Belotserkovskaya R, Raga Gil E, Lawrence N, Butler R, Clifford G, Wilson M, et al. PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1. Nat Commun. 2020;11:819 pubmed publisher

Fagan Solis K, Simpson D, Kumar R, Martelotto L, Mose L, Rashid N, et al. A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability. Cell Rep. 2020;30:1385-1399.e7 pubmed publisher

Igarashi R, Yamashita S, Yamashita T, Inoue K, Fukuda T, Fukuchi T, et al. Gemcitabine induces Parkin-independent mitophagy through mitochondrial-resident E3 ligase MUL1-mediated stabilization of PINK1. Sci Rep. 2020;10:1465 pubmed publisher

Hu Q, Klages Mundt N, Wang R, Lynn E, Kuma Saha L, Zhang H, et al. The ARK Assay Is a Sensitive and Versatile Method for the Global Detection of DNA-Protein Crosslinks. Cell Rep. 2020;30:1235-1245.e4 pubmed publisher

Su D, Feng X, Colic M, Wang Y, Zhang C, Wang C, et al. CRISPR/CAS9-based DNA damage response screens reveal gene-drug interactions. DNA Repair (Amst). 2020;87:102803 pubmed publisher

Cancela S, Canclini L, Mourglia Ettlin G, Hernández P, Merlino A. Neuroprotective effects of novel nitrones: In vitro and in silico studies. Eur J Pharmacol. 2020;871:172926 pubmed publisher

Rutto K, Lyudyno V, Kudryavtsev I, Kiseleva E. Semaphorin-3A Inhibits Proliferation, but Does Not Affect Apoptosis of Mouse Thymocytes In Vitro. Bull Exp Biol Med. 2020;168:352-355 pubmed publisher

Castelli M, Piobbico D, Chiacchiaretta M, Brunacci C, Pieroni S, Bartoli D, et al. HOPS/TMUB1 retains p53 in the cytoplasm and sustains p53-dependent mitochondrial apoptosis. EMBO Rep. 2020;21:e48073 pubmed publisher

Dokshin G, Davis G, Sawle A, Eldridge M, Nicholls P, Gourley T, et al. GCNA Interacts with Spartan and Topoisomerase II to Regulate Genome Stability. Dev Cell. 2020;52:53-68.e6 pubmed publisher

Chilczuk T, Steinborn C, Breinlinger S, Zimmermann Klemd A, Huber R, Enke H, et al. Hapalindoles from the Cyanobacterium Hapalosiphon sp. Inhibit T Cell Proliferation. Planta Med. 2020;86:96-103 pubmed publisher

Hinderfeld A, Simoes Barbosa A. Vaginal dysbiotic bacteria act as pathobionts of the protozoal pathogen Trichomonas vaginalis. Microb Pathog. 2020;138:103820 pubmed publisher

Celaj A, Gebbia M, Musa L, Coté A, Snider J, Wong V, et al. Highly Combinatorial Genetic Interaction Analysis Reveals a Multi-Drug Transporter Influence Network. Cell Syst. 2020;10:25-38.e10 pubmed publisher

Xu X, Li S, Cui X, Han K, Wang J, Hou X, et al. Inhibition of Ubiquitin Specific Protease 1 Sensitizes Colorectal Cancer Cells to DNA-Damaging Chemotherapeutics. Front Oncol. 2019;9:1406 pubmed publisher

Harbuzariu A, Pitts S, Cespedes J, Harp K, Nti A, Shaw A, et al. Modelling heme-mediated brain injury associated with cerebral malaria in human brain cortical organoids. Sci Rep. 2019;9:19162 pubmed publisher

Kitakaze K, Taniuchi S, Kawano E, Hamada Y, Miyake M, Oyadomari M, et al. Cell-based HTS identifies a chemical chaperone for preventing ER protein aggregation and proteotoxicity. elife. 2019;8: pubmed publisher

Kusunoki M, Hayashi M, Shoji T, Uba T, Tanaka H, Sumi C, et al. Propofol inhibits stromatoxin-1-sensitive voltage-dependent K+ channels in pancreatic β-cells and enhances insulin secretion. Peerj. 2019;7:e8157 pubmed publisher

Schafhauser T, Jahn L, Kirchner N, Kulik A, Flor L, Lang A, et al. Antitumor astins originate from the fungal endophyte Cyanodermella asteris living within the medicinal plant Aster tataricus. Proc Natl Acad Sci U S A. 2019;: pubmed publisher

Alagpulinsa D, Kumar S, Talluri S, Nanjappa P, Buon L, Chakraborty C, et al. Amplification and overexpression of E2 ubiquitin conjugase UBE2T promotes homologous recombination in multiple myeloma. Blood Adv. 2019;3:3968-3972 pubmed publisher

Zapatka M, Pociño Merino I, Heluani Gahete H, Bermúdez López M, Tarres M, Ibars E, et al. Sumoylation of Smc5 Promotes Error-free Bypass at Damaged Replication Forks. Cell Rep. 2019;29:3160-3172.e4 pubmed publisher

Boudichevskaia A, Houben A, Fiebig A, Procházková K, Pecinka A, Lermontova I. Depletion of KNL2 Results in Altered Expression of Genes Involved in Regulation of the Cell Cycle, Transcription, and Development in Arabidopsis. Int J Mol Sci. 2019;20: pubmed publisher

Hazan I, Monin J, Bouwman B, Crosetto N, Aqeilan R. Activation of Oncogenic Super-Enhancers Is Coupled with DNA Repair by RAD51. Cell Rep. 2019;29:560-572.e4 pubmed publisher

Saxena S, Dixit S, Somyajit K, Nagaraju G. ATR Signaling Uncouples the Role of RAD51 Paralogs in Homologous Recombination and Replication Stress Response. Cell Rep. 2019;29:551-559.e4 pubmed publisher

Achuthankutty D, Thakur R, Haahr P, Hoffmann S, Drainas A, Bizard A, et al. Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability. J Cell Biol. 2019;218:3943-3953 pubmed publisher

Laskar P, Somani S, Campbell S, Mullin M, Keating P, Tate R, et al. Camptothecin-based dendrimersomes for gene delivery and redox-responsive drug delivery to cancer cells. Nanoscale. 2019;11:20058-20071 pubmed publisher

Tsui K, Lin Y, Chang K, Hou C, Chen P, Feng T, et al. Transgelin, a p53 and PTEN-Upregulated Gene, Inhibits the Cell Proliferation and Invasion of Human Bladder Carcinoma Cells in Vitro and in Vivo. Int J Mol Sci. 2019;20: pubmed publisher

Wessel S, Mohni K, Luzwick J, Dungrawala H, Cortez D. Functional Analysis of the Replication Fork Proteome Identifies BET Proteins as PCNA Regulators. Cell Rep. 2019;28:3497-3509.e4 pubmed publisher

Bao X, Liu Z, Zhang W, Gladysz K, Fung Y, Tian G, et al. Glutarylation of Histone H4 Lysine 91 Regulates Chromatin Dynamics. Mol Cell. 2019;76:660-675.e9 pubmed publisher

Yan Z, Xue C, Kumar S, Crickard J, Yu Y, Wang W, et al. Rad52 Restrains Resection at DNA Double-Strand Break Ends in Yeast. Mol Cell. 2019;76:699-711.e6 pubmed publisher

Breuel S, Vorm M, Bräuer A, Owczarek Lipska M, Neidhardt J. Combining Engineered U1 snRNA and Antisense Oligonucleotides to Improve the Treatment of a BBS1 Splice Site Mutation. Mol Ther Nucleic Acids. 2019;18:123-130 pubmed publisher

Cristini A, Ricci G, Britton S, Salimbeni S, Huang S, Marinello J, et al. Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks. Cell Rep. 2019;28:3167-3181.e6 pubmed publisher

Babos K, Galloway K, Kisler K, Zitting M, Li Y, Shi Y, et al. Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular Reprogramming. Cell Stem Cell. 2019;25:486-500.e9 pubmed publisher

Zanetti T, Biazi B, Coatti G, Baranoski A, Marques L, Corveloni A, et al. Mitotic spindle defects and DNA damage induced by dimethoxycurcumin lead to an intrinsic apoptosis pathway in HepG2/C3A cells. Toxicol In Vitro. 2019;61:104643 pubmed publisher

Cao L, Liu S, Li Y, Yang G, Luo Y, Li S, et al. The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers. Cell Host Microbe. 2019;26:369-384.e8 pubmed publisher

Cowen L, Luo H, Tang Y. Characterization of SMG7 14-3-3-like domain reveals phosphoserine binding-independent regulation of p53 and UPF1. Sci Rep. 2019;9:13097 pubmed publisher

Sun R, Basu S, Zeng M, Sunsong R, Li L, Ghose R, et al. Xiao-Chai-Hu-Tang (XCHT) Intervening Irinotecan's Disposition: The Potential of XCHT in Alleviating Irinotecan-Induced Diarrhea. Curr Cancer Drug Targets. 2019;19:551-560 pubmed publisher

Leu Y, Chen Y, Chen C, Huang H. Induction of Autophagic Death of Human Hepatocellular Carcinoma Cells by Armillaridin from Armillaria mellea. Am J Chin Med. 2019;47:1365-1380 pubmed publisher

Hustedt N, Saito Y, Zimmermann M, Alvarez Quilón A, Setiaputra D, Adam S, et al. Control of homologous recombination by the HROB-MCM8-MCM9 pathway. Genes Dev. 2019;33:1397-1415 pubmed publisher

Warowicka A, Popenda Ł, Bartkowiak G, Musidlak O, Litowczenko Cybulska J, Kuźma D, et al. Protoberberine compounds extracted from Chelidonium majus L. as novel natural photosensitizers for cancer therapy. Phytomedicine. 2019;64:152919 pubmed publisher

Mancilla I, Coatti G, Biazi B, Zanetti T, Baranoski A, Marques L, et al. Molecular pathways related to the control of proliferation and cell death in 786-O cells treated with plumbagin. Mol Biol Rep. 2019;46:6071-6078 pubmed publisher

Panier S, Maric M, Hewitt G, Mason Osann E, Gali H, Dai A, et al. SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance. Mol Cell. 2019;76:27-43.e11 pubmed publisher

Zhou K, Shi H, Lyu R, Wylder A, Matuszek Ż, Pan J, et al. Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG. Mol Cell. 2019;76:70-81.e9 pubmed publisher

Kahraman D, Kahraman T, Cetin Atalay R. Targeting PI3K/Akt/mTOR Pathway Identifies Differential Expression and Functional Role of IL8 in Liver Cancer Stem Cell Enrichment. Mol Cancer Ther. 2019;18:2146-2157 pubmed publisher

Cao L, Wu G, Zhu J, Tan Z, Shi D, Wu X, et al. Genotoxic stress-triggered β-catenin/JDP2/PRMT5 complex facilitates reestablishing glutathione homeostasis. Nat Commun. 2019;10:3761 pubmed publisher

Wang C, Wu C, Wang Y, Xie C, Shi M, Nile S, et al. Transcription Factor OpWRKY3 Is Involved in the Development and Biosynthesis of Camptothecin and Its Precursors in Ophiorrhiza pumila Hairy Roots. Int J Mol Sci. 2019;20: pubmed publisher

Li Q, Zhou J, Lin L, Zhao H, Miao L, Pan Y. Porphyromonas gingivalis degrades integrin β1 and induces AIF-mediated apoptosis of epithelial cells. Infect Dis (Lond). 2019;51:793-801 pubmed publisher

Ganz M, Vogel C, Czada C, Jörke V, Gwosch E, Kleiner R, et al. The oncoprotein DEK affects the outcome of PARP1/2 inhibition during mild replication stress. PLoS ONE. 2019;14:e0213130 pubmed publisher

Dong Y, Zhang D, Cai M, Luo Z, Zhu Y, Gong L, et al. SPOP regulates the DNA damage response and lung adenocarcinoma cell response to radiation. Am J Cancer Res. 2019;9:1469-1483 pubmed

Salas Armenteros I, Barroso S, Rondon A, Perez M, Andújar E, Luna R, et al. Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability. Cell Rep. 2019;28:1551-1563.e7 pubmed publisher

Sicinska P. Di-n-butyl phthalate, butylbenzyl phthalate, and their metabolites exhibit different apoptotic potential in human peripheral blood mononuclear cells. Food Chem Toxicol. 2019;133:110750 pubmed publisher

Umaña M, Dalmau M, Eim V, Femenia A, Rosselló C. Effects of acoustic power and pH on pectin-enriched extracts obtained from citrus by-products. Modelling of the extraction process. J Sci Food Agric. 2019;99:6893-6902 pubmed publisher

Chen H, Lu A, Yang P, Liang J, Wei Y, Shang Y, et al. MicroRNA-28-5p regulates glioma cell proliferation, invasion and migration by targeting SphK1. Eur Rev Med Pharmacol Sci. 2019;23:6621-6628 pubmed publisher

Pannunzio N, Lieber M. Constitutively active Artemis nuclease recognizes structures containing single-stranded DNA configurations. DNA Repair (Amst). 2019;83:102676 pubmed publisher

Choi Y, An S, Bae S, Jung J. Mdm2 is required for HDAC3 monoubiquitination and stability. Biochem Biophys Res Commun. 2019;517:353-358 pubmed publisher

Rather G, Sharma A, Jeelani S, Misra P, Kaul V, Lattoo S. Metabolic and transcriptional analyses in response to potent inhibitors establish MEP pathway as major route for camptothecin biosynthesis in Nothapodytes nimmoniana (Graham) Mabb. BMC Plant Biol. 2019;19:301 pubmed publisher

Lee J, Park I, Rhee W, Kim H, Shin J. HMGB1 modulates the balance between senescence and apoptosis in response to genotoxic stress. FASEB J. 2019;33:10942-10953 pubmed publisher

Martín Pardillos A, Valls Chiva Á, Bande Vargas G, Hurtado Blanco P, Piñeiro Cid R, Guijarro P, et al. The role of clonal communication and heterogeneity in breast cancer. BMC Cancer. 2019;19:666 pubmed publisher

Park J, Lee J, Lee D. Identification of Protein Phosphatase 4 Inhibitory Protein That Plays an Indispensable Role in DNA Damage Response. Mol Cells. 2019;42:546-556 pubmed publisher

Misaki K, Matsuda S, Matsuda T, Kusakabe T, Shimizu Y. Detection of DNA damage formation by natural organic matter using EGFP-fused MDC1-expressing cells. Chemosphere. 2019;235:169-174 pubmed publisher

Pusuluri A, Krishnan V, Wu D, Shields C, Wang L, Mitragotri S. Role of synergy and immunostimulation in design of chemotherapy combinations: An analysis of doxorubicin and camptothecin. Bioeng Transl Med. 2019;4:e10129 pubmed publisher

Przystupski D, Niemczura M, Górska A, Supplitt S, Kotowski K, Wawryka P, et al. In Search of Panacea-Review of Recent Studies Concerning Nature-Derived Anticancer Agents. Nutrients. 2019;11: pubmed publisher

Boginya A, Detroja R, Matityahu A, Frenkel Morgenstern M, Onn I. The chromatin remodeler Chd1 regulates cohesin in budding yeast and humans. Sci Rep. 2019;9:8929 pubmed publisher

Hsu C, Altschuler S, Wu L. Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy. Cell. 2019;: pubmed publisher

Pandya P, Braiman A, Isakov N. PICOT (GLRX3) is a positive regulator of stress-induced DNA-damage response. Cell Signal. 2019;62:109340 pubmed publisher

Pereira B, Devine O, Vukmanovic Stejic M, Chambers E, Subramanian P, Patel N, et al. Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition. Nat Commun. 2019;10:2387 pubmed publisher

Wu Z, Lee C, Lin H. Hyaluronidase-Responsive Mesoporous Silica Nanoparticles with Dual-Imaging and Dual-Target Function. Cancers (Basel). 2019;11: pubmed publisher

Slobodnyuk K, Radic N, Ivanova S, Lladó A, Trempolec N, Zorzano A, et al. Autophagy-induced senescence is regulated by p38α signaling. Cell Death Dis. 2019;10:376 pubmed publisher

Piechowska K, Switalska M, Cytarska J, Jaroch K, Łuczykowski K, Chałupka J, et al. Discovery of tropinone-thiazole derivatives as potent caspase 3/7 activators, and noncompetitive tyrosinase inhibitors with high antiproliferative activity: Rational design, one-pot tricomponent synthesis, and lipophilicity determination. Eur J Med Chem. 2019;175:162-171 pubmed publisher

Han J, Lee J, Bae Y. Application of digital PCR for assessing DNA fragmentation in cytotoxicity response. Biochim Biophys Acta Gen Subj. 2019;1863:1235-1242 pubmed publisher

Nguyen D, Dinh V, Dang L, Nguyen D, Giang B, Nguyen C, et al. Dual Interactions of Amphiphilic Gelatin Copolymer and Nanocurcumin Improving the Delivery Efficiency of the Nanogels. Polymers (Basel). 2019;11: pubmed publisher

Xin J, Wan Mahtar W, Siah P, Miswan N, Khoo B. Potential use of Pichia pastoris strain SMD1168H expressing DNA topoisomerase I in the screening of potential anti‑breast cancer agents. Mol Med Rep. 2019;19:5368-5376 pubmed publisher

Fievet A, Bellanger D, Rieunier G, Dubois d Enghien C, Sophie J, Calvas P, et al. Functional classification of ATM variants in ataxia-telangiectasia patients. Hum Mutat. 2019;40:1713-1730 pubmed publisher

Nagay B, Dini C, Cordeiro J, Ricomini Filho A, de Avila E, Rangel E, et al. Visible-Light-Induced Photocatalytic and Antibacterial Activity of TiO2 Codoped with Nitrogen and Bismuth: New Perspectives to Control Implant-Biofilm-Related Diseases. ACS Appl Mater Interfaces. 2019;11:18186-18202 pubmed publisher

Fievet A, Bellanger D, Valence S, Mobuchon L, Afenjar A, Giuliano F, et al. Three new cases of ataxia-telangiectasia-like disorder: No impairment of the ATM pathway, but S-phase checkpoint defect. Hum Mutat. 2019;40:1690-1699 pubmed publisher

Weng Q, Zhou L, Xia L, Zheng Y, Zhang X, Li F, et al. In vitro evaluation of FL118 and 9-Q20 cytotoxicity and cellular uptake in 2D and 3D different cell models. Cancer Chemother Pharmacol. 2019;: pubmed publisher

Martinez Useros J, Garcia Carbonero N, Li W, Fernández Aceñero M, Cristobal I, Rincón R, et al. UNR/CSDE1 Expression Is Critical to Maintain Invasive Phenotype of Colorectal Cancer through Regulation of c-MYC and Epithelial-to-Mesenchymal Transition. J Clin Med. 2019;8: pubmed publisher

Delamare Deboutteville J, Kawasaki M, Zoccola E, Heath C, Bowater R, Barnes A. Interactions of head-kidney leucocytes from giant grouper, Epinephelus lanceolatus, with pathogenic Streptococcus agalactiae strains from marine and terrestrial origins. Fish Shellfish Immunol. 2019;90:250-263 pubmed publisher

Lo M, Chen J, Kuo Y, Chen W, Lee H, Wang S. Camptothecin activates SIRT1 to promote lipid catabolism through AMPK/FoxO1/ATGL pathway in C2C12 myogenic cells. Arch Pharm Res. 2019;: pubmed publisher

Liu H, Wu Y, He F, Cheng Z, Zhao Z, Xiang C, et al. Brca1 is involved in tolerance to adefovir dipivoxil‑induced DNA damage. Int J Mol Med. 2019;43:2491-2498 pubmed publisher

Sudo K, Van Dao C, Miyamoto A, Shiraishi M. Comparative analysis of in vitro neurotoxicity of methylmercury, mercury, cadmium, and hydrogen peroxide on SH-SY5Y cells. J Vet Med Sci. 2019;81:828-837 pubmed publisher

Chen S, Yu X. Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies. Sci Adv. 2019;5:eaav4340 pubmed publisher

Siam A, Baker M, Amit L, Regev G, Rabner A, Najar R, et al. Regulation of alternative splicing by p300-mediated acetylation of splicing factors. RNA. 2019;: pubmed publisher

Pedro L, Harmer Q, Mayes E, Shields J. Impact of Locally Administered Carboxydextran-Coated Super-Paramagnetic Iron Nanoparticles on Cellular Immune Function. Small. 2019;15:e1900224 pubmed publisher

El Sayed N, Shirazi A, Sajid M, Park S, Parang K, Tiwari R. Synthesis and Antiproliferative Activities of Conjugates of Paclitaxel and Camptothecin with a Cyclic Cell-Penetrating Peptide. Molecules. 2019;24: pubmed publisher

Miermont A, Antolović V, Lenn T, Nichols J, Millward L, Chubb J. The fate of cells undergoing spontaneous DNA damage during development. Development. 2019;146: pubmed publisher

Miyamoto K, Minegaki T, Tanahashi M, Yamamoto A, Moriyama Y, Wada A, et al. Synergistic Effects of Olaparib and DNA-damaging Agents in Oesophageal Squamous Cell Carcinoma Cell Lines. Anticancer Res. 2019;39:1813-1820 pubmed publisher

Szkaradek N, Sypniewski D, Zelaszczyk D, Gałka S, Borzdziłowska P, Marona H, et al. Influence of New Synthetic Xanthones on the Proliferation and Migration Potential of Cancer Cell Lines In Vitro. Anticancer Agents Med Chem. 2019;19:1949-1965 pubmed publisher

Matsuzaki K, Kondo S, Ishikawa T, Shinohara A. Human RAD51 paralogue SWSAP1 fosters RAD51 filament by regulating the anti-recombinase FIGNL1 AAA+ ATPase. Nat Commun. 2019;10:1407 pubmed publisher

Le T, Beaufay C, Nghiem D, Pham T, Mingeot Leclercq M, Quetin Leclercq J. Evaluation of the Anti-Trypanosomal Activity of Vietnamese Essential Oils, with Emphasis on Curcuma longa L. and Its Components. Molecules. 2019;24: pubmed publisher

Ao Y, Zhang J, Liu Z, Qian M, Li Y, Wu Z, et al. Lamin A buffers CK2 kinase activity to modulate aging in a progeria mouse model. Sci Adv. 2019;5:eaav5078 pubmed publisher

Castillo Morales R, Carreño Otero A, Mendez Sanchez S, da Silva M, Stashenko E, Duque J. Mitochondrial affectation, DNA damage and AChE inhibition induced by Salvia officinalis essential oil on Aedes aegypti larvae. Comp Biochem Physiol C Toxicol Pharmacol. 2019;221:29-37 pubmed publisher

Pillay N, Tighe A, Nelson L, Littler S, Coulson Gilmer C, Bah N, et al. DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors. Cancer Cell. 2019;35:519-533.e8 pubmed publisher

Villani A, Benjaminsen J, Moritz C, Henke K, Hartmann J, Norlin N, et al. Clearance by Microglia Depends on Packaging of Phagosomes into a Unique Cellular Compartment. Dev Cell. 2019;: pubmed publisher

Sheraz M, Cheng J, Tang L, Chang J, Guo J. Cellular DNA Topoisomerases Are Required for the Synthesis of Hepatitis B Virus Covalently Closed Circular DNA. J Virol. 2019;93: pubmed publisher

Kumar R, Almansour A, Arumugam N, Mohammad F, Kotresha D, Menéndez J. Spirooxindole-pyrrolidine heterocyclic hybrids promotes apoptosis through activation of caspase-3. Bioorg Med Chem. 2019;27:2487-2498 pubmed publisher

Jin Z, Wan R, Yan R, Su Y, Huang H, Zi L, et al. Microwave-Assisted Extraction of Multiple Trace Levels of Intermediate Metabolites for Camptothecin Biosynthesis in Camptotheca acuminata and Their Simultaneous Determination by HPLC-LTQ-Orbitrap-MS/MS and HPLC-TSQ-MS. Molecules. 2019;24: pubmed publisher

van Os N, Chessa L, Weemaes C, van Deuren M, Fievet A, van Gaalen J, et al. Genotype-phenotype correlations in ataxia telangiectasia patients with ATM c.3576G>A and c.8147T>C mutations. J Med Genet. 2019;56:308-316 pubmed publisher

Solanki P, Patel S, Devkar R, Patel A. Camptothecin encapsulated into functionalized MCM-41: In vitro release study, cytotoxicity and kinetics. Mater Sci Eng C Mater Biol Appl. 2019;98:1014-1021 pubmed publisher

Iwase M, Fujita K, Nishimura Y, Seba N, Masuo Y, Ishida H, et al. Pazopanib interacts with irinotecan by inhibiting UGT1A1-mediated glucuronidation, but not OATP1B1-mediated hepatic uptake, of an active metabolite SN-38. Cancer Chemother Pharmacol. 2019;: pubmed publisher

Muller V, Oliveira Ferrer L, Steinbach B, Pantel K, Schwarzenbach H. Interplay of lncRNA H19/miR-675 and lncRNA NEAT1/miR-204 in breast cancer. Mol Oncol. 2019;13:1137-1149 pubmed publisher

Ji X, Xu W, Cui J, Ma Y, Zhou S. Goat and buffalo milk fat globule membranes exhibit better effects at inducing apoptosis and reduction the viability of HT-29 cells. Sci Rep. 2019;9:2577 pubmed publisher

Zimmermann Klemd A, Konradi V, Steinborn C, Ücker A, Falanga C, Woelfle U, et al. Influence of traditionally used Nepalese plants on wound healing and immunological properties using primary human cells in vitro. J Ethnopharmacol. 2019;235:415-423 pubmed publisher

Hwang S, Takimoto T, Hemler M. Integrin-independent support of cancer drug resistance by tetraspanin CD151. Cell Mol Life Sci. 2019;76:1595-1604 pubmed publisher

Zahreddine H, Culjkovic Kraljacic B, Gasiorek J, Duchaine J, Borden K. GLI1-Inducible Glucuronidation Targets a Broad Spectrum of Drugs. ACS Chem Biol. 2019;14:348-355 pubmed publisher

Wang F, Zhu S, Fisher L, Wang L, Eurek N, Wahl J, et al. Phosphatase 1 Nuclear Targeting Subunit Mediates Recruitment and Function of Poly (ADP-Ribose) Polymerase 1 in DNA Repair. Cancer Res. 2019;79:2526-2535 pubmed publisher

Chou C, Huang H, Yang C, Dahms H, Liang S, Wang T, et al. Reduced camptothecin sensitivity of estrogen receptor-positive human breast cancer cells following exposure to di(2-ethylhexyl)phthalate (DEHP) is associated with DNA methylation changes. Environ Toxicol. 2019;34:401-414 pubmed publisher

Sroda Pomianek K, Michalak K, Palko Łabuz A, Uryga A, Szcześniak Siega B, Wesołowska O. Simvastatin Strongly Augments Proapoptotic, Anti-inflammatory and Cytotoxic Activity of Oxicam Derivatives in Doxorubicin-resistant Colon Cancer Cells. Anticancer Res. 2019;39:727-734 pubmed publisher

Sanidas I, Morris R, Fella K, Rumde P, Boukhali M, Tai E, et al. A Code of Mono-phosphorylation Modulates the Function of RB. Mol Cell. 2019;73:985-1000.e6 pubmed publisher

Zizza P, Dinami R, Porru M, Cingolani C, Salvati E, Rizzo A, et al. TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment. Nucleic Acids Res. 2019;47:3365-3382 pubmed publisher

Warchal S, Dawson J, Carragher N. Evaluation of Machine Learning Classifiers to Predict Compound Mechanism of Action When Transferred across Distinct Cell Lines. SLAS Discov. 2019;24:224-233 pubmed publisher

So C, Ramachandran S, Martin A. E3 Ubiquitin Ligases RNF20 and RNF40 Are Required for Double-Stranded Break (DSB) Repair: Evidence for Monoubiquitination of Histone H2B Lysine 120 as a Novel Axis of DSB Signaling and Repair. Mol Cell Biol. 2019;39: pubmed publisher

Cabrera García A, Checa Chavarria E, Rivero Buceta E, Moreno V, Fernandez E, Botella P. Amino modified metal-organic frameworks as pH-responsive nanoplatforms for safe delivery of camptothecin. J Colloid Interface Sci. 2019;541:163-174 pubmed publisher

Chlenski A, Park C, Dobratic M, Salwen H, Budke B, Park J, et al. Maternal Embryonic Leucine Zipper Kinase (MELK), a Potential Therapeutic Target for Neuroblastoma. Mol Cancer Ther. 2019;: pubmed publisher

Teoh P, Liau M, Cheong B. Phyla nodiflora L. Extracts Induce Apoptosis and Cell Cycle Arrest in Human Breast Cancer Cell Line, MCF-7. Nutr Cancer. 2019;71:668-675 pubmed publisher

Godoy Herz M, Kubaczka M, Brzyżek G, Servi L, Krzyszton M, Simpson C, et al. Light Regulates Plant Alternative Splicing through the Control of Transcriptional Elongation. Mol Cell. 2019;73:1066-1074.e3 pubmed publisher

Mohiuddin M, Rahman M, Sale J, Pearson C. CtIP-BRCA1 complex and MRE11 maintain replication forks in the presence of chain terminating nucleoside analogs. Nucleic Acids Res. 2019;47:2966-2980 pubmed publisher

Wang Z, D Annessa I, Tesauro C, Ottaviani A, Soren B, Dasari J, et al. The human DNA topoisomerase I mutant Gly717Asp: Higher religation rate is not always associated with camptothecin resistance. Arch Biochem Biophys. 2019;663:165-172 pubmed publisher

Owusu M, Bannauer P, Ferreira da Silva J, Mourikis T, Jones A, Májek P, et al. Mapping the Human Kinome in Response to DNA Damage. Cell Rep. 2019;26:555-563.e6 pubmed publisher

Tahmasebi A, Ebrahimie E, Pakniyat H, Ebrahimi M, Mohammadi Dehcheshmeh M. Tissue-specific transcriptional biomarkers in medicinal plants: Application of large-scale meta-analysis and computational systems biology. Gene. 2019;691:114-124 pubmed publisher

Zhang X, Nguyen K, Rudnick P, Roper N, Kawaler E, Maity T, et al. Quantitative Mass Spectrometry to Interrogate Proteomic Heterogeneity in Metastatic Lung Adenocarcinoma and Validate a Novel Somatic Mutation CDK12-G879V. Mol Cell Proteomics. 2019;18:622-641 pubmed publisher

Franchini D, Lanvin O, Tosolini M, Patras de Campaigno E, Cammas A, Péricart S, et al. Microtubule-Driven Stress Granule Dynamics Regulate Inhibitory Immune Checkpoint Expression in T Cells. Cell Rep. 2019;26:94-107.e7 pubmed publisher

Yang X, Gao J, Guo J, Zhao Z, Zhang S, He Y. Anti-lung cancer activity and inhibitory mechanisms of a novel Calothrixin A derivative. Life Sci. 2019;219:20-30 pubmed publisher

Trinh B, Nguyen H, Nguyen H, Pham P, Ngo N, Nguyen L, et al. Cytotoxic limonoids from the bark of Walsura cochinchinensis. Fitoterapia. 2019;133:75-79 pubmed publisher

Bredrup C, Stokowy T, McGaughran J, Lee S, Sapkota D, Cristea I, et al. A tyrosine kinase-activating variant Asn666Ser in PDGFRB causes a progeria-like condition in the severe end of Penttinen syndrome. Eur J Hum Genet. 2019;27:574-581 pubmed publisher

Bej R, Ghosh S. Glutathione Triggered Cascade Degradation of an Amphiphilic Poly(disulfide)-Drug Conjugate and Targeted Release. Bioconjug Chem. 2019;30:101-110 pubmed publisher

Mohni K, Wessel S, Zhao R, Wojciechowski A, Luzwick J, Layden H, et al. HMCES Maintains Genome Integrity by Shielding Abasic Sites in Single-Strand DNA. Cell. 2019;176:144-153.e13 pubmed publisher

Heyza J, Lei W, Watza D, Zhang H, Chen W, Back J, et al. Identification and Characterization of Synthetic Viability with ERCC1 Deficiency in Response to Interstrand Crosslinks in Lung Cancer. Clin Cancer Res. 2019;25:2523-2536 pubmed publisher

Jo H, Hee Seo S, Na Y, Kwon Y. The synthesis and anticancer activities of chiral epoxy-substituted chromone analogs. Bioorg Chem. 2019;84:347-354 pubmed publisher

Choi J, Lee J, Kim S, You S, Lee C, Shin J, et al. Glucuronorhamnoxylan from Capsosiphon fulvescens inhibits the growth of HT-29 human colon cancer cells in vitro and in vivo via induction of apoptotic cell death. Int J Biol Macromol. 2019;124:1060-1068 pubmed publisher

de Luna L, Zorgi N, de Moraes A, da Silva D, Consonni S, Giorgio S, et al. In vitro immunotoxicological assessment of a potent microbicidal nanocomposite based on graphene oxide and silver nanoparticles. Nanotoxicology. 2019;13:189-203 pubmed publisher

Nishie A, Togao O, Tamura C, Yamato M, Ichikawa K, Nohara S, et al. In Vitro and In Vivo Detection of Drug-induced Apoptosis Using Annexin V-conjugated Ultrasmall Superparamagnetic Iron Oxide (USPIO): A Pilot Study. Magn Reson Med Sci. 2019;18:142-149 pubmed publisher

Nixon B, Sebag S, Glennon M, Hall E, Kounlavong E, Freeman M, et al. Nuclear localized Raf1 isoform alters DNA-dependent protein kinase activity and the DNA damage response. FASEB J. 2019;33:1138-1150 pubmed publisher

Psurski M, Łupicka Słowik A, Adamczyk Woźniak A, Wietrzyk J, Sporzyński A. Discovering simple phenylboronic acid and benzoxaborole derivatives for experimental oncology - phase cycle-specific inducers of apoptosis in A2780 ovarian cancer cells. Invest New Drugs. 2019;37:35-46 pubmed publisher

Pereira T, Sant anna J, Morais J, Yajima J, Mathias P, Franco C, et al. Assessment of bendamustine-induced genotoxicity in eukaryotic cells. Drug Chem Toxicol. 2019;42:394-402 pubmed publisher

Ngo T, Vo C, Pham N, Phan N, Bui T, Ngo Q, et al. Markhacanasin C, cycloartane triterpenoid from the leaves of Markhamia stipulata var. canaense V.S. Dang. Nat Prod Res. 2019;33:174-179 pubmed publisher

Grunewald F, Steinborn C, Huber R, Wille R, Meier S, Alresly Z, et al. Effects of Birch Polypore Mushroom, Piptoporus betulinus (Agaricomycetes), the "Iceman's Fungus", on Human Immune Cells. Int J Med Mushrooms. 2018;20:1135-1147 pubmed publisher

Bhat C, Ilina P, Tilli I, Voráčová M, Bruun T, Barba V, et al. Synthesis and Antiproliferative Activity of Marine Bromotyrosine Purpurealidin I and Its Derivatives. Mar Drugs. 2018;16: pubmed publisher

Marggraf M, Panteleev P, Emelianova A, Sorokin M, Bolosov I, Buzdin A, et al. Cytotoxic Potential of the Novel Horseshoe Crab Peptide Polyphemusin III. Mar Drugs. 2018;16: pubmed publisher

Oh J, Lee S, Rothstein R, Symington L. Xrs2 and Tel1 Independently Contribute to MR-Mediated DNA Tethering and Replisome Stability. Cell Rep. 2018;25:1681-1692.e4 pubmed publisher

Sharma V, Thomas S, Miller D, Rezzoug F. Nucleolin Overexpression Confers Increased Sensitivity to the Anti-Nucleolin Aptamer, AS1411. Cancer Invest. 2018;36:475-491 pubmed publisher

Liu H, Zhang H, Wu X, Ma D, Wu J, Wang L, et al. Nuclear cGAS suppresses DNA repair and promotes tumorigenesis. Nature. 2018;563:131-136 pubmed publisher

Jiang Z, Zhang Z, Cui G, Sun Z, Song G, Liu Y, et al. DNA Topoisomerase 1 Structure-BASED Design, Synthesis, Activity Evaluation and Molecular Simulations Study of New 7-Amide Camptothecin Derivatives Against Spodoptera frugiperda. Front Chem. 2018;6:456 pubmed publisher

Fujiwara C, Muramatsu Y, Nishii M, Tokunaka K, Tahara H, Ueno M, et al. Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells. Sci Rep. 2018;8:14827 pubmed publisher

Man Q, Zhang L, Zhao Y, Liu J, Zheng Y, Zhao Y, et al. Lymphocyte‑derived microparticles stimulate osteoclastogenesis by inducing RANKL in fibroblasts of odontogenic keratocysts. Oncol Rep. 2018;40:3335-3345 pubmed publisher

Somborac Bačura A, Rumora L, Novak R, Rašić D, Dumic J, Cepelak I, et al. Differential expression of heat shock proteins and activation of mitogen-activated protein kinases in A549 alveolar epithelial cells exposed to cigarette smoke extract. Exp Physiol. 2018;103:1666-1678 pubmed publisher

Motadi L, Lekganyane M, Moela P. RBBP6 expressional effects on cell proliferation and apoptosis in breast cancer cell lines with distinct p53 statuses. Cancer Manag Res. 2018;10:3357-3369 pubmed publisher

Huang Q, Li L, Zheng M, Chen F, Long H, Deng G, et al. The Tryptophan decarboxylase 1 Gene From Aegilops variabilis No.1 Regulate the Resistance Against Cereal Cyst Nematode by Altering the Downstream Secondary Metabolite Contents Rather Than Auxin Synthesis. Front Plant Sci. 2018;9:1297 pubmed publisher

Zhang N, Liang X, Gao C, Chen M, Zhou Y, Krueger C, et al. Loading Lovastatin into Camptothecin-Floxuridine Conjugate Nanocapsules for Enhancing Anti-metastatic Efficacy of Cocktail Chemotherapy on Triple-negative Breast Cancer. ACS Appl Mater Interfaces. 2018;10:29385-29397 pubmed publisher

Bosco A, Almeida B, Valadares T, Baptistiolli L, Hoffmann D, Pereira A, et al. Preactivation of neutrophils and systemic oxidative stress in dogs with hyperleptinemia. Vet Immunol Immunopathol. 2018;202:18-24 pubmed publisher

Gupta A, Ajith A, Singh S, Panday R, Samaiya A, Shukla S. PAK2-c-Myc-PKM2 axis plays an essential role in head and neck oncogenesis via regulating Warburg effect. Cell Death Dis. 2018;9:825 pubmed publisher

Evangelista F, Maglott Roth A, Stierlé M, Brino L, Soutoglou E, Tora L. Transcription and mRNA export machineries SAGA and TREX-2 maintain monoubiquitinated H2B balance required for DNA repair. J Cell Biol. 2018;217:3382-3397 pubmed publisher

Alibolandi M, Hoseini F, Mohammadi M, Ramezani P, Einafshar E, Taghdisi S, et al. Curcumin-entrapped MUC-1 aptamer targeted dendrimer-gold hybrid nanostructure as a theranostic system for colon adenocarcinoma. Int J Pharm. 2018;549:67-75 pubmed publisher

Barazeghi E, Prabhawa S, Norlén O, Hellman P, Stalberg P, Westin G. Decrease of 5-hydroxymethylcytosine and TET1 with nuclear exclusion of TET2 in small intestinal neuroendocrine tumors. BMC Cancer. 2018;18:764 pubmed publisher

Michalczyk E, Chen L, Fine D, Zhao Y, Mascariñas E, Grippo P, et al. Pigment Epithelium-Derived Factor (PEDF) as a Regulator of Wound Angiogenesis. Sci Rep. 2018;8:11142 pubmed publisher

Zheng P, Chen Q, Tian X, Qian N, Chai P, Liu B, et al. DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling. Cell Res. 2018;28:833-854 pubmed publisher

Lafont F, Ayadi N, Charlier C, Weigel P, Nabiev I, Benhelli Mokrani H, et al. Assessment of DNA-PKcs kinase activity by quantum dot-based microarray. Sci Rep. 2018;8:10968 pubmed publisher

Alessandrini F, Pezzè L, Menendez D, Resnick M, Ciribilli Y. ETV7-Mediated DNAJC15 Repression Leads to Doxorubicin Resistance in Breast Cancer Cells. Neoplasia. 2018;20:857-870 pubmed publisher

Lin W, Wang W, Lin Y, Leu J, Cheng S, Chen Y, et al. Synergistic effects of tetrandrine combined with ionizing radiation on a murine colorectal carcinoma‑bearing mouse model. Oncol Rep. 2018;40:1390-1400 pubmed publisher

Luczak M, Zhitkovich A. Monoubiquitinated γ-H2AX: Abundant product and specific biomarker for non-apoptotic DNA double-strand breaks. Toxicol Appl Pharmacol. 2018;355:238-246 pubmed publisher

Michelena J, Lezaja A, Teloni F, Schmid T, Imhof R, Altmeyer M. Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance. Nat Commun. 2018;9:2678 pubmed publisher

Amin S, Cook B, Zhou T, Ghazizadeh Z, Lis R, Zhang T, et al. Discovery of a drug candidate for GLIS3-associated diabetes. Nat Commun. 2018;9:2681 pubmed publisher

Hanzlikova H, Kalasová I, Demin A, Pennicott L, Cihlarova Z, Caldecott K. The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication. Mol Cell. 2018;71:319-331.e3 pubmed publisher

Li Y, Li Z, Dong L, Tang M, Zhang P, Zhang C, et al. Histone H1 acetylation at lysine 85 regulates chromatin condensation and genome stability upon DNA damage. Nucleic Acids Res. 2018;46:7716-7730 pubmed publisher

Cornelison R, Wellman S, Park J, Porvasnik S, Song Y, Wachs R, et al. Development of an apoptosis-assisted decellularization method for maximal preservation of nerve tissue structure. Acta Biomater. 2018;77:116-126 pubmed publisher

Bestwick C, Milne L, Dance A, Cochennec G, Cruickshank G, Allain E, et al. Caspase-independence and characterization of bisnaphthalimidopropyl spermidine induced cytotoxicity in HL60 cells. Toxicol In Vitro. 2018;52:342-350 pubmed publisher

Seah K, Loh J, Nguyen T, Tan H, Hutchinson P, Lim K, et al. SAHA and cisplatin sensitize gastric cancer cells to doxorubicin by induction of DNA damage, apoptosis and perturbation of AMPK-mTOR signalling. Exp Cell Res. 2018;370:283-291 pubmed publisher

Negi S, Singh S, Kumar S, Kumar S, Tyagi R. Stable cellular models of nuclear receptor PXR for high-throughput evaluation of small molecules. Toxicol In Vitro. 2018;52:222-234 pubmed publisher

Chhipa R, Fan Q, Anderson J, Muraleedharan R, Huang Y, Ciraolo G, et al. AMP kinase promotes glioblastoma bioenergetics and tumour growth. Nat Cell Biol. 2018;20:823-835 pubmed publisher

Winkler C, Rouget R, Wu D, Beullens M, Van Eynde A, Bollen M. Overexpression of PP1-NIPP1 limits the capacity of cells to repair DNA double-strand breaks. J Cell Sci. 2018;131: pubmed publisher

Sanyal S, Molnarova L, Richterova J, Huraiová B, Benko Z, Polakova S, et al. Mutations that prevent methylation of cohesin render sensitivity to DNA damage in S. pombe. J Cell Sci. 2018;131: pubmed publisher

Rhoads S, Monahan Z, Yee D, Leung A, Newcombe C, O Meally R, et al. The prionlike domain of FUS is multiphosphorylated following DNA damage without altering nuclear localization. Mol Biol Cell. 2018;29:1786-1797 pubmed publisher

Gogola E, Duarte A, de Ruiter J, Wiegant W, Schmid J, de Bruijn R, et al. Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality. Cancer Cell. 2018;33:1078-1093.e12 pubmed publisher

Velimezi G, Robinson Garcia L, Muñoz Martínez F, Wiegant W, Ferreira da Silva J, Owusu M, et al. Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48. Nat Commun. 2018;9:2280 pubmed publisher

Fang S, Yu X, Ding H, Han J, Feng J. Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors. Biochem Biophys Res Commun. 2018;503:297-303 pubmed publisher

Kim Y, Shiba Ishii A, Nakagawa T, Iemura S, Natsume T, Nakano N, et al. Stratifin regulates stabilization of receptor tyrosine kinases via interaction with ubiquitin-specific protease 8 in lung adenocarcinoma. Oncogene. 2018;37:5387-5402 pubmed publisher

Hagiwara Y, Sato H, Permata T, Niimi A, Yamauchi M, Oike T, et al. Analysis of programmed death-ligand 1 expression in primary normal human dermal fibroblasts after DNA damage. Hum Immunol. 2018;79:627-631 pubmed publisher

Oda T, Yamazumi Y, Hiroko T, Kamiya A, Kiriya S, Suyama S, et al. Mex-3B induces apoptosis by inhibiting miR-92a access to the Bim-3'UTR. Oncogene. 2018;37:5233-5247 pubmed publisher

Gay S, Piccini D, Bruhn C, Ricciardi S, Soffientini P, Carotenuto W, et al. A Mad2-Mediated Translational Regulatory Mechanism Promoting S-Phase Cyclin Synthesis Controls Origin Firing and Survival to Replication Stress. Mol Cell. 2018;70:628-638.e5 pubmed publisher

Siriviriyanun A, Tsai Y, Voon S, Kiew S, Imae T, Kiew L, et al. Cyclodextrin- and dendrimer-conjugated graphene oxide as a nanocarrier for the delivery of selected chemotherapeutic and photosensitizing agents. Mater Sci Eng C Mater Biol Appl. 2018;89:307-315 pubmed publisher

Verdelli C, Forno I, Morotti A, Creo P, Guarnieri V, Scillitani A, et al. The aberrantly expressed miR-372 partly impairs sensitivity to apoptosis in parathyroid tumor cells. Endocr Relat Cancer. 2018;25:761-771 pubmed publisher

Bogachev M, Volkov V, Markelov O, Trizna E, Baydamshina D, Melnikov V, et al. Fast and simple tool for the quantification of biofilm-embedded cells sub-populations from fluorescent microscopic images. PLoS ONE. 2018;13:e0193267 pubmed publisher

Fernández Bertólez N, Costa C, Brandão F, Kiliç G, Duarte J, Teixeira J, et al. Toxicological assessment of silica-coated iron oxide nanoparticles in human astrocytes. Food Chem Toxicol. 2018;118:13-23 pubmed publisher

Bassan P, Bhushan S, Kaur T, Arora R, Arora S, Vig A. Extraction, profiling and bioactivity analysis of volatile glucosinolates present in oil extract of Brassica juncea var. raya. Physiol Mol Biol Plants. 2018;24:399-409 pubmed publisher

Kesavan M, Kotla N, Ayyanaar S, Kumar G, Rajagopal G, Sivaraman G, et al. A theranostic nanocomposite system based on iron oxide-drug nanocages for targeted magnetic field responsive chemotherapy. Nanomedicine. 2018;14:1643-1654 pubmed publisher

Trenner A, Godau J, Sartori A. A Short BRCA2-Derived Cell-Penetrating Peptide Targets RAD51 Function and Confers Hypersensitivity toward PARP Inhibition. Mol Cancer Ther. 2018;17:1392-1404 pubmed publisher

Pereira M, Hammes A, Vasconcelos F, Pozzo A, Pereira T, Caffarena E, et al. Antitumor Effect of Pomolic Acid in Acute Myeloid Leukemia Cells Involves Cell Death, Decreased Cell Growth and Topoisomerases Inhibition. Anticancer Agents Med Chem. 2018;18:1457-1468 pubmed publisher

Medeiros A, Soares C, Coelho P, Vieira N, Baqui M, Teixeira F, et al. DNA damage response signaling does not trigger redistribution of SAMHD1 to nuclear foci. Biochem Biophys Res Commun. 2018;499:790-796 pubmed publisher

Hall C, Sanderson L, Lawrence L, Pool B, van der Kroef M, Ashimbayeva E, et al. Blocking fatty acid-fueled mROS production within macrophages alleviates acute gouty inflammation. J Clin Invest. 2018;128:1752-1771 pubmed publisher

Nguyen T, Park E, Lim Y, Hwang S. Nonstructural Protein 5A Impairs DNA Damage Repair: Implications for Hepatitis C Virus-Mediated Hepatocarcinogenesis. J Virol. 2018;92: pubmed publisher

Zhu H, Gu X, Xia L, Zhou Y, Bouamar H, Yang J, et al. A Novel TGFβ Trap Blocks Chemotherapeutics-Induced TGFβ1 Signaling and Enhances Their Anticancer Activity in Gynecologic Cancers. Clin Cancer Res. 2018;24:2780-2793 pubmed publisher

Limpose K, Trego K, Li Z, Leung S, Sarker A, Shah J, et al. Overexpression of the base excision repair NTHL1 glycosylase causes genomic instability and early cellular hallmarks of cancer. Nucleic Acids Res. 2018;46:4515-4532 pubmed publisher

Gorthi A, Romero J, Loranc E, Cao L, Lawrence L, Goodale E, et al. EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma. Nature. 2018;555:387-391 pubmed publisher

Magar T, Seo S, Kadayat T, Jo H, Shrestha A, Bist G, et al. Synthesis and SAR study of new hydroxy and chloro-substituted 2,4-diphenyl 5H-chromeno[4,3-b]pyridines as selective topoisomerase II?-targeting anticancer agents. Bioorg Med Chem. 2018;26:1909-1919 pubmed publisher

Deb A, Andrews N, Raghavan V. Natural polymer functionalized graphene oxide for co-delivery of anticancer drugs: In-vitro and in-vivo. Int J Biol Macromol. 2018;113:515-525 pubmed publisher

Stadlbauer S, Steinborn C, Klemd A, Hattori F, Ohmori K, Suzuki K, et al. Impact of Green Tea Catechin ECG and Its Synthesized Fluorinated Analogue on Prostate Cancer Cells and Stimulated Immunocompetent Cells. Planta Med. 2018;84:813-819 pubmed publisher

Cho J, Lim K, Park S. MED28 increases the colony-forming ability of breast cancer cells by stabilizing the ZNF224 protein upon DNA damage. Oncol Lett. 2018;15:3147-3154 pubmed publisher

Sun X, Aimé P, Dai D, Ramalingam N, Crary J, Burke R, et al. Guanabenz promotes neuronal survival via enhancement of ATF4 and parkin expression in models of Parkinson disease. Exp Neurol. 2018;303:95-107 pubmed publisher

Grabiec A, Goenka A, Fife M, Fujimori T, Hussell T. Axl and MerTK receptor tyrosine kinases maintain human macrophage efferocytic capacity in the presence of viral triggers. Eur J Immunol. 2018;48:855-860 pubmed publisher

Legler K, Rosprim R, Karius T, Eylmann K, Rossberg M, Wirtz R, et al. Reduced mannosidase MAN1A1 expression leads to aberrant N-glycosylation and impaired survival in breast cancer. Br J Cancer. 2018;118:847-856 pubmed publisher

Fiegel V, Harlepp S, Begin Colin S, Begin D, Mertz D. Design of Protein-Coated Carbon Nanotubes Loaded with Hydrophobic Drugs through Sacrificial Templating of Mesoporous Silica Shells. Chemistry. 2018;24:4662-4670 pubmed publisher

Yuan R, Vos H, van Es R, Chen J, Burgering B, Westendorp B, et al. Chk1 and 14-3-3 proteins inhibit atypical E2Fs to prevent a permanent cell cycle arrest. EMBO J. 2018;37: pubmed publisher

Burk O, Kuzikov M, Kronenberger T, Jeske J, Keminer O, Thasler W, et al. Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles. Arch Toxicol. 2018;92:1435-1451 pubmed publisher

Liu P, Tsai K, Hsu C, Tsai W, Cheng J, Chang H, et al. Drug Repurposing Screening Identifies Tioconazole as an ATG4 Inhibitor that Suppresses Autophagy and Sensitizes Cancer Cells to Chemotherapy. Theranostics. 2018;8:830-845 pubmed publisher

Ma P, Sun Y, Chen J, Li H, Zhu H, Gao X, et al. Enhanced anti-hepatocarcinoma efficacy by GLUT1 targeting and cellular microenvironment-responsive PAMAM-camptothecin conjugate. Drug Deliv. 2018;25:153-165 pubmed publisher

Wijenayake S, Luu B, Zhang J, Tessier S, Quintero Galvis J, Gaitán Espitia J, et al. Strategies of biochemical adaptation for hibernation in a South American marsupial Dromiciops gliroides: 1. Mitogen-activated protein kinases and the cell stress response. Comp Biochem Physiol B Biochem Mol Biol. 2018;224:12-18 pubmed publisher

Bloom M, Koshland D, Guacci V. Cohesin Function in Cohesion, Condensation, and DNA Repair Is Regulated by Wpl1p via a Common Mechanism in Saccharomyces cerevisiae. Genetics. 2018;208:111-124 pubmed publisher

Yang Y, Yu H. Partner switching for Ran during the mitosis dance. J Mol Cell Biol. 2018;10:89-90 pubmed publisher

Anisiewicz A, Pawlik A, Filip Psurska B, Turlej E, Dzimira S, Milczarek M, et al. Unfavorable effect of calcitriol and its low-calcemic analogs on metastasis of 4T1 mouse mammary gland cancer. Int J Oncol. 2018;52:103-126 pubmed publisher

Zhao Q, Guan J, Qin Y, Ren P, Zhang Z, Lv J, et al. Curcumin sensitizes lymphoma cells to DNA damage agents through regulating Rad51-dependent homologous recombination. Biomed Pharmacother. 2018;97:115-119 pubmed publisher

Chen X, Hovanesian V, Naqvi S, Lim Y, Tucker R, Donahue J, et al. Systemic infusions of anti-interleukin-1β neutralizing antibodies reduce short-term brain injury after cerebral ischemia in the ovine fetus. Brain Behav Immun. 2018;67:24-35 pubmed publisher

Kukolj E, Kaufmann T, Dick A, Zeillinger R, Gerlich D, Slade D. PARP inhibition causes premature loss of cohesion in cancer cells. Oncotarget. 2017;8:103931-103951 pubmed publisher

Arnould S, Rodier G, Matar G, Vincent C, Pirot N, Delorme Y, et al. Checkpoint kinase 1 inhibition sensitises transformed cells to dihydroorotate dehydrogenase inhibition. Oncotarget. 2017;8:95206-95222 pubmed publisher

Onyango D, Lee G, Stark J. PRPF8 is important for BRCA1-mediated homologous recombination. Oncotarget. 2017;8:93319-93337 pubmed publisher

Lu M, Huang H, Chiou W, Huang R. Induction of Apoptosis by Tithonia diversifolia in Human Hepatoma Cells. Pharmacogn Mag. 2017;13:702-706 pubmed publisher

Soujanya K, Siva R, Mohana Kumara P, Srimany A, Ravikanth G, Mulani F, et al. Camptothecin-producing endophytic bacteria from Pyrenacantha volubilis Hook. (Icacinaceae): A possible role of a plasmid in the production of camptothecin. Phytomedicine. 2017;36:160-167 pubmed publisher

Brickner J, Soll J, Lombardi P, Vågbø C, Mudge M, Oyeniran C, et al. A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair. Nature. 2017;551:389-393 pubmed publisher

Tracz Gaszewska Z, Klimczak M, Biecek P, Herok M, Kosiński M, Olszewski M, et al. Molecular chaperones in the acquisition of cancer cell chemoresistance with mutated TP53 and MDM2 up-regulation. Oncotarget. 2017;8:82123-82143 pubmed publisher

Gioia R, Drouin S, Ouimet M, Caron M, St Onge P, Richer C, et al. LncRNAs downregulated in childhood acute lymphoblastic leukemia modulate apoptosis, cell migration, and DNA damage response. Oncotarget. 2017;8:80645-80650 pubmed publisher

Parvathaneni S, Lu X, Chaudhary R, Lal A, Madhusudan S, Sharma S. RECQ1 expression is upregulated in response to DNA damage and in a p53-dependent manner. Oncotarget. 2017;8:75924-75942 pubmed publisher

Sakasai Sakai A, Takata T, Takino J, Takeuchi M. Impact of intracellular glyceraldehyde-derived advanced glycation end-products on human hepatocyte cell death. Sci Rep. 2017;7:14282 pubmed publisher

Zimmer A, Tendler A, Katzir I, Mayo A, Alon U. Prediction of drug cocktail effects when the number of measurements is limited. PLoS Biol. 2017;15:e2002518 pubmed publisher

Hambsch P, Istomin Y, Tzerkovsky D, Patties I, Neuhaus J, Kortmann R, et al. Efficient cell death induction in human glioblastoma cells by photodynamic treatment with Tetrahydroporphyrin-Tetratosylat (THPTS) and ionizing irradiation. Oncotarget. 2017;8:72411-72423 pubmed publisher

Taglialatela A, Alvarez S, Leuzzi G, Sannino V, Ranjha L, Huang J, et al. Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers. Mol Cell. 2017;68:414-430.e8 pubmed publisher

Borah N, Gunawardana S, Torres H, McDonnell S, Van Slambrouck S. 5,6,7,3',4',5'-Hexamethoxyflavone inhibits growth of triple-negative breast cancer cells via suppression of MAPK and Akt signaling pathways and arresting cell cycle. Int J Oncol. 2017;51:1685-1693 pubmed publisher

Ni Z, Yao C, Zhu X, Gong C, Xu Z, Wang L, et al. Ailanthone inhibits non-small cell lung cancer cell growth through repressing DNA replication via downregulating RPA1. Br J Cancer. 2017;117:1621-1630 pubmed publisher

Schubert L, Ho T, Hoffmann S, Haahr P, Guérillon C, Mailand N. RADX interacts with single-stranded DNA to promote replication fork stability. EMBO Rep. 2017;18:1991-2003 pubmed publisher

Chen M, Li Y, Xu D, Luo J, Kong L. One-step targeted accumulation and detection of camptothecin analogues from fruits of Camptotheca acuminata Decne using bilayer solid-phase extraction coupled with ultra-high-performance liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2017;1524:37-48 pubmed publisher

Fanfone D, Despretz N, Stanicki D, Rubio Magnieto J, Fossépré M, Surin M, et al. Toward a new and noninvasive diagnostic method of papillary thyroid cancer by using peptide vectorized contrast agents targeted to galectin-1. Med Oncol. 2017;34:184 pubmed publisher

López S, Rodríguez Valentín M, Rivera M, Rodríguez M, Babu M, Cubano L, et al. HIV-1 Gp120 clade B/C induces a GRP78 driven cytoprotective mechanism in astrocytoma. Oncotarget. 2017;8:68415-68438 pubmed publisher

Penke M, Schuster S, Gorski T, Gebhardt R, Kiess W, Garten A. Oleate ameliorates palmitate-induced reduction of NAMPT activity and NAD levels in primary human hepatocytes and hepatocarcinoma cells. Lipids Health Dis. 2017;16:191 pubmed publisher

Cyrenne B, Lewis J, Weed J, Carlson K, Mirza F, Foss F, et al. Synergy of BCL2 and histone deacetylase inhibition against leukemic cells from cutaneous T-cell lymphoma patients. Blood. 2017;130:2073-2083 pubmed publisher

Meshram S, Paul D, Manne R, Choppara S, Sankaran G, Agrawal Y, et al. FBXO32 activates NF-κB through IκBα degradation in inflammatory and genotoxic stress. Int J Biochem Cell Biol. 2017;92:134-140 pubmed publisher

Zheng H, Högberg J, Stenius U. ATM-activated autotaxin (ATX) propagates inflammation and DNA damage in lung epithelial cells: a new mode of action for silica-induced DNA damage?. Carcinogenesis. 2017;38:1196-1206 pubmed publisher

Durand S, Trillet K, Uguen A, Saint Pierre A, Le Jossic Corcos C, Corcos L. A transcriptome-based protein network that identifies new therapeutic targets in colorectal cancer. BMC Genomics. 2017;18:758 pubmed publisher

Han K, Kim A, Kim M, Kim D, Go H, Kang D, et al. Protein profiling and angiogenic effect of hypoxia-cultured human umbilical cord blood-derived mesenchymal stem cells in hindlimb ischemia. Tissue Cell. 2017;49:680-690 pubmed publisher

Castrogiovanni C, Waterschoot B, De Backer O, Dumont P. Serine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis. Cell Death Differ. 2017;: pubmed publisher

Alibolandi M, Rezvani R, Farzad S, Taghdisi S, Abnous K, Ramezani M. Tetrac-conjugated polymersomes for integrin-targeted delivery of camptothecin to colon adenocarcinoma in vitro and in vivo. Int J Pharm. 2017;532:581-594 pubmed publisher

Salvia R, Grossi G, Amoresano A, Scieuzo C, Nardiello M, Giangrande C, et al. The multifunctional polydnavirus TnBVANK1 protein: impact on host apoptotic pathway. Sci Rep. 2017;7:11775 pubmed publisher

Konysheva A, Nebogatikov V, Tolmacheva I, Dmitriev M, Grishko V. Synthesis of cytotoxically active derivatives based on alkylated 2,3-seco-triterpenoids. Eur J Med Chem. 2017;140:74-83 pubmed publisher

Chen G, Guo M. Screening for Natural Inhibitors of Topoisomerases I from Rhamnus davurica by Affinity Ultrafiltration and High-Performance Liquid Chromatography-Mass Spectrometry. Front Plant Sci. 2017;8:1521 pubmed publisher

Smith E, Holt S, Hewitson T. FGF23 activates injury-primed renal fibroblasts via FGFR4-dependent signalling and enhancement of TGF-β autoinduction. Int J Biochem Cell Biol. 2017;92:63-78 pubmed publisher

Gong P, Zhao Q, Dai D, Zhang S, Tian Z, Sun L, et al. Functionalized Ultrasmall Fluorinated Graphene with High NIR Absorbance for Controlled Delivery of Mixed Anticancer Drugs. Chemistry. 2017;23:17531-17541 pubmed publisher

Krishnan P, Rajan M, Kumari S, Sakinah S, Priya S, Amira F, et al. Efficiency of newly formulated camptothecin with β-cyclodextrin-EDTA-Fe3O4 nanoparticle-conjugated nanocarriers as an anti-colon cancer (HT29) drug. Sci Rep. 2017;7:10962 pubmed publisher

Vujanovic M, Krietsch J, Raso M, Terraneo N, Zellweger R, Schmid J, et al. Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity. Mol Cell. 2017;67:882-890.e5 pubmed publisher

Xu S, Wu X, Wu L, Castillo A, Liu J, Atkinson E, et al. Abro1 maintains genome stability and limits replication stress by protecting replication fork stability. Genes Dev. 2017;31:1469-1482 pubmed publisher

Asim M, Tarish F, Zecchini H, Sanjiv K, Gelali E, Massie C, et al. Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer. Nat Commun. 2017;8:374 pubmed publisher

Viseshakul N, Dechkhajorn W, Benjathummarak S, Nuamtanong S, Maneerat Y. Excretory-secretory product of third-stage Gnathostoma spinigerum larvae induces apoptosis in human peripheral blood mononuclear cells. Parasitol Res. 2017;116:2783-2794 pubmed publisher

Miranda N, Volpato H, da Silva Rodrigues J, Caetano W, Ueda Nakamura T, de Oliveira Silva S, et al. The photodynamic action of pheophorbide a induces cell death through oxidative stress in Leishmania amazonensis. J Photochem Photobiol B. 2017;174:342-354 pubmed publisher

Zhong J, Ji L, Chen H, Li X, Zhang J, Wang X, et al. Acetylation of hMOF Modulates H4K16ac to Regulate DNA Repair Genes in Response to Oxidative Stress. Int J Biol Sci. 2017;13:923-934 pubmed publisher

Gasparini L, Macedo N, Pimentel E, Fronza M, Junior V, Borges W, et al. In vitro Cell Viability by CellProfiler® Software as Equivalent to MTT Assay. Pharmacogn Mag. 2017;13:S365-S369 pubmed publisher

Kim J, Lee Y, Kim Y, Cho E, Huh E, Bang O, et al. Aqueous extract of Phragmitis rhizoma ameliorates myelotoxicity of docetaxel in vitro and in vivo. BMC Complement Altern Med. 2017;17:393 pubmed publisher

Pyrshev K, Yesylevskyy S, Mely Y, Demchenko A, Klymchenko A. Caspase-3 activation decreases lipid order in the outer plasma membrane leaflet during apoptosis: A fluorescent probe study. Biochim Biophys Acta Biomembr. 2017;1859:2123-2132 pubmed publisher

Almansour A, Arumugam N, Suresh Kumar R, Mahalingam S, Sau S, Bianchini G, et al. Design, synthesis and antiproliferative activity of decarbonyl luotonin analogues. Eur J Med Chem. 2017;138:932-941 pubmed publisher

Liu J, Kruswick A, Dang H, Tran A, Kwon S, Wang X, et al. Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth. Nat Commun. 2017;8:137 pubmed publisher

Rai R, Dyer P, Richardson S, Harbige L, Getti G. Apoptotic induction induces Leishmania aethiopica and L. mexicana spreading in terminally differentiated THP-1 cells. Parasitology. 2017;144:1912-1921 pubmed publisher

Morgado P, Jose S, Wanke R, M Antunes A, Cardoso A, Jordao L. Integration of cellular and molecular endpoints to assess the toxicity of polycyclic aromatic hydrocarbons in HepG2 cell line. Environ Toxicol Chem. 2017;36:3404-3414 pubmed publisher

Lu T, Ganganna B, Pham T, Vo A, Lu T, Nguyen H, et al. Antitumor effect of the integrin ?4 signaling inhibitor JK273 in non-small cell lung cancer NCI-H460 cells. Biochem Biophys Res Commun. 2017;491:355-360 pubmed publisher

Inoue Yamauchi A, Jeng P, Kim K, Chen H, Han S, Ganesan Y, et al. Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy. Nat Commun. 2017;8:16078 pubmed publisher

Zheng S, Koh X, Goh H, Rahmat S, Hwang L, Lane D. Inhibiting p53 Acetylation Reduces Cancer Chemotoxicity. Cancer Res. 2017;77:4342-4354 pubmed publisher

Gorniewska A, Kluzek K, Gackowska L, Kubiszewska I, Zdzienicka M, Bialkowska A. Distinct cellular phenotype linked to defective DNA interstrand crosslink repair and homologous recombination. Mol Med Rep. 2017;16:1885-1899 pubmed publisher

Koo G, Ji J, Cho H, Morgan M, Kim Y. Nuclear TRADD prevents DNA damage-mediated death by facilitating non-homologous end-joining repair. Sci Rep. 2017;7:3332 pubmed publisher

Beyer K, Nikfarjam F, Butting M, Meissner M, König A, Ramirez Bosca A, et al. Photodynamic Treatment of Oral Squamous Cell Carcinoma Cells with Low Curcumin Concentrations. J Cancer. 2017;8:1271-1283 pubmed publisher

Wang H, Nicolay B, Chick J, Gao X, Geng Y, Ren H, et al. The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival. Nature. 2017;546:426-430 pubmed publisher

Tan S, Chadha S, Liu Y, Gabasova E, Perera D, Ahmed K, et al. A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability. Cell. 2017;169:1105-1118.e15 pubmed publisher

Introini A, Boström S, Bradley F, Gibbs A, Glaessgen A, Tjernlund A, et al. Seminal plasma induces inflammation and enhances HIV-1 replication in human cervical tissue explants. PLoS Pathog. 2017;13:e1006402 pubmed publisher

Li S, Guan Q, Meng G, Chang X, Wei J, Wang P, et al. Revealing chemical processes and kinetics of drug action within single living cells via plasmonic Raman probes. Sci Rep. 2017;7:2296 pubmed publisher

Croft L, Ashton N, Paquet N, Bolderson E, O Byrne K, Richard D. hSSB1 associates with and promotes stability of the BLM helicase. BMC Mol Biol. 2017;18:13 pubmed publisher

Carone S, Costa T, Burin S, Cintra A, Zoccal K, Bianchini F, et al. A new l-amino acid oxidase from Bothrops jararacussu snake venom: Isolation, partial characterization, and assessment of pro-apoptotic and antiprotozoal activities. Int J Biol Macromol. 2017;103:25-35 pubmed publisher

Martinez Cruzado L, Tornin J, Rodriguez A, Santos L, Allonca E, Fernández García M, et al. Trabectedin and Campthotecin Synergistically Eliminate Cancer Stem Cells in Cell-of-Origin Sarcoma Models. Neoplasia. 2017;19:460-470 pubmed publisher

Song D, Huang H, Wang J, Zhao Y, Hu X, He F, et al. NF90 regulates PARP1 mRNA stability in hepatocellular carcinoma. Biochem Biophys Res Commun. 2017;488:211-217 pubmed publisher

Chowdhury S, Kumar A, Godinho J, De Macedo Silva S, Zuma A, Saha S, et al. Voacamine alters Leishmania ultrastructure and kills parasite by poisoning unusual bi-subunit topoisomerase IB. Biochem Pharmacol. 2017;138:19-30 pubmed publisher

Schneider T, Westermann M, Glei M. In vitro uptake and toxicity studies of metal nanoparticles and metal oxide nanoparticles in human HT29 cells. Arch Toxicol. 2017;91:3517-3527 pubmed publisher

Wang X, Zhao X. Prior lactose glycation of caseinate via the Maillard reaction affects in vitro activities of the pepsin-trypsin digest toward intestinal epithelial cells. J Dairy Sci. 2017;100:5125-5138 pubmed publisher

Popov J, Gilabert Oriol R, Bally M. Unique therapeutic properties and preparation methodology of multivalent rituximab-lipid nanoparticles. Eur J Pharm Biopharm. 2017;117:256-269 pubmed publisher

Ashton N, Paquet N, Shirran S, Bolderson E, Kariawasam R, Touma C, et al. hSSB1 phosphorylation is dynamically regulated by DNA-PK and PPP-family protein phosphatases. DNA Repair (Amst). 2017;54:30-39 pubmed publisher

Sahli R, Rivière C, Neut C, Bero J, Sahuc M, Smaoui A, et al. An ecological approach to discover new bioactive extracts and products: the case of extremophile plants. J Pharm Pharmacol. 2017;69:1041-1055 pubmed publisher

Liu Y, Wu X, Hu X, Chen Z, Liu H, Takeda S, et al. Multiple repair pathways mediate cellular tolerance to resveratrol-induced DNA damage. Toxicol In Vitro. 2017;42:130-138 pubmed publisher

García González A, Ritter A, Shrestha S, Andersen E, Yilmaz L, Walhout A. Bacterial Metabolism Affects the C. elegans Response to Cancer Chemotherapeutics. Cell. 2017;169:431-441.e8 pubmed publisher

Wu K, Chu J. Antiviral screen identifies EV71 inhibitors and reveals camptothecin-target, DNA topoisomerase 1 as a novel EV71 host factor. Antiviral Res. 2017;143:122-133 pubmed publisher

Gujral T, Kirschner M. Hippo pathway mediates resistance to cytotoxic drugs. Proc Natl Acad Sci U S A. 2017;114:E3729-E3738 pubmed publisher

Shafiq S, Chen C, Yang J, Cheng L, Ma F, Widemann E, et al. DNA Topoisomerase 1 Prevents R-loop Accumulation to Modulate Auxin-Regulated Root Development in Rice. Mol Plant. 2017;10:821-833 pubmed publisher

Bist G, Park S, Song C, Thapa Magar T, Shrestha A, Kwon Y, et al. Dihydroxylated 2,6-diphenyl-4-chlorophenylpyridines: Topoisomerase I and II? dual inhibitors with DNA non-intercalative catalytic activity. Eur J Med Chem. 2017;133:69-84 pubmed publisher

Ortega Atienza S, Krawic C, Watts L, McCarthy C, Luczak M, Zhitkovich A. 20S immunoproteasomes remove formaldehyde-damaged cytoplasmic proteins suppressing caspase-independent cell death. Sci Rep. 2017;7:654 pubmed publisher

Ranieri D, Proietti S, Dinicola S, Masiello M, Rosato B, Ricci G, et al. Simulated microgravity triggers epithelial mesenchymal transition in human keratinocytes. Sci Rep. 2017;7:538 pubmed publisher

Voigt J, Morawski M, Wöstemeyer J. The Cytotoxic Effects of Camptothecin and Mastoparan on the Unicellular Green Alga Chlamydomonas reinhardtii. J Eukaryot Microbiol. 2017;64:806-819 pubmed publisher

Imre G, Berthelet J, Heering J, Kehrloesser S, Melzer I, Lee B, et al. Apoptosis inhibitor 5 is an endogenous inhibitor of caspase-2. EMBO Rep. 2017;18:733-744 pubmed publisher

Jiang D, Wei S, Chen F, Zhang Y, Li J. TET3-mediated DNA oxidation promotes ATR-dependent DNA damage response. EMBO Rep. 2017;18:781-796 pubmed publisher

Barr A, Cooper S, Heldt F, Butera F, Stoy H, Mansfeld J, et al. DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression. Nat Commun. 2017;8:14728 pubmed publisher

Marques L, Semprebon S, Sartori D, de Fatima A, Ribeiro L, Mantovani M. Comparison of the Effects of Monastrol and Oxomonastrol on Human Hepatoma Cell Line HepG2/C3A. Anticancer Res. 2017;37:1197-1204 pubmed

Cubells Baeza N, Gómez Casado C, Tordesillas L, Ramírez Castillejo C, Garrido Arandia M, González Melendi P, et al. Identification of the ligand of Pru p 3, a peach LTP. Plant Mol Biol. 2017;94:33-44 pubmed publisher

Szewczyk M, Fedoryszak Kuśka N, Tkaczuk K, Dobrucki J, Waligórska A, Stepien P. Human SUV3 helicase regulates growth rate of the HeLa cells and can localize in the nucleoli. Acta Biochim Pol. 2017;64:177-181 pubmed publisher

Cao F, Ju E, Liu C, Li W, Zhang Y, Dong K, et al. Encapsulation of aggregated gold nanoclusters in a metal-organic framework for real-time monitoring of drug release. Nanoscale. 2017;9:4128-4134 pubmed publisher

Almeida I, Fernandes L, Biazi B, Vicentini V. Evaluation of the Anticancer Activities of the Plant Alkaloids Sanguinarine and Chelerythrine in Human Breast Adenocarcinoma Cells. Anticancer Agents Med Chem. 2017;17:1586-1592 pubmed publisher

Cheetham A, Lin Y, Lin R, Cui H. Molecular design and synthesis of self-assembling camptothecin drug amphiphiles. Acta Pharmacol Sin. 2017;38:874-884 pubmed publisher

Guha M, Saare M, Maslovskaja J, Kisand K, Liiv I, Haljasorg U, et al. DNA breaks and chromatin structural changes enhance the transcription of autoimmune regulator target genes. J Biol Chem. 2017;292:6542-6554 pubmed publisher

Mallick P, Basu S, Moorthy B, Ghose R. Role of Toll-like receptor 4 in drug-drug interaction between paclitaxel and irinotecan in vitro. Toxicol In Vitro. 2017;41:75-82 pubmed publisher

Colligs V, Hansen S, Imbri D, Seo E, Kadioglu O, Efferth T, et al. Synthesis and biological evaluation of a D-ring-contracted analogue of lamellarin D. Bioorg Med Chem. 2017;25:6137-6148 pubmed publisher

Clarke J, Molinaro A, Cabrera J, DeSilva A, Rabbitt J, Prey J, et al. A phase 1 trial of intravenous liposomal irinotecan in patients with recurrent high-grade glioma. Cancer Chemother Pharmacol. 2017;79:603-610 pubmed publisher

Mandrup O, Lykkemark S, Kristensen P. Targeting of phage particles towards endothelial cells by antibodies selected through a multi-parameter selection strategy. Sci Rep. 2017;7:42230 pubmed publisher

Kasikara C, Kumar S, Kimani S, Tsou W, Geng K, Davra V, et al. Phosphatidylserine Sensing by TAM Receptors Regulates AKT-Dependent Chemoresistance and PD-L1 Expression. Mol Cancer Res. 2017;15:753-764 pubmed publisher

Toots M, Männik A, Mumm K, Tämm K, Tamm T, Ustav E, et al. Identification of several high-risk HPV inhibitors and drug targets with a novel high-throughput screening assay. PLoS Pathog. 2017;13:e1006168 pubmed publisher

Tu Y, Liu H, Zhu X, Shen H, Ma X, Wang F, et al. Ataxin-3 promotes genome integrity by stabilizing Chk1. Nucleic Acids Res. 2017;45:4532-4549 pubmed publisher

Khan M, Palaniyar N. Transcriptional firing helps to drive NETosis. Sci Rep. 2017;7:41749 pubmed publisher

Wang Y, Chen J, Shen R, Yang C, Ma Z, Liu Y. 3-chloromethylene-6-fluorothiochroman-4-one, A novel DNA Topoisomerase poison. Pak J Pharm Sci. 2016;29:2377-2383 pubmed

Alibolandi M, Taghdisi S, Ramezani P, Hosseini Shamili F, Farzad S, Abnous K, et al. Smart AS1411-aptamer conjugated pegylated PAMAM dendrimer for the superior delivery of camptothecin to colon adenocarcinoma in vitro and in vivo. Int J Pharm. 2017;519:352-364 pubmed publisher

Rai A, Saito K, Yamazaki M. Integrated omics analysis of specialized metabolism in medicinal plants. Plant J. 2017;90:764-787 pubmed publisher

Friedman J, Perry H, Brown K, Gao Y, Lin J, Stevenson C, et al. Capsaicin synergizes with camptothecin to induce increased apoptosis in human small cell lung cancers via the calpain pathway. Biochem Pharmacol. 2017;129:54-66 pubmed publisher

Narayanan N, Wang Z, Li L, Yang Y. Arginine methylation of USP9X promotes its interaction with TDRD3 and its anti-apoptotic activities in breast cancer cells. Cell Discov. 2017;3:16048 pubmed publisher

Oksuzoglu E, Tırınoğlu Ç, Kerimoğlu B. The combined effects of proteasome inhibitor bortezomib with topoisomerase I and II inhibitors on topoisomerase enzymes. Turk J Med Sci. 2016;46:1882-1888 pubmed publisher

Won K, Im J, Kim B, Ban H, Jung Y, Jung K, et al. Stability of the cancer target DDIAS is regulated by the CHIP/HSP70 pathway in lung cancer cells. Cell Death Dis. 2017;8:e2554 pubmed publisher

Utaipan T, Athipornchai A, Suksamrarn A, Chunsrivirot S, Chunglok W. Isomahanine induces endoplasmic reticulum stress and simultaneously triggers p38 MAPK-mediated apoptosis and autophagy in multidrug-resistant human oral squamous cell carcinoma cells. Oncol Rep. 2017;37:1243-1252 pubmed publisher

Zanini I, Soneson C, Lorenzi L, Azzalin C. Human cactin interacts with DHX8 and SRRM2 to assure efficient pre-mRNA splicing and sister chromatid cohesion. J Cell Sci. 2017;130:767-778 pubmed publisher

Tran A, Han S, Kim J, Grasso F, Kim I, Han Y. MutY DNA Glycosylase Protects Cells From Tumor Necrosis Factor Alpha-Induced Necroptosis. J Cell Biochem. 2017;118:1827-1838 pubmed publisher

Ayesa U, Gray B, PAK K, Chong P. Liposomes Containing Lipid-Soluble Zn(II)-Bis-dipicolylamine Derivatives Show Potential To Be Targeted to Phosphatidylserine on the Surface of Cancer Cells. Mol Pharm. 2017;14:147-156 pubmed publisher

Hu Y, Zeng F. A theranostic prodrug based on FRET for real-time drug release monitoring in response to biothiols. Mater Sci Eng C Mater Biol Appl. 2017;72:77-85 pubmed publisher

He C, Cai P, Li J, Zhang T, Lin L, Abbasi A, et al. Blood-brain barrier-penetrating amphiphilic polymer nanoparticles deliver docetaxel for the treatment of brain metastases of triple negative breast cancer. J Control Release. 2017;246:98-109 pubmed publisher

Sato T, Shiba Ishii A, Kim Y, Dai T, Husni R, Hong J, et al. miR-3941: A novel microRNA that controls IGBP1 expression and is associated with malignant progression of lung adenocarcinoma. Cancer Sci. 2017;108:536-542 pubmed publisher

Shekhar S, Vatsa N, Kumar V, Singh B, Jamal I, Sharma A, et al. Topoisomerase 1 inhibitor topotecan delays the disease progression in a mouse model of Huntington's disease. Hum Mol Genet. 2017;26:420-429 pubmed publisher

Ouimet M, Drouin S, Lajoie M, Caron M, St Onge P, Gioia R, et al. A childhood acute lymphoblastic leukemia-specific lncRNA implicated in prednisolone resistance, cell proliferation, and migration. Oncotarget. 2017;8:7477-7488 pubmed publisher

Tumini E, Barroso S, Calero C, Aguilera A. Roles of human POLD1 and POLD3 in genome stability. Sci Rep. 2016;6:38873 pubmed publisher

Fytianos K, Chortarea S, Rodríguez Lorenzo L, Blank F, von Garnier C, Petri Fink A, et al. Aerosol Delivery of Functionalized Gold Nanoparticles Target and Activate Dendritic Cells in a 3D Lung Cellular Model. ACS Nano. 2017;11:375-383 pubmed publisher

Li Y, Li Z, Wu R, Han Z, Zhu W. And-1 is required for homologous recombination repair by regulating DNA end resection. Nucleic Acids Res. 2017;45:2531-2545 pubmed publisher

Zhan H, Liang J. Extreme Activity of Drug Nanocrystals Coated with A Layer of Non-Covalent Polymers from Self-Assembled Boric Acid. Sci Rep. 2016;6:38668 pubmed publisher

Zhan H, Jagtiani T, Liang J. Enhanced anticancer activity of drug nanoparticles formulated with β-cyclodextrin. Anticancer Drugs. 2017;28:271-280 pubmed publisher

Shamanna R, Lu H, de Freitas J, Tian J, Croteau D, Bohr V. WRN regulates pathway choice between classical and alternative non-homologous end joining. Nat Commun. 2016;7:13785 pubmed publisher

Zhang H, Sun L, Wang K, Wu D, Trappio M, Witting C, et al. Loss of H3K9me3 Correlates with ATM Activation and Histone H2AX Phosphorylation Deficiencies in Hutchinson-Gilford Progeria Syndrome. PLoS ONE. 2016;11:e0167454 pubmed publisher

Jo U, Cai W, Wang J, Kwon Y, D Andrea A, Kim H. PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress. PLoS Genet. 2016;12:e1006465 pubmed publisher

Kadyrova L, Dahal B, Kadyrov F. The Major Replicative Histone Chaperone CAF-1 Suppresses the Activity of the DNA Mismatch Repair System in the Cytotoxic Response to a DNA-methylating Agent. J Biol Chem. 2016;291:27298-27312 pubmed publisher

Sokolova M, Vinge L, Alfsnes K, Olsen M, Eide L, Kaasbøll O, et al. Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862:234-245 pubmed publisher

de Oliveira P, Damasceno J, Nicolella H, Bertanha C, Pauletti P, Tavares D. Influence of Styrax camporum and of Chemical Markers (Egonol and Homoegonol) on DNA Damage Induced by Mutagens with Different Mechanisms of Action. Biol Pharm Bull. 2016;39:1839-1845 pubmed

Mielańczyk A, Odrobińska J, Grządka S, Mielańczyk Ł, Neugebauer D. Miktoarm star copolymers from D-(-)-salicin core aggregated into dandelion-like structures as anticancer drug delivery systems: synthesis, self-assembly and drug release. Int J Pharm. 2016;515:515-526 pubmed publisher

Ledvina V, Janečková E, Matalová E, Klepárník K. Parallel single-cell analysis of active caspase-3/7 in apoptotic and non-apoptotic cells. Anal Bioanal Chem. 2017;409:269-274 pubmed publisher

El Khoury F, Corcos L, Durand S, Simon B, Le Jossic Corcos C. Acquisition of anticancer drug resistance is partially associated with cancer stemness in human colon cancer cells. Int J Oncol. 2016;49:2558-2568 pubmed publisher

Nalbant A, Kant M. Bacterial Heat Shock Protein GroEL (Hsp64) Exerts Immunoregulatory Effects on T Cells by Utilizing Apoptosis. PLoS ONE. 2016;11:e0164380 pubmed publisher

Tran T, Lowman X, Reid M, Mendez Dorantes C, Pan M, Yang Y, et al. Tumor-associated mutant p53 promotes cancer cell survival upon glutamine deprivation through p21 induction. Oncogene. 2017;36:1991-2001 pubmed publisher

Coucoravas C, Dhanjal S, Henriksson S, Böhm S, Farnebo M. Phosphorylation of the Cajal body protein WRAP53β by ATM promotes its involvement in the DNA damage response. RNA Biol. 2017;14:804-813 pubmed publisher

Jeon K, Yu H, Kwak S, Kwon Y, Na Y. Synthesis and topoisomerases inhibitory activity of heteroaromatic chalcones. Bioorg Med Chem. 2016;24:5921-5928 pubmed publisher

Rank L, Veith S, Gwosch E, Demgenski J, Ganz M, Jongmans M, et al. Analyzing structure-function relationships of artificial and cancer-associated PARP1 variants by reconstituting TALEN-generated HeLa PARP1 knock-out cells. Nucleic Acids Res. 2016;44:10386-10405 pubmed

Kucinska M, Piotrowska Kempisty H, Lisiak N, Kaczmarek M, Dams Kozlowska H, Granig W, et al. Selective anticancer activity of the novel thiobenzanilide 63T against human lung adenocarcinoma cells. Toxicol In Vitro. 2016;37:148-161 pubmed publisher

Islam M, Park S, Song C, Kadi A, Kwon Y, Rahman A. Fluorescein hydrazones: A series of novel non-intercalative topoisomerase II? catalytic inhibitors induce G1 arrest and apoptosis in breast and colon cancer cells. Eur J Med Chem. 2017;125:49-67 pubmed publisher

Yang T, Li W, Duan X, Zhu L, Fan L, Qiao Y, et al. Preparation of Two Types of Polymeric Micelles Based on Poly(β-L-Malic Acid) for Antitumor Drug Delivery. PLoS ONE. 2016;11:e0162607 pubmed publisher

Boyles M, Ranninger C, Reischl R, Rurik M, Tessadri R, Kohlbacher O, et al. Copper oxide nanoparticle toxicity profiling using untargeted metabolomics. Part Fibre Toxicol. 2016;13:49 pubmed publisher

Marques L, Semprebon S, Niwa A, D Epiro G, Sartori D, de Fatima A, et al. Antiproliferative activity of monastrol in human adenocarcinoma (MCF-7) and non-tumor (HB4a) breast cells. Naunyn Schmiedebergs Arch Pharmacol. 2016;389:1279-1288 pubmed

Bala V, Rao S, Bateman E, Keefe D, Wang S, Prestidge C. Enabling Oral SN38-Based Chemotherapy with a Combined Lipophilic Prodrug and Self-Microemulsifying Drug Delivery System. Mol Pharm. 2016;13:3518-3525 pubmed

Ferretti L, Himmels S, Trenner A, Walker C, von Aesch C, Eggenschwiler A, et al. Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection. Nat Commun. 2016;7:12628 pubmed publisher

Saha S, Acharya C, Pal U, Chowdhury S, Sarkar K, Maiti N, et al. A Novel Spirooxindole Derivative Inhibits the Growth of Leishmania donovani Parasites both In Vitro and In Vivo by Targeting Type IB Topoisomerase. Antimicrob Agents Chemother. 2016;60:6281-93 pubmed publisher

Thurlings I, Martínez López L, Westendorp B, Zijp M, Kuiper R, Tooten P, et al. Synergistic functions of E2F7 and E2F8 are critical to suppress stress-induced skin cancer. Oncogene. 2017;36:829-839 pubmed publisher

Dentamaro M, Lux F, Vander Elst L, Dauguet N, Montante S, Moussaron A, et al. Chemical and in vitro characterizations of a promising bimodal AGuIX probe able to target apoptotic cells for applications in MRI and optical imaging. Contrast Media Mol Imaging. 2016;11:381-395 pubmed publisher

Nutmakul T, Pattanapanyasat K, Soonthornchareonnon N, Shiomi K, Mori M, Prathanturarug S. Antiplasmodial activities of a Thai traditional antipyretic formulation, Bencha-Loga-Wichian: A comparative study between the roots and their substitutes, the stems. J Ethnopharmacol. 2016;193:125-132 pubmed publisher

Gemble S, Buhagiar Labarchède G, Onclercq Delic R, Biard D, Lambert S, Amor Gueret M. A balanced pyrimidine pool is required for optimal Chk1 activation to prevent ultrafine anaphase bridge formation. J Cell Sci. 2016;129:3167-77 pubmed publisher

Monteith J, Mellert H, Sammons M, Kuswanto L, Sykes S, Resnick Silverman L, et al. A rare DNA contact mutation in cancer confers p53 gain-of-function and tumor cell survival via TNFAIP8 induction. Mol Oncol. 2016;10:1207-20 pubmed publisher

Meinhardt G, Saleh L, Otti G, Haider S, Velicky P, Fiala C, et al. Wingless ligand 5a is a critical regulator of placental growth and survival. Sci Rep. 2016;6:28127 pubmed publisher

Godin S, Zhang Z, Herken B, Westmoreland J, Lee A, Mihalevic M, et al. The Shu complex promotes error-free tolerance of alkylation-induced base excision repair products. Nucleic Acids Res. 2016;44:8199-215 pubmed publisher

Ahmad P, Woo H, Jun K, Kadi A, Abdel Aziz H, Kwon Y, et al. Design, synthesis, topoisomerase I & II inhibitory activity, antiproliferative activity, and structure-activity relationship study of pyrazoline derivatives: An ATP-competitive human topoisomerase II? catalytic inhibitor. Bioorg Med Chem. 2016;24:1898-908 pubmed publisher

Sato S, Itamochi H, Oumi N, Chiba Y, Oishi T, Shimada M, et al. Establishment and characterization of a novel ovarian clear cell carcinoma cell line, TU-OC-2, with loss of ARID1A expression. Hum Cell. 2016;29:181-7 pubmed publisher

Buchfellner A, Yurlova L, Nüske S, Scholz A, Bogner J, Ruf B, et al. A New Nanobody-Based Biosensor to Study Endogenous PARP1 In Vitro and in Live Human Cells. PLoS ONE. 2016;11:e0151041 pubmed publisher

Datan E, Roy S, Germain G, Zali N, McLean J, Golshan G, et al. Dengue-induced autophagy, virus replication and protection from cell death require ER stress (PERK) pathway activation. Cell Death Dis. 2016;7:e2127 pubmed publisher

Turturro S, Najor M, Ruby C, Cobleigh M, Abukhdeir A. Mutations in PIK3CA sensitize breast cancer cells to physiologic levels of aspirin. Breast Cancer Res Treat. 2016;156:33-43 pubmed publisher

Hsu C, Huang R, Khuc T, Shou D, Bullock J, Grooby S, et al. Identification of approved and investigational drugs that inhibit hypoxia-inducible factor-1 signaling. Oncotarget. 2016;7:8172-83 pubmed publisher

Husain A, Begum N, Taniguchi T, Taniguchi H, Kobayashi M, Honjo T. Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability. Nat Commun. 2016;7:10549 pubmed publisher

Niwa A, de Paula N, Vesenick D, Sartori D, Maistro E, Ribeiro L, et al. Evaluation of lignan (-)-cubebin extracted from Piper cubeba on human colon adenocarcinoma cells (HT29). J Toxicol Environ Health A. 2016;79:92-100 pubmed publisher

Mandal A, Das S, Roy S, Ghosh A, Sardar A, Verma S, et al. Deprivation of L-Arginine Induces Oxidative Stress Mediated Apoptosis in Leishmania donovani Promastigotes: Contribution of the Polyamine Pathway. PLoS Negl Trop Dis. 2016;10:e0004373 pubmed publisher

Rodríguez González J, Wilkins Rodríguez A, Argueta Donohué J, Aguirre García M, Gutiérrez Kobeh L. Leishmania mexicana promastigotes down regulate JNK and p-38 MAPK activation: Role in the inhibition of camptothecin-induced apoptosis of monocyte-derived dendritic cells. Exp Parasitol. 2016;163:57-67 pubmed publisher

Eida S, van Cauteren M, Hotokezaka Y, Katayama I, Sasaki M, Obara M, et al. Length of intact plasma membrane determines the diffusion properties of cellular water. Sci Rep. 2016;6:19051 pubmed publisher

Gupta Y, Pasupuleti V, Du W, Welford S. Macrophage Migration Inhibitory Factor Secretion Is Induced by Ionizing Radiation and Oxidative Stress in Cancer Cells. PLoS ONE. 2016;11:e0146482 pubmed publisher

Wambang N, Schifano Faux N, Aillerie A, Baldeyrou B, Jacquet C, Bal Mahieu C, et al. Synthesis and biological activity of ferrocenyl indeno[1,2-c]isoquinolines as topoisomerase II inhibitors. Bioorg Med Chem. 2016;24:651-60 pubmed publisher

Zhang Y, Wen C, Liu S, Zheng L, Shen B, Tao Y. Shade avoidance 6 encodes an Arabidopsis flap endonuclease required for maintenance of genome integrity and development. Nucleic Acids Res. 2016;44:1271-84 pubmed publisher

Sun L, Li X, Li Z, Li Z, Gou M, Qian Z, et al. Improving Antitumor Activity with N-Trimethyl Chitosan Entrapping Camptothecin in Colon Cancer and Lung Cancer. J Nanosci Nanotechnol. 2015;15:6397-404 pubmed

Claus C, Manssen L, Hübner D, Roßmark S, Bothe V, Petzold A, et al. Activation of the Mitochondrial Apoptotic Signaling Platform during Rubella Virus Infection. Viruses. 2015;7:6108-26 pubmed publisher

Petrova N, Velichko A, Razin S, Kantidze O. Early S-phase cell hypersensitivity to heat stress. Cell Cycle. 2016;15:337-44 pubmed publisher

Adams B, Wali V, Cheng C, Inukai S, Booth C, Agarwal S, et al. miR-34a Silences c-SRC to Attenuate Tumor Growth in Triple-Negative Breast Cancer. Cancer Res. 2016;76:927-39 pubmed publisher

Ajithkumar G, Vinitha A, Binil Raj S, Kartha C. Drug Resistance of Endocardial Endothelial Cells is Related to Higher Endogenous ABCG2. Cardiovasc Toxicol. 2016;16:390-405 pubmed publisher

Wakx A, Regazzetti A, Dargère D, Auzeil N, Gil S, Evain Brion D, et al. New in vitro biomarkers to detect toxicity in human placental cells: The example of benzo[A]pyrene. Toxicol In Vitro. 2016;32:76-85 pubmed publisher

Wu C, Jin X, Yang J, Yang Y, He Y, Ding L, et al. Inhibition of EZH2 by chemo- and radiotherapy agents and small molecule inhibitors induces cell death in castration-resistant prostate cancer. Oncotarget. 2016;7:3440-52 pubmed publisher

Casadó A, Giuffrida M, Sagristá M, Castelli F, Pujol M, Alsina M, et al. Langmuir monolayers and Differential Scanning Calorimetry for the study of the interactions between camptothecin drugs and biomembrane models. Biochim Biophys Acta. 2016;1858:422-33 pubmed publisher

Sun Y, Chen K, Kwon C, Chen K. CK0403, a 9‑aminoacridine, is a potent anti‑cancer agent in human breast cancer cells. Mol Med Rep. 2016;13:933-8 pubmed publisher

Pradhan A, Ustiyan V, Zhang Y, Kalin T, Kalinichenko V. Forkhead transcription factor FoxF1 interacts with Fanconi anemia protein complexes to promote DNA damage response. Oncotarget. 2016;7:1912-26 pubmed publisher

Bala V, Rao S, Li P, Wang S, Prestidge C. Lipophilic Prodrugs of SN38: Synthesis and in Vitro Characterization toward Oral Chemotherapy. Mol Pharm. 2016;13:287-94 pubmed publisher

Bhushan S, Kakkar V, Pal H, Mondhe D, Kaur I. The augmented anticancer potential of AP9-cd loaded solid lipid nanoparticles in human leukemia Molt-4 cells and experimental tumor. Chem Biol Interact. 2016;244:84-93 pubmed publisher

Hargrove A, Martínez T, Hare A, Kurmis A, Phillips J, Sud S, et al. Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide. PLoS ONE. 2015;10:e0143161 pubmed publisher

Akpinar B, Bracht E, Reijnders D, Safaříková B, Jelínková I, Grandien A, et al. 5-Fluorouracil-induced RNA stress engages a TRAIL-DISC-dependent apoptosis axis facilitated by p53. Oncotarget. 2015;6:43679-97 pubmed publisher

Zucal C, D Agostino V, Casini A, Mantelli B, Thongon N, Soncini D, et al. EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition. BMC Cancer. 2015;15:855 pubmed publisher

Yadav P, Owiti N, Kim N. The role of topoisomerase I in suppressing genome instability associated with a highly transcribed guanine-rich sequence is not restricted to preventing RNA:DNA hybrid accumulation. Nucleic Acids Res. 2016;44:718-29 pubmed publisher

Hufbauer M, Cooke J, van der Horst G, Pfister H, Storey A, Akgül B. Human papillomavirus mediated inhibition of DNA damage sensing and repair drives skin carcinogenesis. Mol Cancer. 2015;14:183 pubmed publisher

Liu X, Chandramouly G, Rass E, Guan Y, Wang G, Hobbs R, et al. LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair. Nat Commun. 2015;6:8325 pubmed publisher

Tan Y, Xin X, Coffey F, Wiest D, Dong L, Testa J. Appl1 and Appl2 are Expendable for Mouse Development But Are Essential for HGF-Induced Akt Activation and Migration in Mouse Embryonic Fibroblasts. J Cell Physiol. 2016;231:1142-50 pubmed publisher

Gothwal A, Khan I, Gupta U. Polymeric Micelles: Recent Advancements in the Delivery of Anticancer Drugs. Pharm Res. 2016;33:18-39 pubmed publisher

Boysen G, Barbieri C, Prandi D, Blattner M, Chae S, Dahija A, et al. SPOP mutation leads to genomic instability in prostate cancer. elife. 2015;4: pubmed publisher

Fox S, Ryan K, Berger A, Petro K, Das S, Crowe S, et al. The role of C1q in recognition of apoptotic epithelial cells and inflammatory cytokine production by phagocytes during Helicobacter pylori infection. J Inflamm (Lond). 2015;12:51 pubmed publisher

Vázquez López R, Argueta Donohué J, Wilkins Rodríguez A, Escalona Montaño A, Aguirre García M, Gutiérrez Kobeh L. Leishmania mexicana amastigotes inhibit p38 and JNK and activate PI3K/AKT: role in the inhibition of apoptosis of dendritic cells. Parasite Immunol. 2015;37:579-89 pubmed publisher

Nakazawa D, Shida H, Kusunoki Y, Miyoshi A, Nishio S, Tomaru U, et al. The responses of macrophages in interaction with neutrophils that undergo NETosis. J Autoimmun. 2016;67:19-28 pubmed publisher

Spinella J, Cassart P, Garnier N, Rousseau P, Drullion C, Richer C, et al. A novel somatic mutation in ACD induces telomere lengthening and apoptosis resistance in leukemia cells. BMC Cancer. 2015;15:621 pubmed publisher

Cao L, Ding J, Dong L, Zhao J, Su J, Wang L, et al. Negative Regulation of p21Waf1/Cip1 by Human INO80 Chromatin Remodeling Complex Is Implicated in Cell Cycle Phase G2/M Arrest and Abnormal Chromosome Stability. PLoS ONE. 2015;10:e0137411 pubmed publisher

Maldonado E, Hurtado N, Pérez Castorena A, Martínez M. Cytotoxic 20,24-epoxywithanolides from Physalis angulata. Steroids. 2015;104:72-8 pubmed publisher

Hanschen F, Herz C, Schlotz N, Kupke F, Bartolomé Rodríguez M, Schreiner M, et al. The Brassica epithionitrile 1-cyano-2,3-epithiopropane triggers cell death in human liver cancer cells in vitro. Mol Nutr Food Res. 2015;59:2178-89 pubmed publisher

Zhao M, Gjerset R. Topoisomerase-I PS506 as a Dual Function Cancer Biomarker. PLoS ONE. 2015;10:e0134929 pubmed publisher

Kadayat T, Song C, Kwon Y, Lee E. Modified 2,4-diaryl-5H-indeno[1,2-b]pyridines with hydroxyl and chlorine moiety: Synthesis, anticancer activity, and structure-activity relationship study. Bioorg Chem. 2015;62:30-40 pubmed publisher

Massey A. Multiparametric Cell Cycle Analysis Using the Operetta High-Content Imager and Harmony Software with PhenoLOGIC. PLoS ONE. 2015;10:e0134306 pubmed publisher

Arribas J, Giménez E, Marcos R, Velázquez A. Novel antiapoptotic effect of TBX15: overexpression of TBX15 reduces apoptosis in cancer cells. Apoptosis. 2015;20:1338-46 pubmed publisher

Rybak P, Waligórska A, Bujnowicz Ł, Hoang A, Dobrucki J. Activation of new replication foci under conditions of replication stress. Cell Cycle. 2015;14:2634-47 pubmed publisher

Jain C, Pradhan B, Banerjee S, Mondal N, Majumder S, Bhattacharyya M, et al. Sulfonoquinovosyl diacylglyceride selectively targets acute lymphoblastic leukemia cells and exerts potent anti-leukemic effects in vivo. Sci Rep. 2015;5:12082 pubmed publisher

Gemble S, Ahuja A, Buhagiar Labarchède G, Onclercq Delic R, Dairou J, Biard D, et al. Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA. PLoS Genet. 2015;11:e1005384 pubmed publisher

Chen Y, Tsai T, Ye X, Lin T. Anti-proliferative effect on a colon adenocarcinoma cell line exerted by a membrane disrupting antimicrobial peptide KL15. Cancer Biol Ther. 2015;16:1172-83 pubmed publisher

Alatwi H, Downs J. Removal of H2A.Z by INO80 promotes homologous recombination. EMBO Rep. 2015;16:986-94 pubmed publisher

Joshi A, Iyengar R, Joo J, Li Harms X, Wright C, Marino R, et al. Nuclear ULK1 promotes cell death in response to oxidative stress through PARP1. Cell Death Differ. 2016;23:216-30 pubmed publisher

Sahreen S, Khan M, Khan R, Hadda T. Evaluation of phytochemical content, antimicrobial, cytotoxic and antitumor activities of extract from Rumex hastatus D. Don roots. BMC Complement Altern Med. 2015;15:211 pubmed publisher

Elson K, Fox N, Tipper J, Kirkham J, Hall R, Fisher J, et al. Non-destructive monitoring of viability in an ex vivo organ culture model of osteochondral tissue. Eur Cell Mater. 2015;29:356-69; discussion 369 pubmed

Lu J, Liu C, Wang P, Ghazwani M, Xu J, Huang Y, et al. The self-assembling camptothecin-tocopherol prodrug: An effective approach for formulating camptothecin. Biomaterials. 2015;62:176-87 pubmed publisher

Stückrath I, Rack B, Janni W, Jäger B, Pantel K, Schwarzenbach H. Aberrant plasma levels of circulating miR-16, miR-107, miR-130a and miR-146a are associated with lymph node metastasis and receptor status of breast cancer patients. Oncotarget. 2015;6:13387-401 pubmed

Kadayat T, Song C, Shin S, Magar T, Bist G, Shrestha A, et al. Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of 2-phenyl- or hydroxylated 2-phenyl-4-aryl-5H-indeno[1,2-b]pyridines. Bioorg Med Chem. 2015;23:3499-512 pubmed publisher

Zhao W, Fogg D, Kaplan M. A novel image-based quantitative method for the characterization of NETosis. J Immunol Methods. 2015;423:104-10 pubmed publisher

Rahman S, Kuehle J, Reimann C, Mlambo T, Alzubi J, Maeder M, et al. Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model. PLoS Genet. 2015;11:e1005239 pubmed publisher

Zajkowicz A, Gdowicz Kłosok A, Krześniak M, Ścieglińska D, Rusin M. Actinomycin D and nutlin-3a synergistically promote phosphorylation of p53 on serine 46 in cancer cell lines of different origin. Cell Signal. 2015;27:1677-87 pubmed publisher

Wang G, Lv C, Yuan X, Ye J, Jin H, Shan L, et al. Lanostane-type triterpenoids from Abies faxoniana and their DNA topoisomerase inhibitory activities. Phytochemistry. 2015;116:221-229 pubmed publisher

Wang ondu R, Teal S, Park R, Heston L, Delecluse H, Miller G. DNA Damage Signaling Is Induced in the Absence of Epstein-Barr Virus (EBV) Lytic DNA Replication and in Response to Expression of ZEBRA. PLoS ONE. 2015;10:e0126088 pubmed publisher

Huang N, Wu J, Qiu W, Lyu Q, He J, Xie W, et al. MiR-15a and miR-16 induce autophagy and enhance chemosensitivity of Camptothecin. Cancer Biol Ther. 2015;16:941-8 pubmed publisher

Karki R, Song C, Kadayat T, Magar T, Bist G, Shrestha A, et al. Topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of dihydroxylated 2,6-diphenyl-4-aryl pyridines. Bioorg Med Chem. 2015;23:3638-54 pubmed publisher

Ataei S, Yilmaz S, Ertan Bolelli T, Yildiz I. Generated 3D-common feature hypotheses using the HipHop method for developing new topoisomerase I inhibitors. Arch Pharm (Weinheim). 2015;348:498-507 pubmed publisher

Wang Z, D Annessa I, Tesauro C, Croce S, Ottaviani A, Fiorani P, et al. Mutation of Gly717Phe in human topoisomerase 1B has an effect on enzymatic function, reactivity to the camptothecin anticancer drug and on the linker domain orientation. Biochim Biophys Acta. 2015;1854:860-8 pubmed publisher

Haeger S, Thompson J, Kalra S, Cleaver T, Merrick D, Wang X, et al. Smad4 loss promotes lung cancer formation but increases sensitivity to DNA topoisomerase inhibitors. Oncogene. 2016;35:577-586 pubmed publisher

Satija Y, Das S. Tyr99 phosphorylation determines the regulatory milieu of tumor suppressor p73. Oncogene. 2016;35:513-27 pubmed publisher

Qi Q, Zhao X, Zuo R, Wang T, Gu X, Liu J, et al. Involvement of atypical transcription factor E2F8 in the polyploidization during mouse and human decidualization. Cell Cycle. 2015;14:1842-58 pubmed publisher

Han B, Wang T, Shen S, Yu Y, Mao C, Yao Z, et al. Annonaceous acetogenin mimic AA005 induces cancer cell death via apoptosis inducing factor through a caspase-3-independent mechanism. BMC Cancer. 2015;15:139 pubmed publisher

Yarinich L, Burakova E, Zakharov B, Boldyreva E, Babkina I, Tikunova N, et al. Synthesis and structure-activity relationship of novel 1,4-diazabicyclo[2.2.2]octane derivatives as potent antimicrobial agents. Eur J Med Chem. 2015;95:563-73 pubmed publisher

Buggiano V, Petrillo E, Alló M, Lafaille C, Redal M, Alghamdi M, et al. Effects of airborne particulate matter on alternative pre-mRNA splicing in colon cancer cells. Environ Res. 2015;140:185-90 pubmed publisher

Svobodová J, Kabátková M, Šmerdová L, Brenerová P, Dvořák Z, Machala M, et al. The aryl hydrocarbon receptor-dependent disruption of contact inhibition in rat liver WB-F344 epithelial cells is linked with induction of survivin, but not with inhibition of apoptosis. Toxicology. 2015;333:37-44 pubmed publisher

Conley S, Baker T, Burnett J, Theisen R, Lazarus D, Peters C, et al. CRLX101, an investigational camptothecin-containing nanoparticle-drug conjugate, targets cancer stem cells and impedes resistance to antiangiogenic therapy in mouse models of breast cancer. Breast Cancer Res Treat. 2015;150:559-67 pubmed publisher

Andersen S, Sloan R, Petes T, Jinks Robertson S. Genome-destabilizing effects associated with top1 loss or accumulation of top1 cleavage complexes in yeast. PLoS Genet. 2015;11:e1005098 pubmed publisher

Yeung M, Hurren R, Nemr C, Wang X, Hershenfeld S, Gronda M, et al. Mitochondrial DNA damage by bleomycin induces AML cell death. Apoptosis. 2015;20:811-20 pubmed publisher

Gallina I, Colding C, Henriksen P, Beli P, Nakamura K, Offman J, et al. Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control. Nat Commun. 2015;6:6533 pubmed publisher

Goldwirt L, Beccaria K, Carpentier A, Idbaih A, Schmitt C, Levasseur C, et al. Preclinical impact of bevacizumab on brain and tumor distribution of irinotecan and temozolomide. J Neurooncol. 2015;122:273-81 pubmed publisher

Krishnan S, Nair B, Sareddy G, Roy S, Natarajan M, Suzuki T, et al. Novel role of PELP1 in regulating chemotherapy response in mutant p53-expressing triple negative breast cancer cells. Breast Cancer Res Treat. 2015;150:487-99 pubmed publisher

Kamal R, Kumar A, Davis C, Tzeng W, Nguyen T, Donis R, et al. Emergence of Highly Pathogenic Avian Influenza A(H5N1) Virus PB1-F2 Variants and Their Virulence in BALB/c Mice. J Virol. 2015;89:5835-46 pubmed publisher

Nair H, Snima K, Kamath R, Nair S, Lakshmanan V. Plumbagin Nanoparticles Induce Dose and pH Dependent Toxicity on Prostate Cancer Cells. Curr Drug Deliv. 2015;12:709-16 pubmed

Gaboriau D, Rowling P, Morrison C, Itzhaki L. Protein stability versus function: effects of destabilizing missense mutations on BRCA1 DNA repair activity. Biochem J. 2015;466:613-24 pubmed publisher

Bhattacharjya S, Roy K, Ganguly A, Sarkar S, Panda C, Bhattacharyya D, et al. Inhibition of nucleoporin member Nup214 expression by miR-133b perturbs mitotic timing and leads to cell death. Mol Cancer. 2015;14:42 pubmed publisher

Hara T, Kobayashi E, Ohtsubo K, Kumada S, Kanazawa M, Abe T, et al. Organ-level analysis of idioblast patterning in Egeria densa Planch. leaves. PLoS ONE. 2015;10:e0118965 pubmed publisher

Kang M, Wang J, Makena M, Lee J, Paz N, Hall C, et al. Activity of MM-398, nanoliposomal irinotecan (nal-IRI), in Ewing's family tumor xenografts is associated with high exposure of tumor to drug and high SLFN11 expression. Clin Cancer Res. 2015;21:1139-50 pubmed publisher

Matsuoka K, Iimori M, Niimi S, Tsukihara H, Watanabe S, Kiyonari S, et al. Trifluridine Induces p53-Dependent Sustained G2 Phase Arrest with Its Massive Misincorporation into DNA and Few DNA Strand Breaks. Mol Cancer Ther. 2015;14:1004-13 pubmed publisher

De Gianni E, Turrini E, Milelli A, Maffei F, Carini M, Minarini A, et al. Study of the cytotoxic effects of the new synthetic Isothiocyanate CM9 and its fullerene derivative on human T-leukemia cells. Toxins (Basel). 2015;7:535-52 pubmed publisher

Kamada Y, Kusakabe T, Sugimoto Y. Amyloidogenic lysozymes accumulate in the endoplasmic reticulum accompanied by the augmentation of ER stress signals. Biochim Biophys Acta. 2015;1850:1107-19 pubmed publisher

Kuo W, Lee T, Yang H, Chen C, Au Y, Lu Y, et al. LPS receptor subunits have antagonistic roles in epithelial apoptosis and colonic carcinogenesis. Cell Death Differ. 2015;22:1590-604 pubmed publisher

Teft W, Welch S, Lenehan J, Parfitt J, Choi Y, Winquist E, et al. OATP1B1 and tumour OATP1B3 modulate exposure, toxicity, and survival after irinotecan-based chemotherapy. Br J Cancer. 2015;112:857-65 pubmed publisher

Liu X, Hummon A. Quantitative determination of irinotecan and the metabolite SN-38 by nanoflow liquid chromatography-tandem mass spectrometry in different regions of multicellular tumor spheroids. J Am Soc Mass Spectrom. 2015;26:577-86 pubmed publisher

Sarangi P, Steinacher R, Altmannova V, Fu Q, Paull T, Krejci L, et al. Sumoylation influences DNA break repair partly by increasing the solubility of a conserved end resection protein. PLoS Genet. 2015;11:e1004899 pubmed publisher

Householder K, Diperna D, Chung E, Wohlleb G, Dhruv H, Berens M, et al. Intravenous delivery of camptothecin-loaded PLGA nanoparticles for the treatment of intracranial glioma. Int J Pharm. 2015;479:374-80 pubmed publisher

Fytianos K, Rodríguez Lorenzo L, Clift M, Blank F, Vanhecke D, von Garnier C, et al. Uptake efficiency of surface modified gold nanoparticles does not correlate with functional changes and cytokine secretion in human dendritic cells in vitro. Nanomedicine. 2015;11:633-44 pubmed publisher

Chander H, Brien C, Truesdell P, Watt K, Meens J, Schick C, et al. Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis. Breast Cancer Res. 2014;16:3413 pubmed publisher

Sakata T, Fujii K, Ohno M, Kitabatake M. Crt10 directs the cullin-E3 ligase Rtt101 to nonfunctional 25S rRNA decay. Biochem Biophys Res Commun. 2015;457:90-4 pubmed publisher

Bukowska B, Michałowicz J, Marczak A. The effect of catechol on human peripheral blood mononuclear cells (in vitro study). Environ Toxicol Pharmacol. 2015;39:187-93 pubmed publisher

Kadayat T, Park C, Jun K, Magar T, Bist G, Yoo H, et al. Design and synthesis of novel 2,4-diaryl-5H-indeno[1,2-b]pyridine derivatives, and their evaluation of topoisomerase inhibitory activity and cytotoxicity. Bioorg Med Chem. 2015;23:160-73 pubmed publisher

Marada V, Flörl S, Kühne A, Müller J, Burckhardt G, Hagos Y. Interaction of human organic anion transporter 2 (OAT2) and sodium taurocholate cotransporting polypeptide (NTCP) with antineoplastic drugs. Pharmacol Res. 2015;91:78-87 pubmed publisher

Schink M, Garcia Käufer M, Bertrams J, Duckstein S, Müller M, Huber R, et al. Differential cytotoxic properties of Helleborus niger L. on tumour and immunocompetent cells. J Ethnopharmacol. 2015;159:129-36 pubmed publisher

Lee J, Lee S, Kim S, Choi J, Seo J, Choi D, et al. Corn silk maysin induces apoptotic cell death in PC-3 prostate cancer cells via mitochondria-dependent pathway. Life Sci. 2014;119:47-55 pubmed publisher

Toledo K, Fermino M, Andrade C, Riul T, Alves R, Muller V, et al. Galectin-1 exerts inhibitory effects during DENV-1 infection. PLoS ONE. 2014;9:e112474 pubmed publisher

Guacci V, Stricklin J, Bloom M, Guō X, Bhatter M, Koshland D. A novel mechanism for the establishment of sister chromatid cohesion by the ECO1 acetyltransferase. Mol Biol Cell. 2015;26:117-33 pubmed publisher

Sharma A, Nguyen H, Geng C, Hinman M, Luo G, Lou H. Calcium-mediated histone modifications regulate alternative splicing in cardiomyocytes. Proc Natl Acad Sci U S A. 2014;111:E4920-8 pubmed publisher

Eichelser C, Stückrath I, Müller V, Milde Langosch K, Wikman H, Pantel K, et al. Increased serum levels of circulating exosomal microRNA-373 in receptor-negative breast cancer patients. Oncotarget. 2014;5:9650-63 pubmed

Osakabe A, Takahashi Y, Murakami H, Otawa K, Tachiwana H, Oma Y, et al. DNA binding properties of the actin-related protein Arp8 and its role in DNA repair. PLoS ONE. 2014;9:e108354 pubmed publisher

Jossé R, Martin S, Guha R, Ormanoglu P, Pfister T, Reaper P, et al. ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses. Cancer Res. 2014;74:6968-79 pubmed publisher

Yong J, Choong M, Wang S, Wang Y, Lim S, Lee M. Characterization of ductal carcinoma in situ cell lines established from breast tumor of a Singapore Chinese patient. Cancer Cell Int. 2014;14:94 pubmed publisher

Chou C, Zhuo Y, Jiang Z, Liu Y. The hemodynamically-regulated vascular microenvironment promotes migration of the steroidogenic tissue during its interaction with chromaffin cells in the zebrafish embryo. PLoS ONE. 2014;9:e107997 pubmed publisher

Sugahara R, Mon H, Lee J, Shiotsuki T, Kusakabe T. Differential contribution of the Fanconi anemia-related proteins to repair of several types of DNA damage in cultured silkworm cells. FEBS Lett. 2014;588:3959-63 pubmed publisher

Chen D, Ming L, Zou F, Peng Y, Van Houten B, Yu J, et al. TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity. Oncotarget. 2014;5:8107-22 pubmed

Ghazaly E, Perry J, Kitromilidou C, Powles T, Joel S. Development and validation of an ultra-high performance LC-MS/MS assay for intracellular SN-38 in human solid tumour cell lines: comparison with a validated HPLC-fluorescence method. J Chromatogr B Analyt Technol Biomed Life Sci. 2014;969:213-8 pubmed publisher

González Ruiz V, Olives A, Martín M. Challenging core-shell stationary phases with the separation of closely related anti-cancer compounds: performance studies and application to drug quantitation in cell cultures with multi-well plate clean-up. J Chromatogr A. 2014;1364:83-95 pubmed publisher

Bozza W, Di X, Takeda K, Rivera Rosado L, Pariser S, Zhang B. The use of a stably expressed FRET biosensor for determining the potency of cancer drugs. PLoS ONE. 2014;9:e107010 pubmed publisher

Gole B, Baumann C, Mian E, Ireno C, Wiesmuller L. Endonuclease G initiates DNA rearrangements at the MLL breakpoint cluster upon replication stress. Oncogene. 2015;34:3391-401 pubmed publisher

Lee J, Lee D. Leucine methylation of protein phosphatase PP4C at C-terminal is critical for its cellular functions. Biochem Biophys Res Commun. 2014;452:42-7 pubmed publisher

Natesan S, Sugumaran A, Ponnusamy C, Jeevanesan V, Girija G, Palanichamy R. Development and evaluation of magnetic microemulsion: tool for targeted delivery of camptothecin to BALB/c mice-bearing breast cancer. J Drug Target. 2014;22:913-26 pubmed publisher

Zhao H, Thienpont B, Yesilyurt B, Moisse M, Reumers J, Coenegrachts L, et al. Mismatch repair deficiency endows tumors with a unique mutation signature and sensitivity to DNA double-strand breaks. elife. 2014;3:e02725 pubmed publisher

Shin E, Hay H, Lee M, Goh J, Tan T, Sen Y, et al. DEAD-box helicase DP103 defines metastatic potential of human breast cancers. J Clin Invest. 2014;124:3807-24 pubmed publisher

Karki R, Park C, Jun K, Jee J, Lee J, Thapa P, et al. Synthesis, antitumor activity, and structure-activity relationship study of trihydroxylated 2,4,6-triphenyl pyridines as potent and selective topoisomerase II inhibitors. Eur J Med Chem. 2014;84:555-65 pubmed publisher

Kpadonou Kpoviessi B, Kpoviessi S, Yayi Ladekan E, Gbaguidi F, Frederich M, Moudachirou M, et al. In vitro antitrypanosomal and antiplasmodial activities of crude extracts and essential oils of Ocimum gratissimum Linn from Benin and influence of vegetative stage. J Ethnopharmacol. 2014;155:1417-23 pubmed publisher

Xu H, Xian J, Viré E, McKinney S, Wei V, Wong J, et al. Up-regulation of the interferon-related genes in BRCA2 knockout epithelial cells. J Pathol. 2014;234:386-97 pubmed publisher

Cukras S, Morffy N, Ohn T, Kee Y. Inactivating UBE2M impacts the DNA damage response and genome integrity involving multiple cullin ligases. PLoS ONE. 2014;9:e101844 pubmed publisher

Zeman M, Lin J, Freire R, Cimprich K. DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis. J Cell Biol. 2014;206:183-97 pubmed publisher

Moreno E, Doughty Shenton D, Plano D, Font M, Encio I, Palop J, et al. A dihydroselenoquinazoline inhibits S6 ribosomal protein signalling, induces apoptosis and inhibits autophagy in MCF-7 cells. Eur J Pharm Sci. 2014;63:87-95 pubmed publisher

Ram B, Ramakrishna G. Endoplasmic reticulum vacuolation and unfolded protein response leading to paraptosis like cell death in cyclosporine A treated cancer cervix cells is mediated by cyclophilin B inhibition. Biochim Biophys Acta. 2014;1843:2497-512 pubmed publisher

Rieger D, Assinger A, Einfinger K, Sokolikova B, Geiger M. Protein C inhibitor (PCI) binds to phosphatidylserine exposing cells with implications in the phagocytosis of apoptotic cells and activated platelets. PLoS ONE. 2014;9:e101794 pubmed publisher

Chen Y, Colvin E, Griffin K, Maier B, Fueger P. Mig6 haploinsufficiency protects mice against streptozotocin-induced diabetes. Diabetologia. 2014;57:2066-75 pubmed publisher

Yan H, Huang X, Ke S, Jiang Y, Zhang Y, Wang Y, et al. Interleukin 6 augments lung cancer chemotherapeutic resistance via ataxia-telangiectasia mutated/NF-kappaB pathway activation. Cancer Sci. 2014;105:1220-7 pubmed publisher

Yamamura Y, Tsuchikawa T, Miyauchi K, Takeuchi S, Wada M, Kuwatani T, et al. The key role of calreticulin in immunomodulation induced by chemotherapeutic agents. Int J Clin Oncol. 2015;20:386-94 pubmed publisher

Adamová E, Lišková M, Matalova E, Kleparnik K. A miniaturized device for bioluminescence analysis of caspase-3/7 activity in a single apoptotic cell. Anal Bioanal Chem. 2014;406:5389-94 pubmed publisher

Schmeda Hirschmann G, Quispe C, Theoduloz C, de Sousa P, Parizotto C. Antiproliferative activity and new argininyl bufadienolide esters from the "cururú" toad Rhinella (Bufo) schneideri. J Ethnopharmacol. 2014;155:1076-85 pubmed publisher

Kolokoltsova O, Grant A, Huang C, Smith J, Poussard A, Tian B, et al. RIG-I enhanced interferon independent apoptosis upon Junin virus infection. PLoS ONE. 2014;9:e99610 pubmed publisher

Krześniak M, Zajkowicz A, Matuszczyk I, Rusin M. Rapamycin prevents strong phosphorylation of p53 on serine 46 and attenuates activation of the p53 pathway in A549 lung cancer cells exposed to actinomycin D. Mech Ageing Dev. 2014;139:11-21 pubmed publisher

Kiianitsa K, Maizels N. Ultrasensitive isolation, identification and quantification of DNA-protein adducts by ELISA-based RADAR assay. Nucleic Acids Res. 2014;42:e108 pubmed publisher

Assis P, Espíndola M, Paula Silva F, Rios W, Pereira P, Leão S, et al. Mycobacterium tuberculosis expressing phospholipase C subverts PGE2 synthesis and induces necrosis in alveolar macrophages. BMC Microbiol. 2014;14:128 pubmed publisher

Takahashi K, Yan I, Wood J, Haga H, Patel T. Involvement of extracellular vesicle long noncoding RNA (linc-VLDLR) in tumor cell responses to chemotherapy. Mol Cancer Res. 2014;12:1377-87 pubmed publisher

Goldwirt L, Beccaria K, Carpentier A, Farinotti R, Fernandez C. Irinotecan and temozolomide brain distribution: a focus on ABCB1. Cancer Chemother Pharmacol. 2014;74:185-93 pubmed publisher

González Ruiz V, Pascua I, Fernandez Marcelo T, Ribelles P, Bianchini G, Sridharan V, et al. B-ring-aryl substituted luotonin A analogues with a new binding mode to the topoisomerase 1-DNA complex show enhanced cytotoxic activity. PLoS ONE. 2014;9:e95998 pubmed publisher

Liou J, Wu Y, Yen W, Tang Y, Kakadiya R, Su T, et al. Inhibition of autophagy enhances DNA damage-induced apoptosis by disrupting CHK1-dependent S phase arrest. Toxicol Appl Pharmacol. 2014;278:249-58 pubmed publisher

Deng Y, Saucier Sawyer J, Hoimes C, Zhang J, Seo Y, Andrejecsk J, et al. The effect of hyperbranched polyglycerol coatings on drug delivery using degradable polymer nanoparticles. Biomaterials. 2014;35:6595-602 pubmed publisher

Fatt M, Cancino G, Miller F, Kaplan D. p63 and p73 coordinate p53 function to determine the balance between survival, cell death, and senescence in adult neural precursor cells. Cell Death Differ. 2014;21:1546-59 pubmed publisher

Eid M, Maeda K, Almofty S, Singh S, Shimoda M, Sakaguchi N. GANP regulates the choice of DNA repair pathway by DNA-PKcs interaction in AID-dependent IgV region diversification. J Immunol. 2014;192:5529-39 pubmed publisher

Groh M, Lufino M, Wade Martins R, Gromak N. R-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome. PLoS Genet. 2014;10:e1004318 pubmed publisher

Nair B, Krishnan S, Sareddy G, Mann M, Xu B, Natarajan M, et al. Proline, glutamic acid and leucine-rich protein-1 is essential for optimal p53-mediated DNA damage response. Cell Death Differ. 2014;21:1409-18 pubmed publisher

Remant B, Chandrashekaran V, Cheng B, Chen H, Pena M, Zhang J, et al. Redox potential ultrasensitive nanoparticle for the targeted delivery of camptothecin to HER2-positive cancer cells. Mol Pharm. 2014;11:1897-905 pubmed publisher

Jeetah R, Bhaw Luximon A, Jhurry D. Polymeric nanomicelles for sustained delivery of anti-cancer drugs. Mutat Res. 2014;768:47-59 pubmed publisher

Frese Schaper M, Keil A, Steiner S, Gugger M, Korner M, Kocher G, et al. Low-dose irinotecan improves advanced lupus nephritis in mice potentially by changing DNA relaxation and anti-double-stranded DNA binding. Arthritis Rheumatol. 2014;66:2259-69 pubmed publisher

Kolypetri P, Carayanniotis G. Apoptosis of NOD.H2 h4 thyrocytes by low concentrations of iodide is associated with impaired control of oxidative stress. Thyroid. 2014;24:1170-8 pubmed publisher

Youm I, Agrahari V, Murowchick J, Youan B. Uptake and cytotoxicity of docetaxel-loaded hyaluronic acid-grafted oily core nanocapsules in MDA-MB 231 cancer cells. Pharm Res. 2014;31:2439-52 pubmed publisher

Pehlivan Karakas F, Söhretoğlu D, Liptaj T, Stujber M, Ucar Turker A, Marák J, et al. Isolation of an oleanane-type saponin active from Bellis perennis through antitumor bioassay-guided procedures. Pharm Biol. 2014;52:951-5 pubmed publisher

Peleg R, Bobilev D, Priel E. Topoisomerase I as a target of erlotinib and gefitinib: efficacy of combined treatments with camptothecin. Int J Oncol. 2014;44:934-42 pubmed publisher

Garcia C, Videla Richardson G, Romorini L, Miriuka S, Sevlever G, Scassa M. Topoisomerase I inhibitor, camptothecin, induces apoptogenic signaling in human embryonic stem cells. Stem Cell Res. 2014;12:400-14 pubmed publisher

Teves S, Henikoff S. Transcription-generated torsional stress destabilizes nucleosomes. Nat Struct Mol Biol. 2014;21:88-94 pubmed publisher

Wu Z, Zhao Y, Zhang Y, Zhu L. HY-2, a novel DNA topoisomerase II inhibitor, induces G2/M cell cycle arrest in HCT-116 cells. J Chemother. 2014;26:342-7 pubmed publisher

Iordanova B, Hitchens T, Robison C, Ahrens E. Engineered mitochondrial ferritin as a magnetic resonance imaging reporter in mouse olfactory epithelium. PLoS ONE. 2013;8:e72720 pubmed publisher

Bala V, Rao S, Boyd B, Prestidge C. Prodrug and nanomedicine approaches for the delivery of the camptothecin analogue SN38. J Control Release. 2013;172:48-61 pubmed publisher

Yoshimoto K, Saito H, Munemoto M, Kadoya N, Murata S. [A case of recurrence after resection of gastric cancer successfully treated by combination chemotherapy with CPT-11 and CDDP]. Gan To Kagaku Ryoho. 2013;40:929-32 pubmed

Nishizawa T, Kinoshita S, Sakuno T, Fujiyama Y, Kikuchi M, Kaneko H, et al. [A case of metastatic colon cancer effectively treated by XELOX and IRIS]. Gan To Kagaku Ryoho. 2013;40:807-9 pubmed

Okamura T, Kawachi Y, Nikkuni K, Nishimura A, Makino S, Kawahara M, et al. [A case of hyperammonemic encephalopathy related to 5-FU in an aged patient with recurrent colon cancer treated with FOLFIRI therapy]. Gan To Kagaku Ryoho. 2013;40:671-3 pubmed

Takeda M, Ori T, Ohishi K, Sunayama K. [A case of synchronous liver metastasis originating from advanced gastric cancer treated with combination chemotherapy involving S-1 and surgical intervention]. Gan To Kagaku Ryoho. 2013;40:667-70 pubmed

Katayama K, Nishino T, Takahashi Y, Tanaka T, Okitsu H, Okitsu N. [Approximately four years of survival benefits for a case of gastric cancer postoperative carcinomatous peritonitis by combined modality therapy]. Gan To Kagaku Ryoho. 2013;40:655-8 pubmed

Soda H, Nemoto H, Akatsuka S, Arioka H, Shimada K, Ito T, et al. [Efficacy and safety of cetuximab+irinotecan for unresectable advanced or recurrent colorectal cancer]. Gan To Kagaku Ryoho. 2013;40:605-8 pubmed

Abe H, Mafune K, Minamimura K, Abe M, Umemura A, Hirata T. [Second-line FOLFIRI plus bevacizumab for patients with metastatic colorectal cancer after resection of the primary lesion]. Gan To Kagaku Ryoho. 2013;40:601-4 pubmed

Shah S, Kim Y, Ostrovnaya I, Murali R, Schrader K, Lach F, et al. Assessment of SLX4 Mutations in Hereditary Breast Cancers. PLoS ONE. 2013;8:e66961 pubmed publisher

Prabhakara P, Zenia T, Marina K, Shama K, Girish S, Matapady N. Preparation and evaluation of lipid vesicles of camptothecin as targeted drug delivery system. Pak J Pharm Sci. 2013;26:779-86 pubmed

Walter H, Thomas A. Liver resection following FOLFOXIRI plus bevacizumab: a detailed pathological review. Br J Cancer. 2013;108:2417-8 pubmed publisher

Takano M, Goto T, Hirata J, Furuya K, Horie K, Takahashi M, et al. UGT1A1 genotype-specific phase I and pharmacokinetic study for combination chemotherapy with irinotecan and cisplatin: a Saitama Tumor Board study. Eur J Gynaecol Oncol. 2013;34:120-3 pubmed

Saito M, Yano K, Kamigaki T, Goto S. A patient with scirrhous stomach cancer treated with combination of hyperthermotherapy and 5-aminolevulinic acid (ALA). Anticancer Res. 2013;33:2957-63 pubmed

Zhang S, Chen Z, Yang R, Chen J, Cheng P, He Z, et al. Irinotecan combined with co-stimulatory molecule blockade prolongs survival of cardiac allografts in alloantigen-primed mice. Cell Immunol. 2013;282:85-92 pubmed publisher

Yin X, Sun H, Yu D, Liang Y, Yuan Z, Ge Y. Hydroxycamptothecin induces apoptosis of human tenon's capsule fibroblasts by activating the PERK signaling pathway. Invest Ophthalmol Vis Sci. 2013;54:4749-58 pubmed publisher

Sasaki T, Isayama H, Nakai Y, Takahara N, Satoh Y, Takai D, et al. A pilot study of salvage irinotecan monotherapy for advanced biliary tract cancer. Anticancer Res. 2013;33:2619-22 pubmed

Vangara K, Liu J, PALAKURTHI S. Hyaluronic acid-decorated PLGA-PEG nanoparticles for targeted delivery of SN-38 to ovarian cancer. Anticancer Res. 2013;33:2425-34 pubmed

Ang C, Herran L, Lagunes D, Klimstra D, Kemeny N. A case report of a patient with advanced acinar cell carcinoma of the pancreas: long-term survival with regional, systemic and targeted therapy. Tumori. 2013;99:e61-4 pubmed publisher

McCleary N, Meyerhardt J, Green E, Yothers G, de Gramont A, Van Cutsem E, et al. Impact of age on the efficacy of newer adjuvant therapies in patients with stage II/III colon cancer: findings from the ACCENT database. J Clin Oncol. 2013;31:2600-6 pubmed publisher

Eng C. Will PICCOLO affect metastatic colorectal cancer therapy?. Lancet Oncol. 2013;14:679-80 pubmed publisher

Seymour M, Brown S, Middleton G, Maughan T, Richman S, Gwyther S, et al. Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial. Lancet Oncol. 2013;14:749-59 pubmed publisher

Rebersek K, Cernelc P, Podgornik H. Evaluation of multiple myeloma cell apoptosis in primary bone marrow samples. Clin Lab. 2013;59:389-95 pubmed

Ito Y, Yamada Y, Asada K, Ushijima T, Iwasa S, Kato K, et al. EGFR L2 domain mutation is not correlated with resistance to cetuximab in metastatic colorectal cancer patients. J Cancer Res Clin Oncol. 2013;139:1391-6 pubmed publisher

Loupakis F, Schirripa M, Caparello C, Funel N, Pollina L, Vasile E, et al. Histopathologic evaluation of liver metastases from colorectal cancer in patients treated with FOLFOXIRI plus bevacizumab. Br J Cancer. 2013;108:2549-56 pubmed publisher

Jett J, Schild S, Kesler K, Kalemkerian G. Treatment of small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2013;143:e400S-e419S pubmed publisher

Ryu J, Cho B, Woo H, Cho S, Sohn H. Fabrication and characterization of photoluminescent silicon nanoparticles for drug delivery applications. J Nanosci Nanotechnol. 2013;13:157-60 pubmed

Akiyoshi K, Yamada Y, Honma Y, Iwasa S, Kato K, Hamaguchi T, et al. KRAS mutations in patients with colorectal cancer as detected by high-resolution melting analysis and direct sequencing. Anticancer Res. 2013;33:2129-34 pubmed

Narayanan G, Barbery K, Suthar R, Guerrero G, Arora G. Transarterial chemoembolization using DEBIRI for treatment of hepatic metastases from colorectal cancer. Anticancer Res. 2013;33:2077-83 pubmed

Zhao L, Caot J, Wu Z, Li J, Zhu J. Lab-on-a-Chip for anticancer drug screening using quantum dots probe based apoptosis assay. J Biomed Nanotechnol. 2013;9:348-56 pubmed

Ekinci D, Ekici D, Kargi A, Yalcin A, Didem Yalcin A, Savas B. The role of VEGF and other parameters in tracking the clinical course in metronomic chemotherapy. J BUON. 2013;18:245-52 pubmed

Huang Q, Wang L, Lu W. Evolution in medicinal chemistry of E-ring-modified Camptothecin analogs as anticancer agents. Eur J Med Chem. 2013;63:746-57 pubmed publisher

Beretta G, Gatti L, Perego P, Zaffaroni N. Camptothecin resistance in cancer: insights into the molecular mechanisms of a DNA-damaging drug. Curr Med Chem. 2013;20:1541-65 pubmed

Cottle D, Kretzschmar K, Schweiger P, Quist S, Gollnick H, Natsuga K, et al. c-MYC-induced sebaceous gland differentiation is controlled by an androgen receptor/p53 axis. Cell Rep. 2013;3:427-41 pubmed publisher

Soria G, Almouzni G. Differential contribution of HP1 proteins to DNA end resection and homology-directed repair. Cell Cycle. 2013;12:422-9 pubmed publisher

Pan X, Lei B, Zhou N, Feng B, Yao W, Zhao X, et al. Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library. BMC Genomics. 2012;13:662 pubmed publisher

Tomicic M, Kaina B. Topoisomerase degradation, DSB repair, p53 and IAPs in cancer cell resistance to camptothecin-like topoisomerase I inhibitors. Biochim Biophys Acta. 2013;1835:11-27 pubmed publisher

Beretta G, Zuco V, De Cesare M, Perego P, Zaffaroni N. Namitecan: a hydrophilic camptothecin with a promising preclinical profile. Curr Med Chem. 2012;19:3488-501 pubmed

Baskar S, Wiestner A, Wilson W, Pastan I, Rader C. Targeting malignant B cells with an immunotoxin against ROR1. MAbs. 2012;4:349-61 pubmed publisher

Kamal A, Suresh P, Ramaiah M, Mallareddy A, Imthiajali S, Pushpavalli S, et al. Synthesis and biological evaluation of 4?-sulphonamido and 4?-[(4'-sulphonamido)benzamide]podophyllotoxins as DNA topoisomerase-II? and apoptosis inducing agents. Bioorg Med Chem. 2012;20:2054-66 pubmed publisher

Bose D, Idrees M, Todewale I, Jakka N, Rao J. Hybrids of privileged structures benzothiazoles and pyrrolo[2,1-c] [1,4]benzodiazepin-5-one, and diversity-oriented synthesis of benzothiazoles. Eur J Med Chem. 2012;50:27-38 pubmed publisher

Karki R, Thapa P, Yoo H, Kadayat T, Park P, Na Y, et al. Dihydroxylated 2,4,6-triphenyl pyridines: synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study. Eur J Med Chem. 2012;49:219-28 pubmed publisher

Neagoie C, Vedrenne E, Buron F, Mérour J, Rosca S, Bourg S, et al. Synthesis of chromeno[3,4-b]indoles as Lamellarin D analogues: a novel DYRK1A inhibitor class. Eur J Med Chem. 2012;49:379-96 pubmed publisher

Majeed R, Reddy M, Chinthakindi P, Sangwan P, Hamid A, Chashoo G, et al. Bakuchiol derivatives as novel and potent cytotoxic agents: a report. Eur J Med Chem. 2012;49:55-67 pubmed publisher

Minarini A, Milelli A, Tumiatti V, Ferruzzi L, Marton M, Turrini E, et al. Design, synthesis and biological evaluation of new naphtalene diimides bearing isothiocyanate functionality. Eur J Med Chem. 2012;48:124-31 pubmed publisher

Thuong P, Pham T, Le T, Dao T, Dang T, Nguyen Q, et al. Symmetric dimers of ent-kaurane diterpenoids with cytotoxic activity from Croton tonkinensis. Bioorg Med Chem Lett. 2012;22:1122-4 pubmed publisher

Bartova E, Sustáčková G, Stixova L, Kozubek S, Legartova S, Foltankova V. Recruitment of Oct4 protein to UV-damaged chromatin in embryonic stem cells. PLoS ONE. 2011;6:e27281 pubmed publisher

Kumar A, Shah B, Singh S, Hamid A, Singh S, Sethi V, et al. Acyl derivatives of boswellic acids as inhibitors of NF-?B and STATs. Bioorg Med Chem Lett. 2012;22:431-5 pubmed publisher

Moreno E, Plano D, Lamberto I, Font M, Encio I, Palop J, et al. Sulfur and selenium derivatives of quinazoline and pyrido[2,3-d]pyrimidine: synthesis and study of their potential cytotoxic activity in vitro. Eur J Med Chem. 2012;47:283-98 pubmed publisher

Manita D, Toba Y, Takakusagi Y, Matsumoto Y, Kusayanagi T, Takakusagi K, et al. Camptothecin (CPT) directly binds to human heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and inhibits the hnRNP A1/topoisomerase I interaction. Bioorg Med Chem. 2011;19:7690-7 pubmed publisher

Kamal A, Srikanth Y, Naseer Ahmed Khan M, Ashraf M, Kashi Reddy M, Sultana F, et al. 2-Anilinonicotinyl linked 2-aminobenzothiazoles and [1,2,4]triazolo[1,5-b] [1,2,4]benzothiadiazine conjugates as potential mitochondrial apoptotic inducers. Bioorg Med Chem. 2011;19:7136-50 pubmed publisher

Carta A, Briguglio I, Piras S, Corona P, Boatto G, Nieddu M, et al. Quinoline tricyclic derivatives. Design, synthesis and evaluation of the antiviral activity of three new classes of RNA-dependent RNA polymerase inhibitors. Bioorg Med Chem. 2011;19:7070-84 pubmed publisher

Gan M, Liu M, Liu B, Lin S, Zhang Y, Zi J, et al. Cucurbitane glucosides from the root of Machilus yaoshansis. J Nat Prod. 2011;74:2431-7 pubmed publisher

Lacroix D, Prado S, Kamoga D, Kasenene J, Bodo B. Structure and in vitro antiparasitic activity of constituents of Citropsis articulata root bark. J Nat Prod. 2011;74:2286-9 pubmed publisher

Parthiban P, Pallela R, Kim S, Park D, Jeong Y. Synthesis of polyfunctionalized piperidone oxime ethers and their cytotoxicity on HeLa cells. Bioorg Med Chem Lett. 2011;21:6678-86 pubmed publisher

Shen L, Park E, Kondratyuk T, Guendisch D, Marler L, Pezzuto J, et al. Design, synthesis, and biological evaluation of callophycin A and analogues as potential chemopreventive and anticancer agents. Bioorg Med Chem. 2011;19:6182-95 pubmed publisher

Fan J, Kuang B, Zeng G, Zhao S, Ji C, Zhang Y, et al. Biologically active arborinane-type triterpenoids and anthraquinones from Rubia yunnanensis. J Nat Prod. 2011;74:2069-80 pubmed publisher

Van H, Khadka D, Yang S, Le T, Cho S, Zhao C, et al. Synthesis of benzo[3,4]azepino[1,2-b]isoquinolin-9-ones from 3-arylisoquinolines via ring closing metathesis and evaluation of topoisomerase I inhibitory activity, cytotoxicity and docking study. Bioorg Med Chem. 2011;19:5311-20 pubmed publisher

Dahan Farkas N, Langley C, Rousseau A, Yadav D, Davids H, De Koning C. 6-Substituted imidazo[1,2-a]pyridines: synthesis and biological activity against colon cancer cell lines HT-29 and Caco-2. Eur J Med Chem. 2011;46:4573-83 pubmed publisher

Kiselev E, Deguire S, Morrell A, Agama K, Dexheimer T, Pommier Y, et al. 7-azaindenoisoquinolines as topoisomerase I inhibitors and potential anticancer agents. J Med Chem. 2011;54:6106-16 pubmed publisher

Fronza M, Murillo R, Slusarczyk S, Adams M, Hamburger M, Heinzmann B, et al. In vitro cytotoxic activity of abietane diterpenes from Peltodon longipes as well as Salvia miltiorrhiza and Salvia sahendica. Bioorg Med Chem. 2011;19:4876-81 pubmed publisher

Cal Bakowska M, Litwin I, Bocer T, Wysocki R, Dziadkowiec D. The Swi2-Snf2-like protein Uls1 is involved in replication stress response. Nucleic Acids Res. 2011;39:8765-77 pubmed publisher

Peterson K, Cinelli M, Morrell A, Mehta A, Dexheimer T, Agama K, et al. Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors: investigating the relationships involving stereochemistry, hydrogen bonding, and biological activity. J Med Chem. 2011;54:4937-53 pubmed publisher

Le T, Yang S, Khadka D, Van H, Cho S, Kwon Y, et al. Design and synthesis of 4-amino-2-phenylquinazolines as novel topoisomerase I inhibitors with molecular modeling. Bioorg Med Chem. 2011;19:4399-404 pubmed publisher

Reddy D, Qazi N, Sawant S, Bandey A, Srinivas J, Shankar M, et al. Design and synthesis of spiro derivatives of parthenin as novel anti-cancer agents. Eur J Med Chem. 2011;46:3210-7 pubmed publisher

Thapa U, Thapa P, Karki R, Yun M, Choi J, Jahng Y, et al. Synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship. Eur J Med Chem. 2011;46:3201-9 pubmed publisher

Wu W, Ou J, Huang Z, Chen S, Ou T, Tan J, et al. Synthesis and evaluation of mansonone F derivatives as topoisomerase inhibitors. Eur J Med Chem. 2011;46:3339-47 pubmed publisher

Chen Y, Chen Y, Tseng C, Liang C, Yang C, Yao Y, et al. Discovery of 4-anilinofuro[2,3-b]quinoline derivatives as selective and orally active compounds against non-small-cell lung cancers. J Med Chem. 2011;54:4446-61 pubmed publisher

Ayers S, Graf T, Adcock A, Kroll D, Matthew S, Carcache de Blanco E, et al. Resorcylic acid lactones with cytotoxic and NF-?B inhibitory activities and their structure-activity relationships. J Nat Prod. 2011;74:1126-31 pubmed publisher

Baldeyron C, Soria G, Roche D, Cook A, Almouzni G. HP1alpha recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair. J Cell Biol. 2011;193:81-95 pubmed publisher

Liu W, Zhu L, Guo W, Zhuang C, Zhang Y, Sheng C, et al. Synthesis and biological evaluation of novel 7-acyl homocamptothecins as Topoisomerase I inhibitors. Eur J Med Chem. 2011;46:2408-14 pubmed publisher

Yamada R, Cao X, Butkevich A, Millard M, Odde S, Mordwinkin N, et al. Discovery and preclinical evaluation of a novel class of cytotoxic propynoic acid carbamoyl methyl amides (PACMAs). J Med Chem. 2011;54:2902-14 pubmed publisher

Genès C, Lenglet G, Depauw S, Nhili R, Prado S, David Cordonnier M, et al. Synthesis and biological evaluation of N-substituted benzo[c]phenanthrolines and benzo[c]phenanthrolinones as antiproliferative agents. Eur J Med Chem. 2011;46:2117-31 pubmed publisher

Jun K, Lee E, Jung M, Lee O, Lee E, Park Choo H, et al. Synthesis, biological evaluation, and molecular docking study of 3-(3'-heteroatom substituted-2'-hydroxy-1'-propyloxy) xanthone analogues as novel topoisomerase II? catalytic inhibitor. Eur J Med Chem. 2011;46:1964-71 pubmed publisher

Sirirak T, Kittiwisut S, Janma C, Yuenyongsawad S, Suwanborirux K, Plubrukarn A. Kabiramides J and K, trisoxazole macrolides from the sponge Pachastrissa nux. J Nat Prod. 2011;74:1288-92 pubmed publisher

Chavez K, Feng X, Flanders J, Rodriguez E, Schroeder F. Spirocyclic lignans from Guaiacum (Zygophyllaceae) induce apoptosis in human breast cancer cell lines. J Nat Prod. 2011;74:1293-7 pubmed publisher

Evdokimov N, Van Slambrouck S, Heffeter P, Tu L, Le Calve B, Lamoral Theys D, et al. Structural simplification of bioactive natural products with multicomponent synthesis. 3. Fused uracil-containing heterocycles as novel topoisomerase-targeting agents. J Med Chem. 2011;54:2012-21 pubmed publisher

Khadka D, Le Q, Yang S, Van H, Le T, Cho S, et al. Design, synthesis and docking study of 5-amino substituted indeno[1,2-c]isoquinolines as novel topoisomerase I inhibitors. Bioorg Med Chem. 2011;19:1924-9 pubmed publisher

Duan J, Cai X, Meng F, Sun J, Liu Q, Jung D, et al. 14-Aminocamptothecins: their synthesis, preclinical activity, and potential use for cancer treatment. J Med Chem. 2011;54:1715-23 pubmed publisher

Kaur R, Khan S, Chib R, Kaur T, Sharma P, Singh J, et al. A comparative study of proapoptotic potential of cyano analogues of boswellic acid and 11-keto-boswellic acid. Eur J Med Chem. 2011;46:1356-66 pubmed publisher

Zhang W, Song J, Mu L, Zhang B, Liu L, Xing Y, et al. Improving anticancer activity and selectivity of camptothecin through conjugation with releasable substance P. Bioorg Med Chem Lett. 2011;21:1452-5 pubmed publisher

Singh M, Tandon V. Synthesis and biological activity of novel inhibitors of topoisomerase I: 2-aryl-substituted 2-bis-1H-benzimidazoles. Eur J Med Chem. 2011;46:659-69 pubmed publisher

Na Y, Nam J. Synthesis and topoisomerase II inhibitory and cytotoxic activity of oxiranylmethoxy- and thiiranylmethoxy-chalcone derivatives. Bioorg Med Chem Lett. 2011;21:211-4 pubmed publisher

Ibáñez E, Plano D, Font M, Calvo A, Prior C, Palop J, et al. Synthesis and antiproliferative activity of novel symmetrical alkylthio- and alkylseleno-imidocarbamates. Eur J Med Chem. 2011;46:265-74 pubmed publisher

Khadka D, Cho W. 3-Arylisoquinolines as novel topoisomerase I inhibitors. Bioorg Med Chem. 2011;19:724-34 pubmed publisher

Shi W, Marcus S, Lowary T. Cytotoxicity and topoisomerase I/II inhibition of glycosylated 2-phenyl-indoles, 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans. Bioorg Med Chem. 2011;19:603-12 pubmed publisher

Kamal A, Kumar B, Suresh P, Agrawal S, Chashoo G, Singh S, et al. Synthesis of 4β-N-polyaromatic substituted podophyllotoxins: DNA topoisomerase inhibition, anticancer and apoptosis-inducing activities. Bioorg Med Chem. 2010;18:8493-500 pubmed publisher

Riva E, Comi D, Borrelli S, Colombo F, Danieli B, Borlak J, et al. Synthesis and biological evaluation of new camptothecin derivatives obtained by modification of position 20. Bioorg Med Chem. 2010;18:8660-8 pubmed publisher

Lienkamp S, Ganner A, Boehlke C, Schmidt T, Arnold S, Schäfer T, et al. Inversin relays Frizzled-8 signals to promote proximal pronephros development. Proc Natl Acad Sci U S A. 2010;107:20388-93 pubmed publisher

Fan J, Su J, Peng Y, Li Y, Li J, Zhou Y, et al. Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-?B activation. Bioorg Med Chem. 2010;18:8226-34 pubmed publisher

Issaeva I, Cohen A, Eden E, Cohen Saidon C, Danon T, Cohen L, et al. Generation of double-labeled reporter cell lines for studying co-dynamics of endogenous proteins in individual human cells. PLoS ONE. 2010;5:e13524 pubmed publisher

Lin S, Zhang Y, Liu M, Yang S, Gan M, Zi J, et al. Abietane and C20-norabietane diterpenes from the stem bark of Fraxinus sieboldiana and their biological activities. J Nat Prod. 2010;73:1914-21 pubmed publisher

Dong G, Sheng C, Wang S, Miao Z, Yao J, Zhang W. Selection of evodiamine as a novel topoisomerase I inhibitor by structure-based virtual screening and hit optimization of evodiamine derivatives as antitumor agents. J Med Chem. 2010;53:7521-31 pubmed publisher

Pan L, Kardono L, Riswan S, Chai H, Carcache de Blanco E, Pannell C, et al. Isolation and characterization of minor analogues of silvestrol and other constituents from a large-scale re-collection of Aglaia foveolata. J Nat Prod. 2010;73:1873-8 pubmed publisher

Kularatne S, Venkatesh C, Santhapuram H, Wang K, Vaitilingam B, Henne W, et al. Synthesis and biological analysis of prostate-specific membrane antigen-targeted anticancer prodrugs. J Med Chem. 2010;53:7767-77 pubmed publisher

Simpson N, Lambert W, Watkins R, Giashuddin S, Huang S, Oxelmark E, et al. High levels of Hsp90 cochaperone p23 promote tumor progression and poor prognosis in breast cancer by increasing lymph node metastases and drug resistance. Cancer Res. 2010;70:8446-56 pubmed publisher

Chlipala G, Sturdy M, Krunic A, Lantvit D, Shen Q, Porter K, et al. Cylindrocyclophanes with proteasome inhibitory activity from the Cyanobacterium Nostoc sp. J Nat Prod. 2010;73:1529-37 pubmed publisher

Tseng C, Tzeng C, Yang C, Lu P, Chen H, Li H, et al. Synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives. Part 2. J Med Chem. 2010;53:6164-79 pubmed publisher

Lee B, Nalla A, Stock I, Shear T, Black K, Yu J. Oxidative stimuli-responsive nanoprodrug of camptothecin kills glioblastoma cells. Bioorg Med Chem Lett. 2010;20:5262-8 pubmed publisher

Shen D, Wu Z, Wu X, An Z, Bu X, Gu L, et al. Synthesis and antiproliferative activity of indolizinophthalazine-5,12-dione derivatives, DNA topoisomerase IB inhibitors. Eur J Med Chem. 2010;45:3938-42 pubmed publisher

Cinelli M, Morrell A, Dexheimer T, Agama K, Agrawal S, Pommier Y, et al. The structure-activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding mode. Bioorg Med Chem. 2010;18:5535-52 pubmed publisher

Woo S, Kang D, Nam J, Lee C, Ha E, Lee E, et al. Synthesis and pharmacological evaluation of new methyloxiranylmethoxyxanthone analogues. Eur J Med Chem. 2010;45:4221-8 pubmed publisher

Uday Bhanu M, Kondapi A. Neurotoxic activity of a topoisomerase-I inhibitor, camptothecin, in cultured cerebellar granule neurons. Neurotoxicology. 2010;31:730-7 pubmed publisher

Tseng C, Chen Y, Yang S, Peng S, Cheng C, Han C, et al. Synthesis and antiproliferative evaluation of certain iminonaphtho[2,3-b]furan derivatives. Bioorg Med Chem. 2010;18:5172-82 pubmed publisher

Roumy V, Biabiany M, Hennebelle T, Aliouat E, Pottier M, Joseph H, et al. Antifungal and cytotoxic activity of withanolides from Acnistus arborescens. J Nat Prod. 2010;73:1313-7 pubmed publisher

Santos R, Salvador J, Marin S, Cascante M, Moreira J, Dinis T. Synthesis and structure-activity relationship study of novel cytotoxic carbamate and N-acylheterocyclic bearing derivatives of betulin and betulinic acid. Bioorg Med Chem. 2010;18:4385-96 pubmed publisher

Machín R, Veleiro A, Nicotra V, Oberti J, M Padrón J. Antiproliferative activity of withanolides against human breast cancer cell lines. J Nat Prod. 2010;73:966-8 pubmed publisher

Karki R, Thapa P, Kang M, Jeong T, Nam J, Kim H, et al. Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines. Bioorg Med Chem. 2010;18:3066-77 pubmed publisher

Li Q, Deng X, Zu Y, Lv H, Su L, Yao L, et al. Cytotoxicity and topo I targeting activity of substituted 10--nitrogenous heterocyclic aromatic group derivatives of SN-38. Eur J Med Chem. 2010;45:3200-6 pubmed publisher

Miao Z, Zhang J, You L, Wang J, Sheng C, Yao J, et al. Phosphate ester derivatives of homocamptothecin: synthesis, solution stabilities and antitumor activities. Bioorg Med Chem. 2010;18:3140-6 pubmed publisher

Das B, Srinivas Y, Sudhakar C, Mahender I, Laxminarayana K, Reddy P, et al. New diterpenoids from Caesalpinia species and their cytotoxic activity. Bioorg Med Chem Lett. 2010;20:2847-50 pubmed publisher

Alkhatib R, Hennebelle T, Joha S, Roumy V, Güzel Y, Biabiany M, et al. Humulane and germacrane sesquiterpenes from Ferula lycia. J Nat Prod. 2010;73:780-3 pubmed publisher

Smejkal K, Svacinová J, Slapetová T, Schneiderová K, Dalĺ Acqua S, Innocenti G, et al. Cytotoxic activities of several geranyl-substituted flavanones. J Nat Prod. 2010;73:568-72 pubmed publisher

Thapa P, Karki R, Choi H, Choi J, Yun M, Jeong B, et al. Synthesis of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship. Bioorg Med Chem. 2010;18:2245-2254 pubmed publisher

Beretta G, Cossa G, Gatti L, Zunino F, Perego P. Tyrosyl-DNA phosphodiesterase 1 targeting for modulation of camptothecin-based treatment. Curr Med Chem. 2010;17:1500-8 pubmed

Song Y, Shao Z, Dexheimer T, Scher E, Pommier Y, Cushman M. Structure-based design, synthesis, and biological studies of new anticancer norindenoisoquinoline topoisomerase I inhibitors. J Med Chem. 2010;53:1979-89 pubmed publisher

Cho H, Jung M, Woo S, Kim J, Lee E, Kwon Y, et al. New benzoxanthone derivatives as topoisomerase inhibitors and DNA cross-linkers. Bioorg Med Chem. 2010;18:1010-7 pubmed publisher

Deshmukh M, Chao P, Kutscher H, Gao D, Sinko P. A series of alpha-amino acid ester prodrugs of camptothecin: in vitro hydrolysis and A549 human lung carcinoma cell cytotoxicity. J Med Chem. 2010;53:1038-47 pubmed publisher

Fourches D, Barnes J, Day N, Bradley P, Reed J, Tropsha A. Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chem Res Toxicol. 2010;23:171-83 pubmed publisher

Chee G, Yalowich J, Bodner A, Wu X, Hasinoff B. A diazirine-based photoaffinity etoposide probe for labeling topoisomerase II. Bioorg Med Chem. 2010;18:830-8 pubmed publisher

Basnet A, Thapa P, Karki R, Choi H, Choi J, Yun M, et al. 2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study. Bioorg Med Chem Lett. 2010;20:42-7 pubmed publisher

Thapa P, Karki R, Thapa U, Jahng Y, Jung M, Nam J, et al. 2-Thienyl-4-furyl-6-aryl pyridine derivatives: synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study. Bioorg Med Chem. 2010;18:377-86 pubmed publisher

Cheng W, Zhu C, Xu W, Fan X, Yang Y, Li Y, et al. Chemical constituents of the bark of Machilus wangchiana and their biological activities. J Nat Prod. 2009;72:2145-52 pubmed publisher

Lin Y, Abd El Razek M, Hwang T, Chiang M, Kuo Y, Dai C, et al. Asterolaurins A-F, xenicane diterpenoids from the Taiwanese soft coral Asterospicularia laurae. J Nat Prod. 2009;72:1911-6 pubmed publisher

Han A, Kim J, Lantvit D, Kardono L, Riswan S, Chai H, et al. Cytotoxic xanthone constituents of the stem bark of Garcinia mangostana (mangosteen). J Nat Prod. 2009;72:2028-31 pubmed publisher

Cho H, Jung M, Kwon Y, Na Y. Oxiranylmethyloxy or thiiranylmethyloxy-azaxanthones and -acridone analogues as potential topoisomerase I inhibitors. Bioorg Med Chem Lett. 2009;19:6766-9 pubmed publisher

Rhee H, Lim S, Jung M, Kwon Y, Kim M, Choo H. Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors. Bioorg Med Chem. 2009;17:7537-41 pubmed publisher

Cinelli M, Cordero B, Dexheimer T, Pommier Y, Cushman M. Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: investigating the hypothesis of shared structure-activity relationships. Bioorg Med Chem. 2009;17:7145-55 pubmed publisher

Das S, Doshi J, Tian D, Addo S, Srinivasan B, Hermanson D, et al. Structure-activity relationship and molecular mechanisms of ethyl 2-amino-4-(2-ethoxy-2-oxoethyl)-6-phenyl-4h-chromene-3-carboxylate (sha 14-1) and its analogues. J Med Chem. 2009;52:5937-49 pubmed publisher

Yuan J, Johnson R, Huang R, Wichterman J, Jiang H, Hayton K, et al. Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nat Chem Biol. 2009;5:765-71 pubmed publisher

You Q, Li Z, Huang C, Yang Q, WANG X, Guo Q, et al. Discovery of a novel series of quinolone and naphthyridine derivatives as potential topoisomerase I inhibitors by scaffold modification. J Med Chem. 2009;52:5649-61 pubmed publisher

Chung J, Piao Z, Yoon S, Kim M, Jeong M, Lee S, et al. Pseudomonas aeruginosa eliminates natural killer cells via phagocytosis-induced apoptosis. PLoS Pathog. 2009;5:e1000561 pubmed publisher

Sirikantaramas S, Yamazaki M, Saito K. A survival strategy: the coevolution of the camptothecin biosynthetic pathway and self-resistance mechanism. Phytochemistry. 2009;70:1894-8 pubmed publisher

Xu W, Zhu C, Cheng W, Fan X, Chen X, Yang S, et al. Chemical Constituents of the Roots of Euphorbia micractina. J Nat Prod. 2009;72:1620-6 pubmed publisher

Bar F, Khanfar M, Elnagar A, Liu H, Zaghloul A, Badria F, et al. Rational design and semisynthesis of betulinic acid analogues as potent topoisomerase inhibitors. J Nat Prod. 2009;72:1643-50 pubmed publisher

Leon L, Donadel O, Tonn C, Padron J. Tessaric acid derivatives induce G2/M cell cycle arrest in human solid tumor cell lines. Bioorg Med Chem. 2009;17:6251-6 pubmed publisher

Thuaud F, Bernard Y, Turkeri G, Dirr R, Aubert G, Cresteil T, et al. Synthetic analogue of rocaglaol displays a potent and selective cytotoxicity in cancer cells: involvement of apoptosis inducing factor and caspase-12. J Med Chem. 2009;52:5176-87 pubmed publisher

Cheenpracha S, Karalai C, Ponglimanont C, Kanjana Opas A. Candenatenins A-F, phenolic compounds from the heartwood of Dalbergia candenatensis. J Nat Prod. 2009;72:1395-8 pubmed publisher

Cai X, Park B, Ahn K, Kwon O, Lee H, Oh S. Cytotoxic triterpenoids from the rhizomes of Astilbe chinensis. J Nat Prod. 2009;72:1241-4 pubmed publisher

Li M, Jin W, Jiang C, Zheng C, Tang W, You T, et al. 7-Cycloalkylcamptothecin derivatives: Preparation and biological evaluation. Bioorg Med Chem Lett. 2009;19:4107-9 pubmed publisher

Samorì C, Guerrini A, Varchi G, Fontana G, Bombardelli E, Tinelli S, et al. Semisynthesis, biological activity, and molecular modeling studies of C-ring-modified camptothecins. J Med Chem. 2009;52:1029-39 pubmed publisher

Cuong N, Hsieh M, Huang C. Recent development in nano-sized dosage forms of plant alkaloid camptothecin-derived drugs. Recent Pat Anticancer Drug Discov. 2009;4:254-61 pubmed

Galvez Peralta M, Hackbarth J, Flatten K, Kaufmann S, Hiasa H, Xing C, et al. On the role of topoisomerase I in mediating the cytotoxicity of 9-aminoacridine-based anticancer agents. Bioorg Med Chem Lett. 2009;19:4459-62 pubmed publisher

Fan X, Zi J, Zhu C, Xu W, Cheng W, Yang S, et al. Chemical constituents of Heteroplexis micocephala. J Nat Prod. 2009;72:1184-90 pubmed publisher

Beauchard A, Jaunet A, Murillo L, Baldeyrou B, Lansiaux A, Chérouvrier J, et al. Synthesis and antitumoral activity of novel thiazolobenzotriazole, thiazoloindolo[3,2-c]quinoline and quinolinoquinoline derivatives. Eur J Med Chem. 2009;44:3858-65 pubmed publisher

Lemster T, Pindur U, Lenglet G, Depauw S, Dassi C, David Cordonnier M. Photochemical electrocyclisation of 3-vinylindoles to pyrido[2,3-a]-, pyrido[4,3-a]- and thieno[2,3-a]-carbazoles: design, synthesis, DNA binding and antitumor cell cytotoxicity. Eur J Med Chem. 2009;44:3235-52 pubmed publisher

Lee S, Van H, Yang S, Lee K, Kwon Y, Cho W. Molecular design, synthesis and docking study of benz[b]oxepines and 12-oxobenzo[c]phenanthridinones as topoisomerase 1 inhibitors. Bioorg Med Chem Lett. 2009;19:2444-7 pubmed publisher

Ester K, Hranjec M, Piantanida I, Caleta I, Jarak I, Pavelic K, et al. Novel derivatives of pyridylbenzo[b]thiophene-2-carboxamides and benzo[b]thieno[2,3-c]naphthyridin-2-ones: minor structural variations provoke major differences of antitumor action mechanisms. J Med Chem. 2009;52:2482-92 pubmed publisher

Van H, Cho W. Structural modification of 3-arylisoquinolines to isoindolo[2,1-b]isoquinolinones for the development of novel topoisomerase 1 inhibitors with molecular docking study. Bioorg Med Chem Lett. 2009;19:2551-4 pubmed publisher

Feng W, Satyanarayana M, Tsai Y, Liu A, Liu L, LaVoie E. 12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines as novel topoisomerase I-targeting antitumor agents. Bioorg Med Chem. 2009;17:2877-85 pubmed publisher

Feng W, Satyanarayana M, Tsai Y, Liu A, Liu L, LaVoie E. Novel topoisomerase I-targeting antitumor agents synthesized from the N,N,N-trimethylammonium derivative of ARC-111, 5H-2,3-dimethoxy-8,9-methylenedioxy-5-[(2-N,N,N-trimethylammonium)ethyl]dibenzo[c,h][1,6]naphthyridin-6-one iodide. Eur J Med Chem. 2009;44:3433-8 pubmed publisher

Liu R, Ma S, Yu S, Pei Y, Zhang S, Chen X, et al. Cytotoxic oleanane triterpene saponins from Albizia chinensis. J Nat Prod. 2009;72:632-9 pubmed publisher

Khan Q, Lu J, Hecht S. Calothrixins, a new class of human DNA topoisomerase I poisons. J Nat Prod. 2009;72:438-42 pubmed publisher

Pan L, Chin Y, Chai H, Ninh T, Soejarto D, Kinghorn A. Bioactivity-guided isolation of cytotoxic constituents of Brucea javanica collected in Vietnam. Bioorg Med Chem. 2009;17:2219-24 pubmed publisher

Sharma L, Tsai Y, Liu A, Liu L, LaVoie E. Cytotoxicity and TOP1-targeting activity of 8- and 9-amino derivatives of 5-butyl- and 5-(2-N,N-dimethylamino)ethyl-5H-dibenzo[c,h][1,6]naphthyridin-6-ones. Eur J Med Chem. 2009;44:1471-6 pubmed publisher

McCollum A, Lukasiewicz K, Teneyck C, Lingle W, Toft D, Erlichman C. Cisplatin abrogates the geldanamycin-induced heat shock response. Mol Cancer Ther. 2008;7:3256-64 pubmed publisher

Seo C, Zheng M, Woo M, Lee C, Lee S, Jeong B, et al. Lignans from the roots of Saururus chinensis. J Nat Prod. 2008;71:1771-4 pubmed publisher

Feng W, Satyanarayana M, Cheng L, Liu A, Tsai Y, Liu L, et al. Synthesis of N-substituted 5-[2-(N-alkylamino)ethyl]dibenzo[c,h][1,6]naphthyridines as novel topoisomerase I-targeting antitumor agents. Bioorg Med Chem. 2008;16:9295-301 pubmed publisher

Bakshi R, Sang D, Morrell A, Cushman M, Shapiro T. Activity of indenoisoquinolines against African trypanosomes. Antimicrob Agents Chemother. 2009;53:123-8 pubmed publisher

Liaw C, Shen Y, Lin Y, Hwang T, Kuo Y, Khalil A. Frajunolides E-K, briarane diterpenes from Junceella fragilis. J Nat Prod. 2008;71:1551-6 pubmed publisher

Losasso C, Cretaio E, Fiorani P, D Annessa I, Chillemi G, Benedetti P. A single mutation in the 729 residue modulates human DNA topoisomerase IB DNA binding and drug resistance. Nucleic Acids Res. 2008;36:5635-44 pubmed publisher

Feng W, Satyanarayana M, Tsai Y, Liu A, Liu L, LaVoie E. 11-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine derivatives as novel topoisomerase I-targeting agents. Bioorg Med Chem. 2008;16:8598-606 pubmed publisher

Trisciuoglio D, Uranchimeg B, Cardellina J, Meragelman T, Matsunaga S, Fusetani N, et al. Induction of apoptosis in human cancer cells by candidaspongiolide, a novel sponge polyketide. J Natl Cancer Inst. 2008;100:1233-46 pubmed publisher

Satyanarayana M, Feng W, Cheng L, Liu A, Tsai Y, Liu L, et al. Syntheses and biological evaluation of topoisomerase I-targeting agents related to 11-[2-(N,N-dimethylamino)ethyl]-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-one (ARC-31). Bioorg Med Chem. 2008;16:7824-31 pubmed publisher

Ananthalakshmi K, Bartl T, Aziza M, Novotny L, Marek R, Benes L, et al. Synthesis and structure-activity relationship studies of theophylline analogs on population responses in the rat hippocampus in vitro. Bioorg Med Chem. 2008;16:8142-50 pubmed publisher

Hranjec M, Piantanida I, Kralj M, Suman L, Pavelic K, Karminski Zamola G. Novel amidino-substituted thienyl- and furylvinylbenzimidazole: derivatives and their photochemical conversion into corresponding diazacyclopenta[c]fluorenes. synthesis, interactions with DNA and RNA, and antitumor evaluation. 4. J Med Chem. 2008;51:4899-910 pubmed publisher

Castanys Muñoz E, Pérez Victoria J, Gamarro F, Castanys S. Characterization of an ABCG-like transporter from the protozoan parasite Leishmania with a role in drug resistance and transbilayer lipid movement. Antimicrob Agents Chemother. 2008;52:3573-9 pubmed publisher

Cinelli M, Morrell A, Dexheimer T, Scher E, Pommier Y, Cushman M. Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors. J Med Chem. 2008;51:4609-19 pubmed publisher

Wang S, Li Y, Liu Y, Lu A, You Q. Novel hexacyclic camptothecin derivatives. Part 1: synthesis and cytotoxicity of camptothecins with an A-ring fused 1,3-oxazine ring. Bioorg Med Chem Lett. 2008;18:4095-7 pubmed publisher

Feng W, Satyanarayana M, Tsai Y, Liu A, Liu L, LaVoie E. Facile formation of hydrophilic derivatives of 5H-8,9-dimethoxy-5-[2-(N,N-dimethylamino)ethyl]-2,3-methylenedioxydibenzo[c,h] [1,6]naphthyridin-6-one (ARC-111) and its 12-aza analog via quaternary ammonium intermediates. Bioorg Med Chem Lett. 2008;18:3570-2 pubmed publisher

Liew S, Yang L. Design, synthesis and development of novel camptothecin drugs. Curr Pharm Des. 2008;14:1078-97 pubmed

Giannini G, Marzi M, Cabri W, Marastoni E, Battistuzzi G, Vesci L, et al. E-ring-modified 7-oxyiminomethyl camptothecins: Synthesis and preliminary in vitro and in vivo biological evaluation. Bioorg Med Chem Lett. 2008;18:2910-5 pubmed publisher

Samorì C, Guerrini A, Varchi G, Zunino F, Beretta G, Femoni C, et al. Thiocamptothecin. J Med Chem. 2008;51:3040-4 pubmed publisher

Liu Y, Tian X, Yang L, Zhan Z. First synthesis of novel spin-labeled derivatives of camptothecin as potential antineoplastic agents. Eur J Med Chem. 2008;43:2610-4 pubmed publisher

Cheng Y, An L, Wu N, Wang X, Bu X, Huang Z, et al. Synthesis, cytotoxic activities and structure-activity relationships of topoisomerase I inhibitors: indolizinoquinoline-5,12-dione derivatives. Bioorg Med Chem. 2008;16:4617-25 pubmed publisher

Shen Y, Wang S, Chien C, Kuo Y, Khalil A. Tasumatrols U-Z, taxane diterpene esters from Taxus sumatrana. J Nat Prod. 2008;71:576-80 pubmed publisher

Tseng C, Chen Y, Lu P, Yang C, Tzeng C. Synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives. Bioorg Med Chem. 2008;16:3153-62 pubmed publisher

Kang D, Kim J, Jung M, Lee E, Jahng Y, Kwon Y, et al. New insight for fluoroquinophenoxazine derivatives as possibly new potent topoisomerase I inhibitor. Bioorg Med Chem Lett. 2008;18:1520-4 pubmed publisher

Ma S, Hu Y, Yu S, Zhang Y, Chen X, Liu J, et al. Cytotoxic triterpenoid saponins acylated with monoterpenic acid from Pithecellobium lucidum. J Nat Prod. 2008;71:41-6 pubmed

López Lázaro M, Willmore E, Jobson A, Gilroy K, Curtis H, Padget K, et al. Curcumin induces high levels of topoisomerase I- and II-DNA complexes in K562 leukemia cells. J Nat Prod. 2007;70:1884-8 pubmed

Erez R, Ebner S, Attali B, Shabat D. Chemotherapeutic bone-targeted bisphosphonate prodrugs with hydrolytic mode of activation. Bioorg Med Chem Lett. 2008;18:816-20 pubmed

Nguyen M, Marcellus R, Roulston A, Watson M, Serfass L, Murthy Madiraju S, et al. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc Natl Acad Sci U S A. 2007;104:19512-7 pubmed

Hsin L, Wang H, Kao P, Lee O, Chen W, Chen H, et al. Synthesis, DNA binding, and cytotoxicity of 1,4-bis(2-amino-ethylamino)anthraquinone-amino acid conjugates. Bioorg Med Chem. 2008;16:1006-14 pubmed

Shah B, Kumar A, Gupta P, Sharma M, Sethi V, Saxena A, et al. Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids. Bioorg Med Chem Lett. 2007;17:6411-6 pubmed

Van H, Le Q, Lee K, Lee E, Kwon Y, Kim T, et al. Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex. Bioorg Med Chem Lett. 2007;17:5763-7 pubmed

Morrell A, Placzek M, Parmley S, Antony S, Dexheimer T, Pommier Y, et al. Nitrated indenoisoquinolines as topoisomerase I inhibitors: a systematic study and optimization. J Med Chem. 2007;50:4419-30 pubmed

Sirikantaramas S, Asano T, Sudo H, Yamazaki M, Saito K. Camptothecin: therapeutic potential and biotechnology. Curr Pharm Biotechnol. 2007;8:196-202 pubmed

Morrell A, Placzek M, Parmley S, Grella B, Antony S, Pommier Y, et al. Optimization of the indenone ring of indenoisoquinoline topoisomerase I inhibitors. J Med Chem. 2007;50:4388-404 pubmed

Son J, Zhao L, Basnet A, Thapa P, Karki R, Na Y, et al. Synthesis of 2,6-diaryl-substituted pyridines and their antitumor activities. Eur J Med Chem. 2008;43:675-82 pubmed

Wang L, Sullivan G, Hexamer L, Hasvold L, Thalji R, Przytulinska M, et al. Design, synthesis, and biological activity of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one-based potent and selective Chk-1 inhibitors. J Med Chem. 2007;50:4162-76 pubmed

Rakotondramanana D, Delomenède M, Baltas M, Duran H, Bedos Belval F, Rasoanaivo P, et al. Synthesis of ferulic ester dimers, functionalisation and biological evaluation as potential antiatherogenic and antiplasmodial agents. Bioorg Med Chem. 2007;15:6018-26 pubmed

Phifer S, Lee D, Seo E, Kim N, Graf T, Kroll D, et al. Alvaradoins E-N, antitumor and cytotoxic anthracenone C-glycosides from the leaves of Alvaradoa haitiensis. J Nat Prod. 2007;70:954-61 pubmed

Baccelli C, Navarro I, Block S, Abad A, Morel N, Quetin Leclercq J. Vasorelaxant activity of diterpenes from Croton zambesicus and synthetic trachylobanes and their structure-activity relationships. J Nat Prod. 2007;70:910-7 pubmed

Jayaprakasha G, Mandadi K, Poulose S, Jadegoud Y, Nagana Gowda G, Patil B. Inhibition of colon cancer cell growth and antioxidant activity of bioactive compounds from Poncirus trifoliata (L.) Raf. Bioorg Med Chem. 2007;15:4923-32 pubmed

Cho W, Le Q, My Van H, Youl Lee K, Kang B, Lee E, et al. Design, docking, and synthesis of novel indeno[1,2-c]isoquinolines for the development of antitumor agents as topoisomerase I inhibitors. Bioorg Med Chem Lett. 2007;17:3531-4 pubmed

Chaudhuri P, Majumder H, Bhattacharya S. Synthesis, DNA binding, and Leishmania topoisomerase inhibition activities of a novel series of anthra[1,2-d]imidazole-6,11-dione derivatives. J Med Chem. 2007;50:2536-40 pubmed

Nacro K, Zha C, Guzzo P, Jason Herr R, Peace D, Friedrich T. Synthesis and topoisomerase poisoning activity of A-ring and E-ring substituted luotonin A derivatives. Bioorg Med Chem. 2007;15:4237-46 pubmed

Diamandis P, Wildenhain J, Clarke I, Sacher A, Graham J, Bellows D, et al. Chemical genetics reveals a complex functional ground state of neural stem cells. Nat Chem Biol. 2007;3:268-73 pubmed

López Lázaro M, Willmore E, Austin C. Cells lacking DNA topoisomerase II beta are resistant to genistein. J Nat Prod. 2007;70:763-7 pubmed

Morrell A, Placzek M, Steffen J, Antony S, Agama K, Pommier Y, et al. Investigation of the lactam side chain length necessary for optimal indenoisoquinoline topoisomerase I inhibition and cytotoxicity in human cancer cell cultures. J Med Chem. 2007;50:2040-8 pubmed

Nakagawa Goto K, Nakamura S, Bastow K, Nyarko A, Peng C, Lee F, et al. Antitumor agents. 256. Conjugation of paclitaxel with other antitumor agents: evaluation of novel conjugates as cytotoxic agents. Bioorg Med Chem Lett. 2007;17:2894-8 pubmed

Mattes M. Apoptosis assays with lymphoma cell lines: problems and pitfalls. Br J Cancer. 2007;96:928-36 pubmed

Capranico G, Ferri F, Fogli M, Russo A, Lotito L, Baranello L. The effects of camptothecin on RNA polymerase II transcription: roles of DNA topoisomerase I. Biochimie. 2007;89:482-9 pubmed

Tong Y, Claiborne A, Stewart K, Park C, Kovar P, Chen Z, et al. Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors. Bioorg Med Chem. 2007;15:2759-67 pubmed

Shchekotikhin A, Dezhenkova L, Susova O, Glazunova V, Luzikov Y, Sinkevich Y, et al. Naphthoindole-based analogues of tryptophan and tryptamine: synthesis and cytotoxic properties. Bioorg Med Chem. 2007;15:2651-9 pubmed

Filosa R, Peduto A, de Caprariis P, Saturnino C, Festa M, Petrella A, et al. Synthesis and antiproliferative properties of N3/8-disubstituted 3,8-diazabicyclo[3.2.1]octane analogues of 3,8-bis[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl-piperazine. Eur J Med Chem. 2007;42:293-306 pubmed

Cordeu L, Cubedo E, Bandres E, Rebollo A, Sáenz X, Chozas H, et al. Biological profile of new apoptotic agents based on 2,4-pyrido[2,3-d]pyrimidine derivatives. Bioorg Med Chem. 2007;15:1659-69 pubmed

Rhee H, Park H, Lee S, Lee C, Choo H. Synthesis, cytotoxicity, and DNA topoisomerase II inhibitory activity of benzofuroquinolinediones. Bioorg Med Chem. 2007;15:1651-8 pubmed

Matsuda H, Yoshida K, Miyagawa K, Asao Y, Takayama S, Nakashima S, et al. Rotenoids and flavonoids with anti-invasion of HT1080, anti-proliferation of U937, and differentiation-inducing activity in HL-60 from Erycibe expansa. Bioorg Med Chem. 2007;15:1539-46 pubmed

Legarza K, Yang L. New molecular mechanisms of action of camptothecin-type drugs. Anticancer Res. 2006;26:3301-5 pubmed

Kim J, Rhee H, Park H, Lee I, Lee S, Suh M, et al. Synthesis of 6-chloroisoquinoline-5,8-diones and pyrido[3,4-b]phenazine-5,12-diones and evaluation of their cytotoxicity and DNA topoisomerase II inhibitory activity. Bioorg Med Chem. 2007;15:451-7 pubmed

Torregrossa J, Bubley G, Jones G. Microwave expedited synthesis of 5-aminocamptothecin analogs: Inhibitors of hypoxia inducible factor HIF-1alpha. Bioorg Med Chem Lett. 2006;16:6082-5 pubmed

Nagarajan M, Morrell A, Antony S, Kohlhagen G, Agama K, Pommier Y, et al. Synthesis and biological evaluation of bisindenoisoquinolines as topoisomerase I inhibitors. J Med Chem. 2006;49:5129-40 pubmed

Li Q, Zu Y, Shi R, Yao L. Review camptothecin: current perspectives. Curr Med Chem. 2006;13:2021-39 pubmed

Morrell A, Jayaraman M, Nagarajan M, Fox B, Meckley M, Ioanoviciu A, et al. Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay. Bioorg Med Chem Lett. 2006;16:4395-9 pubmed

Legentil L, Benel L, Bertrand V, Lesur B, Delfourne E. Synthesis and antitumor characterization of pyrazolic analogues of the marine pyrroloquinoline alkaloids: wakayin and tsitsikammamines. J Med Chem. 2006;49:2979-88 pubmed

MacDonald M, Lamerdin J, Owens S, Keon B, Bilter G, Shang Z, et al. Identifying off-target effects and hidden phenotypes of drugs in human cells. Nat Chem Biol. 2006;2:329-37 pubmed

Abel U, Simon W, Eckard P, Hansske F. Design and semisynthesis of novel fredericamycin A derivatives with an improved antitumor profile. Bioorg Med Chem Lett. 2006;16:3292-7 pubmed

Cao S, Radwan M, Norris A, Miller J, Ratovoson F, Mamisoa A, et al. Cytotoxic and other compounds from Didymochlaena truncatula from the Madagascar rain forest. J Nat Prod. 2006;69:284-6 pubmed

Ishikawa T, Ikegami Y, Sano K, Nakagawa H, Sawada S. Transport mechanism-based drug molecular design: novel camptothecin analogues to circumvent ABCG2-associated drug resistance of human tumor cells. Curr Pharm Des. 2006;12:313-25 pubmed

Morrell A, Antony S, Kohlhagen G, Pommier Y, Cushman M. Synthesis of benz[d]indeno[1,2-b]pyran-5,11-diones: versatile intermediates for the design and synthesis of topoisomerase I inhibitors. Bioorg Med Chem Lett. 2006;16:1846-9 pubmed

Matsuda H, Yoshida K, Miyagawa K, Nemoto Y, Asao Y, Yoshikawa M. Nuphar alkaloids with immediately apoptosis-inducing activity from Nuphar pumilum and their structural requirements for the activity. Bioorg Med Chem Lett. 2006;16:1567-73 pubmed

Nakagawa H, Saito H, Ikegami Y, Aida Hyugaji S, Sawada S, Ishikawa T. Molecular modeling of new camptothecin analogues to circumvent ABCG2-mediated drug resistance in cancer. Cancer Lett. 2006;234:81-9 pubmed

Takakusagi Y, Kobayashi S, Sugawara F. Camptothecin binds to a synthetic peptide identified by a T7 phage display screen. Bioorg Med Chem Lett. 2005;15:4850-3 pubmed

Hecht S. Camptothecin: roles of the D and E rings in binding to the topoisomerase I-DNA covalent binary complex. Curr Med Chem Anticancer Agents. 2005;5:353-62 pubmed

Ioanoviciu A, Antony S, Pommier Y, Staker B, Stewart L, Cushman M. Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic analysis. J Med Chem. 2005;48:4803-14 pubmed

Itoh A, Kumashiro T, Yamaguchi M, Nagakura N, Mizushina Y, Nishi T, et al. Indole alkaloids and other constituents of Rauwolfia serpentina. J Nat Prod. 2005;68:848-52 pubmed

Marco E, Laine W, Tardy C, Lansiaux A, Iwao M, Ishibashi F, et al. Molecular determinants of topoisomerase I poisoning by lamellarins: comparison with camptothecin and structure-activity relationships. J Med Chem. 2005;48:3796-807 pubmed

Driver R, Yang L. Synthesis and pharmacology of new camptothecin drugs. Mini Rev Med Chem. 2005;5:425-39 pubmed

Wang G, Li G, Mantei R, Chen Z, Kovar P, Gu W, et al. 1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyanopyrazin-2-yl)ureas [correction of cyanopyrazi] as potent and selective inhibitors of Chk1 kinase: synthesis, preliminary SAR, and biological activities. J Med Chem. 2005;48:3118-21 pubmed

Staker B, Feese M, Cushman M, Pommier Y, Zembower D, Stewart L, et al. Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex. J Med Chem. 2005;48:2336-45 pubmed

Legarza K, Yang L. Novel camptothecin derivatives. In Vivo. 2005;19:283-92 pubmed

Fang X, Shao L, Zhang H, Wang S. CHMIS-C: a comprehensive herbal medicine information system for cancer. J Med Chem. 2005;48:1481-8 pubmed

Alali F, El Elimat T, Li C, Qandil A, Alkofahi A, Tawaha K, et al. New colchicinoids from a native Jordanian meadow saffron, colchicum brachyphyllum: isolation of the first naturally occurring dextrorotatory colchicinoid. J Nat Prod. 2005;68:173-8 pubmed

Lion C, Matthews C, Stevens M, Westwell A. Synthesis, antitumor evaluation, and apoptosis-inducing activity of hydroxylated (E)-stilbenes. J Med Chem. 2005;48:1292-5 pubmed

Ma J, Jones S, Marshall R, Wu X, Hecht S. DNA topoisomerase I inhibitors from Rinorea anguifera. Bioorg Med Chem Lett. 2005;15:813-6 pubmed

Lorence A, Nessler C. Camptothecin, over four decades of surprising findings. Phytochemistry. 2004;65:2735-49 pubmed

Thomas C, Rahier N, Hecht S. Camptothecin: current perspectives. Bioorg Med Chem. 2004;12:1585-604 pubmed

Borovitskaya A, D ARPA P. Replication-dependent and -independent camptothecin cytotoxicity of seven human colon tumor cell lines. Oncol Res. 1998;10:271-6 pubmed

Kaufmann S. Cell death induced by topoisomerase-targeted drugs: more questions than answers. Biochim Biophys Acta. 1998;1400:195-211 pubmed

Pommier Y, Pourquier P, Fan Y, Strumberg D. Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme. Biochim Biophys Acta. 1998;1400:83-105 pubmed

Fan Y, Weinstein J, Kohn K, Shi L, Pommier Y. Molecular modeling studies of the DNA-topoisomerase I ternary cleavable complex with camptothecin. J Med Chem. 1998;41:2216-26 pubmed

Desai S, Liu L, Vazquez Abad D, D ARPA P. Ubiquitin-dependent destruction of topoisomerase I is stimulated by the antitumor drug camptothecin. J Biol Chem. 1997;272:24159-64 pubmed

Morris E, Geller H. Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity. J Cell Biol. 1996;134:757-70 pubmed

Beidler D, Cheng Y. Camptothecin induction of a time- and concentration-dependent decrease of topoisomerase I and its implication in camptothecin activity. Mol Pharmacol. 1995;47:907-14 pubmed