This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
DL-α-Difluoromethylornithine hydrochloride hydrate
catalog :
D193
citations: 31
Reference
Elmetwally M, Halawa A, Lenis Y, Tang W, Wu G, Bazer F. Effects of BPA on expression of apoptotic genes and migration of ovine trophectoderm (oTr1) cells during the peri-implantation period of pregnancy. Reprod Toxicol. 2019;83:73-79 pubmed publisher
Mathieu C, González Salgado A, Wirdnam C, Meier S, Grotemeyer M, Inbar E, et al. Trypanosoma brucei eflornithine transporter AAT6 is a low-affinity low-selective transporter for neutral amino acids. Biochem J. 2014;463:9-18 pubmed publisher
Bespalov V, Alexandrov V, Semenov A, Kovan ko E, Ivanov S. Anticarcinogenic activity of alpha-difluoromethylornithine, ginseng, eleutherococcus, and leuzea on radiation-induced carcinogenesis in female rats. Int J Radiat Biol. 2014;90:1191-200 pubmed publisher
Lewis J, O Brien T, Skorupski K, Krick E, Reiter A, Jennings M, et al. Polyamine inhibitors for treatment of feline oral squamous cell carcinoma: a proof-of-concept study. J Vet Dent. 2013;30:140-5 pubmed
Stich A, Ponte Sucre A, Holzgrabe U. Do we need new drugs against human African trypanosomiasis?. Lancet Infect Dis. 2013;13:733-4 pubmed publisher
Lisitskaia K, Sokueva N, Malysheva I, Ivanov A, Shishkin S, Siatkin S. [Identification of the functional activity of synthetic polyamine analogues using a biotest system based on highly proliferating cultured human cells]. Prikl Biokhim Mikrobiol. 2013;49:124-8 pubmed
Eisinger F, Cancel Tassin G, Azzouzi A, Gravis G, Rossi D, Cussenot O. [Pharmaco and diet based prostate cancer prevention]. Bull Cancer. 2013;100:497-507 pubmed publisher
North M, Grasemann H, Khanna N, Inman M, Gauvreau G, Scott J. Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma. Am J Respir Cell Mol Biol. 2013;48:694-702 pubmed publisher
Samal K, Zhao P, Kendzicky A, Yco L, McClung H, Gerner E, et al. AMXT-1501, a novel polyamine transport inhibitor, synergizes with DFMO in inhibiting neuroblastoma cell proliferation by targeting both ornithine decarboxylase and polyamine transport. Int J Cancer. 2013;133:1323-33 pubmed publisher
Koomoa D, Geerts D, Lange I, Koster J, Pegg A, Feith D, et al. DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma. Int J Oncol. 2013;42:1219-28 pubmed publisher
Kano Y, Soda K, Konishi F. Suppression of LFA-1 expression by spermine is associated with enhanced methylation of ITGAL, the LFA-1 promoter area. PLoS ONE. 2013;8:e56056 pubmed publisher
Gu X, Reid D, Higham D, Gilbert D. Mathematical modelling of polyamine metabolism in bloodstream-form Trypanosoma brucei: an application to drug target identification. PLoS ONE. 2013;8:e53734 pubmed publisher
Pommergaard H, Burcharth J, Rosenberg J, Raskov H. Topical treatment with diclofenac, calcipotriol (vitamin-D3 analog) and difluoromethylornithine (DFMO) does not prevent nonmelanoma skin cancer in mice. Cancer Invest. 2013;31:92-6 pubmed publisher
Raj K, Zell J, Rock C, McLaren C, Zoumas Morse C, Gerner E, et al. Role of dietary polyamines in a phase III clinical trial of difluoromethylornithine (DFMO) and sulindac for prevention of sporadic colorectal adenomas. Br J Cancer. 2013;108:512-8 pubmed publisher
Preeti -, Tapas S, Kumar P, Madhubala R, Tomar S. Structural insight into DFMO resistant ornithine decarboxylase from Entamoeba histolytica: an inkling to adaptive evolution. PLoS ONE. 2013;8:e53397 pubmed publisher
Wen P, Sui J, Li R, Zhao S, Lu W, Chen W. [Effect of polysaccharides from Radix Glycyrrhizae on migration and polyamines contents of IEC-6 cell]. Zhong Yao Cai. 2012;35:1112-6 pubmed
Jeter J, Alberts D. Difluoromethylornithine: the proof is in the polyamines. Cancer Prev Res (Phila). 2012;5:1341-4 pubmed publisher
Schmid C, Kuemmerle A, Blum J, Ghabri S, Kande V, Mutombo W, et al. In-hospital safety in field conditions of nifurtimox eflornithine combination therapy (NECT) for T. b. gambiense sleeping sickness. PLoS Negl Trop Dis. 2012;6:e1920 pubmed publisher
Bespalov V, Aleksandrov V, Semenov A, Kovan ko E, Ivanov S. [Comparative effects of difluoromethylornithine and tincture of Siberian ginseng root on radiation carcinogenesis and life span in rats]. Adv Gerontol. 2012;25:293-300 pubmed
Zeng X, Mao X, Huang Z, Wang F, Wu G, Qiao S. Arginine enhances embryo implantation in rats through PI3K/PKB/mTOR/NO signaling pathway during early pregnancy. Reproduction. 2013;145:1-7 pubmed publisher
Alirol E, Schrumpf D, Amici Heradi J, Riedel A, de Patoul C, Quere M, et al. Nifurtimox-eflornithine combination therapy for second-stage gambiense human African trypanosomiasis: Médecins Sans Frontières experience in the Democratic Republic of the Congo. Clin Infect Dis. 2013;56:195-203 pubmed publisher
Kreul S, Havighurst T, Kim K, Mendonca E, Wood G, Snow S, et al. A phase III skin cancer chemoprevention study of DFMO: long-term follow-up of skin cancer events and toxicity. Cancer Prev Res (Phila). 2012;5:1368-74 pubmed publisher
Kedia G, Sonnenberg J, Kuczyk M, Uckert S. Arginase enzymes in the human prostate: expression of arginase isoenzymes and effects of arginase inhibitors on isolated human prostate tissue. BJU Int. 2012;110:E1196-201 pubmed publisher
Rial N, Zell J, Cohen A, Gerner E. Clinical end points for developing pharmaceuticals to manage patients with a sporadic or genetic risk of colorectal cancer. Expert Rev Gastroenterol Hepatol. 2012;6:507-17 pubmed publisher
Zell J, Lin B, Madson N, McLaren C, Gerner E, Meyskens F. Role of obesity in a randomized placebo-controlled trial of difluoromethylornithine (DFMO) + sulindac for the prevention of sporadic colorectal adenomas. Cancer Causes Control. 2012;23:1739-44 pubmed publisher
Franks S. The investigation and management of hirsutism. J Fam Plann Reprod Health Care. 2012;38:182-6 pubmed publisher
Vincent I, Creek D, Burgess K, Woods D, Burchmore R, Barrett M. Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma brucei. PLoS Negl Trop Dis. 2012;6:e1618 pubmed publisher
Zou T, Rao J, Liu L, Xiao L, Cui Y, Jiang Z, et al. Polyamines inhibit the assembly of stress granules in normal intestinal epithelial cells regulating apoptosis. Am J Physiol Cell Physiol. 2012;303:C102-11 pubmed publisher
Zhou P, Cheng S, Yang R, Wang B, Liu J. Combination chemoprevention: future direction of colorectal cancer prevention. Eur J Cancer Prev. 2012;21:231-40 pubmed publisher
Derech Haim S, Teiblum G, Kadosh R, Rahav G, Bonda E, Sredni B, et al. Ribonuclease activity of p53 in cytoplasm in response to various stress signals. Cell Cycle. 2012;11:1400-13 pubmed publisher
Rehman R, Aslam M, Soomro M. Reversal of difluoromethylornithine effects by the administration of putrescine in rats. J Pak Med Assoc. 2011;61:752-5 pubmed
product information
Catalog Number :
D193
Product Name :
DL-α-Difluoromethylornithine hydrochloride hydrate
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
solid, ≥97% (NMR)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA