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Wei M, Tong Y, Wang H, Wang L, Yu L. Low pressure steam expansion pretreatment as a competitive approach to improve diosgenin yield and the production of fermentable sugar from Dioscorea zingiberensis C.H. Wright. Bioresour Technol. 2016;206:50-56 pubmed publisher

Wang J, Lu C, Liu D, Xu Y, Zhu Y, Wu H. Constituents from Polygonatum sibiricum and their inhibitions on the formation of advanced glycosylation end products. J Asian Nat Prod Res. 2016;18:697-704 pubmed publisher

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Ren Y, Chen Y, Hu B, Wu H, Lai F, Li X. Microwave-assisted extraction and a new determination method for total steroid saponins from Dioscorea zingiberensis C.H. Wright. Steroids. 2015;104:145-52 pubmed publisher

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Zheng D, Bao J, Lu J, Lv Q. Biodegradation of furfural by Bacillus subtilis strain DS3. J Environ Biol. 2015;36 Spec No:727-32 pubmed

Chen C, Wang Z, Hsu C, Lin H, Chen J. In Vivo Protective Effects of Diosgenin against Doxorubicin-Induced Cardiotoxicity. Nutrients. 2015;7:4938-54 pubmed publisher

Romero Hernández L, Merino Montiel P, Montiel Smith S, Meza Reyes S, Vega Báez J, Abasolo I, et al. Diosgenin-based thio(seleno)ureas and triazolyl glycoconjugates as hybrid drugs. Antioxidant and antiproliferative profile. Eur J Med Chem. 2015;99:67-81 pubmed publisher

Li Y, Wang X, Cheng S, Du J, Deng Z, Zhang Y, et al. Diosgenin induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma cells. Oncol Rep. 2015;33:693-8 pubmed publisher

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Badalzadeh R, Yousefi B, Majidinia M, Ebrahimi H. Anti-arrhythmic effect of diosgenin in reperfusion-induced myocardial injury in a rat model: activation of nitric oxide system and mitochondrial KATP channel. J Physiol Sci. 2014;64:393-400 pubmed publisher

Tong Q, Qing Y, Wu Y, Hu X, Jiang L, Wu X. Dioscin inhibits colon tumor growth and tumor angiogenesis through regulating VEGFR2 and AKT/MAPK signaling pathways. Toxicol Appl Pharmacol. 2014;281:166-73 pubmed publisher

McKoy M, Thomas P, Asemota H, Omoruyi F, Simon O. Effects of Jamaican bitter yam (Dioscorea polygonoides) and diosgenin on blood and fecal cholesterol in rats. J Med Food. 2014;17:1183-8 pubmed publisher

Okawara M, Hashimoto F, Todo H, Sugibayashi K, Tokudome Y. Effect of liquid crystals with cyclodextrin on the bioavailability of a poorly water-soluble compound, diosgenin, after its oral administration to rats. Int J Pharm. 2014;472:257-61 pubmed publisher

Hamid A, Hasanain M, Singh A, Bhukya B, Omprakash -, Vasudev P, et al. Synthesis of novel anticancer agents through opening of spiroacetal ring of diosgenin. Steroids. 2014;87:108-18 pubmed publisher

Manivannan J, Shanthakumar J, Arunagiri P, Raja B, Balamurugan E. Diosgenin interferes coronary vasoconstriction and inhibits osteochondrogenic transdifferentiation of aortic VSMC in CRF rats. Biochimie. 2014;102:183-7 pubmed publisher

He Z, Chen H, Li G, Zhu H, Gao Y, Zhang L, et al. Diosgenin inhibits the migration of human breast cancer MDA-MB-231 cells by suppressing Vav2 activity. Phytomedicine. 2014;21:871-6 pubmed publisher

Wang W, Liu S, Chang W, Shiue Y, Hsieh P, Hung T, et al. The effects of diosgenin in the regulation of renal proximal tubular fibrosis. Exp Cell Res. 2014;323:255-62 pubmed publisher

Qu X, Zhai Z, Liu X, Li H, Ouyang Z, Wu C, et al. Dioscin inhibits osteoclast differentiation and bone resorption though down-regulating the Akt signaling cascades. Biochem Biophys Res Commun. 2014;443:658-65 pubmed publisher

Sangeetha M, Shrishri Mal N, Atmaja K, Sali V, Vasanthi H. PPAR's and Diosgenin a chemico biological insight in NIDDM. Chem Biol Interact. 2013;206:403-10 pubmed publisher

Manrique Moreno M, Londoño Londoño J, Jemioła Rzemińska M, Strzałka K, Villena F, Avello M, et al. Structural effects of the Solanum steroids solasodine, diosgenin and solanine on human erythrocytes and molecular models of eukaryotic membranes. Biochim Biophys Acta. 2014;1838:266-77 pubmed publisher

Qin J, Kang Y, Xu Z, Zang C, Fang B, Liu X. Dioscin prevents the mitochondrial apoptosis and attenuates oxidative stress in cardiac H9c2 cells. Drug Res (Stuttg). 2014;64:47-52 pubmed publisher

Chen P, Wang P, Song N, Li M. Convergent synthesis and cytotoxic activities of 26-thio- and selenodioscin. Steroids. 2013;78:959-66 pubmed publisher

Sánchez Flores J, Romero Avila M, Rosado Abón A, Flores Alamo M, Iglesias Arteaga M. Diacetoxyiodobenzene-mediated synthesis of unnatural furospirostane sapogenins derived from diosgenin and tigogenin. Steroids. 2013;78:798-802 pubmed publisher

Ali Z, Smillie T, Khan I. Two spirostan steroid glycoside fatty esters from Dioscorea cayenensis. Nat Prod Commun. 2013;8:323-6 pubmed

Wang L, Meng Q, Wang C, Liu Q, Peng J, Huo X, et al. Dioscin restores the activity of the anticancer agent adriamycin in multidrug-resistant human leukemia K562/adriamycin cells by down-regulating MDR1 via a mechanism involving NF-?B signaling inhibition. J Nat Prod. 2013;76:909-14 pubmed publisher

Kwong C, Gilman Sachs A, Beaman K. An independent endocytic pathway stimulates different monocyte subsets by the a2 N-terminus domain of vacuolar-ATPase. Oncoimmunology. 2013;2:e22978 pubmed

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Okawara M, Tokudome Y, Todo H, Sugibayashi K, Hashimoto F. Enhancement of diosgenin distribution in the skin by cyclodextrin complexation following oral administration. Biol Pharm Bull. 2013;36:36-40 pubmed

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Cho J, Choi H, Lee J, Kim M, Sohn H, Lee D. The antifungal activity and membrane-disruptive action of dioscin extracted from Dioscorea nipponica. Biochim Biophys Acta. 2013;1828:1153-8 pubmed publisher

Liu C, Wang Y, Wu C, Pei R, Song J, Chen S, et al. Dioscin's antiviral effect in vitro. Virus Res. 2013;172:9-14 pubmed publisher

Guo X, Xin G, He S, Wang Y, Huang B, Zhao H, et al. Novel organic gelators based on pentose derivatized diosgenyl saponins. Org Biomol Chem. 2013;11:821-7 pubmed publisher

Jagadeesan J, Nandakumar N, Rengarajan T, Balasubramanian M. Diosgenin, a steroidal saponin, exhibits anticancer activity by attenuating lipid peroxidation via enhancing antioxidant defense system during NMU-induced breast carcinoma. J Environ Pathol Toxicol Oncol. 2012;31:121-9 pubmed

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Liang C, Lim J, Kim S, Kim D. Dioscin: a synergistic tyrosinase inhibitor from the roots of Smilax china. Food Chem. 2012;134:1146-8 pubmed publisher

Rosado Abón A, de Dios Bravo G, Rodríguez Sotres R, Iglesias Arteaga M. Synthesis and plant growth promoting activity of dinorcholanic lactones bearing the 5α-hydroxy-6-oxo moiety. J Steroid Biochem Mol Biol. 2013;134:45-50 pubmed publisher

Das S, Dey K, Dey G, Pal I, Majumder A, Maitichoudhury S, et al. Antineoplastic and apoptotic potential of traditional medicines thymoquinone and diosgenin in squamous cell carcinoma. PLoS ONE. 2012;7:e46641 pubmed publisher

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Wu S, Gao W, Qiu F, Man S, Fu S, Liu C. Simultaneous quantification of Polyphyllin D and Paris H, two potential antitumor active components in Paris polyphylla by liquid chromatography-tandem mass spectrometry and the application to pharmacokinetics in rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2012;905:54-60 pubmed publisher

Yin X, Qu C, Li Z, Zhai Y, Cao S, Lin L, et al. Simultaneous determination and pharmacokinetic study of polyphyllin I, polyphyllin II, polyphyllin VI and polyphyllin VII in beagle dog plasma after oral administration of Rhizoma Paridis extracts by LC-MS-MS. Biomed Chromatogr. 2013;27:343-8 pubmed publisher

Rajalingam K, Sugunadevi G, Vijayaanand M, Sathiyapriya J, Sivakumar K, Suresh K. Anticlastogenic effect of diosgenin on 7,12-dimethylbenz(a)anthracene treated experimental animals. Toxicol Mech Methods. 2013;23:77-85 pubmed publisher

Kim Y, Kim E, Park K, Lee S, Kim M, Sohn H, et al. Dioscin sensitizes cells to TRAIL-induced apoptosis through downregulation of c-FLIP and Bcl-2. Oncol Rep. 2012;28:1910-6 pubmed publisher

Tohda C, Urano T, Umezaki M, Nemere I, Kuboyama T. Diosgenin is an exogenous activator of 1,25D?-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice. Sci Rep. 2012;2:535 pubmed publisher

Lei J, Niu H, Li T, Huang W. A novel β-glucosidase from Aspergillus fumigates releases diosgenin from spirostanosides of Dioscorea zingiberensis C. H. Wright (DZW). World J Microbiol Biotechnol. 2012;28:1309-14 pubmed publisher

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