This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
N G ,N G -Dimethylarginine dihydrochloride
catalog :
D4268
citations: 163
Reference
Musiani D, Giambruno R, Massignani E, Ippolito M, Maniaci M, Jammula S, et al. PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin. Cell Rep. 2020;30:1208-1222.e9 pubmed publisher
Abdel Magied N, Shedid S. Impact of zinc oxide nanoparticles on thioredoxin-interacting protein and asymmetric dimethylarginine as biochemical indicators of cardiovascular disorders in gamma-irradiated rats. Environ Toxicol. 2020;35:430-442 pubmed publisher
Sankowski B, Księżarczyk K, Raćkowska E, Szlufik S, Koziorowski D, Giebułtowicz J. Higher cerebrospinal fluid to plasma ratio of p-cresol sulfate and indoxyl sulfate in patients with Parkinson's disease. Clin Chim Acta. 2020;501:165-173 pubmed publisher
Chen Y, Sheen J, Hsu M, Hsiao C, Wang S, Huang L. Melatonin rescued methotrexate-induced spatial deficit and hyperhomocysteinemia and increased asymmetric dimethylarginine in plasma and dorsal hippocampus in developing rats. Life Sci. 2020;242:116931 pubmed publisher
Berlinguer F, Porcu C, Molle G, Cabiddu A, Dattena M, Gallus M, et al. Circulating Concentrations of Key Regulators of Nitric Oxide Production in Undernourished Sheep Carrying Single and Multiple Fetuses. Animals (Basel). 2019;10: pubmed publisher
Duś Żuchowska M, Walkowiak J, Morawska A, Krzyżanowska Jankowska P, Miśkiewicz Chotnicka A, Przyslawski J, et al. Amaranth Oil Increases Total and LDL Cholesterol Levels without Influencing Early Markers of Atherosclerosis in an Overweight and Obese Population: A Randomized Double-Blind Cross-Over Study in Comparison with Rapeseed Oil Supplementation. Nutrients. 2019;11: pubmed publisher
He H, Qiao Y, Zhou Q, Wang Z, Chen X, Liu D, et al. Iron Overload Damages the Endothelial Mitochondria via the ROS/ADMA/DDAHII/eNOS/NO Pathway. Oxid Med Cell Longev. 2019;2019:2340392 pubmed publisher
Lin H, Lee T, Lin S, Yeh Y, Lu T, Hsu C. DDAH-2 alleviates contrast medium iopromide-induced acute kidney injury through nitric oxide synthase. Clin Sci (Lond). 2019;133:2361-2378 pubmed publisher
Zebrowska A, Jastrzebski D, Sadowska Krepa E, Sikora M, Di Giulio C. Comparison of the Effectiveness of High-Intensity Interval Training in Hypoxia and Normoxia in Healthy Male Volunteers: A Pilot Study. Biomed Res Int. 2019;2019:7315714 pubmed publisher
Hsu C, Lu P, Lo M, Lin I, Tain Y. The Association between Nitric Oxide Pathway, Blood Pressure Abnormalities, and Cardiovascular Risk Profile in Pediatric Chronic Kidney Disease. Int J Mol Sci. 2019;20: pubmed publisher
Wu C, Hsieh M, Lee C, Chuang S, Chung M, Lin C. Dimethylarginine Dimethylaminohydrolase 1 Polymorphisms and Venous Intimal Hyperplasia in Hemodialysis Patients. Am J Nephrol. 2019;50:454-464 pubmed publisher
Fernández Macías J, Ochoa Martínez Á, Varela Silva J, Pérez Maldonado I. Atherogenic Index of Plasma: Novel Predictive Biomarker for Cardiovascular Illnesses. Arch Med Res. 2019;50:285-294 pubmed publisher
Fleszar M, Wisniewski J, Zboch M, Diakowska D, Gamian A, Krzystek Korpacka M. Targeted metabolomic analysis of nitric oxide/L-arginine pathway metabolites in dementia: association with pathology, severity, and structural brain changes. Sci Rep. 2019;9:13764 pubmed publisher
Sheen J, Yu H, Tain Y, Chen Y, Hsu M, Huang L. Young rats with increased circulatory asymmetric dimethylarginine exhibited spatial deficit and alterations in dorsal hippocampus brain-derived neurotrophic factor and asymmetric dimethylarginine: Effects of melatonin. Int J Dev Neurosci. 2019;78:83-89 pubmed publisher
Hande L, Thunhaug H, Enebakk T, Ludviksen J, Pettersen K, Hovland A, et al. Addition of marine omega-3 fatty acids to statins in familial hypercholesterolemia does not affect in vivo or in vitro endothelial function. J Clin Lipidol. 2019;13:762-770 pubmed publisher
Ottosson F, Ericson U, Almgren P, Smith E, Brunkwall L, Hellstrand S, et al. Dimethylguanidino Valerate: A Lifestyle-Related Metabolite Associated With Future Coronary Artery Disease and Cardiovascular Mortality. J Am Heart Assoc. 2019;8:e012846 pubmed publisher
Sarker R, Conlon T, Morrone C, Srivastava B, Konyalilar N, Verleden S, et al. CARM1 regulates senescence during airway epithelial cell injury in COPD pathogenesis. Am J Physiol Lung Cell Mol Physiol. 2019;317:L602-L614 pubmed publisher
Hsu C, Lin Y, Yu H, Lin I, Sheen J, Huang L, et al. Protection of Male Rat Offspring against Hypertension Programmed by Prenatal Dexamethasone Administration and Postnatal High-Fat Diet with the Nrf2 Activator Dimethyl Fumarate during Pregnancy. Int J Mol Sci. 2019;20: pubmed publisher
Brites Anselmi G, Azevedo A, Miyazaki A, Pinheiro L, Coeli Lacchini F, de Andrade M, et al. DDAH1 and DDAH2 polymorphisms associate with asymmetrical dimethylarginine plasma levels in erectile dysfunction patients but not in healthy controls. Nitric Oxide. 2019;92:11-17 pubmed publisher
Gessner A, Mieth M, Auge D, Chafai A, Müller F, Fromm M, et al. Establishment of reference values for the lysine acetylation marker Nɛ-acetyllysine in small volume human plasma samples by a multi-target LC-MS/MS method. Amino Acids. 2019;51:1259-1271 pubmed publisher
Shao Z, Schuster A, Borowski A, Thakur A, Li L, Wilson Tang W. Soluble angiotensin converting enzyme 2 levels in chronic heart failure is associated with decreased exercise capacity and increased oxidative stress-mediated endothelial dysfunction. Transl Res. 2019;212:80-88 pubmed publisher
Hammer A, Moertl D, Schlager O, Matschuck M, Seidinger D, Koppensteiner R, et al. Effects of n-3 PUFA on endothelial function in patients with peripheral arterial disease: a randomised, placebo-controlled, double-blind trial. Br J Nutr. 2019;122:698-706 pubmed publisher
Morishita T, Uzui H, Ikeda H, Amaya N, Kaseno K, Ishida K, et al. Effects of Sitagliptin on the Coronary Flow Reserve, Circulating Endothelial Progenitor Cells and Stromal Cell-derived Factor-1alpha. Intern Med. 2019;58:2773-2781 pubmed publisher
Zhao J, Adams A, Weinman S, Tikhanovich I. Hepatocyte PRMT1 protects from alcohol induced liver injury by modulating oxidative stress responses. Sci Rep. 2019;9:9111 pubmed publisher
Iwasaki J, Afify M, Bleilevens C, Klinge U, Weiskirchen R, Steitz J, et al. The Impact of a Nitric Oxide Synthase Inhibitor (L-NAME) on Ischemia⁻Reperfusion Injury of Cholestatic Livers by Pringle Maneuver and Liver Resection after Bile Duct Ligation in Rats. Int J Mol Sci. 2019;20: pubmed publisher
Simonsen U, Winther A, Oliván Viguera A, Comerma Steffensen S, Köhler R, Bek T. Extracellular l-arginine Enhances Relaxations Induced by Opening of Calcium-Activated SKCa Channels in Porcine Retinal Arteriole. Int J Mol Sci. 2019;20: pubmed publisher
Hussein J, Rasheed W, Ramzy T, Nabeeh M, Harvy M, El Toukhy S, et al. Synthesis of docosahexaenoic acid-loaded silver nanoparticles for improving endothelial dysfunctions in experimental diabetes. Hum Exp Toxicol. 2019;38:962-973 pubmed publisher
Andrade F, Villate O, Couce M, Bueno M, Alcalde C, de las Heras J, et al. Asymmetric dimethylarginine as a potential biomarker for management and follow-up of phenylketonuria. Eur J Pediatr. 2019;178:903-911 pubmed publisher
Chen W, Shie C, Yang C, Lee T. Blockade of Cardiac Proton Pump Impairs Ventricular Remodeling Through a Superoxide-DDAH-Dependent Pathway in Infarcted Rats. Acta Cardiol Sin. 2019;35:165-178 pubmed publisher
Martins J, Zachariah J, Selamet Tierney E, Truong U, Morris S, Kutty S, et al. Impact of Treatment Modality on Vascular Function in Coarctation of the Aorta: The LOVE - COARCT Study. J Am Heart Assoc. 2019;8:e011536 pubmed publisher
Guise E, Engel J, Williams M, Mahdi F, Bidwell G, Chade A. Biopolymer-delivered vascular endothelial growth factor improves renal outcomes following revascularization. Am J Physiol Renal Physiol. 2019;316:F1016-F1025 pubmed publisher
Taghikhani E, Maas R, Fromm M, Konig J. The renal transport protein OATP4C1 mediates uptake of the uremic toxin asymmetric dimethylarginine (ADMA) and efflux of cardioprotective L-homoarginine. PLoS ONE. 2019;14:e0213747 pubmed publisher
Matshitse R, Ngoy B, Managa M, Mack J, Nyokong T. Photophysical properties and photodynamic therapy activities of detonated nanodiamonds-BODIPY-phthalocyanines nanoassemblies. Photodiagnosis Photodyn Ther. 2019;26:101-110 pubmed publisher
Pannkuk E, Laiakis E, Gill K, Jain S, Mehta K, Nishita D, et al. Liquid Chromatography-Mass Spectrometry-Based Metabolomics of Nonhuman Primates after 4 Gy Total Body Radiation Exposure: Global Effects and Targeted Panels. J Proteome Res. 2019;18:2260-2269 pubmed publisher
Wu M, Lin P, Li L, Chen D, Yang X, Xu L, et al. Reduced asymmetric dimethylarginine accumulation through inhibition of the type I protein arginine methyltransferases promotes renal fibrosis in obstructed kidneys. FASEB J. 2019;33:6948-6956 pubmed publisher
Patel L, Kilbride H, Stevens P, Eaglestone G, Knight S, L Carter J, et al. Symmetric dimethylarginine is a stronger predictor of mortality risk than asymmetric dimethylarginine among older people with kidney disease. Ann Clin Biochem. 2019;56:367-374 pubmed publisher
Szychowski K, Gminski J. The VGVAPG Peptide Regulates the Production of Nitric Oxide Synthases and Reactive Oxygen Species in Mouse Astrocyte Cells In Vitro. Neurochem Res. 2019;44:1127-1137 pubmed publisher
Uslan C, Köksoy B, Durmus M, Durmuş İşleyen N, Öztürk Y, Cakar Z, et al. The synthesis and investigation of photochemical, photophysical and biological properties of new lutetium, indium, and zinc phthalocyanines substituted with PEGME-2000 blocks. J Biol Inorg Chem. 2019;24:191-210 pubmed publisher
Gao G, Shah P, Liu T, Stansbury J. Step-growth Production of Nanogels for Use as Macromers with Dimethacrylate Monomers. React Funct Polym. 2019;134:85-92 pubmed publisher
Bollenbach A, Tsikas D. Pharmacological activation of dimethylarginine dimethylaminohydrolase (DDAH) activity by inorganic nitrate and DDAH inhibition by NG-hydroxy-L-arginine, Nω,Nω-dimethyl-L-citrulline and Nω,Nω-dimethyl-Nδ-hydroxy-L-citrulline: results and overview. Amino Acids. 2019;51:483-494 pubmed publisher
Radujkovic A, Dai H, Kordelas L, Beelen D, Rachakonda S, Muller Tidow C, et al. Asymmetric dimethylarginine serum levels are associated with early mortality after allogeneic stem cell transplantation. Haematologica. 2019;104:827-834 pubmed publisher
Huang F, del Rio Navarro B, Leija Martinez J, Torres Alcantara S, Ruiz Bedolla E, Hernandez Cadena L, et al. Effect of omega-3 fatty acids supplementation combined with lifestyle intervention on adipokines and biomarkers of endothelial dysfunction in obese adolescents with hypertriglyceridemia. J Nutr Biochem. 2019;64:162-169 pubmed publisher
Ochoa Martínez Á, RuÍz Vera T, Almendarez Reyna C, Zarazúa S, Carrizales Yáñez L, Pérez Maldonado I. Impact of arsenic exposure on clinical biomarkers indicative of cardiovascular disease risk in Mexican women. Ecotoxicol Environ Saf. 2019;169:678-686 pubmed publisher
Ercan M, Mungan S, Guzel I, Celik H, Bal C, Abusoglu S, et al. Serum asymmetric dimethylarginine and nitric oxide levels in Turkish patients with acute ischemic stroke. Adv Clin Exp Med. 2019;28:693-698 pubmed publisher
Yu E, Ruiz Canela M, Razquin C, Guasch Ferré M, Toledo E, Wang D, et al. Changes in arginine are inversely associated with type 2 diabetes: A case-cohort study in the PREDIMED trial. Diabetes Obes Metab. 2019;21:397-401 pubmed publisher
Lillard D, Molloy E, Zan H. Television and Magazine Alcohol Advertising: Exposure and Trends by Sex and Age. J Stud Alcohol Drugs. 2018;79:881-892 pubmed
Tain Y, Chan J, Lee C, Hsu C. Maternal Melatonin Therapy Attenuates Methyl-Donor Diet-Induced Programmed Hypertension in Male Adult Rat Offspring. Nutrients. 2018;10: pubmed publisher
Pajek M, Jerman A, Osredkar J, Ponikvar J, Pajek J. Association of Uremic Toxins and Inflammatory Markers with Physical Performance in Dialysis Patients. Toxins (Basel). 2018;10: pubmed publisher
Hsu C, Lin Y, Lu P, Tain Y. Maternal Resveratrol Therapy Protects Male Rat Offspring against Programmed Hypertension Induced by TCDD and Dexamethasone Exposures: Is It Relevant to Aryl Hydrocarbon Receptor?. Int J Mol Sci. 2018;19: pubmed publisher
Matlou G, Oluwole D, Prinsloo E, Nyokong T. Photodynamic therapy activity of zinc phthalocyanine linked to folic acid and magnetic nanoparticles. J Photochem Photobiol B. 2018;186:216-224 pubmed publisher
Burstein Teitelbaum G, Er J, Monzingo A, Tuley A, Fast W. Dissection, Optimization, and Structural Analysis of a Covalent Irreversible DDAH1 Inhibitor. Biochemistry. 2018;57:4574-4582 pubmed publisher
Hou L, Guo J, Xu F, Weng X, Yue W, Ge J. Cardiomyocyte dimethylarginine dimethylaminohydrolase1 attenuates left-ventricular remodeling after acute myocardial infarction: involvement in oxidative stress and apoptosis. Basic Res Cardiol. 2018;113:28 pubmed publisher
Fleszar M, Wisniewski J, Krzystek Korpacka M, Misiak B, Frydecka D, Piechowicz J, et al. Quantitative Analysis of l-Arginine, Dimethylated Arginine Derivatives, l-Citrulline, and Dimethylamine in Human Serum Using Liquid Chromatography-Mass Spectrometric Method. Chromatographia. 2018;81:911-921 pubmed publisher
Dube E, Oluwole D, Nwaji N, Nyokong T. Glycosylated zinc phthalocyanine-gold nanoparticle conjugates for photodynamic therapy: Effect of nanoparticle shape. Spectrochim Acta A Mol Biomol Spectrosc. 2018;203:85-95 pubmed publisher
Karakeçili F, Cikman A, Aydin M, Gülhan B. Asymmetrical Dimethylarginine Levels in Hepatitis B Virus-Positive Patients. Ann Lab Med. 2018;38:446-449 pubmed publisher
Tain Y, Lee W, Wu K, Leu S, Chan J. Resveratrol Prevents the Development of Hypertension Programmed by Maternal Plus Post-Weaning High-Fructose Consumption through Modulation of Oxidative Stress, Nutrient-Sensing Signals, and Gut Microbiota. Mol Nutr Food Res. 2018;:e1800066 pubmed publisher
Cheung P, Vallania F, Warsinske H, Donato M, Schaffert S, Chang S, et al. Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic Variations with Aging. Cell. 2018;173:1385-1397.e14 pubmed publisher
Bell T, Araujo M, Luo Z, Tomlinson J, Leiper J, Welch W, et al. Regulation of fluid reabsorption in rat or mouse proximal renal tubules by asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase 1. Am J Physiol Renal Physiol. 2018;315:F74-F78 pubmed publisher
Hsu M, Chen Y, Sheen J, Li S, Huang L. Melatonin prevented spatial deficits and increases in brain asymmetric dimethylarginine in young bile duct ligation rats. Neuroreport. 2018;29:541-546 pubmed publisher
Wang C, Luo Z, Carter G, Wellstein A, Jose P, Tomlinson J, et al. NRF2 prevents hypertension, increased ADMA, microvascular oxidative stress, and dysfunction in mice with two weeks of ANG II infusion. Am J Physiol Regul Integr Comp Physiol. 2018;314:R399-R406 pubmed publisher
Vargas Hernandez A, Mace E, Zimmerman O, Zerbe C, Freeman A, Rosenzweig S, et al. Ruxolitinib partially reverses functional natural killer cell deficiency in patients with signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations. J Allergy Clin Immunol. 2018;141:2142-2155.e5 pubmed publisher
Hintenberger R, Falkinger A, Danninger K, Pieringer H. Cardiovascular disease in patients with autoinflammatory syndromes. Rheumatol Int. 2018;38:37-50 pubmed publisher
Snauwaert E, Van Biesen W, Raes A, Holvoet E, Glorieux G, Van Hoeck K, et al. Accumulation of uraemic toxins is reflected only partially by estimated GFR in paediatric patients with chronic kidney disease. Pediatr Nephrol. 2018;33:315-323 pubmed publisher
Balasubramanian V, Mehta G, Jones H, Sharma V, Davies N, Jalan R, et al. Post-Transcriptional Regulation of Hepatic DDAH1 with TNF Blockade Leads to Improved eNOS Function and Reduced Portal Pressure In Cirrhotic Rats. Sci Rep. 2017;7:17900 pubmed publisher
Pang P, Abbott M, Abdi M, Fucci Q, Chauhan N, Mistri M, et al. Pre-clinical model of severe glutathione peroxidase-3 deficiency and chronic kidney disease results in coronary artery thrombosis and depressed left ventricular function. Nephrol Dial Transplant. 2017;: pubmed publisher
Chancharoenthana W, Leelahavanichkul A, Taratummarat S, Wongphom J, Tiranathanagul K, Eiam Ong S. Cilostazol attenuates intimal hyperplasia in a mouse model of chronic kidney disease. PLoS ONE. 2017;12:e0187872 pubmed publisher
Gursel O, Tapan S, Sertoglu E, Tascilar E, Eker I, Ileri T, et al. Elevated plasma asymmetric dimethylarginine levels in children with beta-thalassemia major may be an early marker for endothelial dysfunction. Hematology. 2017;:1-5 pubmed publisher
Saarenhovi M, Salo P, Scheinin M, Lehto J, Lovró Z, Tiihonen K, et al. The effect of an apple polyphenol extract rich in epicatechin and flavan-3-ol oligomers on brachial artery flow-mediated vasodilatory function in volunteers with elevated blood pressure. Nutr J. 2017;16:73 pubmed publisher
Azevedo A, Brites Anselmi G, Pinheiro L, de Almeida Belo V, Coeli Lacchini F, Molina C, et al. Relationship between asymmetric dimethylarginine, nitrite and genetic polymorphisms: Impact on erectile dysfunction therapy. Nitric Oxide. 2017;71:44-51 pubmed publisher
Tain Y, Lin Y, Chan J, Lee C, Hsu C. Maternal melatonin or agomelatine therapy prevents programmed hypertension in male offspring of mother exposed to continuous light. Biol Reprod. 2017;97:636-643 pubmed publisher
Snauwaert E, Van Biesen W, Raes A, Glorieux G, Van Bogaert V, Van Hoeck K, et al. Concentrations of representative uraemic toxins in a healthy versus non-dialysis chronic kidney disease paediatric population. Nephrol Dial Transplant. 2017;: pubmed publisher
Guo W, Diao Z, Liu W. Asymmetric dimethylarginine downregulates sarco/endoplasmic reticulum calcium‑ATPase 3 and induces endoplasmic reticulum stress in human umbilical vein endothelial cells. Mol Med Rep. 2017;16:7541-7547 pubmed publisher
Wang Y, Wang C, Lin W, Tsai Y, Chang C, Lee Y, et al. Identification, chromosomal arrangements and expression analyses of the evolutionarily conserved prmt1 gene in chicken in comparison with its vertebrate paralogue prmt8. PLoS ONE. 2017;12:e0185042 pubmed publisher
Collado S, Coll E, Nicolau C, Azqueta M, Pons M, Cruzado J, et al. Serum osteoprotegerin in prevalent hemodialysis patients: associations with mortality, atherosclerosis and cardiac function. BMC Nephrol. 2017;18:290 pubmed publisher
Ekambaram P, Parasuraman P. Differential expression of sirtuin 2 and adipocyte maturation restriction: an adaptation process during hypoxia in fish. Biol Open. 2017;6:1375-1382 pubmed publisher
Andrade F, López Suárez O, Llarena M, Couce M, Aldámiz Echevarría L. Influence of phenylketonuria's diet on dimethylated arginines and methylation cycle. Medicine (Baltimore). 2017;96:e7392 pubmed publisher
Chuang C, Chang C, Lee Y, Lin W, Chang W, Wu J, et al. PRMT1 expression is elevated in head and neck cancer and inhibition of protein arginine methylation by adenosine dialdehyde or PRMT1 knockdown downregulates proliferation and migration of oral cancer cells. Oncol Rep. 2017;38:1115-1123 pubmed publisher
Donabedian P, Creyer M, Monge F, Schanze K, Chi E, Whitten D. Detergent-induced self-assembly and controllable photosensitizer activity of diester phenylene ethynylenes. Proc Natl Acad Sci U S A. 2017;114:7278-7282 pubmed publisher
Kim K, Jeong S, Han N, Oh J, Oh K, Kim I. Identification of differentially expressed miRNAs associated with chronic kidney disease-mineral bone disorder. Front Med. 2017;11:378-385 pubmed publisher
Shin S, Thapa S, Fung H. Cellular interactions between L-arginine and asymmetric dimethylarginine: Transport and metabolism. PLoS ONE. 2017;12:e0178710 pubmed publisher
Jayachandran I, Sundararajan S, Paramasivam P, Venkatesan B, Subramanian S, Balasubramanyam M, et al. Association of circulatory asymmetric dimethylarginine (ADMA) with diabetic nephropathy in Asian Indians and its causative role in renal cell injury. Clin Biochem. 2017;50:835-842 pubmed publisher
Tan X, Li J, Sun J, Jiao P, Wang Y, Wu Z, et al. The asymmetric dimethylarginine-mediated inhibition of nitric oxide in the rostral ventrolateral medulla contributes to regulation of blood pressure in hypertensive rats. Nitric Oxide. 2017;67:58-67 pubmed publisher
Tajti G, Gesztelyi R, Pak K, Papp C, Kéki S, Szilasi M, et al. Positive correlation of airway resistance and serum asymmetric dimethylarginine level in COPD patients with systemic markers of low-grade inflammation. Int J Chron Obstruct Pulmon Dis. 2017;12:873-884 pubmed publisher
Furtado D, de Moura Leite F, Barreto C, Faria B, Jedlicka L, de Jesus Silva E, et al. Profiles of amino acids and biogenic amines in the plasma of Cri-du-Chat patients. J Pharm Biomed Anal. 2017;140:137-145 pubmed publisher
Guan J, Yan C, Gao Q, Li J, Wang L, Hong M, et al. Analysis of risk factors in patients with leukoaraiosis. Medicine (Baltimore). 2017;96:e6153 pubmed publisher
Kanou A, Kako K, Hirota K, Fukamizu A. PRMT-5 converts monomethylarginines into symmetrical dimethylarginines in Caenorhabditis elegans. J Biochem. 2017;161:231-235 pubmed publisher
Lin Y, Feng M, Lu C, Lei Y, He Z, Xiong Y. Preservation of vascular DDAH activity contributes to the protection of captopril against endothelial dysfunction in hyperlipidemic rabbits. Eur J Pharmacol. 2017;798:43-48 pubmed publisher
Cui K, Luan Y, Tang Z, Rao K, Wang T, Chen Z, et al. Involvement of DDAH/ADMA/NOS/cGMP and COX-2/PTGIS/cAMP Pathways in Human Tissue Kallikrein 1 Protecting Erectile Function in Aged Rats. PLoS ONE. 2017;12:e0170427 pubmed publisher
Shafi T, Hostetter T, Meyer T, Hwang S, Hai X, Melamed M, et al. Serum Asymmetric and Symmetric Dimethylarginine and Morbidity and Mortality in Hemodialysis Patients. Am J Kidney Dis. 2017;70:48-58 pubmed publisher
Arashida N, Nishimoto R, Harada M, Shimbo K, Yamada N. Highly sensitive quantification for human plasma-targeted metabolomics using an amine derivatization reagent. Anal Chim Acta. 2017;954:77-87 pubmed publisher
Feng J, Chen H, Pi L, Wang J, Zhan D. Protective effect of tanshinone IIA against cardiac hypertrophy in spontaneously hypertensive rats through inhibiting the Cys-C/Wnt signaling pathway. Oncotarget. 2017;8:10161-10170 pubmed publisher
Akter K, Mansour M, Hyodo T, Senga T. FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression. Int J Biochem Cell Biol. 2017;84:1-13 pubmed publisher
Duś Żuchowska M, Madry E, Krzyzanowska P, Bogdański P, Walkowiak J. Twelve-week-conjugated linoleic acid supplementation has no effects on the selected markers of atherosclerosis in obese and overweight women. Food Nutr Res. 2016;60:32776 pubmed publisher
Lu T, Hsu C, Chang C, Lin C, Lee T, Lin S, et al. Asymmetric dimethylarginine predicts the risk of contrast-induced acute kidney injury in patients undergoing cardiac catheterization. Atherosclerosis. 2016;254:161-166 pubmed publisher
Tain Y, Lee W, Wu K, Leu S, Chan J. Targeting arachidonic acid pathway to prevent programmed hypertension in maternal fructose-fed male adult rat offspring. J Nutr Biochem. 2016;38:86-92 pubmed publisher
de la Morena M, Leonard D, Torgerson T, Cabral Marques O, Slatter M, Aghamohammadi A, et al. Long-term outcomes of 176 patients with X-linked hyper-IgM syndrome treated with or without hematopoietic cell transplantation. J Allergy Clin Immunol. 2017;139:1282-1292 pubmed publisher
Huang S, Zou D, Peng W, Jiang X, Shao K, Xia L, et al. The prediction roles of asymmetric dimethyl-arginine, adiponectin and apelin for macroangiopathy in patients with impaired glucose regulation. Ann Endocrinol (Paris). 2016;77:633-640 pubmed publisher
Czarnecka A, Milewski K, Jaźwiec R, Zielińska M. Intracerebral Administration of S-Adenosylhomocysteine or S-Adenosylmethionine Attenuates the Increases in the Cortical Extracellular Levels of Dimethylarginines Without Affecting cGMP Level in Rats with Acute Liver Failure. Neurotox Res. 2017;31:99-108 pubmed publisher
Kirkby N, Tesfai A, Ahmetaj Shala B, Gashaw H, Sampaio W, Etelvino G, et al. Ibuprofen arginate retains eNOS substrate activity and reverses endothelial dysfunction: implications for the COX-2/ADMA axis. FASEB J. 2016;30:4172-4179 pubmed
Haissman J, Haugaard A, Knudsen A, Kristoffersen U, Seljeflot I, Pedersen K, et al. Marker of Endothelial Dysfunction Asymmetric Dimethylarginine Is Elevated in HIV Infection but Not Associated With Subclinical Atherosclerosis. J Acquir Immune Defic Syndr. 2016;73:507-513 pubmed
Huang F, del Rio Navarro B, Torres Alcantara S, Pérez Ontiveros J, Ruiz Bedolla E, Saucedo Ramírez O, et al. Adipokines, asymmetrical dimethylarginine, and pulmonary function in adolescents with asthma and obesity. J Asthma. 2017;54:153-161 pubmed publisher
Kavurt S, Demirel N, Bas A, Ulubas Isik D, Ozcan B, Aydemir O. Increased ADMA levels are associated with poor pulmonary outcome in preterm neonates. J Matern Fetal Neonatal Med. 2017;30:864-869 pubmed publisher
Chen D, Zhang K, Li B, Sun D, Zhang H, Fu Q. Epigallocatechin-3-gallate ameliorates erectile function in aged rats via regulation of PRMT1/DDAH/ADMA/NOS metabolism pathway. Asian J Androl. 2017;19:291-297 pubmed publisher
Wang Y, Dong X. Nebivolol ameliorates asymmetric dimethylarginine-induced vascular response in rat aorta via β3 adrenoceptor-mediated mechanism. Clin Exp Hypertens. 2016;38:252-9 pubmed publisher
Tuncer S, Kaldirim U, Eyi Y, Yildirim A, Ekinci S, Kara K, et al. Neopterin, homocysteine, and ADMA levels during and after urticaria attack. Turk J Med Sci. 2015;45:1251-5 pubmed
Pektaş M, Sadi G, Koca H, Yüksel Y, Vurmaz A, Koca T, et al. Resveratrol Ameliorates the Components of Hepatic Inflammation and Apoptosis in a Rat Model of Streptozotocin-Induced Diabetes. Drug Dev Res. 2016;77:12-9 pubmed publisher
Rodionov R, Martens Lobenhoffer J, Brilloff S, Burdin D, Jarzebska N, Demyanov A, et al. Acetylation of asymmetric and symmetric dimethylarginine: an undercharacterized pathway of metabolism of endogenous methylarginines. Nephrol Dial Transplant. 2016;31:57-63 pubmed publisher
Xiao H, Liu Z, Lu X, Deng C, Luo Z. Icariin regulates PRMT/ADMA/DDAH pathway to improve endothelial function. Pharmacol Rep. 2015;67:1147-54 pubmed publisher
Maeda M, Hasegawa H, Sugiyama M, Hyodo T, Ito S, Chen D, et al. Arginine methylation of ubiquitin-associated protein 2-like is required for the accurate distribution of chromosomes. FASEB J. 2016;30:312-23 pubmed publisher
Marcovecchio M, Gravina M, Gallina S, D Adamo E, De Caterina R, Chiarelli F, et al. Increased left atrial size in obese children and its association with insulin resistance: a pilot study. Eur J Pediatr. 2016;175:121-30 pubmed publisher
Ma J, Zhao S, Gao G, Chang H, Ma P, Jin B. Probucol Protects Against Asymmetric Dimethylarginine-Induced Apoptosis in the Cultured Human Brain Microvascular Endothelial Cells. J Mol Neurosci. 2015;57:546-53 pubmed publisher
Klawitter J, McFann K, Pennington A, Wang W, Klawitter J, Christians U, et al. Pravastatin Therapy and Biomarker Changes in Children and Young Adults with Autosomal Dominant Polycystic Kidney Disease. Clin J Am Soc Nephrol. 2015;10:1534-41 pubmed publisher
Alkaitis M, Nardone G, Chertow J, Ackerman H. Resolution and quantification of arginine, monomethylarginine, asymmetric dimethylarginine, and symmetric dimethylarginine in plasma using HPLC with internal calibration. Biomed Chromatogr. 2016;30:294-300 pubmed publisher
Kayacelebi A, Langen J, Weigt Usinger K, Chobanyan Jürgens K, Mariotti F, Schneider J, et al. Biosynthesis of homoarginine (hArg) and asymmetric dimethylarginine (ADMA) from acutely and chronically administered free L-arginine in humans. Amino Acids. 2015;47:1893-908 pubmed publisher
Li Z, Lian H, Liang Q, Zeng F, Zheng D. Effects of rosuvastatin combined with fasudil therapy on rabbits with dyslipidemia. Lipids Health Dis. 2015;14:52 pubmed publisher
Sandri M, Viehmann M, Adams V, Rabald K, Mangner N, Höllriegel R, et al. Chronic heart failure and aging - effects of exercise training on endothelial function and mechanisms of endothelial regeneration: Results from the Leipzig Exercise Intervention in Chronic heart failure and Aging (LEICA) study. Eur J Prev Cardiol. 2016;23:349-58 pubmed publisher
Wang J, Chen D, Zhang K, Zhang H, Fu Q. Effect of DDAH/ADMA/NOS regulation pathway on cavernae corporum cavernosorum rat penis of different age. Andrologia. 2016;48:262-7 pubmed publisher
Gao Q, Fan Y, Mu L, Ma L, Song Z, Zhang Y. S100B and ADMA in cerebral small vessel disease and cognitive dysfunction. J Neurol Sci. 2015;354:27-32 pubmed publisher
Hadjikyriacou A, Yang Y, Espejo A, Bedford M, Clarke S. Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2. J Biol Chem. 2015;290:16723-43 pubmed publisher
Sitar M, Kayacelebi A, Beckmann B, Kielstein J, Tsikas D. Asymmetric dimethylarginine (ADMA) in human blood: effects of extended haemodialysis in the critically ill patient with acute kidney injury, protein binding to human serum albumin and proteolysis by thermolysin. Amino Acids. 2015;47:1983-93 pubmed publisher
Lendeckel U, Wolke C, Bernstein H, Keilhoff G. Effects of nitric oxide synthase deficiency on a disintegrin and metalloproteinase domain-containing protein 12 expression in mouse brain samples. Mol Med Rep. 2015;12:2253-62 pubmed publisher
Akimov A, Prezhdo O. Large-Scale Computations in Chemistry: A Bird's Eye View of a Vibrant Field. Chem Rev. 2015;115:5797-890 pubmed publisher
Gremmel T, Perkmann T, Kopp C, Seidinger D, Eichelberger B, Koppensteiner R, et al. Interleukin-6 and asymmetric dimethylarginine are associated with platelet activation after percutaneous angioplasty with stent implantation. PLoS ONE. 2015;10:e0122586 pubmed publisher
Mommersteeg P, Schoemaker R, Eisel U, Garrelds I, Schalkwijk C, Kop W. Nitric oxide dysregulation in patients with heart failure: the association of depressive symptoms with L-arginine, asymmetric dimethylarginine, symmetric dimethylarginine, and isoprostane. Psychosom Med. 2015;77:292-302 pubmed publisher
Mori Kawabe M, Yasuda Y, Ito M, Matsuo S. Reduction of NO-mediated Relaxing Effects in the Thoracic Aorta in an Experimental Chronic Kidney Disease Mouse Model. J Atheroscler Thromb. 2015;22:845-53 pubmed publisher
Yang Y, Hadjikyriacou A, Xia Z, Gayatri S, Kim D, Zurita Lopez C, et al. PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145. Nat Commun. 2015;6:6428 pubmed publisher
Bilgiç Ã, Altınyazar H, Baran H, Ünlü A. Serum homocysteine, asymmetric dimethyl arginine (ADMA) and other arginine-NO pathway metabolite levels in patients with psoriasis. Arch Dermatol Res. 2015;307:439-44 pubmed publisher
May M, Kayacelebi A, Batkai S, Jordan J, Tsikas D, Engeli S. Plasma and tissue homoarginine concentrations in healthy and obese humans. Amino Acids. 2015;47:1847-52 pubmed publisher
Berg I, van der Heijde D, Dagfinrud H, Seljeflot I, Olsen I, Kvien T, et al. Disease activity in ankylosing spondylitis and associations to markers of vascular pathology and traditional cardiovascular disease risk factors: a cross-sectional study. J Rheumatol. 2015;42:645-53 pubmed publisher
Lanza D, Perna A, Oliva A, Vanholder R, Pletinck A, Guastafierro S, et al. Impact of the uremic milieu on the osteogenic potential of mesenchymal stem cells. PLoS ONE. 2015;10:e0116468 pubmed publisher
Sato T, Yamaguchi H, Kogawa T, Abe T, Mano N. Organic anion transporting polypeptides 1B1 and 1B3 play an important role in uremic toxin handling and drug-uremic toxin interactions in the liver. J Pharm Pharm Sci. 2014;17:475-84 pubmed
Notsu Y, Yano S, Shibata H, Nagai A, Nabika T. Plasma arginine/ADMA ratio as a sensitive risk marker for atherosclerosis: Shimane CoHRE study. Atherosclerosis. 2015;239:61-6 pubmed publisher
Trøseid M, Nestvold T, Nielsen E, Thoresen H, Seljeflot I, Lappegård K. Soluble CD14 is associated with markers of vascular dysfunction in bariatric surgery patients. Metab Syndr Relat Disord. 2015;13:119-24 pubmed publisher
Moonen R, Huizing M, Cavallaro G, González Luis G, Bas Suárez P, Bakker J, et al. Plasma levels of dimethylarginines in preterm very low birth weight neonates: its relation with perinatal factors and short-term outcome. Int J Mol Sci. 2014;16:19-39 pubmed publisher
Petrica L, Vlad A, Gluhovschi G, Gadalean F, Dumitrascu V, Vlad D, et al. Glycated peptides are associated with the variability of endothelial dysfunction in the cerebral vessels and the kidney in type 2 diabetes mellitus patients: a cross-sectional study. J Diabetes Complications. 2015;29:230-7 pubmed publisher
Kandavar R, Fernandez C, Sander G, Kim C, Velaga S, Sukhanov S, et al. Digital plethysmography and arginine metabolism in prehypertension: effect of nebivolol therapy. J Clin Hypertens (Greenwich). 2015;17:14-9 pubmed publisher
Hsu C, Hsu P, Chung M, Lin S, Lu T. Asymmetric dimethylarginine and long-term adverse cardiovascular events in patients with type 2 diabetes: relation with the glycemic control. Cardiovasc Diabetol. 2014;13:156 pubmed publisher
Tang W, Wang Z, Shrestha K, Borowski A, Wu Y, Troughton R, et al. Intestinal microbiota-dependent phosphatidylcholine metabolites, diastolic dysfunction, and adverse clinical outcomes in chronic systolic heart failure. J Card Fail. 2015;21:91-6 pubmed publisher
Makulska I, Szczepańska M, Drożdż D, Polak Jonkisz D, Zwolińska D. Skin autofluorescence as a novel marker of vascular damage in children and adolescents with chronic kidney disease. Pediatr Nephrol. 2015;30:811-9 pubmed publisher
Hosoya K, Minakuchi H, Wakino S, Fujimura K, Hasegawa K, Komatsu M, et al. Insulin resistance in chronic kidney disease is ameliorated by spironolactone in rats and humans. Kidney Int. 2015;87:749-60 pubmed publisher
Sasser J, Cunningham M, Baylis C. Serelaxin reduces oxidative stress and asymmetric dimethylarginine in angiotensin II-induced hypertension. Am J Physiol Renal Physiol. 2014;307:F1355-62 pubmed publisher
Bal F, Bekpinar S, Unlucerci Y, Küskü Kiraz Z, Önder S, Uysal M, et al. Antidiabetic drug metformin is effective on the metabolism of asymmetric dimethylarginine in experimental liver injury. Diabetes Res Clin Pract. 2014;106:295-302 pubmed publisher
Andrade F, Llarena M, Lage S, Aldámiz Echevarría L. Quantification of arginine and its methylated derivatives in healthy children by liquid chromatography-tandem mass spectrometry. J Chromatogr Sci. 2015;53:787-92 pubmed publisher
Cure E, Cure M, Tumkaya L, Kalkan Y, Aydin I, Kirbas A, et al. Topiramate ameliorates abdominal aorta cross-clamping induced liver injury in rats. Saudi J Gastroenterol. 2014;20:297-303 pubmed publisher
Rowland M, Ragina N, Sarkar J, Uyehara C, Senagore A. Is arginine/asymetric dimethylarginine ratio depletion an indicator of insufficient resuscitation in a porcine model of hemorrhage-reperfusion?. Surgery. 2014;156:861-8 pubmed publisher
Hong D, Gao H, Wang X, Li L, Li C, Luo Y, et al. Asymmetric dimethylarginine triggers macrophage apoptosis via the endoplasmic reticulum stress pathway. Mol Cell Biochem. 2015;398:31-8 pubmed publisher
Zebrowska A, Mizia Stec K, Mizia M, Gasior Z, Poprzęcki S. Omega-3 fatty acids supplementation improves endothelial function and maximal oxygen uptake in endurance-trained athletes. Eur J Sport Sci. 2015;15:305-14 pubmed publisher
Zhang F, Li X, Dong Q, Wang Y, Zhang H. Risk of acute cerebral infarction and plasma asymmetrical dimethylarginine and homocysteine levels: a clinical correlation analysis of Chinese population. J Stroke Cerebrovasc Dis. 2014;23:2225-32 pubmed publisher
Hackenhaar F, Fumagalli F, Li Volti G, Sorrenti V, Russo I, Staszewsky L, et al. Relationship between post-cardiac arrest myocardial oxidative stress and myocardial dysfunction in the rat. J Biomed Sci. 2014;21:70 pubmed publisher
Charytan D, Padera R, Helfand A, Zeisberg M, Xu X, Liu X, et al. Increased concentration of circulating angiogenesis and nitric oxide inhibitors induces endothelial to mesenchymal transition and myocardial fibrosis in patients with chronic kidney disease. Int J Cardiol. 2014;176:99-109 pubmed publisher
Aydemir O, Ozcan B, Yücel H, Bas A, Demirel N. Asymmetric dimethylarginine and L-arginine levels in neonatal sepsis and septic shock. J Matern Fetal Neonatal Med. 2015;28:977-82 pubmed publisher
Kanugula A, Gollavilli P, Vasamsetti S, Karnewar S, Gopoju R, Ummanni R, et al. Statin-induced inhibition of breast cancer proliferation and invasion involves attenuation of iron transport: intermediacy of nitric oxide and antioxidant defence mechanisms. FEBS J. 2014;281:3719-38 pubmed publisher
Leng Y, Qiu N, Fang W, Zhang M, He Z, Xiong Y. Involvement of increased endogenous asymmetric dimethylarginine in the hepatic endoplasmic reticulum stress of type 2 diabetic rats. PLoS ONE. 2014;9:e97125 pubmed publisher
Sakatani Y, Miyoshi T, Oe H, Noda Y, Ohno Y, Nakamura K, et al. Pioglitazone prevents the endothelial dysfunction induced by ischemia and reperfusion in healthy subjects. J Cardiovasc Pharmacol. 2014;64:326-31 pubmed publisher
Hsu C, Lee C, Huang L, Tain Y. Aliskiren in early postnatal life prevents hypertension and reduces asymmetric dimethylarginine in offspring exposed to maternal caloric restriction. J Renin Angiotensin Aldosterone Syst. 2015;16:506-13 pubmed publisher
Yousefi B, Faghfoori Z, Samadi N, Karami H, Ahmadi Y, Badalzadeh R, et al. The effects of Ramadan fasting on endothelial function in patients with cardiovascular diseases. Eur J Clin Nutr. 2014;68:835-9 pubmed publisher
Wahlström M, Olivecrona M, Ahlm C, Bengtsson A, Koskinen L, Naredi S, et al. Effects of prostacyclin on the early inflammatory response in patients with traumatic brain injury-a randomised clinical study. Springerplus. 2014;3:98 pubmed publisher
Cordina R, Grieve S, Barnett M, Lagopoulos J, Malitz N, Celermajer D. Brain volumetric, regional cortical thickness and radiographic findings in adults with cyanotic congenital heart disease. Neuroimage Clin. 2014;4:319-25 pubmed publisher
Forst T, Anastassiadis E, Diessel S, Löffler A, Pfutzner A. Effect of linagliptin compared with glimepiride on postprandial glucose metabolism, islet cell function and vascular function parameters in patients with type 2 diabetes mellitus receiving ongoing metformin treatment. Diabetes Metab Res Rev. 2014;30:582-9 pubmed publisher
Strauchmann J, Wallbach M, Bramlage C, Puls M, Konstantinides S, Mueller G, et al. Lipoprotein apheresis reduces biomarkers of plaque destabilization and cardiovascular risk. J Clin Apher. 2014;29:235-42 pubmed publisher
Verbeke L, Farre R, Trebicka J, Komuta M, Roskams T, Klein S, et al. Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats. Hepatology. 2014;59:2286-98 pubmed publisher
Butler J, Zurita Lopez C, Clarke S, Bedford M, Dent S. Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes. J Biol Chem. 2011;286:12234-44 pubmed publisher
Vallance P, Leone A, Calver A, Collier J, Moncada S. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet. 1992;339:572-5 pubmed
product information
Catalog Number :
D4268
Product Name :
N G ,N G -Dimethylarginine dihydrochloride
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA