This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
protein
product name :
DT Diaphorase (NQO1) human
catalog :
D1315
citations: 12
Reference
Luo S, Kang S, Wang Z, Liu X, Day J, Wu Z, et al. Akt Phosphorylates NQO1 and Triggers its Degradation, Abolishing Its Antioxidative Activities in Parkinson's Disease. J Neurosci. 2019;39:7291-7305 pubmed publisher
Oh E, Park H. Implications of NQO1 in cancer therapy. BMB Rep. 2015;48:609-17 pubmed
Zhao Y, Ren Y, Zhang X, Zhao P, Tao W, Zhong J, et al. Ficolin-2 inhibits hepatitis C virus infection, whereas apolipoprotein E3 mediates viral immune escape. J Immunol. 2014;193:783-96 pubmed publisher
Ma Y, Kong J, Yan G, Ren X, Jin D, Jin T, et al. NQO1 overexpression is associated with poor prognosis in squamous cell carcinoma of the uterine cervix. BMC Cancer. 2014;14:414 pubmed publisher
Yang Y, Zhang Y, Wu Q, Cui X, Lin Z, Liu S, et al. Clinical implications of high NQO1 expression in breast cancers. J Exp Clin Cancer Res. 2014;33:14 pubmed publisher
Lam K, Zheng X, Forestieri R, Balgi A, Nodwell M, Vollett S, et al. Nitazoxanide stimulates autophagy and inhibits mTORC1 signaling and intracellular proliferation of Mycobacterium tuberculosis. PLoS Pathog. 2012;8:e1002691 pubmed publisher
Vehniäinen E, Schultz E, Lehtivuori H, Ihalainen J, Oikari A. More accuracy to the EROD measurements--the resorufin fluorescence differs between species and individuals. Aquat Toxicol. 2012;116-117:102-8 pubmed publisher
Munoz P, Paris I, Sanders L, Greenamyre J, Segura Aguilar J. Overexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity. Biochim Biophys Acta. 2012;1822:1125-36 pubmed publisher
Flader C, Liu J, Borch R. Development of novel quinone phosphorodiamidate prodrugs targeted to DT-diaphorase. J Med Chem. 2000;43:3157-67 pubmed
Skelly J, Sanderson M, Suter D, Baumann U, Read M, Gregory D, et al. Crystal structure of human DT-diaphorase: a model for interaction with the cytotoxic prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954). J Med Chem. 1999;42:4325-30 pubmed
Chen S, Wu K, Zhang D, Sherman M, Knox R, Yang C. Molecular characterization of binding of substrates and inhibitors to DT-diaphorase: combined approach involving site-directed mutagenesis, inhibitor-binding analysis, and computer modeling. Mol Pharmacol. 1999;56:272-8 pubmed
Chen S, Knox R, Wu K, Deng P, Zhou D, Bianchet M, et al. Molecular basis of the catalytic differences among DT-diaphorase of human, rat, and mouse. J Biol Chem. 1997;272:1437-9 pubmed
product information
Catalog Number :
D1315
Product Name :
DT Diaphorase (NQO1) human
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
lyophilized powder, recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA