This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Diethylstilbestrol
catalog :
D4628
citations: 101
Reference
Hölzel B, Pfannkuche K, Allner B, Allner H, Hescheler J, Derichsweiler D, et al. Following the adverse outcome pathway from micronucleus to cancer using H2B-eGFP transgenic healthy stem cells. Arch Toxicol. 2020;: pubmed publisher
Singh D, Irani D, Bhagat S, Vanage G. Cypermethrin exposure during perinatal period affects fetal development and impairs reproductive functions of F1 female rats. Sci Total Environ. 2020;707:135945 pubmed publisher
Priyanka -, Trivedi A, Maske P, Mote C, Dighe V. Gestational and lactational exposure to triclosan causes impaired fertility of F1 male offspring and developmental defects in F2 generation. Environ Pollut. 2020;257:113617 pubmed publisher
Pino M, Ronchetti S, Cordeiro G, Bollani S, Duvilanski B, Cabilla J. Soluble Guanylyl Cyclase Alpha1 Subunit: A New Marker for Estrogenicity of Endocrine Disruptor Compounds. Environ Toxicol Chem. 2019;38:2719-2728 pubmed publisher
Isaacson D, Shen J, Cao M, Sinclair A, Yue X, Cunha G, et al. Renal Subcapsular xenografing of human fetal external genital tissue - A new model for investigating urethral development. Differentiation. 2017;98:1-13 pubmed publisher
Feng J, Sun M, Bu Y, Luo C. Development of a functionalized polymeric ionic liquid monolith for solid-phase microextraction of polar endocrine disrupting chemicals in aqueous samples coupled to high-performance liquid chromatography. Anal Bioanal Chem. 2015;407:7025-35 pubmed publisher
Küblbeck J, Anttila T, Pulkkinen J, Honkakoski P. Improved assays for xenosensor activation based on reverse transfection. Toxicol In Vitro. 2015;29:1759-65 pubmed publisher
Yuan K, Kang H, Yue Z, Yang L, Lin L, Wang X, et al. Determination of 13 endocrine disrupting chemicals in sediments by gas chromatography-mass spectrometry using subcritical water extraction coupled with dispersed liquid-liquid microextraction and derivatization. Anal Chim Acta. 2015;866:41-7 pubmed publisher
Roth R, Hess E, Kaminsky A. Of fires and frying pans. JAMA. 2015;313:632 pubmed publisher
van der Burg B, Pieterse B, Buist H, Lewin G, van der Linden S, Man H, et al. A high throughput screening system for predicting chemically-induced reproductive organ deformities. Reprod Toxicol. 2015;55:95-103 pubmed publisher
Lim W, Bae S, Jo G, Bazer F, Choi Y, Song G. Prostaglandin Dâ‚‚ synthase related to estrogen in the female reproductive tract. Biochem Biophys Res Commun. 2015;456:355-60 pubmed publisher
Wen Y, Niu Z, Ma Y, Ma J, Chen L. Graphene oxide-based microspheres for the dispersive solid-phase extraction of non-steroidal estrogens from water samples. J Chromatogr A. 2014;1368:18-25 pubmed publisher
Iwamune M, Nakamura K, Kitahara Y, Minegishi T. MicroRNA-376a regulates 78-kilodalton glucose-regulated protein expression in rat granulosa cells. PLoS ONE. 2014;9:e108997 pubmed publisher
Koong L, Watson C. Direct estradiol and diethylstilbestrol actions on early- versus late-stage prostate cancer cells. Prostate. 2014;74:1589-603 pubmed publisher
Bhan A, Hussain I, Ansari K, Bobzean S, Perrotti L, Mandal S. Histone methyltransferase EZH2 is transcriptionally induced by estradiol as well as estrogenic endocrine disruptors bisphenol-A and diethylstilbestrol. J Mol Biol. 2014;426:3426-41 pubmed publisher
Smith C, Martin S, Sugunan K, Russek S, Gibbs T, Farb D. A role for picomolar concentrations of pregnenolone sulfate in synaptic activity-dependent Ca2+ signaling and CREB activation. Mol Pharmacol. 2014;86:390-8 pubmed publisher
Mi X, Li S, Li Y, Wang K, Zhu D, Chen G. Quantitative determination of 26 steroids in eggs from various species using liquid chromatography-triple quadrupole-mass spectrometry. J Chromatogr A. 2014;1356:54-63 pubmed publisher
Iparraguirre A, Navarro P, Rodil R, Prieto A, Olivares M, Etxebarria N, et al. Matrix effect during the membrane-assisted solvent extraction coupled to liquid chromatography tandem mass spectrometry for the determination of a variety of endocrine disrupting compounds in wastewater. J Chromatogr A. 2014;1356:163-70 pubmed publisher
Wang S, Rijk J, Besselink H, Houtman R, Peijnenburg A, Brouwer A, et al. Extending an in vitro panel for estrogenicity testing: the added value of bioassays for measuring antiandrogenic activities and effects on steroidogenesis. Toxicol Sci. 2014;141:78-89 pubmed publisher
Gorga M, Insa S, Petrovic M, Barcelo D. Analysis of endocrine disrupters and related compounds in sediments and sewage sludge using on-line turbulent flow chromatography-liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2014;1352:29-37 pubmed publisher
Romer M, Eichner J, Metzger U, Templin M, Plummer S, Ellinger Ziegelbauer H, et al. Cross-platform toxicogenomics for the prediction of non-genotoxic hepatocarcinogenesis in rat. PLoS ONE. 2014;9:e97640 pubmed publisher
Banerjee S, Banerjee S, Saraswat G, Bandyopadhyay S, Kabir S. Female reproductive aging is master-planned at the level of ovary. PLoS ONE. 2014;9:e96210 pubmed publisher
Nakamura E, Otsuka F, Terasaka T, Inagaki K, Hosoya T, Tsukamoto Yamauchi N, et al. Melatonin counteracts BMP-6 regulation of steroidogenesis by rat granulosa cells. J Steroid Biochem Mol Biol. 2014;143:233-9 pubmed publisher
Tournaire M, Epelboin S, Devouche E. [Diethylstilbestrol story]. Therapie. 2014;69:101-14 pubmed publisher
Zhang H, Chen H, Li X, Zhang Q, Sun Y, Liu C, et al. Pharmacokinetics and safety profiles of novel diethylstilbestrol orally dissolving film in comparison with diethylstilbestrol capsules in healthy Chinese male subjects. Int J Clin Pharmacol Ther. 2014;52:407-15 pubmed publisher
Haeno S, Maeda N, Yagi T, Tahata S, Sato M, Sakaguchi K, et al. Diethylstilbestrol decreased adrenal cholesterol and corticosterone in rats. J Endocrinol. 2014;221:261-72 pubmed publisher
Bhan A, Hussain I, Ansari K, Bobzean S, Perrotti L, Mandal S. Bisphenol-A and diethylstilbestrol exposure induces the expression of breast cancer associated long noncoding RNA HOTAIR in vitro and in vivo. J Steroid Biochem Mol Biol. 2014;141:160-70 pubmed publisher
Imai F, Kishi H, Nakao K, Nishimura T, Minegishi T. IL-6 up-regulates the expression of rat LH receptors during granulosa cell differentiation. Endocrinology. 2014;155:1436-44 pubmed publisher
Omlin A, Pezaro C, Zaidi S, Lorente D, Mukherji D, Bianchini D, et al. Reply: 'Comment on Anti-tumour activity of abiraterone and diethylstilboestrol when administered sequentially to men with castration-resistant prostate cancer'. Br J Cancer. 2014;110:267-8 pubmed publisher
Shamash J, Sarker S. Comment on 'Anti-tumour activity of abiraterone and diethylstilboestrol when administered sequentially to men with castration-resistant prostate cancer'. Br J Cancer. 2014;110:266-7 pubmed publisher
Teixeira C, Simões R, Santos M, Calió M, Soares J, Simoes M, et al. Soybean concentrated extract counteracts oxidative stress in the uterus of rats. Climacteric. 2014;17:402-9 pubmed publisher
Mahalingaiah S, Hart J, Wise L, Terry K, BOYNTON JARRETT R, Missmer S. Prenatal diethylstilbestrol exposure and risk of uterine leiomyomata in the Nurses' Health Study II. Am J Epidemiol. 2014;179:186-91 pubmed publisher
Alves M, Oliveira P. Effects of non-steroidal estrogen diethylstilbestrol on pH and ion transport in the mantle epithelium of a bivalve Anodonta cygnea. Ecotoxicol Environ Saf. 2013;97:230-5 pubmed publisher
Omlin A, Pezaro C, Zaidi S, Lorente D, Mukherji D, Bianchini D, et al. Antitumour activity of abiraterone and diethylstilboestrol when administered sequentially to men with castration-resistant prostate cancer. Br J Cancer. 2013;109:1079-84 pubmed publisher
Reed C, Fenton S. Exposure to diethylstilbestrol during sensitive life stages: a legacy of heritable health effects. Birth Defects Res C Embryo Today. 2013;99:134-46 pubmed publisher
Campinho M, Power D. Waterborne exposure of zebrafish embryos to micromole concentrations of ioxynil and diethylstilbestrol disrupts thyrocyte development. Aquat Toxicol. 2013;140-141:279-87 pubmed publisher
Laronda M, Unno K, Ishi K, Serna V, Butler L, Mills A, et al. Diethylstilbestrol induces vaginal adenosis by disrupting SMAD/RUNX1-mediated cell fate decision in the Müllerian duct epithelium. Dev Biol. 2013;381:5-16 pubmed publisher
Mongiat Artus P. [Castration in the treatment of locally advanced or metastatic prostate cancer]. Rev Prat. 2013;63:509-10 pubmed
Bastos Sales L, Kamstra J, Cenijn P, van Rijt L, Hamers T, Legler J. Effects of endocrine disrupting chemicals on in vitro global DNA methylation and adipocyte differentiation. Toxicol In Vitro. 2013;27:1634-43 pubmed publisher
Miyoshi T, Otsuka F, Shimasaki S. GRK-6 mediates FSH action synergistically enhanced by estrogen and the oocyte in rat granulosa cells. Biochem Biophys Res Commun. 2013;434:401-6 pubmed publisher
Han H, Kim B, Lee S, Kim J. An optimised method for the accurate determination of zeranol and diethylstilbestrol in animal tissues using isotope dilution-liquid chromatography/mass spectrometry. Food Chem. 2013;140:44-51 pubmed publisher
Lin S, Huang J, Wu L, Wu T, Cui L. Prevention of osteopenia and dyslipidemia in rats after ovariectomy with combined aspirin and low-dose diethylstilbestrol. Biomed Environ Sci. 2013;26:249-57 pubmed publisher
Zhang S, Lei Y, Xu X, Shi W, Chen S. [Synthesis of artificial diethylstilbestrol antigen for preparation of polyclonal antibodies]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2013;42:25-31 pubmed
MACKAY H, Patterson Z, Khazall R, Patel S, Tsirlin D, Abizaid A. Organizational effects of perinatal exposure to bisphenol-A and diethylstilbestrol on arcuate nucleus circuitry controlling food intake and energy expenditure in male and female CD-1 mice. Endocrinology. 2013;154:1465-75 pubmed publisher
Bosquiazzo V, Vigezzi L, Muñoz de Toro M, Luque E. Perinatal exposure to diethylstilbestrol alters the functional differentiation of the adult rat uterus. J Steroid Biochem Mol Biol. 2013;138:1-9 pubmed publisher
Kakuta H, Matsushita A, Arikawa K, Iguchi T, Sato T. Cholesterol homeostasis in the ovaries of neonatally diethylstilbestrol-treated mice. Exp Clin Endocrinol Diabetes. 2013;121:94-101 pubmed publisher
Hilakivi Clarke L, de Assis S, Warri A. Exposures to synthetic estrogens at different times during the life, and their effect on breast cancer risk. J Mammary Gland Biol Neoplasia. 2013;18:25-42 pubmed publisher
Kuzbari O, Peterson C, Franklin M, Hathaway L, Johnstone E, Hammoud A, et al. Comparative analysis of human CYP3A4 and rat CYP3A1 induction and relevant gene expression by bisphenol A and diethylstilbestrol: implications for toxicity testing paradigms. Reprod Toxicol. 2013;37:24-30 pubmed publisher
D Aloisio A, DeRoo L, Baird D, Weinberg C, Sandler D. Prenatal and infant exposures and age at menarche. Epidemiology. 2013;24:277-84 pubmed publisher
Bechi N, Sorda G, Spagnoletti A, Bhattacharjee J, Vieira Ferro E, de Freitas Barbosa B, et al. Toxicity assessment on trophoblast cells for some environment polluting chemicals and 17β-estradiol. Toxicol In Vitro. 2013;27:995-1000 pubmed publisher
Anawalt B. The silent spermatozoon: are man-made endocrine disruptors killing male fertility?. Asian J Androl. 2013;15:165-8 pubmed publisher
Ivell R, Heng K, Nicholson H, Anand Ivell R. Brief maternal exposure of rats to the xenobiotics dibutyl phthalate or diethylstilbestrol alters adult-type Leydig cell development in male offspring. Asian J Androl. 2013;15:261-8 pubmed publisher
Niang L, Ndoye M, Ouattara A, Jalloh M, Labou M, Thiam I, et al. [Management of prostate cancer in Senegal: what is being done?]. Prog Urol. 2013;23:36-41 pubmed publisher
N Tumba Byn T, Moison D, Lacroix M, Lecureuil C, Lesage L, Prud homme S, et al. Differential effects of bisphenol A and diethylstilbestrol on human, rat and mouse fetal leydig cell function. PLoS ONE. 2012;7:e51579 pubmed publisher
Romero Durán E, Chávez Bravo N, García Rodríguez A. [Clear cells cervical adenocarcinoma in a girl no exposed to dietiletilbestrol]. Rev Med Inst Mex Seguro Soc. 2012;50:549-52 pubmed
Zhao Y, Chen X, Yao S, Li X, Jin M. [Analysis of six phenolic environmental estrogens in bullfrog blood by using dispersive solid-phase extraction and ultrafast liquid chromatography-tandem mass spectrometry]. Se Pu. 2012;30:665-71 pubmed
Fraser C. Regarding how safe is "safe"?. Birth Defects Res A Clin Mol Teratol. 2013;97:67 pubmed publisher
Lim W, Jeong W, Kim J, Yoshimura Y, Bazer F, Han J, et al. Expression and regulation of beta-defensin 11 in the oviduct in response to estrogen and in ovarian tumors of chickens. Mol Cell Endocrinol. 2013;366:1-8 pubmed publisher
Haddad R, Kasneci A, Mepham K, Sebag I, Chalifour L. Gestational exposure to diethylstilbestrol alters cardiac structure/function, protein expression and DNA methylation in adult male mice progeny. Toxicol Appl Pharmacol. 2013;266:27-37 pubmed publisher
Zhu L, Ge G, Liu Y, Guo Z, Peng C, Zhang F, et al. Characterization of UDP-glucuronosyltransferases involved in glucuronidation of diethylstilbestrol in human liver and intestine. Chem Res Toxicol. 2012;25:2663-9 pubmed publisher
Wilkins A, Shahidi M, Parker C, Gunapala R, Thomas K, Huddart R, et al. Diethylstilbestrol in castration-resistant prostate cancer. BJU Int. 2012;110:E727-35 pubmed publisher
Fagin D. Toxicology: The learning curve. Nature. 2012;490:462-5 pubmed publisher
Uno M, Nishimura S, Fukuchi K, Kaneta Y, Oda Y, Komori H, et al. Identification of physiologically active substances as novel ligands for MRGPRD. J Biomed Biotechnol. 2012;2012:816159 pubmed publisher
Nassouri A, Archambeaud F, Desailloud R. [Endocrine disruptors: echoes of congress of Endocrinology in 2012]. Ann Endocrinol (Paris). 2012;73 Suppl 1:S36-44 pubmed publisher
Hill K, Jordan D, Ray J, Mays A, Griffin K. Medical therapy for acquired urinary incontinence in dogs. Int J Pharm Compd. 2012;16:369-75 pubmed
Davis V, Newbold R, Couse J, Rea S, Gallagher K, Hamilton K, et al. Expression of a dominant negative estrogen receptor alpha variant in transgenic mice accelerates uterine cancer induced by the potent estrogen diethylstilbestrol. Reprod Toxicol. 2012;34:512-21 pubmed publisher
Okumu L, Bruinton S, Braden T, Simon L, Goyal H. Estrogen-induced maldevelopment of the penis involves down-regulation of myosin heavy chain 11 (MYH11) expression, a biomarker for smooth muscle cell differentiation. Biol Reprod. 2012;87:109 pubmed publisher
Zhang X, Li J, Ma L, Huang T, Jiang X. Diethylstilbestrol impairs the morphology and function of mouse gubernaculum testis in culture. Cell Biol Toxicol. 2012;28:397-407 pubmed publisher
Yang X, Jiang X, Duan S, Qi Y, Zhang X, Li J. [Diethylstilbestrol affects LGR8 expression in mouse gubernaculum testis]. Zhonghua Nan Ke Xue. 2012;18:681-6 pubmed
Laronda M, Unno K, Butler L, Kurita T. The development of cervical and vaginal adenosis as a result of diethylstilbestrol exposure in utero. Differentiation. 2012;84:252-60 pubmed publisher
Bosset P, Albiges L, Seisen T, de La Motte Rouge T, Phé V, Bitker M, et al. Current role of diethylstilbestrol in the management of advanced prostate cancer. BJU Int. 2012;110:E826-9 pubmed publisher
Kebir O, Krebs M. Diethylstilbestrol and risk of psychiatric disorders: a critical review and new insights. World J Biol Psychiatry. 2012;13:84-95 pubmed publisher
Pryde D, Dalvie D, Hu Q, Jones P, Obach R, Tran T. Aldehyde oxidase: an enzyme of emerging importance in drug discovery. J Med Chem. 2010;53:8441-60 pubmed publisher
Dobrydneva Y, Williams R, Blackmore P. Diethylstilbestrol and other nonsteroidal estrogens: novel class of store-operated calcium channel modulators. J Cardiovasc Pharmacol. 2010;55:522-30 pubmed publisher
Fourches D, Barnes J, Day N, Bradley P, Reed J, Tropsha A. Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chem Res Toxicol. 2010;23:171-83 pubmed publisher
Waibel M, De Angelis M, Stossi F, Kieser K, Carlson K, Katzenellenbogen B, et al. Bibenzyl- and stilbene-core compounds with non-polar linker atom substituents as selective ligands for estrogen receptor beta. Eur J Med Chem. 2009;44:3412-24 pubmed publisher
Scott S, Selvy P, Buck J, Cho H, Criswell T, Thomas A, et al. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol. 2009;5:108-17 pubmed publisher
Pedersen J, Matsson P, Bergström C, Norinder U, Hoogstraate J, Artursson P. Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). J Med Chem. 2008;51:3275-87 pubmed publisher
Newbold R. Prenatal exposure to diethylstilbestrol (DES). Fertil Steril. 2008;89:e55-6 pubmed publisher
Urbaniak M, Tabudravu J, Msaki A, Matera K, Brenk R, Jaspars M, et al. Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness. Bioorg Med Chem Lett. 2006;16:5744-7 pubmed
Newbold R, Padilla Banks E, Jefferson W. Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations. Endocrinology. 2006;147:S11-7 pubmed
Yamashita S. Expression of estrogen-regulated genes during development in the mouse uterus exposed to diethylstilbestrol neonatally. Curr Pharm Des. 2006;12:1505-20 pubmed
Selassie C, Kapur S, Verma R, Rosario M. Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study. J Med Chem. 2005;48:7234-42 pubmed
Lill M, Winiger F, Vedani A, Ernst B. Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals. J Med Chem. 2005;48:5666-74 pubmed
Lauver D, Nelles K, Hanson K. The health effects of diethylstilbestrol revisited. J Obstet Gynecol Neonatal Nurs. 2005;34:494-9 pubmed
Zuercher W, Gaillard S, Orband Miller L, Chao E, Shearer B, Jones D, et al. Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma. J Med Chem. 2005;48:3107-9 pubmed
Couse J, Korach K. Estrogen receptor-alpha mediates the detrimental effects of neonatal diethylstilbestrol (DES) exposure in the murine reproductive tract. Toxicology. 2004;205:55-63 pubmed
Blunt E. Diethylstilbestrol exposure: it's still an issue. Holist Nurs Pract. 2004;18:187-91 pubmed
Newbold R. Lessons learned from perinatal exposure to diethylstilbestrol. Toxicol Appl Pharmacol. 2004;199:142-50 pubmed
Schrager S, Potter B. Diethylstilbestrol exposure. Am Fam Physician. 2004;69:2395-400 pubmed
Scherr D, Pitts W. The nonsteroidal effects of diethylstilbestrol: the rationale for androgen deprivation therapy without estrogen deprivation in the treatment of prostate cancer. J Urol. 2003;170:1703-8 pubmed
Bamigboye A, Morris J. Oestrogen supplementation, mainly diethylstilbestrol, for preventing miscarriages and other adverse pregnancy outcomes. Cochrane Database Syst Rev. 2003;:CD004353 pubmed
Nakagawa M. [Estrogen therapy--high-dose intravenous diethylstilbestrol diphosphate therapy for advanced or hormone refractory prostate cancer]. Nihon Rinsho. 2002;60 Suppl 11:199-204 pubmed
Hammes B, Laitman C. Diethylstilbestrol (DES) update: recommendations for the identification and management of DES-exposed individuals. J Midwifery Womens Health. 2003;48:19-29 pubmed
Carmichael P, Mills J, Campbell M, Basu M, Caldwell J. Mechanisms of hormonal carcinogenesis in the p53+/- hemizygous knockout mouse: studies with diethylstilbestrol. Toxicol Pathol. 2001;29 Suppl:155-60 pubmed
Treffers P, Hanselaar A, Helmerhorst T, Koster M, van Leeuwen F. [Consequences of diethylstilbestrol during pregnancy; 50 years later still a significant problem]. Ned Tijdschr Geneeskd. 2001;145:675-80 pubmed
Malkowicz S. The role of diethylstilbestrol in the treatment of prostate cancer. Urology. 2001;58:108-13 pubmed
Jørgensen M, Vendelbo B, Skakkebaek N, Leffers H. Assaying estrogenicity by quantitating the expression levels of endogenous estrogen-regulated genes. Environ Health Perspect. 2000;108:403-12 pubmed
Kitamura T, Nishimura S, Sasahara K, Yoshida M, Ando J, Takahashi M, et al. Transplacental administration of diethylstilbestrol (DES) causes lesions in female reproductive organs of Donryu rats, including endometrial neoplasia. Cancer Lett. 1999;141:219-28 pubmed
Silva E, Tornos C, Deavers M, Kaisman K, Gray K, Gershenson D. Induction of epithelial neoplasms in the ovaries of guinea pigs by estrogenic stimulation. Gynecol Oncol. 1998;71:240-6 pubmed
Kuiper G, Carlsson B, Grandien K, Enmark E, Haggblad J, Nilsson S, et al. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology. 1997;138:863-70 pubmed
product information
Catalog Number :
D4628
Product Name :
Diethylstilbestrol
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥99% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA