Fine J, Stroebel B, Faltesek K, Terai K, Haase L, Knutzen K, et al. Intranasal delivery of low-dose insulin ameliorates motor dysfunction and dopaminergic cell death in a 6-OHDA rat model of Parkinson's Disease. Neurosci Lett. 2020;714:134567 pubmed publisher

Zhang X, Chen W, Li P, Calvo R, Southall N, Hu X, et al. Agonist-specific voltage-dependent gating of lysosomal two-pore Na+ channels. elife. 2019;8: pubmed publisher

Roca F, Whitworth L, Redmond S, Jones A, Ramakrishnan L. TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit. Cell. 2019;178:1344-1361.e11 pubmed publisher

Eugenin E, Valdebenito S, Górska A, Martinez A, Bitran M, Saez J. Gap junctions coordinate the propagation of glycogenolysis induced by norepinephrine in the pineal gland. J Neurochem. 2019;151:558-569 pubmed publisher

Amin M, D Cruz B, Madkour M, Al Hetlani E. Magnetic nanocomposite-based SELDI probe for extraction and detection of drugs, amino acids and fatty acids. Mikrochim Acta. 2019;186:503 pubmed publisher

Coleman R, Aguirre K, Spiegel H, Pecos C, Carr J, Harris B. The plus maze and scototaxis test are not valid behavioral assays for anxiety assessment in the South African clawed frog. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2019;: pubmed publisher

Xiong X, Lee C, Li W, Yu J, Zhu L, Kim Y, et al. Acid Sphingomyelinase regulates the localization and trafficking of palmitoylated proteins. Biol Open. 2019;: pubmed publisher

Cartier E, Garcia Olivares J, Janezic E, Viana J, Moore M, Lin M, et al. The SUMO-Conjugase Ubc9 Prevents the Degradation of the Dopamine Transporter, Enhancing Its Cell Surface Level and Dopamine Uptake. Front Cell Neurosci. 2019;13:35 pubmed publisher

Su J, Huang P, Qin M, Lu Q, Sang X, Cai Y, et al. Reduction of HIP2 expression causes motor function impairment and increased vulnerability to dopaminergic degeneration in Parkinson's disease models. Cell Death Dis. 2018;9:1020 pubmed publisher

Menegas W, Akiti K, Amo R, Uchida N, Watabe Uchida M. Dopamine neurons projecting to the posterior striatum reinforce avoidance of threatening stimuli. Nat Neurosci. 2018;21:1421-1430 pubmed publisher

Snider M, Harmon D, Klotz J. Pharmacologic assessment of bovine ruminal and mesenteric vascular serotonin receptor populations. J Anim Sci. 2018;96:1570-1578 pubmed publisher

Klotz J, McDowell K. Tall fescue ergot alkaloids are vasoactive in equine vasculature. J Anim Sci. 2017;95:5151-5160 pubmed publisher

von Linstow C, Waider J, Grebing M, Metaxas A, Lesch K, Finsen B. Serotonin augmentation therapy by escitalopram has minimal effects on amyloid-? levels in early-stage Alzheimer's-like disease in mice. Alzheimers Res Ther. 2017;9:74 pubmed publisher

Jin G, Guo Z, Xiao Y, Yan J, Dong X, Shen A, et al. Practical method for the definition of chromatographic peak parameters in preparative liquid chromatography. J Sep Sci. 2016;39:3917-3926 pubmed publisher

Mitchell N, Koek W, Daws L. Antidepressant-like effects and basal immobility depend on age and serotonin transporter genotype. Genes Brain Behav. 2015;14:543-549 pubmed publisher

Sousa J, Vieira Rocha M, Arribas S, González M, Fresco P, Diniz C. Endothelial and Neuronal Nitric Oxide Activate Distinct Pathways on Sympathetic Neurotransmission in Rat Tail and Mesenteric Arteries. PLoS ONE. 2015;10:e0129224 pubmed publisher

LaRocca T, Stivison E, Mal Sarkar T, Hooven T, Hod E, Spitalnik S, et al. CD59 signaling and membrane pores drive Syk-dependent erythrocyte necroptosis. Cell Death Dis. 2015;6:e1773 pubmed publisher

Hasebe S, Ago Y, Nishiyama S, Oka S, Hashimoto H, Takuma K, et al. Pharmacological profile of encounter-induced hyperactivity in isolation-reared mice. Behav Pharmacol. 2015;26:681-90 pubmed publisher

Wang T, Duan S, Wang S, Lu Y, Zhu Q, Wang L, et al. Coadministration of hydroxysafflor yellow A with levodopa attenuates the dyskinesia. Physiol Behav. 2015;147:193-7 pubmed publisher

Olianas M, Dedoni S, Onali P. Antidepressants activate the lysophosphatidic acid receptor LPA(1) to induce insulin-like growth factor-I receptor transactivation, stimulation of ERK1/2 signaling and cell proliferation in CHO-K1 fibroblasts. Biochem Pharmacol. 2015;95:311-23 pubmed publisher

Liu K, Li J, Tan H, Du C, Xie W, Zhang Y, et al. Serotonin₆ receptors in the dorsal hippocampus regulate depressive-like behaviors in unilateral 6-hydroxydopamine-lesioned Parkinson's rats. Neuropharmacology. 2015;95:290-8 pubmed publisher

dos Santos T, Krüger J, Melleu F, Herold C, Zilles K, Poli A, et al. Distribution of serotonin 5-HT1A-binding sites in the brainstem and the hypothalamus, and their roles in 5-HT-induced sleep and ingestive behaviors in rock pigeons (Columba livia). Behav Brain Res. 2015;295:45-63 pubmed publisher

Chang C, Chen M, Lu J. Effect of antidepressant drugs on the vmPFC-limbic circuitry. Neuropharmacology. 2015;92:116-24 pubmed publisher

Galea C, Mangelings D, Heyden Y. Method development for impurity profiling in SFC: The selection of a dissimilar set of stationary phases. J Pharm Biomed Anal. 2015;111:333-43 pubmed publisher

Kucinski A, Albin R, Lustig C, Sarter M. Modeling falls in Parkinson's disease: Slow gait, freezing episodes and falls in rats with extensive striatal dopamine loss. Behav Brain Res. 2015;282:155-64 pubmed publisher

Li L, Zhang L, Sun Y, Han L, Wu Z, Zhang Q, et al. Activation of serotonin2A receptors in the medial septum-diagonal band of Broca complex enhanced working memory in the hemiparkinsonian rats. Neuropharmacology. 2015;91:23-33 pubmed publisher

Martinez A, Morgese M, Pisanu A, Macheda T, Paquette M, Seillier A, et al. Activation of PPAR gamma receptors reduces levodopa-induced dyskinesias in 6-OHDA-lesioned rats. Neurobiol Dis. 2015;74:295-304 pubmed publisher

Grimm S, Höfner G, Wanner K. Development and validation of an LC-ESI-MS/MS method for the triple reuptake inhibitor indatraline enabling its quantification in MS Binding Assays. Anal Bioanal Chem. 2015;407:471-85 pubmed publisher

Sousa J, Fresco P, Diniz C. Endothelial dysfunction impairs vascular neurotransmission in tail arteries. Neurochem Int. 2015;80:7-13 pubmed publisher

Loh C, Suwanarusk R, Lee Y, Chan K, Choy K, Renia L, et al. Characterization of the commercially-available fluorescent chloroquine-BODIPY conjugate, LynxTag-CQGREEN, as a marker for chloroquine resistance and uptake in a 96-well plate assay. PLoS ONE. 2014;9:e110800 pubmed publisher

Fernández Dueñas V, Gómez Soler M, López Cano M, Taura J, Ledent C, Watanabe M, et al. Uncovering caffeine's adenosine A2A receptor inverse agonism in experimental parkinsonism. ACS Chem Biol. 2014;9:2496-501 pubmed publisher

Han B, Jin H, Song M, Wang T, Zhao H. A potential target for the treatment of Parkinson's disease: effect of lateral habenula lesions. Parkinsonism Relat Disord. 2014;20:1191-5 pubmed publisher

Chotibut T, Fields V, Salvatore M. Norepinephrine transporter inhibition with desipramine exacerbates L-DOPA-induced dyskinesia: role for synaptic dopamine regulation in denervated nigrostriatal terminals. Mol Pharmacol. 2014;86:675-85 pubmed publisher

Padovan Neto F, Cavalcanti Kiwiatkoviski R, Carolino R, Anselmo Franci J, Del Bel E. Effects of prolonged neuronal nitric oxide synthase inhibition on the development and expression of L-DOPA-induced dyskinesia in 6-OHDA-lesioned rats. Neuropharmacology. 2015;89:87-99 pubmed publisher

Falcon E, Maier K, Robinson S, Hill Smith T, Lucki I. Effects of buprenorphine on behavioral tests for antidepressant and anxiolytic drugs in mice. Psychopharmacology (Berl). 2015;232:907-15 pubmed publisher

Lindenbach D, Palumbo N, Ostock C, Vilceus N, Conti M, Bishop C. Side effect profile of 5-HT treatments for Parkinson's disease and L-DOPA-induced dyskinesia in rats. Br J Pharmacol. 2015;172:119-30 pubmed publisher

Nowacka M, Paul Samojedny M, Bielecka A, Obuchowicz E. Chronic social instability stress enhances vulnerability of BDNF response to LPS in the limbic structures of female rats: a protective role of antidepressants. Neurosci Res. 2014;88:74-83 pubmed publisher

Lever J, Miller D, Fergason Cantrell E, Green C, Watkinson L, Carmack T, et al. Relationship between cerebral sigma-1 receptor occupancy and attenuation of cocaine's motor stimulatory effects in mice by PD144418. J Pharmacol Exp Ther. 2014;351:153-63 pubmed publisher

Wang Y, Wang H, Wang T, Huang C, Liu J. L-DOPA-induced dyskinesia in a rat model of Parkinson's disease is associated with the fluctuational release of norepinephrine in the sensorimotor striatum. J Neurosci Res. 2014;92:1733-45 pubmed publisher

Zhao R, Lu W, Fang X, Guo L, Yang Z, Ye N, et al. (6aR)-11-amino-N-propyl-noraporphine, a new dopamine D2 and serotonin 5-HT1A dual agonist, elicits potent antiparkinsonian action and attenuates levodopa-induced dyskinesia in a 6-OHDA-lesioned rat model of Parkinson's disease. Pharmacol Biochem Behav. 2014;124:204-10 pubmed publisher

Carr F, Géranton S, Hunt S. Descending controls modulate inflammatory joint pain and regulate CXC chemokine and iNOS expression in the dorsal horn. Mol Pain. 2014;10:39 pubmed publisher

Mori T, Uzawa N, Kazawa H, Watanabe H, Mochizuki A, Shibasaki M, et al. Differential substitution for the discriminative stimulus effects of 3,4-methylenedioxymethamphetamine and methylphenidate in rats. J Pharmacol Exp Ther. 2014;350:403-11 pubmed publisher

Navailles S, Milan L, Khalki H, Di Giovanni G, Lagière M, De Deurwaerdère P. Noradrenergic terminals regulate L-DOPA-derived dopamine extracellular levels in a region-dependent manner in Parkinsonian rats. CNS Neurosci Ther. 2014;20:671-8 pubmed publisher

Killian L, Docherty J. Cardiovascular stimulant actions of bupropion in comparison to cocaine in the rat. Eur J Pharmacol. 2014;735:32-7 pubmed publisher

Wang Y, Zhang Q, Wang H, Wang T, Liu J. Genome-wide microarray analysis identifies a potential role for striatal retrograde endocannabinoid signaling in the pathogenesis of experimental L-DOPA-induced dyskinesia. Synapse. 2014;68:332-43 pubmed publisher

Shaughnessy R, Retamal C, Oyanadel C, Norambuena A, López A, Bravo Zehnder M, et al. Epidermal growth factor receptor endocytic traffic perturbation by phosphatidate phosphohydrolase inhibition: new strategy against cancer. FEBS J. 2014;281:2172-89 pubmed publisher

Der Avakian A, Mazei Robison M, Kesby J, Nestler E, Markou A. Enduring deficits in brain reward function after chronic social defeat in rats: susceptibility, resilience, and antidepressant response. Biol Psychiatry. 2014;76:542-9 pubmed publisher

Yang J, Bae H, Ki H, Oh J, Kim W, Lee H, et al. Different role of spinal 5-HT(hydroxytryptamine)7 receptors and descending serotonergic modulation in inflammatory pain induced in formalin and carrageenan rat models. Br J Anaesth. 2014;113:138-47 pubmed publisher

Prinz A, Selesnew L, Liss B, Roeper J, Carlsson T. Increased excitability in serotonin neurons in the dorsal raphe nucleus in the 6-OHDA mouse model of Parkinson's disease. Exp Neurol. 2013;248:236-45 pubmed publisher

Stratinaki M, Varidaki A, Mitsi V, Ghose S, Magida J, Dias C, et al. Regulator of G protein signaling 4 [corrected] is a crucial modulator of antidepressant drug action in depression and neuropathic pain models. Proc Natl Acad Sci U S A. 2013;110:8254-9 pubmed publisher

Bäck S, Peranen J, Galli E, Pulkkila P, Lonka Nevalaita L, Tamminen T, et al. Gene therapy with AAV2-CDNF provides functional benefits in a rat model of Parkinson's disease. Brain Behav. 2013;3:75-88 pubmed publisher

Zhang Y, Zhen H, Yao W, Bian F, Mao X, Yang X, et al. Antidepressant drug, desipramine, alleviates allergic rhinitis by regulating Treg and Th17 cells. Int J Immunopathol Pharmacol. 2013;26:107-15 pubmed

Dil mukhametova L, Pronina T, Ugriumov M. [Noradrenaline role in regulation of dopamine-producing neurons in rat arcuate nucleus]. Ross Fiziol Zh Im I M Sechenova. 2012;98:1507-19 pubmed

Naegeli K, O Connor J, Banerjee P, Morilak D. Effects of milnacipran on cognitive flexibility following chronic stress in rats. Eur J Pharmacol. 2013;703:62-6 pubmed publisher

Nichols A, Abell M, Madelyn A, Chen Y, Behrle J, Frick G, et al. Effects of desvenlafaxine on the pharmacokinetics of desipramine in healthy adults. Int Clin Psychopharmacol. 2013;28:99-105 pubmed publisher

Lin H, Yeh W, Huang B, Lin C, Lai C, Lin H, et al. Desipramine protects neuronal cell death and induces heme oxygenase-1 expression in Mes23.5 dopaminergic neurons. PLoS ONE. 2012;7:e50138 pubmed publisher

Platt B, Schulenberg J, Klee N, Nizami M, Clark J. A depressive phenotype induced by Bacille Calmette Guérin in 'susceptible' animals: sensitivity to antidepressants. Psychopharmacology (Berl). 2013;226:501-13 pubmed publisher

Shanks J, Mane S, Ryan R, Paterson D. Ganglion-specific impairment of the norepinephrine transporter in the hypertensive rat. Hypertension. 2013;61:187-93 pubmed publisher

Legates T, Altimus C, Wang H, Lee H, Yang S, Zhao H, et al. Aberrant light directly impairs mood and learning through melanopsin-expressing neurons. Nature. 2012;491:594-8 pubmed publisher

Wu X, Jiang H, Yu L, Hu X, Liu W. Desipramine pretreatment improves sympathetic remodeling and ventricular fibrillation threshold after myocardial ischemia. J Biomed Biotechnol. 2012;2012:732909 pubmed publisher

O Leary O, Zandy S, Dinan T, Cryan J. Lithium augmentation of the effects of desipramine in a mouse model of treatment-resistant depression: a role for hippocampal cell proliferation. Neuroscience. 2013;228:36-46 pubmed publisher

O Connor R, Pusceddu M, O Leary O, Savignac H, Bravo J, El Yacoubi M, et al. Hippocampal group III mGlu receptor mRNA levels are not altered in specific mouse models of stress, depression and antidepressant action. Pharmacol Biochem Behav. 2013;103:561-7 pubmed publisher

Watts A, Gritton H, Sweigart J, Poe G. Antidepressant suppression of non-REM sleep spindles and REM sleep impairs hippocampus-dependent learning while augmenting striatum-dependent learning. J Neurosci. 2012;32:13411-20 pubmed

Jozwiak J, Dietze A, Grover R, Savtschenko A, Etz C, Mohr F, et al. Desipramine prevents cardiac gap junction uncoupling. Naunyn Schmiedebergs Arch Pharmacol. 2012;385:1063-75 pubmed publisher

Ma J, Hou L, Rong Z, Liang P, Fang C, Li H, et al. Antidepressant desipramine leads to C6 glioma cell autophagy: implication for the adjuvant therapy of cancer. Anticancer Agents Med Chem. 2013;13:254-60 pubmed

Polasek T, Patel F, Jensen B, Sorich M, Wiese M, Doogue M. Predicted metabolic drug clearance with increasing adult age. Br J Clin Pharmacol. 2013;75:1019-28 pubmed publisher

Saraji M, Mehrafza N, Bidgoli A, Jafari M. Determination of desipramine in biological samples using liquid-liquid-liquid microextraction combined with in-syringe derivatization, gas chromatography, and nitrogen/phosphorus detection. J Sep Sci. 2012;35:2637-44 pubmed publisher

Lopes Rocha F, Fuzikawa C, Riera R, Ramos M, Hara C. Antidepressant combination for major depression in incomplete responders--a systematic review. J Affect Disord. 2013;144:1-6 pubmed publisher

Kubera M, Curzytek K, Majewska Szczepanik M, Szczepanik M, Marcińska K, Ptak W, et al. Inhibitory effect of antidepressant drugs on contact hypersensitivity reaction. Pharmacol Rep. 2012;64:714-22 pubmed

Pechlivanova D, Tchekalarova J, Alova L, Petkov V, Nikolov R, Yakimova K. Effect of long-term caffeine administration on depressive-like behavior in rats exposed to chronic unpredictable stress. Behav Pharmacol. 2012;23:339-47 pubmed publisher

Kim S, Kubomoto S, Chua K, Amichai M, Pimentel M. "Pre-cebo": an unrecognized issue in the interpretation of adequate relief during irritable bowel syndrome drug trials. J Clin Gastroenterol. 2012;46:686-90 pubmed publisher

Simpson J, Kelly J. The effects of isolated and enriched housing conditions on baseline and drug-induced behavioural responses in the male rat. Behav Brain Res. 2012;234:175-83 pubmed publisher

Osakai T, Imoto M, Sato Y, Sakaki T. Application of the mixed-potential theory to the interpretation of the potential response of a PVC membrane ion-selective electrode for desipramine. Anal Sci. 2012;28:565-70 pubmed

Kohno T, Kimura M, Sasaki M, Obata H, Amaya F, Saito S. Milnacipran inhibits glutamatergic N-methyl-D-aspartate receptor activity in spinal dorsal horn neurons. Mol Pain. 2012;8:45 pubmed publisher

Piechal A, Blecharz Klin K, Wyszogrodzka E, Kołomańska P, Rok Bujko P, Krzaścik P, et al. Neonatal serotonin (5-HT) depletion does not affect spatial learning and memory in rats. Pharmacol Rep. 2012;64:266-74 pubmed

Zwang T, Patel R, Johal M, SELASSIE C. Desolvation of BSA-ligand complexes measured using the quartz crystal microbalance and dual polarization interferometer. Langmuir. 2012;28:9616-20 pubmed publisher

Farghaly H, Abdel Zaher A, Mostafa M, Kotb H. Comparative evaluation of the effect of tricyclic antidepressants on inducible nitric oxide synthase expression in neuropathic pain model. Nitric Oxide. 2012;27:88-94 pubmed publisher

Furmaga H, Carreño F, Frazer A. Vagal nerve stimulation rapidly activates brain-derived neurotrophic factor receptor TrkB in rat brain. PLoS ONE. 2012;7:e34844 pubmed publisher

Kang J, Lee K, Lee K, Cho S, Seo J, Hur E, et al. Desipramine inhibits histamine H1 receptor-induced Ca2+ signaling in rat hypothalamic cells. PLoS ONE. 2012;7:e36185 pubmed publisher

Gaska M, Kusmider M, Solich J, Faron Górecka A, Krawczyk M, Kułakowski K, et al. Analysis of region-specific changes in gene expression upon treatment with citalopram and desipramine reveals temporal dynamics in response to antidepressant drugs at the transcriptome level. Psychopharmacology (Berl). 2012;223:281-97 pubmed publisher

Mason B, Thomas S, Lightman S, Pariante C. Desipramine treatment has minimal effects on the brain accumulation of glucocorticoids in P-gp-deficient and wild-type mice. Psychoneuroendocrinology. 2011;36:1351-60 pubmed publisher

Torres G, Gainetdinov R, Caron M. Plasma membrane monoamine transporters: structure, regulation and function. Nat Rev Neurosci. 2003;4:13-25 pubmed

Smith N, Levi R. LLC-PK(1) cells stably expressing the human norepinephrine transporter: A functional model of carrier-mediated norepinephrine release in protracted myocardial ischemia. J Pharmacol Exp Ther. 1999;291:456-63 pubmed

Okugawa G, Omori K, Suzukawa J, Fujiseki Y, Kinoshita T, Inagaki C. Long-term treatment with antidepressants increases glucocorticoid receptor binding and gene expression in cultured rat hippocampal neurones. J Neuroendocrinol. 1999;11:887-95 pubmed

Zhu M, Blakely R, Apparsundaram S, Ordway G. Down-regulation of the human norepinephrine transporter in intact 293-hNET cells exposed to desipramine. J Neurochem. 1998;70:1547-55 pubmed