This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Diphtheria Toxin from Corynebacterium diphtheriae
catalog :
D0564
citations: 69
Reference
Santana Magal N, Farhat Younis L, Gutwillig A, Gleiberman A, Rasoulouniriana D, Tal L, et al. Melanoma-Secreted Lysosomes Trigger Monocyte-Derived Dendritic Cell Apoptosis and Limit Cancer Immunotherapy. Cancer Res. 2020;80:1942-1956 pubmed publisher
Rasmussen R, Matsumoto A, Dahlstrup Sietam M, Yonehara K. A segregated cortical stream for retinal direction selectivity. Nat Commun. 2020;11:831 pubmed publisher
Fu D, Wang L, Chouairi F, Rose I, Abetov D, Miller A, et al. Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5-CD44+ cells. Nat Commun. 2020;11:84 pubmed publisher
Ye J, Mills B, Zhao T, Han B, Murphy J, Patel A, et al. Assessing the Magnitude of Immunogenic Cell Death Following Chemotherapy and Irradiation Reveals a New Strategy to Treat Pancreatic Cancer. Cancer Immunol Res. 2020;8:94-107 pubmed publisher
Wu S, Chiang C. Distinct Role of CD11b+Ly6G-Ly6C- Myeloid-Derived Cells on the Progression of the Primary Tumor and Therapy-Associated Recurrent Brain Tumor. Cells. 2019;9: pubmed publisher
Seishima R, Leung C, Yada S, Murad K, Tan L, Hajamohideen A, et al. Neonatal Wnt-dependent Lgr5 positive stem cells are essential for uterine gland development. Nat Commun. 2019;10:5378 pubmed publisher
Chen Q, Liu Y, Jeong H, Stehling M, Dinh V, Zhou B, et al. Apelin+ Endothelial Niche Cells Control Hematopoiesis and Mediate Vascular Regeneration after Myeloablative Injury. Cell Stem Cell. 2019;25:768-783.e6 pubmed publisher
Min S, Chang R, Prescott S, Beeler B, Joshi N, Strochlic D, et al. Arterial Baroreceptors Sense Blood Pressure through Decorated Aortic Claws. Cell Rep. 2019;29:2192-2201.e3 pubmed publisher
Madaro L, Torcinaro A, De Bardi M, Contino F, Pelizzola M, Diaferia G, et al. Macrophages fine tune satellite cell fate in dystrophic skeletal muscle of mdx mice. PLoS Genet. 2019;15:e1008408 pubmed publisher
Mo M, Eyo U, Xie M, Peng J, Bosco D, Umpierre A, et al. Microglial P2Y12 Receptor Regulates Seizure-Induced Neurogenesis and Immature Neuronal Projections. J Neurosci. 2019;39:9453-9464 pubmed publisher
Wang Z, Zeng Y, Yang P, Jin L, Xiong W, Zhu M, et al. Axonal iron transport in the brain modulates anxiety-related behaviors. Nat Chem Biol. 2019;15:1214-1222 pubmed publisher
Menares E, Gálvez Cancino F, Cáceres Morgado P, Ghorani E, Lopez E, Diaz X, et al. Tissue-resident memory CD8+ T cells amplify anti-tumor immunity by triggering antigen spreading through dendritic cells. Nat Commun. 2019;10:4401 pubmed publisher
Bonnardel J, T Jonck W, Gaublomme D, Browaeys R, Scott C, Martens L, et al. Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche. Immunity. 2019;51:638-654.e9 pubmed publisher
Han S, Fink J, Jörg D, Lee E, Yum M, Chatzeli L, et al. Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells. Cell Stem Cell. 2019;25:342-356.e7 pubmed publisher
Nikolakopoulou A, Montagne A, Kisler K, Dai Z, Wang Y, Huuskonen M, et al. Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss. Nat Neurosci. 2019;22:1089-1098 pubmed publisher
Zhang J, Supakorndej T, Krambs J, Rao M, Abou Ezzi G, Ye R, et al. Bone marrow dendritic cells regulate hematopoietic stem/progenitor cell trafficking. J Clin Invest. 2019;129:2920-2931 pubmed publisher
Miao Y, Yang H, Levorse J, Yuan S, Polak L, Sribour M, et al. Adaptive Immune Resistance Emerges from Tumor-Initiating Stem Cells. Cell. 2019;177:1172-1186.e14 pubmed publisher
Jiang Xie L, Yin L, Zhao S, Prevosto V, Han B, Dzirasa K, et al. A Common Neuroendocrine Substrate for Diverse General Anesthetics and Sleep. Neuron. 2019;102:1053-1065.e4 pubmed publisher
Tuncel J, Benoist C, Mathis D. T cell anergy in perinatal mice is promoted by T reg cells and prevented by IL-33. J Exp Med. 2019;216:1328-1344 pubmed publisher
Yoshikawa S, Oh Hora M, Hashimoto R, Nagao T, Peters L, Egawa M, et al. Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3-stimulated murine basophils. Sci Signal. 2019;12: pubmed publisher
Uderhardt S, Martins A, Tsang J, Lämmermann T, Germain R. Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell. 2019;177:541-555.e17 pubmed publisher
Takeoka A, Arber S. Functional Local Proprioceptive Feedback Circuits Initiate and Maintain Locomotor Recovery after Spinal Cord Injury. Cell Rep. 2019;27:71-85.e3 pubmed publisher
Li Y, Zhao C, Liu J, Lu Z, Lu M, Gu J, et al. CD1d highly expressed on DCs reduces lung tumor burden by enhancing antitumor immunity. Oncol Rep. 2019;41:2679-2688 pubmed publisher
Furuyama K, Chera S, van Gurp L, Oropeza D, Ghila L, Damond N, et al. Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells. Nature. 2019;567:43-48 pubmed publisher
Zhan L, Krabbe G, Du F, Jones I, Reichert M, Telpoukhovskaia M, et al. Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain. PLoS Biol. 2019;17:e3000134 pubmed publisher
Zhao M, Tao F, Venkatraman A, Li Z, Smith S, Unruh J, et al. N-Cadherin-Expressing Bone and Marrow Stromal Progenitor Cells Maintain Reserve Hematopoietic Stem Cells. Cell Rep. 2019;26:652-669.e6 pubmed publisher
Chen H, Hu B, Lv X, Zhu S, Zhen G, Wan M, et al. Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis. Nat Commun. 2019;10:181 pubmed publisher
Siddiqui I, Schaeuble K, Chennupati V, Fuertes Marraco S, Calderon Copete S, Pais Ferreira D, et al. Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy. Immunity. 2019;50:195-211.e10 pubmed publisher
Yellon S, Greaves E, Heuerman A, Dobyns A, Norman J. Effects of macrophage depletion on characteristics of cervix remodeling and pregnancy in CD11b-dtr mice. Biol Reprod. 2019;100:1386-1394 pubmed publisher
Huang T, Lin S, Malewicz N, Zhang Y, Zhang Y, Goulding M, et al. Identifying the pathways required for coping behaviours associated with sustained pain. Nature. 2019;565:86-90 pubmed publisher
Yrlid U, Holm M, Levin M, Alsén S, Lindbom M, Glise L, et al. Endothelial repair is dependent on CD11c+ leukocytes to establish regrowing endothelial sheets with high cellular density. J Leukoc Biol. 2019;105:195-202 pubmed publisher
Tang C, Wang M, Wang P, Wang L, Wu Q, Guo W. Neural Stem Cells Behave as a Functional Niche for the Maturation of Newborn Neurons through the Secretion of PTN. Neuron. 2018;: pubmed publisher
Liu Y, Latremoliere A, Li X, Zhang Z, Chen M, Wang X, et al. Touch and tactile neuropathic pain sensitivity are set by corticospinal projections. Nature. 2018;561:547-550 pubmed publisher
Zwick R, Rudolph M, Shook B, Holtrup B, Roth E, Lei V, et al. Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation. Nat Commun. 2018;9:3592 pubmed publisher
Bauche D, Joyce Shaikh B, Jain R, Grein J, Ku K, Blumenschein W, et al. LAG3+ Regulatory T Cells Restrain Interleukin-23-Producing CX3CR1+ Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis. Immunity. 2018;49:342-352.e5 pubmed publisher
Dhandapani R, Arokiaraj C, Taberner F, Pacifico P, Raja S, Nocchi L, et al. Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons. Nat Commun. 2018;9:1640 pubmed publisher
Panduro M, Benoist C, Mathis D. Treg cells limit IFN-? production to control macrophage accrual and phenotype during skeletal muscle regeneration. Proc Natl Acad Sci U S A. 2018;115:E2585-E2593 pubmed publisher
Meier L, Auger J, Engelson B, Cowan H, Breed E, Gonzalez Torres M, et al. CD301b/MGL2+ Mononuclear Phagocytes Orchestrate Autoimmune Cardiac Valve Inflammation and Fibrosis. Circulation. 2018;137:2478-2493 pubmed publisher
Gaya M, Barral P, Burbage M, Aggarwal S, Montaner B, Warren Navia A, et al. Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells. Cell. 2018;172:517-533.e20 pubmed publisher
Eilken H, Diéguez Hurtado R, Schmidt I, Nakayama M, Jeong H, Arf H, et al. Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1. Nat Commun. 2017;8:1574 pubmed publisher
Wu Y, Pons V, Goudet A, Panigai L, Fischer A, Herweg J, et al. ABMA, a small molecule that inhibits intracellular toxins and pathogens by interfering with late endosomal compartments. Sci Rep. 2017;7:15567 pubmed publisher
Duerrschmid C, He Y, Wang C, Li C, Bournat J, Romere C, et al. Asprosin is a centrally acting orexigenic hormone. Nat Med. 2017;23:1444-1453 pubmed publisher
Wang X, Liu Y, Li X, Zhang Z, Yang H, Zhang Y, et al. Deconstruction of Corticospinal Circuits for Goal-Directed Motor Skills. Cell. 2017;171:440-455.e14 pubmed publisher
Lee J, Tammela T, Hofree M, Choi J, Marjanovic N, Han S, et al. Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6. Cell. 2017;170:1149-1163.e12 pubmed publisher
Nawaz A, Aminuddin A, Kado T, Takikawa A, Yamamoto S, Tsuneyama K, et al. CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors. Nat Commun. 2017;8:286 pubmed publisher
Liu Y, Wang X, Li W, Zhang Q, Li Y, Zhang Z, et al. A Sensitized IGF1 Treatment Restores Corticospinal Axon-Dependent Functions. Neuron. 2017;95:817-833.e4 pubmed publisher
O Sullivan M, Punal V, Kerstein P, Brzezinski J, Glaser T, Wright K, et al. Astrocytes follow ganglion cell axons to establish an angiogenic template during retinal development. Glia. 2017;65:1697-1716 pubmed publisher
Finger Stadler A, Patel M, Pacholczyk R, Cutler C, Arce R. Long-term sustainable dendritic cell-specific depletion murine model for periodontitis research. J Immunol Methods. 2017;449:7-14 pubmed publisher
Davies M, Parekh N, Kaminsky L, Soni C, Reider I, Krouse T, et al. A systemic macrophage response is required to contain a peripheral poxvirus infection. PLoS Pathog. 2017;13:e1006435 pubmed publisher
Zhang L, Wang T, Chang M, Kaiser C, Kim J, Wu T, et al. Teriparatide Treatment Improves Bone Defect Healing Via Anabolic Effects on New Bone Formation and Non-Anabolic Effects on Inhibition of Mast Cells in a Murine Cranial Window Model. J Bone Miner Res. 2017;32:1870-1883 pubmed publisher
Hillier D, Fiscella M, Drinnenberg A, Trenholm S, Rompani S, Raics Z, et al. Causal evidence for retina-dependent and -independent visual motion computations in mouse cortex. Nat Neurosci. 2017;20:960-968 pubmed publisher
Braz B, Belforte J, Murer M, Galiñanes G. Properties of the corticostriatal long term depression induced by medial prefrontal cortex high frequency stimulation in vivo. Neuropharmacology. 2017;121:278-286 pubmed publisher
Martos Y, Braz B, Beccaria J, Murer M, Belforte J. Compulsive Social Behavior Emerges after Selective Ablation of Striatal Cholinergic Interneurons. J Neurosci. 2017;37:2849-2858 pubmed publisher
Schmitner N, Kohno K, Meyer D. ptf1a+ , ela3l- cells are developmentally maintained progenitors for exocrine regeneration following extreme loss of acinar cells in zebrafish larvae. Dis Model Mech. 2017;10:307-321 pubmed publisher
Jing Y, He L, Mei C. Translationally-controlled tumor protein activates the transcription of Oct-4 in kidney-derived stem cells. Exp Ther Med. 2017;13:280-284 pubmed publisher
Fontana M, de Melo G, Anidi C, Hamburger R, Kim C, Lee S, et al. Macrophage Colony Stimulating Factor Derived from CD4+ T Cells Contributes to Control of a Blood-Borne Infection. PLoS Pathog. 2016;12:e1006046 pubmed publisher
Hung C, Chow Y, Liles W, Altemeier W, Schnapp L. Ablation of Pericyte-Like Cells in Lungs by Oropharyngeal Aspiration of Diphtheria Toxin. Am J Respir Cell Mol Biol. 2017;56:160-167 pubmed publisher
Park S, Chung H, Shin D, Jung K, Lee H, Moon J, et al. Adenovirus-mediated Foxp3 expression in lung epithelial cells reduces airway inflammation in ovalbumin and cockroach-induced asthma model. Exp Mol Med. 2016;48:e259 pubmed publisher
Grunddal K, Ratner C, Svendsen B, Sommer F, Engelstoft M, Madsen A, et al. Neurotensin Is Coexpressed, Coreleased, and Acts Together With GLP-1 and PYY in Enteroendocrine Control of Metabolism. Endocrinology. 2016;157:176-94 pubmed publisher
Petrenko V, Mihhailova J, Salmon P, Kiss J. Apoptotic neurons induce proliferative responses of progenitor cells in the postnatal neocortex. Exp Neurol. 2015;273:126-37 pubmed publisher
Kostallari E, Baba Amer Y, Alonso Martin S, Ngoh P, Relaix F, Lafuste P, et al. Pericytes in the myovascular niche promote post-natal myofiber growth and satellite cell quiescence. Development. 2015;142:1242-53 pubmed publisher
Corbeaux T, Hess I, Swann J, Kanzler B, Haas Assenbaum A, Boehm T. Thymopoiesis in mice depends on a Foxn1-positive thymic epithelial cell lineage. Proc Natl Acad Sci U S A. 2010;107:16613-8 pubmed publisher
Tatum A, Watson A, Schell T. Direct presentation regulates the magnitude of the CD8+ T cell response to cell-associated antigen through prolonged T cell proliferation. J Immunol. 2010;185:2763-72 pubmed publisher
Thorel F, Nepote V, Avril I, Kohno K, Desgraz R, Chera S, et al. Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature. 2010;464:1149-54 pubmed publisher
Tobin V, Hashimoto H, Wacker D, Takayanagi Y, Langnaese K, Caquineau C, et al. An intrinsic vasopressin system in the olfactory bulb is involved in social recognition. Nature. 2010;464:413-7 pubmed publisher
Vakoc B, Lanning R, Tyrrell J, Padera T, Bartlett L, Stylianopoulos T, et al. Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging. Nat Med. 2009;15:1219-23 pubmed publisher
Tian S, Liu Z, Donahue C, Noh H, Falo L, You Z. Transcriptional IL-15-directed in vivo DC targeting DNA vaccine. Gene Ther. 2009;16:1260-70 pubmed publisher
Hu H, Huynh P, Murphy J, vanderSpek J. The effects of helix breaking mutations in the diphtheria toxin transmembrane domain helix layers of the fusion toxin DAB389IL-2. Protein Eng. 1998;11:811-7 pubmed
Uherek C, Fominaya J, Wels W. A modular DNA carrier protein based on the structure of diphtheria toxin mediates target cell-specific gene delivery. J Biol Chem. 1998;273:8835-41 pubmed
product information
Catalog Number :
D0564
Product Name :
Diphtheria Toxin from Corynebacterium diphtheriae
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
lyophilized powder, Product is in unnicked form
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA