This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
other
product name :
DNA Ligase from T4-infected Escherichia coli
catalog :
D2886
citations: 35
Reference
Zhou Y, Paull T. DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM). J Biol Chem. 2013;288:37112-25 pubmed publisher
Kaur S. Human DNA ligase i (ligi) gene and risk of cervical cancer in North Indian women. Exp Oncol. 2013;35:226-8 pubmed
Liu S, Liu X, Kamdar R, Wanotayan R, Sharma M, Adachi N, et al. C-Terminal region of DNA ligase IV drives XRCC4/DNA ligase IV complex to chromatin. Biochem Biophys Res Commun. 2013;439:173-8 pubmed publisher
Chen F, Zhao Y, Qi L, Fan C. One-step highly sensitive florescence detection of T4 polynucleotide kinase activity and biological small molecules by ligation-nicking coupled reaction-mediated signal amplification. Biosens Bioelectron. 2013;47:218-24 pubmed publisher
Vigasová D, Sarangi P, Kolesar P, Vlasáková D, Slezakova Z, Altmannova V, et al. Lif1 SUMOylation and its role in non-homologous end-joining. Nucleic Acids Res. 2013;41:5341-53 pubmed publisher
Wang C, Lees Miller S. Detection and repair of ionizing radiation-induced DNA double strand breaks: new developments in nonhomologous end joining. Int J Radiat Oncol Biol Phys. 2013;86:440-9 pubmed publisher
Yue J, Lu H, Lan S, Liu J, Stein M, Haffty B, et al. Identification of the DNA repair defects in a case of Dubowitz syndrome. PLoS ONE. 2013;8:e54389 pubmed publisher
Cottarel J, Frit P, Bombarde O, Salles B, Négrel A, Bernard S, et al. A noncatalytic function of the ligation complex during nonhomologous end joining. J Cell Biol. 2013;200:173-86 pubmed publisher
Oh S, Wang Y, Zimbric J, Hendrickson E. Human LIGIV is synthetically lethal with the loss of Rad54B-dependent recombination and is required for certain chromosome fusion events induced by telomere dysfunction. Nucleic Acids Res. 2013;41:1734-49 pubmed publisher
Srivastava M, Nambiar M, Sharma S, Karki S, Goldsmith G, Hegde M, et al. An inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progression. Cell. 2012;151:1474-87 pubmed publisher
Bacon C, Wilkinson S, Spickett G, Barge D, Lucraft H, Jackson G, et al. Epstein-Barr virus-independent diffuse large B-cell lymphoma in DNA ligase 4 deficiency. J Allergy Clin Immunol. 2013;131:1237-9, 1239.e1 pubmed publisher
De Ioannes P, Malu S, Cortes P, Aggarwal A. Structural basis of DNA ligase IV-Artemis interaction in nonhomologous end-joining. Cell Rep. 2012;2:1505-12 pubmed publisher
Zhu H, Bhattarai H, Yan H, Shuman S, Glickman M. Characterization of Mycobacterium smegmatis PolD2 and PolD1 as RNA/DNA polymerases homologous to the POL domain of bacterial DNA ligase D. Biochemistry. 2012;51:10147-58 pubmed publisher
Petrova T, Bezsudnova E, Boyko K, Mardanov A, Polyakov K, Volkov V, et al. ATP-dependent DNA ligase from Thermococcus sp. 1519 displays a new arrangement of the OB-fold domain. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012;68:1440-7 pubmed publisher
Grundy G, Rulten S, Zeng Z, Arribas Bosacoma R, Iles N, Manley K, et al. APLF promotes the assembly and activity of non-homologous end joining protein complexes. EMBO J. 2013;32:112-25 pubmed publisher
Nishizawa Yokoi A, Nonaka S, Saika H, Kwon Y, Osakabe K, Toki S. Suppression of Ku70/80 or Lig4 leads to decreased stable transformation and enhanced homologous recombination in rice. New Phytol. 2012;196:1048-59 pubmed publisher
Zhou L, Luan H, Dong X, Jin G, Man D, Shang H. Lack of association between LIG4 gene polymorphisms and the risk of breast cancer: a HuGE review and meta-analysis. Asian Pac J Cancer Prev. 2012;13:3417-22 pubmed
Sassa A, Beard W, Prasad R, Wilson S. DNA sequence context effects on the glycosylase activity of human 8-oxoguanine DNA glycosylase. J Biol Chem. 2012;287:36702-10 pubmed publisher
Sugrue T, Brown J, Lowndes N, Ceredig R. Multiple facets of the DNA damage response contribute to the radioresistance of mouse mesenchymal stromal cell lines. Stem Cells. 2013;31:137-45 pubmed publisher
Peng Z, Liao Z, Dziegielewska B, Matsumoto Y, Thomas S, Wan Y, et al. Phosphorylation of serine 51 regulates the interaction of human DNA ligase I with replication factor C and its participation in DNA replication and repair. J Biol Chem. 2012;287:36711-9 pubmed publisher
Kantartzis A, Williams G, Balakrishnan L, Roberts R, Surtees J, Bambara R. Msh2-Msh3 interferes with Okazaki fragment processing to promote trinucleotide repeat expansions. Cell Rep. 2012;2:216-22 pubmed publisher
Sparks J, Chon H, Cerritelli S, Kunkel T, Johansson E, Crouch R, et al. RNase H2-initiated ribonucleotide excision repair. Mol Cell. 2012;47:980-6 pubmed publisher
Cheng X, Ivessa A. Accumulation of linear mitochondrial DNA fragments in the nucleus shortens the chronological life span of yeast. Eur J Cell Biol. 2012;91:782-8 pubmed publisher
Robertson A, Matson S. Reconstitution of the very short patch repair pathway from Escherichia coli. J Biol Chem. 2012;287:32953-66 pubmed
Ochiai H, Sakamoto N, Fujita K, Nishikawa M, Suzuki K, Matsuura S, et al. Zinc-finger nuclease-mediated targeted insertion of reporter genes for quantitative imaging of gene expression in sea urchin embryos. Proc Natl Acad Sci U S A. 2012;109:10915-20 pubmed publisher
Ochi T, Wu Q, Chirgadze D, Grossmann J, Bolanos Garcia V, Blundell T. Structural insights into the role of domain flexibility in human DNA ligase IV. Structure. 2012;20:1212-22 pubmed publisher
Gu W, Wang T, Maltais F, Ledford B, Kennedy J, Wei Y, et al. Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part I: aminoalkoxypyrimidine carboxamides. Bioorg Med Chem Lett. 2012;22:3693-8 pubmed publisher
Wang T, Duncan L, Gu W, O Dowd H, Wei Y, Perola E, et al. Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part 2: 4-amino-pyrido[2,3-d]pyrimidin-5(8H)-ones. Bioorg Med Chem Lett. 2012;22:3699-703 pubmed publisher
Gilson T, Greer A, Vindigni A, Ketner G, HANAKAHI L. The α2 helix in the DNA ligase IV BRCT-1 domain is required for targeted degradation of ligase IV during adenovirus infection. Virology. 2012;428:128-35 pubmed publisher
Weiss B, Richardson C. Enzymatic breakage and joining of deoxyribonucleic acid, I. Repair of single-strand breaks in DNA by an enzyme system from Escherichia coli infected with T4 bacteriophage. Proc Natl Acad Sci U S A. 1967;57:1021-8 pubmed
Bertazzoni U, Mathelet M, Campagnari F. Purification and properties of a polynucleotide ligase from calf thymus glands. Biochim Biophys Acta. 1972;287:404-14 pubmed
Becker A, Lyn G, Gefter M, Hurwitz J. The enzymatic repair of DNA, II. Characterization of phage-induced sealase. Proc Natl Acad Sci U S A. 1967;58:1996-2003 pubmed
Rusche J, Howard Flanders P. Hexamine cobalt chloride promotes intermolecular ligation of blunt end DNA fragments by T4 DNA ligase. Nucleic Acids Res. 1985;13:1997-2008 pubmed
Upcroft P, Healey A. Rapid and efficient method for cloning of blunt-ended DNA fragments. Gene. 1987;51:69-75 pubmed
Moore M, Sharp P. Site-specific modification of pre-mRNA: the 2'-hydroxyl groups at the splice sites. Science. 1992;256:992-7 pubmed
product information
Catalog Number :
D2886
Product Name :
DNA Ligase from T4-infected Escherichia coli
Product Type :
CLONING AND EXPRESSION
Product Group :
Molecular Platforms
Product Description :
buffered aqueous glycerol solution
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA