed publisher
Uehara S, Uno Y, Inoue T, Kawano M, Shimizu M, Toda A, et al. Novel Marmoset Cytochrome P450 2C19 in Livers Efficiently Metabolizes Human P450 2C9 and 2C19 Substrates, S-Warfarin, Tolbutamide, Flurbiprofen, and Omeprazole. Drug Metab Dispos. 2015;43:1408-16 pubmed publisher
Sekhon Loodu S, Ziaullah Z, Rupasinghe H, Wang Y, Kulka M, Shahidi F. Novel quercetin-3-O-glucoside eicosapentaenoic acid ester ameliorates inflammation and hyperlipidemia. Inflammopharmacology. 2015;23:173-85 pubmed publisher
Nagelreiter C, Mahrhauser D, Wiatschka K, Skipiol S, Valenta C. Importance of a suitable working protocol for tape stripping experiments on porcine ear skin: Influence of lipophilic formulations and strip adhesion impairment. Int J Pharm. 2015;491:162-9 pubmed publisher
Kumar A, Agarwal K, Maurya A, Shanker K, Bushra U, Tandon S, et al. Pharmacological and phytochemical evaluation of Ocimum sanctum root extracts for its antiinflammatory, analgesic and antipyretic activities. Pharmacogn Mag. 2015;11:S217-24 pubmed publisher
Atasoy M. Efficacy and Safety of Endovenous Laser Ablation in Very Large and Tortuous Great Saphenous Veins. J Vasc Interv Radiol. 2015;26:1347-52 pubmed publisher
Choudhary S, Talele P, Kishore N. Thermodynamic insights into drug-surfactant interactions: Study of the interactions of naporxen, diclofenac sodium, neomycin, and lincomycin with hexadecytrimethylammonium bromide by using isothermal titration calorimetry. Colloids Surf B Biointerfaces. 2015;132:313-21 pubmed publisher
Yao M, Wang L, Yao D, Yao D. Abnormal expressions of inflammatory-related mediators and inhibition of fat metabolism in mice infected with influenza a virus. Pak J Pharm Sci. 2015;28:1109-14 pubmed
Oliveira L, Antunes S, Gonçalves F, Rocha O, Nunes B. Evaluation of ecotoxicological effects of drugs on Daphnia magna using different enzymatic biomarkers. Ecotoxicol Environ Saf. 2015;119:123-31 pubmed publisher
Okunlola A, Odeku O, Lamprecht A, Oyagbemi A, Oridupa O, Aina O. Design of cissus-alginate microbeads revealing mucoprotection properties in anti-inflammatory therapy. Int J Biol Macromol. 2015;79:226-34 pubmed publisher
Ramírez J, Mirkov S, House L, Ratain M. Glucuronidation of OTS167 in Humans Is Catalyzed by UDP-Glucuronosyltransferases UGT1A1, UGT1A3, UGT1A8, and UGT1A10. Drug Metab Dispos. 2015;43:928-35 pubmed publisher
Liu W, Lirio S, Yang Y, Wu L, Hsiao S, Huang H. A poly(alkyl methacrylate-divinylbenzene-vinylbenzyl trimethylammonium chloride) monolithic column for solid-phase microextraction. J Chromatogr A. 2015;1395:32-40 pubmed publisher
Mennecozzi M, Landesmann B, Palosaari T, Harris G, Whelan M. Sex differences in liver toxicity-do female and male human primary hepatocytes react differently to toxicants in vitro?. PLoS ONE. 2015;10:e0122786 pubmed publisher
Oda S, Fujiwara R, Kutsuno Y, Fukami T, Itoh T, Yokoi T, et al. Targeted screen for human UDP-glucuronosyltransferases inhibitors and the evaluation of potential drug-drug interactions with zafirlukast. Drug Metab Dispos. 2015;43:812-8 pubmed publisher
Singer D, Kennedy J, Wittpenn J. Topical NSAIDs effect on corneal sensitivity. Cornea. 2015;34:541-3 pubmed publisher
Wu J, Li M. Inhibitory effects of pain relief drugs on neurological enzymes: implications on their potential neurotoxicity to aquatic animals. Environ Toxicol Pharmacol. 2015;39:898-905 pubmed publisher
Castangia I, Manca M, Matricardi P, Catalan Latorre A, Nácher A, Díez Sales O, et al. Effects of ethanol and diclofenac on the organization of hydrogenated phosphatidylcholine bilayer vesicles and their ability as skin carriers. J Mater Sci Mater Med. 2015;26:137 pubmed publisher
Sabourin G. [Diclofenac. Caution]. Perspect Infirm. 2015;12:63 pubmed
Sekhon Loodu S, Ziaullah -, Rupasinghe H. Docosahexaenoic acid ester of phloridzin inhibit lipopolysaccharide-induced inflammation in THP-1 differentiated macrophages. Int Immunopharmacol. 2015;25:199-206 pubmed publisher
Akdemir A, Yildirim N, Zeybek B, Karaman S, Sendag F. Single incision trans-umbilical total hysterectomy: robotic or laparoscopic?. Gynecol Obstet Invest. 2015;80:93-8 pubmed publisher
Kondo T, Oshima T, Tomita T, Fukui H, Okada H, Watari J, et al. The Nonsteroidal Anti-inflammatory Drug Diclofenac Reduces Acid-Induced Heartburn Symptoms in Healthy Volunteers. Clin Gastroenterol Hepatol. 2015;13:1249-1255.e1 pubmed publisher
Magiera S, Baranowska I. A rapid method for determination of 22 selected drugs in human urine by UHPLC/MS/MS for clinical application. J AOAC Int. 2014;97:1526-37 pubmed
Galea C, Mangelings D, Heyden Y. Method development for impurity profiling in SFC: The selection of a dissimilar set of stationary phases. J Pharm Biomed Anal. 2015;111:333-43 pubmed publisher
Cirillo G, Spataro T, Curcio M, Spizzirri U, Nicoletta F, Picci N, et al. Tunable thermo-responsive hydrogels: synthesis, structural analysis and drug release studies. Mater Sci Eng C Mater Biol Appl. 2015;48:499-510 pubmed publisher
Bannuru R, Schmid C, Kent D, Vaysbrot E, Wong J, McAlindon T. Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis. Ann Intern Med. 2015;162:46-54 pubmed publisher
Miller T, McEneff G, Brown R, Owen S, Bury N, Barron L. Pharmaceuticals in the freshwater invertebrate, Gammarus pulex, determined using pulverised liquid extraction, solid phase extraction and liquid chromatography-tandem mass spectrometry. Sci Total Environ. 2015;511:153-60 pubmed publisher
Nadaf S, Nnamani P, Jadhav N. Evaluation of Prosopis africana Seed Gum as an Extended Release Polymer for Tablet Formulation. AAPS PharmSciTech. 2015;16:716-29 pubmed publisher
Moniruzzaman M, Ferdous A, Irin S. Evaluation of antinociceptive effect of ethanol extract of Hedyotis corymbosa Linn. whole plant in mice. J Ethnopharmacol. 2015;161:82-5 pubmed publisher
Derry C, Derry S, Moore R. Caffeine as an analgesic adjuvant for acute pain in adults. Cochrane Database Syst Rev. 2014;:CD009281 pubmed publisher
Lu Z, Fassihi R. Influence of colloidal silicon dioxide on gel strength, robustness, and adhesive properties of diclofenac gel formulation for topical application. AAPS PharmSciTech. 2015;16:636-44 pubmed publisher
Margalida A, Bogliani G, Bowden C, Donázar J, Genero F, Gilbert M, et al. Science and regulation. One Health approach to use of veterinary pharmaceuticals. Science. 2014;346:1296-8 pubmed publisher
Nagelreiter C, Kratochvilova E, Valenta C. Dilution of semi-solid creams: influence of various production parameters on rheological properties and skin penetration. Int J Pharm. 2015;478:429-38 pubmed publisher
Chiu H, Yeh N. Sudden onset of generalized blisters. JAMA. 2014;312:2281-2 pubmed publisher
Wang Y, Liu H, Liu G, Xie Y, Gao S. Oxidation of diclofenac by potassium ferrate (VI): reaction kinetics and toxicity evaluation. Sci Total Environ. 2015;506-507:252-8 pubmed publisher
Shi F, Zhou D, Ji Z, Xu Z, Yang H. Anti-arthritic activity of luteolin in Freund's complete adjuvant-induced arthritis in rats by suppressing P2X4 pathway. Chem Biol Interact. 2015;226:82-7 pubmed publisher
Pingsusaen P, Kunanusorn P, Khonsung P, Chiranthanut N, Panthong A, Rujjanawate C. Investigation of anti-inflammatory, antinociceptive and antipyretic activities of Stahlianthus involucratus rhizome ethanol extract. J Ethnopharmacol. 2015;162:199-206 pubmed publisher
Pescina S, Govoni P, Potenza A, Padula C, Santi P, Nicoli S. Development of a convenient ex vivo model for the study of the transcorneal permeation of drugs: histological and permeability evaluation. J Pharm Sci. 2015;104:63-71 pubmed publisher
Crowe M, Leishman E, Banks M, Gujjar R, Mahadevan A, Bradshaw H, et al. Combined inhibition of monoacylglycerol lipase and cyclooxygenases synergistically reduces neuropathic pain in mice. Br J Pharmacol. 2015;172:1700-12 pubmed publisher
Kosugi Y, Takahashi J. Species differences and substrate specificity of CYP3A heteroactivation by efavirenz. Xenobiotica. 2015;45:345-52 pubmed publisher
Shimokawa Y, Sasahara K, Yoda N, Mizuno K, Umehara K. Delamanid does not inhibit or induce cytochrome p450 enzymes in vitro. Biol Pharm Bull. 2014;37:1727-35 pubmed
Solanki H, Shah D, Maheriya P, Patel C. Evaluation of anti-inflammatory activity of probiotic on carrageenan-induced paw edema in Wistar rats. Int J Biol Macromol. 2015;72:1277-82 pubmed
Keller D, Ermlich B, Schiltz N, Champagne B, Reynolds H, Stein S, et al. The effect of transversus abdominis plane blocks on postoperative pain in laparoscopic colorectal surgery: a prospective, randomized, double-blind trial. Dis Colon Rectum. 2014;57:1290-7 pubmed publisher
Yauw S, Hoesseini A, Lomme R, van Goor H. Serosal abrasion of bowel ends does not enhance anastomotic healing. J Surg Res. 2015;193:634-41 pubmed publisher
Dang Y, Mu Y, Li L, Mu Y, Liu S, Zhang C, et al. Comparison of dexamethasone intravitreal implant and intravitreal triamcinolone acetonide for the treatment of pseudophakic cystoid macular edema in diabetic patients. Drug Des Devel Ther. 2014;8:1441-9 pubmed publisher
McCarberg B, Cryer B. Evolving therapeutic strategies to improve nonsteroidal anti-inflammatory drug safety. Am J Ther. 2015;22:e167-78 pubmed publisher
Ghatak H. Comparative removal of commercial diclofenac sodium by electro-oxidation on platinum anode and combined electro-oxidation and electrocoagulation on stainless steel anode. Environ Technol. 2014;35:2483-92 pubmed
Yan Y, Xing J, Xu W, Zhao G, Dong K, Zhang L, et al. Hydroxypropyl-β-cyclodextrin grafted polyethyleneimine used as transdermal penetration enhancer of diclofenac sodium. Int J Pharm. 2014;474:182-92 pubmed publisher
Lee C, Shin Y, Nam M, Jeong K, Lee J. A new analytical method to determine non-steroidal anti-inflammatory drugs in surface water using in situ derivatization combined with ultrasound-assisted emulsification microextraction followed by gas chromatography-mass spectrometry. Talanta. 2014;129:552-9 pubmed publisher
Gotoh M, Nagano A, Tsukahara R, Murofushi H, Morohoshi T, Otsuka K, et al. Cyclic phosphatidic acid relieves osteoarthritis symptoms. Mol Pain. 2014;10:52 pubmed publisher
Sidney L, Heathman T, Britchford E, Abed A, Rahman C, Buttery L. Investigation of localized delivery of diclofenac sodium from poly(D,L-lactic acid-co-glycolic acid)/poly(ethylene glycol) scaffolds using an in vitro osteoblast inflammation model. Tissue Eng Part A. 2015;21:362-73 pubmed publisher
Ragam A, Kolomeyer A, Kim J, Nayak N, Fang C, Kim E, et al. Topical cyclosporine a 1% for the treatment of chronic ocular surface inflammation. Eye Contact Lens. 2014;40:283-8 pubmed publisher
Celik U, Bozkurt E, Celik B, Demirok A, Yilmaz O. Pain, wound healing and refractive comparison of mechanical and transepithelial debridement in photorefractive keratectomy for myopia: results of 1 year follow-up. Cont Lens Anterior Eye. 2014;37:420-6 pubmed publisher
Nie E, Yang M, Wang D, Yang X, Luo X, Zheng Z. Degradation of diclofenac by ultrasonic irradiation: kinetic studies and degradation pathways. Chemosphere. 2014;113:165-70 pubmed publisher
Zhou Z, Jiang J. Treatment of selected pharmaceuticals by ferrate(VI): performance, kinetic studies and identification of oxidation products. J Pharm Biomed Anal. 2015;106:37-45 pubmed publisher
Corcoll N, Acuña V, Barcelo D, Casellas M, Guasch H, Huerta B, et al. Pollution-induced community tolerance to non-steroidal anti-inflammatory drugs (NSAIDs) in fluvial biofilm communities affected by WWTP effluents. Chemosphere. 2014;112:185-93 pubmed publisher
Zhao X, Bao J, Hu C, Ding H, Liu X, Mei Q, et al. Effect of diclofenac on the levels of lipoxin A4 and Resolvin D1 and E1 in the post-ERCP pancreatitis. Dig Dis Sci. 2014;59:2992-6 pubmed publisher
Paíga P, Lolić A, Hellebuyck F, Santos L, Correia M, Delerue Matos C. Development of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater. J Pharm Biomed Anal. 2015;106:61-70 pubmed publisher
Dodgen L, Li J, Wu X, Lu Z, Gan J. Transformation and removal pathways of four common PPCP/EDCs in soil. Environ Pollut. 2014;193:29-36 pubmed publisher
Moon C, Kwon O, Woo C, Ahn H, Kwon Y, Park S, et al. Therapeutic effect of irradiation of magnetic infrared laser on osteoarthritis rat model. Photochem Photobiol. 2014;90:1150-9 pubmed publisher
de Monteverde Robb D, House T. Diclofenac sodium in Hartmanns solution. Anaesthesia. 2014;69:797-8 pubmed publisher
Hammond T, Meng X, Jenkins R, Maggs J, Castelazo A, Regan S, et al. Mass spectrometric characterization of circulating covalent protein adducts derived from a drug acyl glucuronide metabolite: multiple albumin adductions in diclofenac patients. J Pharmacol Exp Ther. 2014;350:387-402 pubmed publisher
Velásquez G, Santa Cruz L, Espinoza M. Ketoprofen is more effective than diclofenac after oral surgery when used as a preemptive analgesic: a pilot study. J Oral Facial Pain Headache. 2014;28:153-8 pubmed publisher
Chen J, Gao H, Zhang Y, Zhang Y, Zhou X, Li C, et al. Developmental toxicity of diclofenac and elucidation of gene regulation in zebrafish (Danio rerio). Sci Rep. 2014;4:4841 pubmed publisher
Yu T, Chen X, Wang Y, Zhao R, Mao S. Modulatory effects of extracts of vinegar-baked Radix Bupleuri and saikosaponins on the activity of cytochrome P450 enzymes in vitro. Xenobiotica. 2014;44:861-7 pubmed publisher
Niu X, de Graaf I, Langelaar Makkinje M, Horvatovich P, Groothuis G. Diclofenac toxicity in human intestine ex vivo is not related to the formation of intestinal metabolites. Arch Toxicol. 2015;89:107-19 pubmed publisher
Kutsuno Y, Itoh T, Tukey R, Fujiwara R. Glucuronidation of drugs and drug-induced toxicity in humanized UDP-glucuronosyltransferase 1 mice. Drug Metab Dispos. 2014;42:1146-52 pubmed publisher
Agotegaray M, Palma S, Lassalle V. Novel chitosan coated magnetic nanocarriers for the targeted Diclofenac delivery. J Nanosci Nanotechnol. 2014;14:3343-7 pubmed
Camiña A, Garrido J, Martin J, Lopez Hernández C, Alfaro R. A new threat to European vultures. Science. 2014;344:150 pubmed publisher
Pawar H, Boateng J, Ayensu I, Tetteh J. Multifunctional medicated lyophilised wafer dressing for effective chronic wound healing. J Pharm Sci. 2014;103:1720-33 pubmed publisher
Ishola I, Agbaje E, Adeyemi O, Shukla R. Analgesic and anti-inflammatory effects of the methanol root extracts of some selected Nigerian medicinal plants. Pharm Biol. 2014;52:1208-16 pubmed publisher
Sawazaki R, Ishihara T, Usui S, Hayashi E, Tahara K, Hoshino T, et al. Diclofenac protects cultured human corneal epithelial cells against hyperosmolarity and ameliorates corneal surface damage in a rat model of dry eye. Invest Ophthalmol Vis Sci. 2014;55:2547-56 pubmed publisher
Alam M, Al jenoobi F, Al Mohizea A. High-throughput ultra-performance LC-MS-MS method for analysis of diclofenac sodium in rabbit plasma. J Chromatogr Sci. 2015;53:47-53 pubmed publisher
Naderkhani E, Isaksson J, Ryzhakov A, Flaten G. Development of a biomimetic phospholipid vesicle-based permeation assay for the estimation of intestinal drug permeability. J Pharm Sci. 2014;103:1882-90 pubmed publisher
Palac Z, Engesland A, Flaten G, Skalko Basnet N, Filipovic Grcic J, Vanić Z. Liposomes for (trans)dermal drug delivery: the skin-PVPA as a novel in vitro stratum corneum model in formulation development. J Liposome Res. 2014;24:313-22 pubmed publisher
Gonzalez Rey M, Mattos J, Piazza C, Bainy A, Bebianno M. Effects of active pharmaceutical ingredients mixtures in mussel Mytilus galloprovincialis. Aquat Toxicol. 2014;153:12-26 pubmed publisher
Millan Parrilla F, Rodrigo Nicolas B, Molés Poveda P, Armengot Carbó M, Quecedo Estébanez E, Gimeno Carpio E. Improvement of Darier disease with diclofenac sodium 3% gel. J Am Acad Dermatol. 2014;70:e89-e90 pubmed publisher
Colak S, Gunes H, Afacan M, Kandis H, Erdoğan M, Ayranci M, et al. Anaphylaxis after intramuscular injection of diclofenac sodium. Am J Emerg Med. 2014;32:815.e1-2 pubmed publisher
MOYER K, Dewilde A, Law C. Cystoid macular edema from cancer-associated retinopathy. Optom Vis Sci. 2014;91:S66-70 pubmed publisher
Salmani J, Lv H, Asghar S, Zhou J. Amorphous solid dispersion with increased gastric solubility in tandem with oral disintegrating tablets: a successful approach to improve the bioavailability of atorvastatin. Pharm Dev Technol. 2015;20:465-72 pubmed publisher
Kambayashi A, Blume H, Dressman J. Predicting the oral pharmacokinetic profiles of multiple-unit (pellet) dosage forms using a modeling and simulation approach coupled with biorelevant dissolution testing: case example diclofenac sodium. Eur J Pharm Biopharm. 2014;87:236-43 pubmed publisher
Madden G. Co-administering diclofenac with intravenous paracetamol or Hartmann's solution. Anaesthesia. 2014;69:191-2 pubmed publisher
Kołodziejczyk M, Nachajski M, Lukosek M, Zgoda M. Solubilizing properties of new surface-active agents, products of catalytic oxyethylation of cholic acid. Acta Pol Pharm. 2013;70:1065-77 pubmed
Roberts M, Pulcini L, Mostafa S, Cuppok Rosiaux Y, Marchaud D. Preparation and characterization of Compritol 888 ATO matrix tablets for the sustained release of diclofenac sodium. Pharm Dev Technol. 2015;20:507-12 pubmed publisher
Mahamid M, Francis A, Khalaila W, Nseir W. Diclofenac-lnduced coronary spasm in the absence of anaphylaxis or allergic manifestation. Isr Med Assoc J. 2013;15:522-3 pubmed
Lee M, Borgiani P, Johansson I, Oteri F, Mkrtchian S, Falconi M, et al. High warfarin sensitivity in carriers of CYP2C9*35 is determined by the impaired interaction with P450 oxidoreductase. Pharmacogenomics J. 2014;14:343-9 pubmed publisher
Emara L, Taha N, El Ashmawy A, Raslan H, Mursi N. Controlled porosity osmotic pump system for the delivery of diclofenac sodium: in-vitro and in-vivo evaluation. Pharm Dev Technol. 2014;19:681-91 pubmed publisher
Satoh H, Amagase K, Takeuchi K. Mucosal protective agents prevent exacerbation of NSAID-induced small intestinal lesions caused by antisecretory drugs in rats. J Pharmacol Exp Ther. 2014;348:227-35 pubmed publisher
Boerma J, Vermeulen N, Commandeur J. One-electron oxidation of diclofenac by human cytochrome P450s as a potential bioactivation mechanism for formation of 2'-(glutathion-S-yl)-deschloro-diclofenac. Chem Biol Interact. 2014;207:32-40 pubmed publisher
Dragovic S, Venkataraman H, Begheijn S, Vermeulen N, Commandeur J. Effect of human glutathione S-transferase hGSTP1-1 polymorphism on the detoxification of reactive metabolites of clozapine, diclofenac and acetaminophen. Toxicol Lett. 2014;224:272-81 pubmed publisher
Cilurzo F, Gennari C, Selmin F, Franzé S, Musazzi U, Minghetti P. On the characterization of medicated plasters containing NSAIDs according to novel indications of USP and EMA: adhesive property and in vitro skin permeation studies. Drug Dev Ind Pharm. 2015;41:183-9 pubmed publisher
Cinar Y, Cingü A, Türkcü F, Cınar T, Yuksel H, Ozkurt Z, et al. Comparison of accelerated and conventional corneal collagen cross-linking for progressive keratoconus. Cutan Ocul Toxicol. 2014;33:218-22 pubmed publisher
Radulović N, Jovanovic I, Ilić I, Randjelović P, Stojanović N, Miltojević A. Methyl and isopropyl N-methylanthranilates attenuate diclofenac- and ethanol-induced gastric lesions in rats. Life Sci. 2013;93:840-6 pubmed publisher
Gibofsky A, Silberstein S, Argoff C, Daniels S, Jensen S, Young C. Lower-dose diclofenac submicron particle capsules provide early and sustained acute patient pain relief in a phase 3 study. Postgrad Med. 2013;125:130-8 pubmed publisher
Senthilkumaran S, Menezes R, Ibrahim S, Thirumalaikolundusubramanian P. Cardiac anaphylaxis: searching for clarity. Am J Emerg Med. 2014;32:86 pubmed publisher
Sakat S, Mani K, Demidchenko Y, Gorbunov E, Tarasov S, Mathur A, et al. Release-active dilutions of diclofenac enhance anti-inflammatory effect of diclofenac in carrageenan-induced rat paw edema model. Inflammation. 2014;37:1-9 pubmed publisher
Peserico A, Neri L, Calzavara Pinton P, Catricala C, Pellacani G, Peris K, et al. Key Opinion Leader (KOL) Consensus for actinic keratosis management in Italy: the AKTUAL Workshop. G Ital Dermatol Venereol. 2013;148:515-24 pubmed
Bickel M, Khaykin P, Stephan C, Schmidt K, Buettner M, Amann K, et al. Acute kidney injury caused by tenofovir disoproxil fumarate and diclofenac co-administration. HIV Med. 2013;14:633-8 pubmed publisher
Ramm S, Mally A. Role of drug-independent stress factors in liver injury associated with diclofenac intake. Toxicology. 2013;312:83-96 pubmed publisher
Klein S. Influence of different test parameters on in vitro drug release from topical diclofenac formulations in a vertical diffusion cell setup. Pharmazie. 2013;68:565-71 pubmed
Cwiertnia B. Effect of water soluble carrier on dissolution profiles of diclofenac sodium. Acta Pol Pharm. 2013;70:721-6 pubmed
Fuessl H. [Problematic: analgesics before the marathon]. MMW Fortschr Med. 2013;155:33 pubmed
Dodgen L, Li J, Parker D, Gan J. Uptake and accumulation of four PPCP/EDCs in two leafy vegetables. Environ Pollut. 2013;182:150-6 pubmed publisher
Crilly M, Mangoni A, Knights K. Aldosterone glucuronidation inhibition as a potential mechanism for arterial dysfunction associated with chronic celecoxib and diclofenac use in patients with rheumatoid arthritis. Clin Exp Rheumatol. 2013;31:691-8 pubmed
Cinar Y, Cingü A, Türkcü F, Yuksel H, Sahin A, Yıldırım A, et al. Accelerated corneal collagen cross-linking for progressive keratoconus. Cutan Ocul Toxicol. 2014;33:168-71 pubmed publisher
Rocha Rodrigues S, Santos Alves E, Coxito P, Marques Aleixo I, Passos E, Guimarães J, et al. Combined effects of aging and in vitro non-steroid anti-inflammatory drugs on kidney and liver mitochondrial physiology. Life Sci. 2013;93:329-37 pubmed publisher
Chaudhary H, Kohli K, Kumar V. Nano-transfersomes as a novel carrier for transdermal delivery. Int J Pharm. 2013;454:367-80 pubmed publisher
Kalhapure R, Akamanchi K. Oleodendrimers: a novel class of multicephalous heterolipids as chemical penetration enhancers for transdermal drug delivery. Int J Pharm. 2013;454:158-66 pubmed publisher
Zhang D, Gersberg R, Hua T, Zhu J, Goyal M, Ng W, et al. Fate of pharmaceutical compounds in hydroponic mesocosms planted with Scirpus validus. Environ Pollut. 2013;181:98-106 pubmed publisher
Kirac M, Tepeler A, Bozkurt O, Elbir F, Ozluk C, Armagan A, et al. The efficacy of bupivacaine infiltration on the nephrostomy tract in tubeless and standard percutaneous nephrolithotomy: a prospective, randomized, multicenter study. Urology. 2013;82:526-31 pubmed publisher
Alok A, Adhikari J, Chaudhury N. Radioprotective role of clinical drug diclofenac sodium. Mutat Res. 2013;755:156-62 pubmed publisher
Souza J, Meira A, Volpato N, Mayorga P, Gottfried C. Effect of phonophoresis on skin permeation of commercial anti-inflammatory gels: sodium diclofenac and ketoprofen. Ultrasound Med Biol. 2013;39:1623-30 pubmed publisher
Wise J. Diclofenac shouldn't be prescribed to people with heart problems, drug agency says. BMJ. 2013;347:f4285 pubmed publisher
Fouad S, Basalious E, El Nabarawi M, Tayel S. Microemulsion and poloxamer microemulsion-based gel for sustained transdermal delivery of diclofenac epolamine using in-skin drug depot: in vitro/in vivo evaluation. Int J Pharm. 2013;453:569-78 pubmed publisher
Joshi K, Nerurkar R. Anti-inflammatory effect of the serratiopeptidase--rationale or fashionable: a study in rat paw oedema model induced by the carrageenan. Indian J Physiol Pharmacol. 2012;56:367-74 pubmed
Vithani K, Cuppok Y, Mostafa S, Slipper I, Snowden M, Douroumis D. Diclofenac sodium sustained release hot melt extruded lipid matrices. Pharm Dev Technol. 2014;19:531-8 pubmed publisher
Vithani K, Maniruzzaman M, Slipper I, Mostafa S, Miolane C, Cuppok Y, et al. Sustained release solid lipid matrices processed by hot-melt extrusion (HME). Colloids Surf B Biointerfaces. 2013;110:403-10 pubmed publisher
Ayorinde J, Itiola A, Odeniyi M. Effects of excipients and formulation types on compressional properties of diclofenac. Acta Pol Pharm. 2013;70:557-66 pubmed
Saluja S, Kasha P, Paturi J, Anderson C, Morris R, Banga A. A novel electronic skin patch for delivery and pharmacokinetic evaluation of donepezil following transdermal iontophoresis. Int J Pharm. 2013;453:395-9 pubmed publisher
Bhala N, Emberson J, Merhi A, Abramson S, Arber N, Baron J, et al. Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials. Lancet. 2013;382:769-79 pubmed publisher
Řemínek R, Zeisbergerova M, Langmajerová M, Glatz Z. New capillary electrophoretic method for on-line screenings of drug metabolism mediated by cytochrome P450 enzymes. Electrophoresis. 2013;34:2705-11 pubmed publisher
Tummala K, Maniyal V, Chandrashekaran R, Mathew N, Ganeshwala G. Cardiac anaphylaxis: a case of acute ST-segment elevation myocardial infarction after IM epinephrine for anaphylactic shock. Am J Emerg Med. 2013;31:1157.e1-3 pubmed publisher
Dickson R. Not all diclofenac is equal. CMAJ. 2013;185:687 pubmed publisher
Nau J. [Domperidone, diclofenac: the time has come for drug alerts]. Rev Med Suisse. 2013;9:852-3 pubmed
Gu L, Qiu X, Zhao Y, Qin W, Dong F. [Case-control study on stiletto needle and Dichofenac Diethylammon for the treatment of knee osteoarthritis pain]. Zhongguo Gu Shang. 2012;25:1036-9 pubmed
Bajerová M, Muselik J, Gajdziok J, Masteikova R, Dvorácková K. The influence of process variables of preparation of oxycellulose beads on their dissolution profile. Acta Pol Pharm. 2013;70:271-81 pubmed
Davey J. The advantages and limitations of the analgesics available for control of postoperative pain after a dental procedure. SAAD Dig. 2013;29:70-81 pubmed
Marí Cotino J, Suriano M, De La Cruz Aguiló R, Vila Arteaga J. Central toxic keratopathy: a clinical case series. Br J Ophthalmol. 2013;97:701-3 pubmed publisher
Mustafa S, Elgazzar A. Effect of the NSAID diclofenac on 99mTc-MAG3 and 99mTc-DTPA renography. J Nucl Med. 2013;54:801-6 pubmed publisher
Magaña Villa M, Rocha González H, Fernández Del Valle Laisequilla C, Granados Soto V, Rodríguez Silverio J, Flores Murrieta F, et al. B-vitamin mixture improves the analgesic effect of diclofenac in patients with osteoarthritis: a double blind study. Drug Res (Stuttg). 2013;63:289-92 pubmed publisher
Dama M. Fostering public support for vulture protection. Science. 2013;339:1383 pubmed publisher
van Swelm R, Laarakkers C, Pertijs J, Verweij V, Masereeuw R, Russel F. Urinary proteomic profiling reveals diclofenac-induced renal injury and hepatic regeneration in mice. Toxicol Appl Pharmacol. 2013;269:141-9 pubmed publisher
Stěpánová S, Praskova E, Chromcova L, Plhalova L, Prokes M, Blahova J, et al. The effects of diclofenac on early life stages of common carp (Cyprinus carpio). Environ Toxicol Pharmacol. 2013;35:454-60 pubmed publisher
Vieira A, Serra A, Carvalho R, Gonsalves A, Figueiras A, Veiga F, et al. Microwave synthesis and in vitro stability of diclofenac-β-cyclodextrin conjugate for colon delivery. Carbohydr Polym. 2013;93:512-7 pubmed publisher
Nezvalová Henriksen K, Spigset O, Nordeng H. Effects of ibuprofen, diclofenac, naproxen, and piroxicam on the course of pregnancy and pregnancy outcome: a prospective cohort study. BJOG. 2013;120:948-59 pubmed publisher
Rossi L, Queloz P, Brovelli A, Margot J, Barry D. Enhancement of micropollutant degradation at the outlet of small wastewater treatment plants. PLoS ONE. 2013;8:e58864 pubmed publisher
Ebrahim A, Mozaffar R, Nadia B, Ali J. Preoperative prescription of suppository diclofenac for spinal anesthesia. Ann Afr Med. 2013;12:53-4 pubmed publisher
El Fattah A, Ramzy E. Pre-emptive triple analgesia protocol for tonsillectomy pain control in children: double-blind, randomised, controlled, clinical trial. J Laryngol Otol. 2013;127:383-91 pubmed publisher
Spitz S. Diclofenac linked to increased risk of C. difficile. CMAJ. 2013;185:471 pubmed publisher
Zhao L, Bajrami B, Rusling J. Rapid LC-MS drug metabolite profiling using bioreactor particles. Methods Mol Biol. 2013;987:129-34 pubmed publisher
Spitz S. Physicians should be cautious when prescribing diclofenac. CMAJ. 2013;185:470 pubmed publisher
Niempoog S, Siriarchavatana P, Kajsongkram T. The efficacy of Plygersic gel for use in the treatment of osteoarthritis of the knee. J Med Assoc Thai. 2012;95 Suppl 10:S113-9 pubmed
Duan Y, Ji M, Lu X. Simultaneous high-performance liquid chromatographic determination of a rhein-diclofenac prodrug and its active compounds. Pharmazie. 2013;68:12-4 pubmed
Danda D, Iliyas M, Chandy S, Chandra C, Mathew A. How safe is Celecoxib for Asian-Indian patients with rheumatic diseases?. Int J Rheum Dis. 2013;16:24-9 pubmed publisher
. Remove diclofenac from lists of essential drugs. BMJ. 2013;346:f1053 pubmed publisher
Kinsey S, Wise L, Ramesh D, Abdullah R, Selley D, Cravatt B, et al. Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects. J Pharmacol Exp Ther. 2013;345:492-501 pubmed publisher
Castillo A, Gracia Lor E, Roig Navarro A, Vicente Sancho J, Rodriguez Gonzalez P, Garcia Alonso J. Isotope pattern deconvolution-tandem mass spectrometry for the determination and confirmation of diclofenac in wastewaters. Anal Chim Acta. 2013;765:77-85 pubmed publisher
Esmann S, Jemec G. Patients' perceptions of topical treatments of actinic keratosis. J Dermatolog Treat. 2014;25:375-9 pubmed publisher
Martin G, Stockfleth E. Diclofenac sodium 3% gel for the management of actinic keratosis: 10+ years of cumulative evidence of efficacy and safety. J Drugs Dermatol. 2012;11:600-8 pubmed
Aygun D, Kaplan S, Odaci E, Onger M, Altunkaynak M. Toxicity of non-steroidal anti-inflammatory drugs: a review of melatonin and diclofenac sodium association. Histol Histopathol. 2012;27:417-36 pubmed publisher
Kumar A, Lohan P, Aneja D, Gupta G, Kaushik D, Prakash O. Design, synthesis, computational and biological evaluation of some new hydrazino derivatives of DHA and pyranopyrazoles. Eur J Med Chem. 2012;50:81-9 pubmed publisher
Dekhane D, Pawar S, Gupta S, Shingare M, Patil C, Thore S. Synthesis and anti-inflammatory activity of some new 4,5-dihydro-1,5-diaryl-1H-pyrazole-3-substituted-heteroazole derivatives. Bioorg Med Chem Lett. 2011;21:6527-32 pubmed publisher
el Sayed M, Abdel Aziz N, Abdel Aziz A, El Azab A, Asiri Y, Eltahir K. Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study. Bioorg Med Chem. 2011;19:3416-24 pubmed publisher
Matveev A, Koniaeva E. [Diclofenac sodium in osteoarthritis. Is there risk of hepatotoxicity? A systematic review]. Eksp Klin Gastroenterol. 2010;:93-100 pubmed
Ramesh B, Bhalgat C. Novel dihydropyrimidines and its pyrazole derivatives: synthesis and pharmacological screening. Eur J Med Chem. 2011;46:1882-91 pubmed publisher
Choi S, Kelly J. A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin. Bioorg Med Chem. 2011;19:1505-14 pubmed publisher
Bandgar B, Sarangdhar R, Ahamed F, Viswakarma S. Synthesis, characterization, and biological evaluation of novel diclofenac prodrugs. J Med Chem. 2011;54:1202-10 pubmed publisher
Manjunatha K, Poojary B, Lobo P, Fernandes J, Kumari N. Synthesis and biological evaluation of some 1,3,4-oxadiazole derivatives. Eur J Med Chem. 2010;45:5225-33 pubmed publisher
Sharma S, Chattopadhyay S, Trivedi P, Bawankule D. Synthesis and anti-inflammatory activity of derivatives of coumarino-lignoid, cleomiscosin A and its methyl ether. Eur J Med Chem. 2010;45:5150-6 pubmed publisher
Girisha K, Kalluraya B, Narayana V, Padmashree -. Synthesis and pharmacological study of 1-acetyl/propyl-3-aryl-5-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-pyrazoline. Eur J Med Chem. 2010;45:4640-4 pubmed publisher
Joshi R, Mandhane P, Diwakar S, Dabhade S, Gill C. Synthesis, analgesic and anti-inflammatory activities of some novel pyrazolines derivatives. Bioorg Med Chem Lett. 2010;20:3721-5 pubmed publisher
El Sayed N, Awadallah F, Ibrahim N, El Saadi M. Synthesis, anti-inflammatory and ulcerogenicity studies of some substituted pyrimido[1,6-a]azepine derivatives. Eur J Med Chem. 2010;45:3147-54 pubmed publisher
Abu Hashem A, Gouda M, Badria F. Synthesis of some new pyrimido[2',1':2,3]thiazolo[4,5-b]quinoxaline derivatives as anti-inflammatory and analgesic agents. Eur J Med Chem. 2010;45:1976-81 pubmed publisher
El Gamal M, Bayomi S, El Ashry S, Said S, Abdel Aziz A, Abdel Aziz N. Synthesis and anti-inflammatory activity of novel (substituted)benzylidene acetone oxime ether derivatives: molecular modeling study. Eur J Med Chem. 2010;45:1403-14 pubmed publisher
Isloor A, Kalluraya B, Sridhar Pai K. Synthesis, characterization and biological activities of some new benzo[b]thiophene derivatives. Eur J Med Chem. 2010;45:825-30 pubmed publisher
Eissa A, Farag N, Soliman G. Synthesis, biological evaluation and docking studies of novel benzopyranone congeners for their expected activity as anti-inflammatory, analgesic and antipyretic agents. Bioorg Med Chem. 2009;17:5059-70 pubmed publisher
El Gazzar A, Hafez H. Synthesis of 4-substituted pyrido[2,3-d]pyrimidin-4(1H)-one as analgesic and anti-inflammatory agents. Bioorg Med Chem Lett. 2009;19:3392-7 pubmed publisher
Brickelmaier M, Lugovskoy A, Kartikeyan R, Reviriego Mendoza M, Allaire N, Simon K, et al. Identification and characterization of mefloquine efficacy against JC virus in vitro. Antimicrob Agents Chemother. 2009;53:1840-9 pubmed publisher
Rostom S, El Ashmawy I, Abd El Razik H, Badr M, Ashour H. Design and synthesis of some thiazolyl and thiadiazolyl derivatives of antipyrine as potential non-acidic anti-inflammatory, analgesic and antimicrobial agents. Bioorg Med Chem. 2009;17:882-95 pubmed publisher
Farooqui M, Bora R, Patil C. Synthesis, analgesic and anti-inflammatory activities of novel 3-(4-acetamido-benzyl)-5-substituted-1,2,4-oxadiazoles. Eur J Med Chem. 2009;44:794-9 pubmed publisher
Zgoda M, Nachajski M, Kołodziejczyk M, Woskowicz M, Lukosek M. Solubilizing properties of new surface-active agents, products of selective oxyethylation of cholic acid. Part I. Polim Med. 2007;37:21-38 pubmed
Brunskole M, Stefane B, Zorko K, Anderluh M, Stojan J, Lanisnik Rizner T, et al. Towards the first inhibitors of trihydroxynaphthalene reductase from Curvularia lunata: synthesis of artificial substrate, homology modelling and initial screening. Bioorg Med Chem. 2008;16:5881-9 pubmed publisher
el Gazzar A, Youssef M, Youssef A, Abu Hashem A, Badria F. Design and synthesis of azolopyrimidoquinolines, pyrimidoquinazolines as anti-oxidant, anti-inflammatory and analgesic activities. Eur J Med Chem. 2009;44:609-24 pubmed publisher
Bhandari S, Bothara K, Raut M, Patil A, Sarkate A, Mokale V. Design, synthesis and evaluation of antiinflammatory, analgesic and ulcerogenicity studies of novel S-substituted phenacyl-1,3,4-oxadiazole-2-thiol and Schiff bases of diclofenac acid as nonulcerogenic derivatives. Bioorg Med Chem. 2008;16:1822-31 pubmed publisher
McCormack P, Scott L. Diclofenac sodium injection (Dyloject): in postoperative pain. Drugs. 2008;68:123-30 pubmed
Diamandis P, Wildenhain J, Clarke I, Sacher A, Graham J, Bellows D, et al. Chemical genetics reveals a complex functional ground state of neural stem cells. Nat Chem Biol. 2007;3:268-73 pubmed
Mathew V, Keshavayya J, Vaidya V, Giles D. Studies on synthesis and pharmacological activities of 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and their dihydro analogues. Eur J Med Chem. 2007;42:823-40 pubmed
Llinas A, Burley J, Box K, Glen R, Goodman J. Diclofenac solubility: independent determination of the intrinsic solubility of three crystal forms. J Med Chem. 2007;50:979-83 pubmed
Chhabria M, Bhatt H, Raval H, Oza P. Synthesis and biological evaluation of some 5-ethoxycarbonyl-6-isopropylamino-4-(substitutedphenyl)aminopyrimidines as potent analgesic and anti-inflammatory agents. Bioorg Med Chem Lett. 2007;17:1022-4 pubmed
Vijaya Raj K, Narayana B, Ashalatha B, Suchetha Kumari N, Sarojini B. Synthesis of some bioactive 2-bromo-5-methoxy-N'-[4-(aryl)-1,3-thiazol-2-yl]benzohydrazide derivatives. Eur J Med Chem. 2007;42:425-9 pubmed
Navidpour L, Amini M, Shafaroodi H, Abdi K, Ghahremani M, Dehpour A, et al. Design and synthesis of new water-soluble tetrazolide derivatives of celecoxib and rofecoxib as selective cyclooxygenase-2 (COX-2) inhibitors. Bioorg Med Chem Lett. 2006;16:4483-7 pubmed
Gobec S, Brozic P, Rizner T. Nonsteroidal anti-inflammatory drugs and their analogues as inhibitors of aldo-keto reductase AKR1C3: new lead compounds for the development of anticancer agents. Bioorg Med Chem Lett. 2005;15:5170-5 pubmed
Khan I, Kulkarni M, Gopal M, Shahabuddin M, Sun C. Synthesis and biological evaluation of novel angularly fused polycyclic coumarins. Bioorg Med Chem Lett. 2005;15:3584-7 pubmed
Caron G, Ermondi G. Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). J Med Chem. 2005;48:3269-79 pubmed
Kennedy J, Korn N, Thurston R. Prostaglandin levels in seminal plasma and sperm extracts of the domestic turkey, and the effects of cyclooxygenase inhibitors on sperm mobility. Reprod Biol Endocrinol. 2003;1:74 pubmed
Brogden R, Heel R, Pakes G, Speight T, Avery G. Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin. Drugs. 1980;20:24-48 pubmed
Todd P, Sorkin E. Diclofenac sodium. A reappraisal of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs. 1988;35:244-85 pubmed
Small R. Diclofenac sodium. Clin Pharm. 1989;8:545-58 pubmed
Soler Rosello A, Morote Robles J, Garcia Rojo D, Vila Barja J, Prera Vilaseca A. [Diclofenac sodium therapy in irritating micturition syndrome following TUR for benign prostatic hyperplasia]. Arch Esp Urol. 1990;43:831-5 pubmed
product information
Catalog Number :
D6899
Product Name :
Diclofenac sodium salt
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA