This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
5′-Deoxy-5′-(methylthio)adenosine
catalog :
D5011
citations: 70
Reference
Strobl C, Schäffer S, Haug T, Völkl S, Peter K, Singer K, et al. Selective PRMT5 Inhibitors Suppress Human CD8+ T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA. Mol Cancer Ther. 2020;19:409-419 pubmed publisher
Veyel D, Sokolowska E, Moreno J, Kierszniowska S, Cichon J, Wojciechowska I, et al. PROMIS, global analysis of PROtein-metabolite interactions using size separation in Arabidopsis thaliana. J Biol Chem. 2018;293:12440-12453 pubmed publisher
Jassey V, Signarbieux C, Hättenschwiler S, Bragazza L, Buttler A, Delarue F, et al. An unexpected role for mixotrophs in the response of peatland carbon cycling to climate warming. Sci Rep. 2015;5:16931 pubmed publisher
Zhang L, Tran N, Su H, Wang R, Lu Y, Tang H, et al. Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing. elife. 2015;4: pubmed publisher
Saravia J, You D, Shrestha B, Jaligama S, Siefker D, Lee G, et al. Respiratory Syncytial Virus Disease Is Mediated by Age-Variable IL-33. PLoS Pathog. 2015;11:e1005217 pubmed publisher
Kohli M, Yamaguchi M, Setzer F, Karabucak B. Spectrophotometric Analysis of Coronal Tooth Discoloration Induced by Various Bioceramic Cements and Other Endodontic Materials. J Endod. 2015;41:1862-6 pubmed publisher
He W, Shi F, Zhou Z, Li B, Zhang K, Zhang X, et al. A bioinformatic and mechanistic study elicits the antifibrotic effect of ursolic acid through the attenuation of oxidative stress with the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in human hepatic stellate cells and rat liver. Drug Des Devel Ther. 2015;9:3989-4104 pubmed publisher
Willmann L, Erbes T, Halbach S, Brummer T, Jager M, Hirschfeld M, et al. Exometabolom analysis of breast cancer cell lines: Metabolic signature. Sci Rep. 2015;5:13374 pubmed publisher
Dawood A, Manton D, Parashos P, Wong R, Palamara J, Reynolds E. Push-out bond strength of CPP-ACP-modified calcium silicate-based cements. Dent Mater J. 2015;34:490-4 pubmed publisher
Rodríguez Benítez S, Stambolsky C, Gutiérrez Pérez J, Torres Lagares D, Segura Egea J. Pulp Revascularization of Immature Dog Teeth with Apical Periodontitis Using Triantibiotic Paste and Platelet-rich Plasma: A Radiographic Study. J Endod. 2015;41:1299-304 pubmed publisher
Nowicka A, Wilk G, Lipski M, Kołecki J, Buczkowska Radlińska J. Tomographic Evaluation of Reparative Dentin Formation after Direct Pulp Capping with Ca(OH)2, MTA, Biodentine, and Dentin Bonding System in Human Teeth. J Endod. 2015;41:1234-40 pubmed publisher
Jang Y, Song M, Yoo I, Song Y, Roh B, Kim E. A Randomized Controlled Study of the Use of ProRoot Mineral Trioxide Aggregate and Endocem as Direct Pulp Capping Materials: 3-month versus 1-year Outcomes. J Endod. 2015;41:1201-6 pubmed publisher
Kaup M, Dammann C, Schäfer E, Dammaschke T. Shear bond strength of Biodentine, ProRoot MTA, glass ionomer cement and composite resin on human dentine ex vivo. Head Face Med. 2015;11:14 pubmed publisher
Khalil W, Abunasef S. Can Mineral Trioxide Aggregate and Nanoparticulate EndoSequence Root Repair Material Produce Injurious Effects to Rat Subcutaneous Tissues?. J Endod. 2015;41:1151-6 pubmed publisher
Hsu T, Yeh C, Kao C, Chen Y, Huang T, Yang J, et al. Antibacterial and Odontogenesis Efficacy of Mineral Trioxide Aggregate Combined with CO2 Laser Treatment. J Endod. 2015;41:1073-80 pubmed publisher
Kayisli U, Basar M, Guzeloglu Kayisli O, Semerci N, Atkinson H, Shapiro J, et al. Long-acting progestin-only contraceptives impair endometrial vasculature by inhibiting uterine vascular smooth muscle cell survival. Proc Natl Acad Sci U S A. 2015;112:5153-8 pubmed publisher
Marques M, Wesselink P, Shemesh H. Outcome of Direct Pulp Capping with Mineral Trioxide Aggregate: A Prospective Study. J Endod. 2015;41:1026-31 pubmed publisher
Suzuki Y, Hayashi M, Yasukawa T, Kobayashi H, Makino K, Hirano Y, et al. Development of a novel fluorapatite-forming calcium phosphate cement with calcium silicate: in vitro and in vivo characteristics. Dent Mater J. 2015;34:263-9 pubmed publisher
Sheng Z, Yang W, Zhu J. Metallothionein from Pseudosciaena crocea: expression and response to cadmium-induced injury in the testes. Ecotoxicology. 2015;24:779-94 pubmed publisher
Louwakul P, Lertchirakarn V. Response of inflamed pulps of rat molars after capping with pulp-capping material containing fluocinolone acetonide. J Endod. 2015;41:508-12 pubmed publisher
Bücher K, Metz I, Pitchika V, Hickel R, Kühnisch J. Survival characteristics of composite restorations in primary teeth. Clin Oral Investig. 2015;19:1653-62 pubmed publisher
Elster N, Cremona M, Morgan C, Toomey S, Carr A, O Grady A, et al. A preclinical evaluation of the PI3K alpha/delta dominant inhibitor BAY 80-6946 in HER2-positive breast cancer models with acquired resistance to the HER2-targeted therapies trastuzumab and lapatinib. Breast Cancer Res Treat. 2015;149:373-83 pubmed publisher
Müller J, Krijgsman O, Tsoi J, Robert L, Hugo W, Song C, et al. Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma. Nat Commun. 2014;5:5712 pubmed publisher
Yang Y, Huang L, Dong Y, Zhang H, Zhou W, Ban J, et al. In vitro antibacterial activity of a novel resin-based pulp capping material containing the quaternary ammonium salt MAE-DB and Portland cement. PLoS ONE. 2014;9:e112549 pubmed publisher
Symeonidis T, Tamiolakis I, Armatas G, Lykakis I. Green photocatalytic organic transformations by polyoxometalates vs. mesoporous TiO2 nanoparticles: selective aerobic oxidation of alcohols. Photochem Photobiol Sci. 2015;14:563-8 pubmed publisher
Li T, Peng H, Yang H, Kurniawidjaja S, Panthaki P, Zheng Y, et al. S-Adenosylmethionine and methylthioadenosine inhibit β-catenin signaling by multiple mechanisms in liver and colon cancer. Mol Pharmacol. 2015;87:77-86 pubmed publisher
Hou X, Song J, Su J, Huang D, Gao W, Yan J, et al. CD4(+)Foxp3(+) Tregs protect against innate immune cell-mediated fulminant hepatitis in mice. Mol Immunol. 2015;63:420-7 pubmed publisher
Hernandez Morato I, Isseroff T, Sharma S, Pitman M. Differential expression of glial-derived neurotrophic factor in rat laryngeal muscles during reinnervation. Laryngoscope. 2014;124:2750-6 pubmed publisher
Halley Stott R, Jullien J, Pasque V, Gurdon J. Mitosis gives a brief window of opportunity for a change in gene transcription. PLoS Biol. 2014;12:e1001914 pubmed publisher
Fekrazad R, Seraj B, Ghadimi S, Tamiz P, Mottahary P, Dehghan M. The effect of low-level laser therapy (810 nm) on root development of immature permanent teeth in dogs. Lasers Med Sci. 2015;30:1251-7 pubmed publisher
Kang X, Zhao Y, Jiang D, Li X, Wang X, Wu Y, et al. Crystal structure and biochemical studies of Brucella melitensis 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase. Biochem Biophys Res Commun. 2014;446:965-70 pubmed publisher
Ifrim D, Quintin J, Joosten L, Jacobs C, Jansen T, Jacobs L, et al. Trained immunity or tolerance: opposing functional programs induced in human monocytes after engagement of various pattern recognition receptors. Clin Vaccine Immunol. 2014;21:534-45 pubmed publisher
Guan R, Tyler P, Evans G, Schramm V. Thermodynamic analysis of transition-state features in picomolar inhibitors of human 5'-methylthioadenosine phosphorylase. Biochemistry. 2013;52:8313-22 pubmed publisher
Zhang Y, Song M, Ng T, Zhao L, Liu F. Purification and characterization of antioxidant components from the fruiting bodies of Pleurotus abalonus including 9-beta-d-ribofuranosidoadenine, 5'-deoxy-5'-(methylthio)adenosine, and a triterpenoid. Environ Toxicol Pharmacol. 2013;36:689-696 pubmed publisher
Limm K, Ott C, Wallner S, Mueller D, Oefner P, Hellerbrand C, et al. Deregulation of protein methylation in melanoma. Eur J Cancer. 2013;49:1305-13 pubmed publisher
Gao Q, Zheng D, Yuan Z. Substrate preference of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase in Burkholderia thailandensis. FEMS Microbiol Lett. 2013;339:110-6 pubmed publisher
Warlick B, Imker H, Sriram J, Tabita F, Gerlt J. Mechanistic diversity in the RuBisCO superfamily: RuBisCO from Rhodospirillum rubrum is not promiscuous for reactions catalyzed by RuBisCO-like proteins. Biochemistry. 2012;51:9470-9 pubmed publisher
Guan R, Ho M, Fröhlich R, Tyler P, Almo S, Schramm V. Methylthioadenosine deaminase in an alternative quorum sensing pathway in Pseudomonas aeruginosa. Biochemistry. 2012;51:9094-103 pubmed publisher
Erb T, Evans B, Cho K, Warlick B, Sriram J, Wood B, et al. A RubisCO-like protein links SAM metabolism with isoprenoid biosynthesis. Nat Chem Biol. 2012;8:926-32 pubmed publisher
Marti Arbona R, Teshima M, Anderson P, Nowak Lovato K, Hong Geller E, Unkefer C, et al. Identification of new ligands for the methionine biosynthesis transcriptional regulator (MetJ) by FAC-MS. J Mol Microbiol Biotechnol. 2012;22:205-14 pubmed publisher
Ko D, Gamazon E, Shukla K, Pfuetzner R, Whittington D, Holden T, et al. Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death. Proc Natl Acad Sci U S A. 2012;109:E2343-52 pubmed publisher
Zhang Y, Zwart P, Ealick S. A corrected space group for Sulfolobus sulfataricus 5'-deoxy-5'-methylthioadenosine phosphorylase II. Acta Crystallogr D Biol Crystallogr. 2012;68:249-52 pubmed publisher
Waduwara Jayabahu I, Oppermann Y, Wirtz M, Hull Z, Schoor S, Plotnikov A, et al. Recycling of methylthioadenosine is essential for normal vascular development and reproduction in Arabidopsis. Plant Physiol. 2012;158:1728-44 pubmed publisher
Collins C, Volik S, Lapuk A, Wang Y, Gout P, Wu C, et al. Next generation sequencing of prostate cancer from a patient identifies a deficiency of methylthioadenosine phosphorylase, an exploitable tumor target. Mol Cancer Ther. 2012;11:775-83 pubmed publisher
Wang S, Lim J, Thomas K, Yan F, Angeletti R, Schramm V. A complex of methylthioadenosine/S-adenosylhomocysteine nucleosidase, transition state analogue, and nucleophilic water identified by mass spectrometry. J Am Chem Soc. 2012;134:1468-70 pubmed publisher
Buckoreelall K, Sun Y, Hobrath J, Wilson L, Parker W. Identification of Rv0535 as methylthioadenosine phosphorylase from Mycobacterium tuberculosis. Tuberculosis (Edinb). 2012;92:139-47 pubmed publisher
Park A, Hayakawa S, Honda E, Mine Y, Yoshida K, Munakata H. Conditioned media from lung cancer cell line A549 and PC9 inactivate pulmonary fibroblasts by regulating protein phosphorylation. Arch Biochem Biophys. 2012;518:133-41 pubmed publisher
Roe B, Kensicki E, Mohney R, Hall W. Metabolomic profile of hepatitis C virus-infected hepatocytes. PLoS ONE. 2011;6:e23641 pubmed publisher
Garcia Manteiga J, Mari S, Godejohann M, Spraul M, Napoli C, Cenci S, et al. Metabolomics of B to plasma cell differentiation. J Proteome Res. 2011;10:4165-76 pubmed publisher
Chung J, Goo E, Yu S, Choi O, Lee J, Kim J, et al. Small-molecule inhibitor binding to an N-acyl-homoserine lactone synthase. Proc Natl Acad Sci U S A. 2011;108:12089-94 pubmed publisher
Hemeon I, Gutierrez J, Ho M, Schramm V. Characterizing DNA methyltransferases with an ultrasensitive luciferase-linked continuous assay. Anal Chem. 2011;83:4996-5004 pubmed publisher
Pommerrenig B, Feussner K, Zierer W, Rabinovych V, Klebl F, Feussner I, et al. Phloem-specific expression of Yang cycle genes and identification of novel Yang cycle enzymes in Plantago and Arabidopsis. Plant Cell. 2011;23:1904-19 pubmed publisher
Pitakpornpreecha T, Plubrukarn A, Wititsuwannakul R. Quantification of 5'-deoxy-5'-methylthioadenosine in heat-treated natural rubber latex serum. Phytochem Anal. 2012;23:12-5 pubmed publisher
Bretes E, Guranowski A, Nuc K. 5'-methylthioadenosine nucleosidase from yellow lupine (Lupinus luteus): molecular characterization and mutational analysis. Protein Pept Lett. 2011;18:817-24 pubmed
Kirovski G, Stevens A, Czech B, Dettmer K, Weiss T, Wild P, et al. Down-regulation of methylthioadenosine phosphorylase (MTAP) induces progression of hepatocellular carcinoma via accumulation of 5'-deoxy-5'-methylthioadenosine (MTA). Am J Pathol. 2011;178:1145-52 pubmed publisher
Bertino J, Waud W, Parker W, Lubin M. Targeting tumors that lack methylthioadenosine phosphorylase (MTAP) activity: current strategies. Cancer Biol Ther. 2011;11:627-32 pubmed
Demick J, Lanzilotta W. Radical SAM activation of the B12-independent glycerol dehydratase results in formation of 5'-deoxy-5'-(methylthio)adenosine and not 5'-deoxyadenosine. Biochemistry. 2011;50:440-2 pubmed publisher
Basu I, Locker J, Cassera M, Belbin T, Merino E, Dong X, et al. Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5'-methylthioadenosine phosphorylase. J Biol Chem. 2011;286:4902-11 pubmed publisher
Yamaji S, Droggiti A, Lu S, Martinez Chantar M, Warner A, Varela Rey M. S-Adenosylmethionine regulates connexins sub-types expressed by hepatocytes. Eur J Cell Biol. 2011;90:312-22 pubmed publisher
Farrar C, Siu K, Howell P, Jarrett J. Biotin synthase exhibits burst kinetics and multiple turnovers in the absence of inhibition by products and product-related biomolecules. Biochemistry. 2010;49:9985-96 pubmed publisher
Cataldi T, Bianco G, Losito I, Carulli S. A validated interpretation of the collision-induced dissociation of protonated 5'-methylthioadenosine through selected A+1 and A+2 isotope fragmentations by tandem mass spectrometry. Rapid Commun Mass Spectrom. 2010;24:2925-30 pubmed publisher
Longshaw A, Adanitsch F, Gutierrez J, Evans G, Tyler P, Schramm V. Design and synthesis of potent "sulfur-free" transition state analogue inhibitors of 5'-methylthioadenosine nucleosidase and 5'-methylthioadenosine phosphorylase. J Med Chem. 2010;53:6730-46 pubmed publisher
Kobayashi M, Saito K, Tamogami S, Takashima J, Kasuga K, Kojima I. Identification of a 2-cell stage specific inhibitor of the cleavage of preimplantation mouse embryos synthesized by rat hepatoma cells as 5'-deoxy-5'-methylthioadenosine. Zygote. 2011;19:117-25 pubmed publisher
Tapia O, Bengoechea R, Berciano M, Lafarga M. Nucleolar targeting of coilin is regulated by its hypomethylation state. Chromosoma. 2010;119:527-40 pubmed publisher
Sommer J, Itani D, Homlar K, Keedy V, Halpern J, Holt G, et al. Methylthioadenosine phosphorylase and activated insulin-like growth factor-1 receptor/insulin receptor: potential therapeutic targets in chordoma. J Pathol. 2010;220:608-17 pubmed publisher
Chen C, Jin J, James D, Adams Cioaba M, Park J, Guo Y, et al. Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi. Proc Natl Acad Sci U S A. 2009;106:20336-41 pubmed publisher
Vagin V, Wohlschlegel J, Qu J, Jonsson Z, Huang X, Chuma S, et al. Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members. Genes Dev. 2009;23:1749-62 pubmed publisher
Sekowska A, Dénervaud V, Ashida H, Michoud K, Haas D, Yokota A, et al. Bacterial variations on the methionine salvage pathway. BMC Microbiol. 2004;4:9 pubmed
Sekowska A, Danchin A. The methionine salvage pathway in Bacillus subtilis. BMC Microbiol. 2002;2:8 pubmed
Sekowska A, Mulard L, Krogh S, Tse J, Danchin A. MtnK, methylthioribose kinase, is a starvation-induced protein in Bacillus subtilis. BMC Microbiol. 2001;1:15 pubmed
product information
Catalog Number :
D5011
Product Name :
5′-Deoxy-5′-(methylthio)adenosine
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA