Hampoelz B, Schwarz A, Ronchi P, Bragulat Teixidor H, Tischer C, Gaspar I, et al. Nuclear Pores Assemble from Nucleoporin Condensates During Oogenesis. Cell. 2019;179:671-686.e17 pubmed publisher

Urbaniak A, Jousheghany F, Yuan Y, Pina Oviedo S, Huczyński A, Delgado M, et al. The response of phyllodes tumor of the breast to anticancer therapy: An in vitro and ex vivo study. Oncol Lett. 2019;18:5097-5106 pubmed publisher

Bailleul R, Curantz C, Desmarquet Trin Dinh C, Hidalgo M, Touboul J, Manceau M. Symmetry breaking in the embryonic skin triggers directional and sequential plumage patterning. PLoS Biol. 2019;17:e3000448 pubmed publisher

Kashyap A, Fernandez Rodriguez L, Zhao Y, Monaco G, Trefny M, Yoshida N, et al. GEF-H1 Signaling upon Microtubule Destabilization Is Required for Dendritic Cell Activation and Specific Anti-tumor Responses. Cell Rep. 2019;28:3367-3380.e8 pubmed publisher

Kim N, Shin S, Shin G, Bang O. Genotoxicity evaluation of a Phragmitis rhizoma extract using a standard battery of in vitro and in vivo assays. J Ethnopharmacol. 2019;241:112025 pubmed publisher

Silva K, Ghiarone T, Schreiber K, Grant D, White T, Frisard M, et al. Angiotensin II suppresses autophagy and disrupts ultrastructural morphology and function of mitochondria in mouse skeletal muscle. J Appl Physiol (1985). 2019;126:1550-1562 pubmed publisher

Oost L, Kustermann M, Armani A, Blaauw B, Romanello V. Fibroblast growth factor 21 controls mitophagy and muscle mass. J Cachexia Sarcopenia Muscle. 2019;10:630-642 pubmed publisher

Warchal S, Dawson J, Carragher N. Evaluation of Machine Learning Classifiers to Predict Compound Mechanism of Action When Transferred across Distinct Cell Lines. SLAS Discov. 2019;24:224-233 pubmed publisher

Giarma E, Mpampali Z, Lialiaris T, Mourelatos D. Cytoprotective and genotoxic effects of vitamins K1 and B1 on irinotecan in vitro. Mutat Res Genet Toxicol Environ Mutagen. 2019;837:60-64 pubmed publisher

Gill N, Ly C, Nyberg K, Lee L, Qi D, Tofig B, et al. A scalable filtration method for high throughput screening based on cell deformability. Lab Chip. 2019;19:343-357 pubmed publisher

Bressy C, Droby G, Maldonado B, Steuerwald N, Grdzelishvili V. Cell Cycle Arrest in G2/M Phase Enhances Replication of Interferon-Sensitive Cytoplasmic RNA Viruses via Inhibition of Antiviral Gene Expression. J Virol. 2019;93: pubmed publisher

Çelikkan F, Mungan C, Sucu M, Ulus A, Cinar O, Ili E, et al. Optimizing the transport and storage conditions of current Good Manufacturing Practice -grade human umbilical cord mesenchymal stromal cells for transplantation (HUC-HEART Trial). Cytotherapy. 2019;21:64-75 pubmed publisher

Dias M, Fonseca C, Zeidler J, Albuquerque L, Da Silva M, Cararo Lopes E, et al. Fibroblast Growth Factor 2 lethally sensitizes cancer cells to stress-targeted therapeutic inhibitors. Mol Oncol. 2019;13:290-306 pubmed publisher

Visetsouk M, Falat E, Garde R, Wendlick J, Gutzman J. Basal epithelial tissue folding is mediated by differential regulation of microtubules. Development. 2018;145: pubmed publisher

Tovey C, Tubman C, Hamrud E, Zhu Z, Dyas A, Butterfield A, et al. ?-TuRC Heterogeneity Revealed by Analysis of Mozart1. Curr Biol. 2018;28:2314-2323.e6 pubmed publisher

Gagnon D, Petryszyn S, Sanchez M, Bories C, Beaulieu J, De Koninck Y, et al. Striatal Neurons Expressing D1 and D2 Receptors are Morphologically Distinct and Differently Affected by Dopamine Denervation in Mice. Sci Rep. 2017;7:41432 pubmed publisher

Zhang L, Hernandez V, Vázquez Juárez E, Chay F, Barrio R. Thirst Is Associated with Suppression of Habenula Output and Active Stress Coping: Is there a Role for a Non-canonical Vasopressin-Glutamate Pathway?. Front Neural Circuits. 2016;10:13 pubmed publisher

Liu B, Luo H, Wu G, Liu J, Pan J, Liu Z. Low expression of spindle checkpoint protein, Cenp-E, causes numerical chromosomal abnormalities in HepG-2 human hepatoma cells. Oncol Lett. 2015;10:2699-2704 pubmed

Cisneros E, Roza C, Jackson N, López García J. A New Regulatory Mechanism for Kv7.2 Protein During Neuropathy: Enhanced Transport from the Soma to Axonal Terminals of Injured Sensory Neurons. Front Cell Neurosci. 2015;9:470 pubmed publisher

Chrisam M, Pirozzi M, Castagnaro S, Blaauw B, Polishchuck R, Cecconi F, et al. Reactivation of autophagy by spermidine ameliorates the myopathic defects of collagen VI-null mice. Autophagy. 2015;11:2142-52 pubmed publisher

Lee S, Seki S, Katayama N, Yoshizaki G. Production of viable trout offspring derived from frozen whole fish. Sci Rep. 2015;5:16045 pubmed publisher

De Amicis A, Sanctis S, Cristofaro S, Franchini V, Lista F, Regalbuto E, et al. Biological effects of in vitro THz radiation exposure in human foetal fibroblasts. Mutat Res Genet Toxicol Environ Mutagen. 2015;793:150-60 pubmed publisher

Su B, Shieh G, Tseng Y, Shiau A, Wu C. Etoposide enhances antitumor efficacy of MDR1-driven oncolytic adenovirus through autoupregulation of the MDR1 promoter activity. Oncotarget. 2015;6:38308-26 pubmed publisher

Froidevaux Klipfel L, Targa B, Cantaloube I, Ahmed Zaïd H, Poüs C, Baillet A. Septin cooperation with tubulin polyglutamylation contributes to cancer cell adaptation to taxanes. Oncotarget. 2015;6:36063-80 pubmed publisher

Cabet E, Batonnet Pichon S, Delort F, Gausserès B, Vicart P, Lilienbaum A. Antioxidant Treatment and Induction of Autophagy Cooperate to Reduce Desmin Aggregation in a Cellular Model of Desminopathy. PLoS ONE. 2015;10:e0137009 pubmed publisher

Wang Q, Ye M, Xu L, Shi Z. A reversed-phase/hydrophilic interaction mixed-mode C18-Diol stationary phase for multiple applications. Anal Chim Acta. 2015;888:182-90 pubmed publisher

Schweizer N, Pawar N, Weiss M, Maiato H. An organelle-exclusion envelope assists mitosis and underlies distinct molecular crowding in the spindle region. J Cell Biol. 2015;210:695-704 pubmed publisher

Movahedi Naini S, Sheridan A, Force T, Shah J, Bonventre J. Group IVA Cytosolic Phospholipase A2 Regulates the G2-to-M Transition by Modulating the Activity of Tumor Suppressor SIRT2. Mol Cell Biol. 2015;35:3768-84 pubmed publisher

Kogel U, Gonzalez Suarez I, Xiang Y, Dossin E, Guy P, Mathis C, et al. Biological impact of cigarette smoke compared to an aerosol produced from a prototypic modified risk tobacco product on normal human bronchial epithelial cells. Toxicol In Vitro. 2015;29:2102-15 pubmed publisher

Galdíková M, Sivikova K, Holeckova B, Dianovsky J, Drážovská M, Schwarzbacherová V. The effect of thiacloprid formulation on DNA/chromosome damage and changes in GST activity in bovine peripheral lymphocytes. J Environ Sci Health B. 2015;50:698-707 pubmed publisher

Blasiak A, Siwiec M, Grabowiecka A, Blasiak T, Czerw A, Blasiak E, et al. Excitatory orexinergic innervation of rat nucleus incertus--Implications for ascending arousal, motivation and feeding control. Neuropharmacology. 2015;99:432-47 pubmed publisher

Jhang J, Lu C, Ho C, Cheng Y, Yen G. Protective Effects of Catechin against Monosodium Urate-Induced Inflammation through the Modulation of NLRP3 Inflammasome Activation. J Agric Food Chem. 2015;63:7343-52 pubmed publisher

Kanagaraj K, Abdul Syed Basheerudeen S, Tamizh Selvan G, Jose M, Ozhimuthu A, Panneer Selvam S, et al. Assessment of dose and DNA damages in individuals exposed to low dose and low dose rate ionizing radiations during computed tomography imaging. Mutat Res Genet Toxicol Environ Mutagen. 2015;789-790:1-6 pubmed publisher

Kuznetsova A, Seget K, Moeller G, de Pagter M, de Roos J, Dürrbaum M, et al. Chromosomal instability, tolerance of mitotic errors and multidrug resistance are promoted by tetraploidization in human cells. Cell Cycle. 2015;14:2810-20 pubmed publisher

Ciriello J. Sex and estrogen affect the distribution of urocortin-1 immunoreactivity in brainstem autonomic nuclei of the rat. Brain Res Bull. 2015;116:81-92 pubmed publisher

Garcia Belinchón M, Sánchez Osuna M, Martínez Escardó L, Granados Colomina C, Pascual Guiral S, Iglesias Guimarais V, et al. An Early and Robust Activation of Caspases Heads Cells for a Regulated Form of Necrotic-like Cell Death. J Biol Chem. 2015;290:20841-55 pubmed publisher

Nagamine T, Hayakawa K, Nakazato K, Iha M. Determination of the active transport of fucoidan derived from Okinawa Mozuku across the human intestinal Caco-2 cells as assessed by size-exclusion chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;997:187-93 pubmed publisher

Burla R, Carcuro M, Raffa G, Galati A, Raimondo D, Rizzo A, et al. AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance. PLoS Genet. 2015;11:e1005167 pubmed publisher

Imai H, Kano K, Fujii W, Takasawa K, Wakitani S, Hiyama M, et al. Tetraploid Embryonic Stem Cells Maintain Pluripotency and Differentiation Potency into Three Germ Layers. PLoS ONE. 2015;10:e0130585 pubmed publisher

Vicario R, Peg V, Morancho B, Zacarías Fluck M, Zhang J, Martínez Barriocanal Ã, et al. Patterns of HER2 Gene Amplification and Response to Anti-HER2 Therapies. PLoS ONE. 2015;10:e0129876 pubmed publisher

Nahar J, Haam J, Chen C, Jiang Z, Glatzer N, Muglia L, et al. Rapid Nongenomic Glucocorticoid Actions in Male Mouse Hypothalamic Neuroendocrine Cells Are Dependent on the Nuclear Glucocorticoid Receptor. Endocrinology. 2015;156:2831-42 pubmed publisher

Nemeth C, Yang C, Kasprzak P, Hubbart S, Scholefield D, Mehra S, et al. Generation of amphidiploids from hybrids of wheat and related species from the genera Aegilops, Secale, Thinopyrum, and Triticum as a source of genetic variation for wheat improvement. Genome. 2015;58:71-9 pubmed publisher

Feng L, He L, Wang Y, Du L, Xu C, Liu Q, et al. Eight-year follow-up study of three individuals accidentally exposed to (60)Co radiation: Chromosome aberration and micronucleus analysis. Mutat Res Genet Toxicol Environ Mutagen. 2015;784-785:10-4 pubmed publisher

Sana T, Baumann C, Merdes A, Soscia C, Rattei T, Hachani A, et al. Internalization of Pseudomonas aeruginosa Strain PAO1 into Epithelial Cells Is Promoted by Interaction of a T6SS Effector with the Microtubule Network. MBio. 2015;6:e00712 pubmed publisher

Stromberg T, Feng X, Delforoush M, Berglund M, Lin Y, Axelson M, et al. Picropodophyllin inhibits proliferation and survival of diffuse large B-cell lymphoma cells. Med Oncol. 2015;32:188 pubmed publisher

Vasudevan S, Thomas S, Sivakumar K, Komalam R, Sreerekha K, Rajasekharan K, et al. Diaminothiazoles evade multidrug resistance in cancer cells and xenograft tumour models and develop transient specific resistance: understanding the basis of broad-spectrum versus specific resistance. Carcinogenesis. 2015;36:883-93 pubmed publisher

Beesley N, Cwiklinski K, Williams D, Hodgkinson J. Fasciola hepatica from naturally infected sheep and cattle in Great Britain are diploid. Parasitology. 2015;142:1196-201 pubmed publisher

Occhetta P, Centola M, Tonnarelli B, Redaelli A, Martin I, Rasponi M. High-Throughput Microfluidic Platform for 3D Cultures of Mesenchymal Stem Cells, Towards Engineering Developmental Processes. Sci Rep. 2015;5:10288 pubmed publisher

Sepúlveda Crespo D, Serramía M, Tager A, Vrbanac V, Gómez R, de la Mata F, et al. Prevention vaginally of HIV-1 transmission in humanized BLT mice and mode of antiviral action of polyanionic carbosilane dendrimer G2-S16. Nanomedicine. 2015;11:1299-308 pubmed publisher

Lin H, Li Z, Bai L, Baloch S, Wang F, Qiu H, et al. Synthesis of aryl dihydrothiazol acyl shikonin ester derivatives as anticancer agents through microtubule stabilization. Biochem Pharmacol. 2015;96:93-106 pubmed publisher

Ashraf S, Beech R, Hancock M, Prichard R. Ivermectin binds to Haemonchus contortus tubulins and promotes stability of microtubules. Int J Parasitol. 2015;45:647-54 pubmed publisher

Lian N, Jiang Y, Zhang F, Jin H, Lu C, Wu X, et al. Curcumin regulates cell fate and metabolism by inhibiting hedgehog signaling in hepatic stellate cells. Lab Invest. 2015;95:790-803 pubmed publisher

Tamura Y, Kitaoka Y, Matsunaga Y, Hoshino D, Hatta H. Daily heat stress treatment rescues denervation-activated mitochondrial clearance and atrophy in skeletal muscle. J Physiol. 2015;593:2707-20 pubmed publisher

Lawrence K, Chau T, Engebrecht J. DNA damage response and spindle assembly checkpoint function throughout the cell cycle to ensure genomic integrity. PLoS Genet. 2015;11:e1005150 pubmed publisher

Lozoya Agulló I, Gonzalez Alvarez I, Gonzalez Alvarez M, Merino Sanjuán M, Bermejo M. In Situ Perfusion Model in Rat Colon for Drug Absorption Studies: Comparison with Small Intestine and Caco-2 Cell Model. J Pharm Sci. 2015;104:3136-45 pubmed publisher

Piper M, Lee A, van Horck F, McNeilly H, Lu T, Harris W, et al. Differential requirement of F-actin and microtubule cytoskeleton in cue-induced local protein synthesis in axonal growth cones. Neural Dev. 2015;10:3 pubmed publisher

Li Y, Wang H, Sun T, Chen J, Guo L, Shen H, et al. Biological characteristics of a new human glioma cell line transformed into A2B5(+) stem cells. Mol Cancer. 2015;14:75 pubmed publisher

Cui Z, Hui M, Liu Y, Song C, Li X, Li Y, et al. High-density linkage mapping aided by transcriptomics documents ZW sex determination system in the Chinese mitten crab Eriocheir sinensis. Heredity (Edinb). 2015;115:206-15 pubmed publisher

Rizopoulos Z, Balistreri G, Kilcher S, Martin C, Syedbasha M, Helenius A, et al. Vaccinia Virus Infection Requires Maturation of Macropinosomes. Traffic. 2015;16:814-31 pubmed publisher

Itoh S, Igarashi M, Nagata M, Hattori C. Assessment of a twice dosing regimen both before and after partial hepatectomy in the rat liver micronucleus test. Mutat Res Genet Toxicol Environ Mutagen. 2015;782:18-23 pubmed publisher

De Pieri C, Vuch J, De Martino E, Bianco A, Ronfani L, Athanasakis E, et al. Genetic profiling of autoinflammatory disorders in patients with periodic fever: a prospective study. Pediatr Rheumatol Online J. 2015;13:11 pubmed publisher

Peake P, Pianta T, Succar L, Fernando M, Buckley N, Endre Z. Fab fragments of ovine antibody to colchicine enhance its clearance in the rat. Clin Toxicol (Phila). 2015;53:427-32 pubmed publisher

Kesselheim A, Franklin J, Kim S, Seeger J, Solomon D. Reductions in Use of Colchicine after FDA Enforcement of Market Exclusivity in a Commercially Insured Population. J Gen Intern Med. 2015;30:1633-8 pubmed publisher

Wu X, Zhang F, Xiong X, Lu C, Lian N, Lu Y, et al. Tetramethylpyrazine reduces inflammation in liver fibrosis and inhibits inflammatory cytokine expression in hepatic stellate cells by modulating NLRP3 inflammasome pathway. IUBMB Life. 2015;67:312-21 pubmed publisher

Mast C, Lyan B, Joly C, Centeno D, Giacomoni F, Martin J, et al. Assessment of protein modifications in liver of rats under chronic treatment with paracetamol (acetaminophen) using two complementary mass spectrometry-based metabolomic approaches. J Proteomics. 2015;120:194-203 pubmed publisher

Arulanandam R, Batenchuk C, Varette O, Zakaria C, Garcia V, Forbes N, et al. Microtubule disruption synergizes with oncolytic virotherapy by inhibiting interferon translation and potentiating bystander killing. Nat Commun. 2015;6:6410 pubmed publisher

Yi F, Catudio Garrett E, Gábriel R, Wilhelm M, Erdelyi F, Szabo G, et al. Hippocampal "cholinergic interneurons" visualized with the choline acetyltransferase promoter: anatomical distribution, intrinsic membrane properties, neurochemical characteristics, and capacity for cholinergic modulation. Front Synaptic Neurosci. 2015;7:4 pubmed publisher

Basu A, Ghosh P, Bhattacharjee A, Patra A, Bhattacharya S. Prevention of myelosuppression and genotoxicity induced by cisplatin in murine bone marrow cells: effect of an organovanadium compound vanadium(III)-l-cysteine. Mutagenesis. 2015;30:509-17 pubmed publisher

Chen Y, Wang H, Ho C, Chen H, Li S, Chan H, et al. 5-demethylnobiletin promotes the formation of polymerized tubulin, leads to G2/M phase arrest and induces autophagy via JNK activation in human lung cancer cells. J Nutr Biochem. 2015;26:484-504 pubmed publisher

Itoh S, Nagata M, Hattori C, Takasaki W. Effect of buprenorphine on genotoxicity evaluation of chemicals by the rat liver micronucleus test with partial hepatectomy. J Toxicol Sci. 2015;40:109-14 pubmed publisher

Arslan M, Ila H. Deferasirox-induced cytogenetic responses. Environ Toxicol Pharmacol. 2015;39:787-93 pubmed publisher

Rytlewski J, Alejandra Aldon M, Lewis E, Suggs L. Mechanisms of tubulogenesis and endothelial phenotype expression by MSCs. Microvasc Res. 2015;99:26-35 pubmed publisher

Carraz M, Lavergne C, Jullian V, Wright M, Gairin J, Gonzales de la Cruz M, et al. Antiproliferative activity and phenotypic modification induced by selected Peruvian medicinal plants on human hepatocellular carcinoma Hep3B cells. J Ethnopharmacol. 2015;166:185-99 pubmed publisher

Zheng Y, Benet L, Okochi H, Chen X. pH Dependent but not P-gp Dependent Bidirectional Transport Study of S-propranolol: The Importance of Passive Diffusion. Pharm Res. 2015;32:2516-26 pubmed publisher

Siriboon C, Lin Y, Kere M, Chen C, Chen L, Chen C, et al. Putative porcine embryonic stem cell lines derived from aggregated four-celled cloned embryos produced by oocyte bisection cloning. PLoS ONE. 2015;10:e0118165 pubmed publisher

Lee J. Ruling revives gout drug competition. Mod Healthc. 2015;45:17 pubmed

Zhu S, Zhang Y, Sheng X, Xu M, Wu S, Shen Y, et al. Deacetyl-mycoepoxydiene, isolated from plant endophytic fungi Phomosis sp. demonstrates anti-microtubule activity in MCF-7 cells. Biomed Pharmacother. 2015;69:82-9 pubmed publisher

Istifli E, Topaktas M. In vitro genotoxicity and cytotoxicity of a particular combination of pemetrexed and cefixime in human peripheral blood lymphocytes. Springerplus. 2015;4:35 pubmed publisher

Gerić M, Gajski G, Oreščanin V, Kollar R, Franekić J, Garaj Vrhovac V. Toxicological assessment and management options for boat pressure-washing wastewater. Ecotoxicol Environ Saf. 2015;114:164-70 pubmed publisher

Rees F, Doherty M. Patients with gout can be cured in primary care. Practitioner. 2014;258:15-9, 2 pubmed

Moskalenko M, Pan M, Fu Y, de Moll E, Hashimoto D, Mortha A, et al. Requirement for innate immunity and CD90⁺ NK1.1⁻ lymphocytes to treat established melanoma with chemo-immunotherapy. Cancer Immunol Res. 2015;3:296-304 pubmed publisher

Del Priore L, Pigozzi M. Sex-specific recombination maps for individual macrochromosomes in the Japanese quail (Coturnix japonica). Chromosome Res. 2015;23:199-210 pubmed publisher

Vulić A, Durgo K, Pleadin J, Herceg L, Kopjar N. Mutagenicity and DNA-damaging potential of clenbuterol and its metabolite 4-amino-3,5-dichlorobenzoic acid in vitro. Food Chem Toxicol. 2015;77:82-92 pubmed publisher

Lee H, Lin Y, Duh C, Huang S, Wang H, Wu S, et al. Lemnalol attenuates mast cell activation and osteoclast activity in a gouty arthritis model. J Pharm Pharmacol. 2015;67:274-85 pubmed publisher

Yano K, Mita S, Morimoto K, Haraguchi T, Arakawa H, Yoshida M, et al. Multiple Linear Regression Analysis Indicates Association of P-Glycoprotein Substrate or Inhibitor Character with Bitterness Intensity, Measured with a Sensor. J Pharm Sci. 2015;104:2789-94 pubmed publisher

Ferreira V, Dizzell S, Nazli A, Kafka J, Mueller K, Nguyen P, et al. Medroxyprogesterone Acetate Regulates HIV-1 Uptake and Transcytosis but Not Replication in Primary Genital Epithelial Cells, Resulting in Enhanced T-Cell Infection. J Infect Dis. 2015;211:1745-56 pubmed publisher

Nava F, Ghilotti F, Maggi L, Hatemi G, Del Bianco A, Merlo C, et al. Biologics, colchicine, corticosteroids, immunosuppressants and interferon-alpha for Neuro-Behçet's Syndrome. Cochrane Database Syst Rev. 2014;:CD010729 pubmed publisher

LeWinter M. Clinical practice. Acute pericarditis. N Engl J Med. 2014;371:2410-6 pubmed publisher

O Donnell A, Moollan A, Baneham S, Ozgul M, Pabari R, Cox D, et al. Intranasal and intravenous administration of octa-arginine modified poly(lactic-co-glycolic acid) nanoparticles facilitates central nervous system delivery of loperamide. J Pharm Pharmacol. 2015;67:525-36 pubmed publisher

Konieczny M, Buɬakowska A, Pirska D, Konieczny W, Skladanowski A, Sabisz M, et al. Structural factors affecting affinity of cytotoxic oxathiole-fused chalcones toward tubulin. Eur J Med Chem. 2015;89:733-42 pubmed publisher

Chen Y, Li X, Boini K, Pitzer A, Gulbins E, Zhang Y, et al. Endothelial Nlrp3 inflammasome activation associated with lysosomal destabilization during coronary arteritis. Biochim Biophys Acta. 2015;1853:396-408 pubmed publisher

Poloni A, Maurizi G, Anastasi S, Mondini E, Mattiucci D, Discepoli G, et al. Plasticity of human dedifferentiated adipocytes toward endothelial cells. Exp Hematol. 2015;43:137-46 pubmed publisher

Huczyński A, Rutkowski J, Popiel K, Maj E, Wietrzyk J, Stefańska J, et al. Synthesis, antiproliferative and antibacterial evaluation of C-ring modified colchicine analogues. Eur J Med Chem. 2015;90:296-301 pubmed publisher

Vilanova C, Díaz Oltra S, Murga J, Falomir E, Carda M, Redondo Horcajo M, et al. Design and synthesis of pironetin analogue/colchicine hybrids and study of their cytotoxic activity and mechanisms of interaction with tubulin. J Med Chem. 2014;57:10391-403 pubmed publisher

Li H, Zhong X, Chau K, Santistevan N, Guo W, Kong G, et al. Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway. Nat Commun. 2014;5:5601 pubmed publisher

Kathawala R, Wei L, Anreddy N, Chen K, Patel A, Alqahtani S, et al. The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated paclitaxel resistance: a preclinical and pharmacokinetic study. Oncotarget. 2015;6:510-21 pubmed

Wason S, Mount D, Faulkner R. Single-dose, open-label study of the differences in pharmacokinetics of colchicine in subjects with renal impairment, including end-stage renal disease. Clin Drug Investig. 2014;34:845-55 pubmed publisher

Choi B, Chattopadhaya S, Thanh L, Feng L, Nguyen Q, Lim C, et al. Suprafenacine, an indazole-hydrazide agent, targets cancer cells through microtubule destabilization. PLoS ONE. 2014;9:e110955 pubmed publisher

Upadhyaya J, Singh N, Sikarwar A, Chakraborty R, Pydi S, Bhullar R, et al. Dextromethorphan mediated bitter taste receptor activation in the pulmonary circuit causes vasoconstriction. PLoS ONE. 2014;9:e110373 pubmed publisher

Kamal A, Balakrishna M, Nayak V, Shaik T, Faazil S, Nimbarte V. Design and synthesis of imidazo[2,1-b]thiazole-chalcone conjugates: microtubule-destabilizing agents. ChemMedChem. 2014;9:2766-80 pubmed publisher

Aoyama A, Katayama R, Oh hara T, Sato S, Okuno Y, Fujita N. Tivantinib (ARQ 197) exhibits antitumor activity by directly interacting with tubulin and overcomes ABC transporter-mediated drug resistance. Mol Cancer Ther. 2014;13:2978-90 pubmed publisher

Castro A, Frederico M, Cazarolli L, Mendes C, Bretanha L, Schmidt E, et al. The mechanism of action of ursolic acid as insulin secretagogue and insulinomimetic is mediated by cross-talk between calcium and kinases to regulate glucose balance. Biochim Biophys Acta. 2015;1850:51-61 pubmed publisher

Fediuk J, Sikarwar A, Lizotte P, Hinton M, Nolette N, Dakshinamurti S. Hypoxia increases pulmonary arterial thromboxane receptor internalization independent of receptor sensitization. Pulm Pharmacol Ther. 2015;30:1-10 pubmed publisher

Kurt R, Doğan A, Dogan M, Albayrak A, Kurt S, Eren F, et al. Protective effect of colchicine on ovarian ischemia-reperfusion injury: an experimental study. Reprod Sci. 2015;22:545-50 pubmed publisher

Li X, He C, Wu W, Huang H, Li W, Yin Y. Anti‑fibrotic effects of Acremoniumterricola milleretal mycelium on immunological hepatic fibrosis in rats. Mol Med Rep. 2014;10:3327-33 pubmed publisher

Waraky A, Akopyan K, Parrow V, Strömberg T, Axelson M, Abrahmsén L, et al. Picropodophyllin causes mitotic arrest and catastrophe by depolymerizing microtubules via insulin-like growth factor-1 receptor-independent mechanism. Oncotarget. 2014;5:8379-92 pubmed

Tsukimoto M, Ohashi R, Torimoto N, Togo Y, Suzuki T, Maeda T, et al. Effects of the inhibition of intestinal P-glycoprotein on aliskiren pharmacokinetics in cynomolgus monkeys. Biopharm Drug Dispos. 2015;36:15-33 pubmed publisher

Gong Q, Qiu S, Li S, Ma Y, Chen M, Yao Y, et al. Proapoptotic PEDF functional peptides inhibit prostate tumor growth--a mechanistic study. Biochem Pharmacol. 2014;92:425-37 pubmed publisher

Silva Pereira L, da Rocha C, Cunha L, da Costa E, Guimarães A, Pontes T, et al. Protective effect of prolactin against methylmercury-induced mutagenicity and cytotoxicity on human lymphocytes. Int J Environ Res Public Health. 2014;11:9822-34 pubmed publisher

Vranjkovic O, Gasser P, Gerndt C, Baker D, Mantsch J. Stress-induced cocaine seeking requires a beta-2 adrenergic receptor-regulated pathway from the ventral bed nucleus of the stria terminalis that regulates CRF actions in the ventral tegmental area. J Neurosci. 2014;34:12504-14 pubmed publisher

Alabed S, Cabello J, Irving G, Qintar M, Burls A. Colchicine for pericarditis. Cochrane Database Syst Rev. 2014;:CD010652 pubmed publisher

Kim J, Yamamoto T, Lee J, Yashiro T, Hamada T, Hayashi S, et al. CGRP, a neurotransmitter of enteric sensory neurons, contributes to the development of food allergy due to the augmentation of microtubule reorganization in mucosal mast cells. Biomed Res. 2014;35:285-93 pubmed

Das A, Ali N. Combining cationic liposomal delivery with MPL-TDM for cysteine protease cocktail vaccination against Leishmania donovani: evidence for antigen synergy and protection. PLoS Negl Trop Dis. 2014;8:e3091 pubmed publisher

van Echteld I, Wechalekar M, Schlesinger N, Buchbinder R, Aletaha D. Colchicine for acute gout. Cochrane Database Syst Rev. 2014;:CD006190 pubmed publisher

Yokooji T, Nouma H, Matsuo H. Characterization of ovalbumin absorption pathways in the rat intestine, including the effects of aspirin. Biol Pharm Bull. 2014;37:1359-65 pubmed

Maguma H, Datta De D, Bhave S, Dewey W, Akbarali H. Specific localization of β-Arrestin2 in myenteric plexus of mouse gastrointestinal tract. PLoS ONE. 2014;9:e103894 pubmed publisher

Hattermann V, Xenitidis T, Ioanoviciu S, Horger M. [Modern imaging of gouty arthritis]. Rofo. 2014;186:729-34 pubmed publisher

Gajski G, Gerić M, Garaj Vrhovac V. Evaluation of the in vitro cytogenotoxicity profile of antipsychotic drug haloperidol using human peripheral blood lymphocytes. Environ Toxicol Pharmacol. 2014;38:316-24 pubmed publisher

Melemedjian O, Tillu D, Moy J, Asiedu M, Mandell E, Ghosh S, et al. Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity. Mol Pain. 2014;10:45 pubmed publisher

Gul A. Treatment of familial Mediterranean fever: colchicine and beyond. Isr Med Assoc J. 2014;16:281-4 pubmed

Lin P, Lou H, Chang C. A rare cause of diffuse abdominal pain and fullness in a 57-year-old man. Gastroenterology. 2014;147:e5-6 pubmed publisher

Wang Y, Kathawala R, Zhang Y, Patel A, Kumar P, Shukla S, et al. Motesanib (AMG706), a potent multikinase inhibitor, antagonizes multidrug resistance by inhibiting the efflux activity of the ABCB1. Biochem Pharmacol. 2014;90:367-78 pubmed publisher

Uchida R, Yokota S, Matsuda D, Matsumoto A, Iwamoto S, Onodera H, et al. Habiterpenol, a novel abrogator of bleomycin-induced G2 arrest in Jurkat cells, produced by Phytohabitans suffuscus 3787_5. J Antibiot (Tokyo). 2014;67:777-81 pubmed publisher

Zhang H, Zhang Y, Wang Y, Kathawala R, Patel A, Zhu H, et al. WHI-P154 enhances the chemotherapeutic effect of anticancer agents in ABCG2-overexpressing cells. Cancer Sci. 2014;105:1071-8 pubmed publisher

Bekker S, Huismans H, van Staden V. Factors that affect the intracellular localization and trafficking of African horse sickness virus core protein, VP7. Virology. 2014;456-457:279-91 pubmed publisher

Lorendeau D, Dury L, Genoux Bastide E, Lecerf Schmidt F, Simões Pires C, Carrupt P, et al. Collateral sensitivity of resistant MRP1-overexpressing cells to flavonoids and derivatives through GSH efflux. Biochem Pharmacol. 2014;90:235-45 pubmed publisher

Zhu Y, Cheng L, Cheng L, Huang F, Hu Q, Li L, et al. Folate and TAT peptide co-modified liposomes exhibit receptor-dependent highly efficient intracellular transport of payload in vitro and in vivo. Pharm Res. 2014;31:3289-303 pubmed publisher

Smith R, Astrand O, Nguyen L, Elvestrand T, Hagelin G, Solberg R, et al. Synthesis of a novel legumain-cleavable colchicine prodrug with cell-specific toxicity. Bioorg Med Chem. 2014;22:3309-15 pubmed publisher

Kinlock B, Wang Y, Turner T, Wang C, Liu B. Transcytosis of HIV-1 through vaginal epithelial cells is dependent on trafficking to the endocytic recycling pathway. PLoS ONE. 2014;9:e96760 pubmed publisher

Nagami G, Plumer A, Beyda R, Schachter O. Effects of acid challenges on type 2 angiotensin II receptor-sensitive ammonia production by the proximal tubule. Am J Physiol Renal Physiol. 2014;307:F53-7 pubmed publisher

Liao L, Liao C, Liu C, Yang T, Wang G. Evaluation of an electrochemical biosensor for uric acid measurement in human whole blood samples. Clin Chim Acta. 2014;436:72-7 pubmed publisher

Watterson J, Imfeld A, Cornthwaite H. Determination of colchicine and O-demethylated metabolites in decomposed skeletal tissues by microwave assisted extraction, microplate solid phase extraction and ultra-high performance liquid chromatography (MAE-MPSPE-UHPLC). J Chromatogr B Analyt Technol Biomed Life Sci. 2014;960:145-50 pubmed publisher

Huang H, Gao S, Wang D, Huang P, Li J. Autotetraploidy induced in nianmaohuangqin (Radix Scutellariae Viscidulae) with colchicine in vitro. J Tradit Chin Med. 2014;34:199-205 pubmed

Armstead A, Arena C, Li B. Exploring the potential role of tungsten carbide cobalt (WC-Co) nanoparticle internalization in observed toxicity toward lung epithelial cells in vitro. Toxicol Appl Pharmacol. 2014;278:1-8 pubmed publisher

Chen P, Singhal S, Bushyhead D, Broder Fingert S, Wolfe J. Colchicine-induced degeneration of the micronucleus during conjugation in Tetrahymena. Biol Open. 2014;3:353-61 pubmed publisher

Wang W, Wang Y, Meng T, Yi J, Huan X, Ma L, et al. MCL-1 degradation mediated by JNK activation via MEKK1/TAK1-MKK4 contributes to anticancer activity of new tubulin inhibitor MT189. Mol Cancer Ther. 2014;13:1480-91 pubmed publisher

Kimura Y, Fujimura C, Ito Y, Takahashi T, Aiba S. Evaluation of the Multi-ImmunoTox Assay composed of 3 human cytokine reporter cells by examining immunological effects of drugs. Toxicol In Vitro. 2014;28:759-68 pubmed publisher

Ozen S, Demirkaya E, Duzova A, Erdogan O, Erken E, Gul A, et al. FMF50: a score for assessing outcome in familial Mediterranean fever. Ann Rheum Dis. 2014;73:897-901 pubmed publisher

Goldfinger S. A randomized trial of colchicine for acute pericarditis. N Engl J Med. 2014;370:780 pubmed publisher

Imazio M, Brucato A, Adler Y. A randomized trial of colchicine for acute pericarditis. N Engl J Med. 2014;370:781 pubmed publisher

Prota A, Danel F, Bachmann F, Bargsten K, Buey R, Pohlmann J, et al. The novel microtubule-destabilizing drug BAL27862 binds to the colchicine site of tubulin with distinct effects on microtubule organization. J Mol Biol. 2014;426:1848-60 pubmed publisher

Zhang C, Chen B, Guo A, Zhu Y, Miller J, Gao S, et al. Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte transverse-tubule remodeling and Ca2+ handling dysfunction in heart failure. Circulation. 2014;129:1742-50 pubmed publisher

Fleischmann R, Kerr B, Yeh L, Suster M, Shen Z, Polvent E, et al. Pharmacodynamic, pharmacokinetic and tolerability evaluation of concomitant administration of lesinurad and febuxostat in gout patients with hyperuricaemia. Rheumatology (Oxford). 2014;53:2167-74 pubmed publisher

Jung L, Tropel P, Moal Y, Teletin M, Jeandidier E, Gayon R, et al. ONSL and OSKM cocktails act synergistically in reprogramming human somatic cells into induced pluripotent stem cells. Mol Hum Reprod. 2014;20:538-49 pubmed publisher

Roddy E, Mallen C, Doherty M. Gout. BMJ. 2013;347:f5648 pubmed publisher

Jordan G, Carson C, Lipshultz L. Minimally invasive treatment of Peyronie's disease: evidence-based progress. BJU Int. 2014;114:16-24 pubmed publisher

Chen G, Yue A, Ruan Z, Yin Y, Wang R, Ren Y, et al. Monitoring the biology stability of human umbilical cord-derived mesenchymal stem cells during long-term culture in serum-free medium. Cell Tissue Bank. 2014;15:513-21 pubmed publisher

Minota S, Nara M, Kawamura H, Migita K, Sano H. [Organ damage in collagen vascular diseases: toward the understanding of the complicated conditions (discussion)]. Nihon Naika Gakkai Zasshi. 2013;102:2653-666; quiz 2667-70 pubmed

Stumpf J, Toniolo M, Alkadhi H, Haller C. [New aspects of diagnosis and therapy of gout]. Praxis (Bern 1994). 2013;103:7-14; quiz 15-6 pubmed publisher

George M, Pullman Mooar S, Hussain F, Schumacher H. Evaluating appropriate use of prophylactic colchicine for gout flare prevention. Arthritis Care Res (Hoboken). 2014;66:1258-62 pubmed publisher

Moreno A, Santi C, Gabbi T, Aoki V, Hashimoto T, Maruta C. IgA pemphigus: case series with emphasis on therapeutic response. J Am Acad Dermatol. 2014;70:200-1 pubmed publisher

Kilic S, Alaygut D, Unal E, Koç E, Patiroglu T. Acute colchicine intoxication complicated with extramedullary hematopoiesis due to filgrastim in a child. J Pediatr Hematol Oncol. 2014;36:e460-2 pubmed publisher

Lilly L. Response to letter regarding article "Treatment of acute and recurrent pericarditis". Circulation. 2013;128:e392 pubmed publisher

Chhabra L, Spodick D. Letter by Chhabra and Spodick regarding article, "Treatment of acute and recurrent idiopathic pericarditis". Circulation. 2013;128:e391 pubmed publisher

Romagnoli R, Baraldi P, Lopez Cara C, Preti D, Aghazadeh Tabrizi M, Balzarini J, et al. Concise synthesis and biological evaluation of 2-Aroyl-5-amino benzo[b]thiophene derivatives as a novel class of potent antimitotic agents. J Med Chem. 2013;56:9296-309 pubmed publisher

Juhem A, Boumendjel A, Touquet B, Guillot A, Popov A, Ronot X, et al. AG11, a novel dichloroflavanone derivative with anti-mitotic activity towards human bladder cancer cells. Anticancer Res. 2013;33:4445-52 pubmed

Capron J, Grateau G, Steichen O. Is recurrent aseptic meningitis a manifestation of familial Mediterranean fever? A systematic review. Clin Exp Rheumatol. 2013;31:127-32 pubmed

Gemici A, Sevindik O, Akar S, Tunca M. Vitamin B12 levels in familial Mediterranean fever patients treated with colchicine. Clin Exp Rheumatol. 2013;31:57-9 pubmed

La Regina M, Ben Chetrit E, Gasparyan A, Livneh A, Ozdogan H, Manna R. Current trends in colchicine treatment in familial Mediterranean fever. Clin Exp Rheumatol. 2013;31:41-6 pubmed

Deftereos S, Giannopoulos G, Papoutsidakis N, Panagopoulou V, Kossyvakis C, Raisakis K, et al. Colchicine and the heart: pushing the envelope. J Am Coll Cardiol. 2013;62:1817-25 pubmed publisher

Hadimani M, Macdonough M, Ghatak A, Strecker T, Lopez R, Sriram M, et al. Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent. J Nat Prod. 2013;76:1668-78 pubmed publisher

Imazio M, Brucato A, Cemin R, Ferrua S, Maggiolini S, Beqaraj F, et al. A randomized trial of colchicine for acute pericarditis. N Engl J Med. 2013;369:1522-8 pubmed publisher

Gaspari S, Marsili M, Imazio M, Brucato A, Di Blasi Lo Cuccio C, Chiarelli F, et al. New insights in the pathogenesis and therapy of idiopathic recurrent pericarditis in children. Clin Exp Rheumatol. 2013;31:788-94 pubmed

Mejia Chew C, Torres R, de Miguel E, Puig J. Resolution of massive tophaceous gout with three urate-lowering drugs. Am J Med. 2013;126:e9-10 pubmed publisher

Helsen V, Decoutere L, Spriet I, Fagard K, Boonen S, Tournoy J. Ergotamine-induced pleural and pericardial effusion successfully treated with colchicine. Acta Clin Belg. 2013;68:113-5 pubmed

Da C, Mooberry S, Gupton J, Kellogg G. How to deal with low-resolution target structures: using SAR, ensemble docking, hydropathic analysis, and 3D-QSAR to definitively map the ??-tubulin colchicine site. J Med Chem. 2013;56:7382-95 pubmed publisher

Guan T, Gao B, Chen G, Chen X, Janssen M, Uttarwar L, et al. Colchicine attenuates renal injury in a model of hypertensive chronic kidney disease. Am J Physiol Renal Physiol. 2013;305:F1466-76 pubmed publisher

Frolova L, Magedov I, Romero A, Karki M, Otero I, Hayden K, et al. Exploring natural product chemistry and biology with multicomponent reactions. 5. Discovery of a novel tubulin-targeting scaffold derived from the rigidin family of marine alkaloids. J Med Chem. 2013;56:6886-900 pubmed publisher

Paschke S, Weidner A, Paust T, Marti O, Beil M, Ben Chetrit E. Technical advance: Inhibition of neutrophil chemotaxis by colchicine is modulated through viscoelastic properties of subcellular compartments. J Leukoc Biol. 2013;94:1091-6 pubmed publisher

Lin Z, Wu C, Chuang Y, Chuang W. Anti-cancer mechanisms of clinically acceptable colchicine concentrations on hepatocellular carcinoma. Life Sci. 2013;93:323-8 pubmed publisher

Grattagliano I, Bonfrate L, Ruggiero V, Scaccianoce G, Palasciano G, Portincasa P. Novel therapeutics for the treatment of familial Mediterranean fever: from colchicine to biologics. Clin Pharmacol Ther. 2014;95:89-97 pubmed publisher

Manukyan G, Petrek M, Tomankova T, Martirosyan A, Tatyan M, Navratilova Z, et al. Colchicine modulates expression of pro-inflammatory genes in neutrophils from patients with familial Mediterranean fever and healthy subjects. J Biol Regul Homeost Agents. 2013;27:329-36 pubmed

Imazio M, Belli R, Brucato A, Ferrazzi P, Patrini D, Martinelli L, et al. Rationale and design of the COlchicine for Prevention of the Post-pericardiotomy Syndrome and Post-operative Atrial Fibrillation (COPPS-2 trial): a randomized, placebo-controlled, multicenter study on the use of colchicine for the primary prevention . Am Heart J. 2013;166:13-9 pubmed publisher

Freeman G, Krock R, Aton S, Thaben P, Herzog E. GABA networks destabilize genetic oscillations in the circadian pacemaker. Neuron. 2013;78:799-806 pubmed publisher

Zarowitz B, O Shea T. Demographic and clinical profile of nursing facility residents with gout. Consult Pharm. 2013;28:370-82 pubmed publisher

Takeiri A, Motoyama S, Matsuzaki K, Harada A, Taketo J, Katoh C, et al. New DNA probes to detect aneugenicity in rat bone marrow micronucleated cells by a pan-centromeric FISH analysis. Mutat Res. 2013;755:73-80 pubmed publisher

Thompson M, Corbett G, Cherian A, Nicol E. A massive occult pericardial effusion in an athletic young male. J R Army Med Corps. 2013;159:126-8 pubmed publisher

Mohan R, Katrukha E, Doodhi H, Smal I, Meijering E, Kapitein L, et al. End-binding proteins sensitize microtubules to the action of microtubule-targeting agents. Proc Natl Acad Sci U S A. 2013;110:8900-5 pubmed publisher

Patel A, Tiwari A, Chufan E, Sodani K, Anreddy N, Singh S, et al. PD173074, a selective FGFR inhibitor, reverses ABCB1-mediated drug resistance in cancer cells. Cancer Chemother Pharmacol. 2013;72:189-99 pubmed publisher

Sahin S, Yalcin I, Senel S, Ataseven H, Uslu A, Yildirim O, et al. Assesment life quality of familial Mediterranean fever patients by short form-36 and its relationship with disease parameters. Eur Rev Med Pharmacol Sci. 2013;17:958-63 pubmed

Frenkel J, Bemelman F, Potter Van Loon B, Simon A. [Familial Mediterranean fever: not to be missed]. Ned Tijdschr Geneeskd. 2013;157:A5784 pubmed

Lilly L. Treatment of acute and recurrent idiopathic pericarditis. Circulation. 2013;127:1723-6 pubmed publisher

Sandbo N, Ngam C, Torr E, Kregel S, Kach J, Dulin N. Control of myofibroblast differentiation by microtubule dynamics through a regulated localization of mDia2. J Biol Chem. 2013;288:15466-73 pubmed publisher

Chakrabarti R, Rawat P, Cooke B, Coppel R, Patankar S. Cellular effects of curcumin on Plasmodium falciparum include disruption of microtubules. PLoS ONE. 2013;8:e57302 pubmed publisher

Deftereos S, Giannopoulos G, Raisakis K, Kossyvakis C, Kaoukis A, Panagopoulou V, et al. Colchicine treatment for the prevention of bare-metal stent restenosis in diabetic patients. J Am Coll Cardiol. 2013;61:1679-85 pubmed publisher

Strauss B. Diabetic patients receiving bare-metal stents: no option patients?. J Am Coll Cardiol. 2013;61:1686-7 pubmed publisher

Laque A, Zhang Y, Gettys S, Nguyen T, Bui K, Morrison C, et al. Leptin receptor neurons in the mouse hypothalamus are colocalized with the neuropeptide galanin and mediate anorexigenic leptin action. Am J Physiol Endocrinol Metab. 2013;304:E999-1011 pubmed publisher

Yu J, Farias A, Hwang I, Fernandes Alnemri T, Alnemri E. Ribotoxic stress through p38 mitogen-activated protein kinase activates in vitro the human pyrin inflammasome. J Biol Chem. 2013;288:11378-83 pubmed publisher

Preau S, Montaigne D, Modine T, Fayad G, Koussa M, Tardivel M, et al. Macrophage migration inhibitory factor induces contractile and mitochondria dysfunction by altering cytoskeleton network in the human heart. Crit Care Med. 2013;41:e125-33 pubmed publisher

Gresham C, Utting K, Williams C, Schep L. Colchicine poisoning: defusing the ticking time bomb. N Z Med J. 2013;126:115-6 pubmed

Oropesa Avila M, Fernández Vega A, De La Mata M, Maraver J, Cordero M, Cotán D, et al. Apoptotic microtubules delimit an active caspase free area in the cellular cortex during the execution phase of apoptosis. Cell Death Dis. 2013;4:e527 pubmed publisher

Yurttutan S, Ozdemir R, Canpolat F, Oncel M, Uysal B, Unverdi H, et al. Protective effects of colchicine in an experimental model of necrotizing enterocolitis in neonatal rats. J Surg Res. 2013;183:156-62 pubmed publisher

Koncicki M, Dewan M. A teenager with multiple organ system dysfunction. Pediatr Emerg Care. 2013;29:399-401 pubmed publisher

Davis M, Wason S, DiGiacinto J. Colchicine-antimicrobial drug interactions: what pharmacists need to know in treating gout. Consult Pharm. 2013;28:176-83 pubmed publisher

Nardemir G, Yanmis D, Alpsoy L, Gulluce M, Agar G, Aslan A. Genotoxic, antigenotoxic and antioxidant properties of methanol extracts obtained from Peltigera horizontalis and Peltigera praetextata. Toxicol Ind Health. 2015;31:602-13 pubmed publisher

Aguayo Ortiz R, Méndez Lucio O, Medina Franco J, Castillo R, Yepez Mulia L, Hernández Luis F, et al. Towards the identification of the binding site of benzimidazoles to ?-tubulin of Trichinella spiralis: insights from computational and experimental data. J Mol Graph Model. 2013;41:12-9 pubmed publisher

Romagnoli R, Baraldi P, Kimatrai Salvador M, Preti D, Aghazadeh Tabrizi M, Bassetto M, et al. Synthesis and biological evaluation of 2-(alkoxycarbonyl)-3-anilinobenzo[b]thiophenes and thieno[2,3-b]pyridines as new potent anticancer agents. J Med Chem. 2013;56:2606-18 pubmed publisher

Gajula P, Asthana J, Panda D, Chakraborty T. A synthetic dolastatin 10 analogue suppresses microtubule dynamics, inhibits cell proliferation, and induces apoptotic cell death. J Med Chem. 2013;56:2235-45 pubmed publisher

Markel G, Imazio M, Brucato A, Adler Y. Prevention of recurrent pericarditis with colchicine in 2012. Clin Cardiol. 2013;36:125-8 pubmed publisher

Roubille F, Kritikou E, Busseuil D, Barrère Lemaire S, Tardif J. Colchicine: an old wine in a new bottle?. Antiinflamm Antiallergy Agents Med Chem. 2013;12:14-23 pubmed

Wasserscheid K, Backendorf A, Michna D, Mallmann R, Hoffmann B. Long-term outcome after suicidal colchicine intoxication in a 14-year-old girl: case report and review of literature. Pediatr Emerg Care. 2013;29:89-92 pubmed publisher

Sivakumar G. Colchicine semisynthetics: chemotherapeutics for cancer?. Curr Med Chem. 2013;20:892-8 pubmed

Imazio M. [Prevention of the postpericardiotomy syndrome, postoperative effusions, and atrial fibrillation after cardiac surgery, efficacy and safety of colchicine: evidence from the COPPS trial and substudies]. G Ital Cardiol (Rome). 2012;13:665-72 pubmed publisher

Korkmaz C. Therapeutic approach to patients with familial Mediterranean fever-related amyloidosis resistant to colchicine. Clin Exp Rheumatol. 2012;30:S104-7 pubmed

Paydas S, Paydas S, Balal M. The permanent improvement of proteinuria and renal failure with colchicine and enalapril in a leukemic patient with renal amyloidosis secondary to ankylosing spondylitis: a review of the literature. Am J Ther. 2013;20:344-6 pubmed publisher

Babu Y, Manjunath S, Bakkannavar S, Acharya J, Kumar G. Colchicine poisoning: a case report and review of literature. Med Sci Law. 2012;52:205-6 pubmed publisher

Lu Y, Chen J, Xiao M, Li W, Miller D. An overview of tubulin inhibitors that interact with the colchicine binding site. Pharm Res. 2012;29:2943-71 pubmed publisher

Imazio M, Adler Y. Treatment with aspirin, NSAID, corticosteroids, and colchicine in acute and recurrent pericarditis. Heart Fail Rev. 2013;18:355-60 pubmed publisher

Tseng H, Chuah Q, Yang P, Chen C, Chao J, Lin M, et al. Securin enhances the anti-cancer effects of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075) in human colorectal cancer cells. PLoS ONE. 2012;7:e36006 pubmed publisher

Villamañán E, Larrubia Y, Ruano M. [Colchicine: what's up, doc?]. Med Clin (Barc). 2012;139:295-9 pubmed publisher

Imazio M, Brucato A, Forno D, Ferro S, Belli R, Trinchero R, et al. Efficacy and safety of colchicine for pericarditis prevention. Systematic review and meta-analysis. Heart. 2012;98:1078-82 pubmed publisher

Both T, van Laar J, Bonte Mineur F, van Hagen P, van Daele P. [Colchicine has no negative effect on fertility and pregnancy]. Ned Tijdschr Geneeskd. 2012;156:A4196 pubmed

Yang X, Wen Q, Zhao T, Sun J, Li X, Xing M, et al. Synthesis, biological evaluation, and molecular docking studies of cinnamic acyl 1,3,4-thiadiazole amide derivatives as novel antitubulin agents. Bioorg Med Chem. 2012;20:1181-7 pubmed publisher

Liu Z, Shi Q, Ding D, Kelly R, Fang H, Tong W. Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS Comput Biol. 2011;7:e1002310 pubmed publisher

Hu Y, Lu X, Chen K, Yan R, Li Q, Zhu H. Design, synthesis, biological evaluation and molecular modeling of 1,3,4-oxadiazoline analogs of combretastatin-A4 as novel antitubulin agents. Bioorg Med Chem. 2012;20:903-9 pubmed publisher

Ruan B, Lu X, Li T, Tang J, Wei Y, Wang X, et al. Synthesis, biological evaluation and molecular docking studies of resveratrol derivatives possessing curcumin moiety as potent antitubulin agents. Bioorg Med Chem. 2012;20:1113-21 pubmed publisher

Lee H, Chang J, Nien C, Kuo C, Shih K, Wu C, et al. 5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors. Part 2. The impact of bridging groups at position C-2. J Med Chem. 2011;54:8517-25 pubmed publisher

La Regina G, Bai R, Rensen W, Coluccia A, Piscitelli F, Gatti V, et al. Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability. J Med Chem. 2011;54:8394-406 pubmed publisher

Massarotti A, Coluccia A, Silvestri R, Sorba G, Brancale A. The tubulin colchicine domain: a molecular modeling perspective. ChemMedChem. 2012;7:33-42 pubmed publisher

Fortin S, Wei L, Moreau E, Lacroix J, Côté M, Petitclerc E, et al. Substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonamides as antimitotics. Antiproliferative, antiangiogenic and antitumoral activity, and quantitative structure-activity relationships. Eur J Med Chem. 2011;46:5327-42 pubmed publisher

Meireles A, Dzhindzhev N, Ohkura H. Kebab: kinetochore and EB1 associated basic protein that dynamically changes its localisation during Drosophila mitosis. PLoS ONE. 2011;6:e24174 pubmed publisher

Zefirova O, Nurieva E, Shishov D, Baskin I, Fuchs F, Lemcke H, et al. Synthesis and SAR requirements of adamantane-colchicine conjugates with both microtubule depolymerizing and tubulin clustering activities. Bioorg Med Chem. 2011;19:5529-38 pubmed publisher

Reddy M, Jain N, Yada D, Kishore C, Vangala J, P Surendra R, et al. Design and synthesis of resveratrol-based nitrovinylstilbenes as antimitotic agents. J Med Chem. 2011;54:6751-60 pubmed publisher

Dainese L, Cappai A, Biglioli P. Recurrent pericardial effusion after cardiac surgery: the use of colchicine after recalcitrant conventional therapy. J Cardiothorac Surg. 2011;6:96 pubmed publisher

Luo Y, Qiu K, Lu X, Liu K, Fu J, Zhu H. Synthesis, biological evaluation, and molecular modeling of cinnamic acyl sulfonamide derivatives as novel antitubulin agents. Bioorg Med Chem. 2011;19:4730-8 pubmed publisher

Chen J, Li C, Wang J, Ahn S, Wang Z, Lu Y, et al. Synthesis and antiproliferative activity of novel 2-aryl-4-benzoyl-imidazole derivatives targeting tubulin polymerization. Bioorg Med Chem. 2011;19:4782-95 pubmed publisher

Flynn B, Gill G, Grobelny D, Chaplin J, Paul D, Leske A, et al. Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. J Med Chem. 2011;54:6014-27 pubmed publisher

Li Y, Tan C, Gao C, Zhang C, Luan X, Chen X, et al. Discovery of benzimidazole derivatives as novel multi-target EGFR, VEGFR-2 and PDGFR kinase inhibitors. Bioorg Med Chem. 2011;19:4529-35 pubmed publisher

Di Bucchianico S, Poma A, Giardi M, Di Leandro L, Valle F, Biscarini F, et al. Atomic Force Microscope nanolithography on chromosomes to generate single-cell genetic probes. J Nanobiotechnology. 2011;9:27 pubmed publisher

Prinz H, Schmidt P, Böhm K, Baasner S, Muller K, Gerlach M, et al. Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization. Bioorg Med Chem. 2011;19:4183-91 pubmed publisher

Lai M, Chang J, Lee H, Kuo C, Lin M, Hsieh H, et al. Synthesis and biological evaluation of 1-(4'-Indolyl and 6'-Quinolinyl) indoles as a new class of potent anticancer agents. Eur J Med Chem. 2011;46:3623-9 pubmed publisher

Chen M, Vijay V, Shi Q, Liu Z, Fang H, Tong W. FDA-approved drug labeling for the study of drug-induced liver injury. Drug Discov Today. 2011;16:697-703 pubmed publisher

Magedov I, Frolova L, Manpadi M, Bhoga U, Tang H, Evdokimov N, et al. Anticancer properties of an important drug lead podophyllotoxin can be efficiently mimicked by diverse heterocyclic scaffolds accessible via one-step synthesis. J Med Chem. 2011;54:4234-46 pubmed publisher

Fortin S, Wei L, Moreau E, Lacroix J, Côté M, Petitclerc E, et al. Design, synthesis, biological evaluation, and structure-activity relationships of substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new tubulin inhibitors mimicking combretastatin A-4. J Med Chem. 2011;54:4559-80 pubmed publisher

Luan X, Gao C, Zhang N, Chen Y, Sun Q, Tan C, et al. Exploration of acridine scaffold as a potentially interesting scaffold for discovering novel multi-target VEGFR-2 and Src kinase inhibitors. Bioorg Med Chem. 2011;19:3312-9 pubmed publisher

Prinz H, Chamasmani B, Vogel K, Böhm K, Aicher B, Gerlach M, et al. N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2011;54:4247-63 pubmed publisher

Lu Y, Li C, Wang Z, Chen J, Mohler M, Li W, et al. Design, synthesis, and SAR studies of 4-substituted methoxylbenzoyl-aryl-thiazoles analogues as potent and orally bioavailable anticancer agents. J Med Chem. 2011;54:4678-93 pubmed publisher

Li Y, Liu J, Liu N, Shi D, Zhou X, Lv J, et al. Imidazolone-amide bridges and their effects on tubulin polymerization in cis-locked vinylogous combretastatin-A4 analogues: synthesis and biological evaluation. Bioorg Med Chem. 2011;19:3579-84 pubmed publisher

Raffa D, Maggio B, Plescia F, Cascioferro S, Plescia S, Raimondi M, et al. Synthesis, antiproliferative activity, and mechanism of action of a series of 2-{[(2E)-3-phenylprop-2-enoyl]amino}benzamides. Eur J Med Chem. 2011;46:2786-96 pubmed publisher

Wardle N, Kalber T, Bell J, Bligh S. Synthesis and characterisation of a novel tubulin-directed DO3A-colchicine conjugate with potential theranostic features. Bioorg Med Chem Lett. 2011;21:3346-8 pubmed publisher

Xie F, Zhao H, Li D, Chen H, Quan H, Shi X, et al. Synthesis and biological evaluation of 2,4,5-substituted pyrimidines as a new class of tubulin polymerization inhibitors. J Med Chem. 2011;54:3200-5 pubmed publisher

Ruan B, Lu X, Tang J, Wei Y, Wang X, Zhang Y, et al. Synthesis, biological evaluation, and molecular docking studies of resveratrol derivatives possessing chalcone moiety as potential antitubulin agents. Bioorg Med Chem. 2011;19:2688-95 pubmed publisher

Nakagawa Goto K, Wu P, Lai C, Hamel E, Zhu H, Zhang L, et al. Antitumor agents. 284. New desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents. J Med Chem. 2011;54:1244-55 pubmed publisher

Andorfer P, Rotheneder H. EAPP: gatekeeper at the crossroad of apoptosis and p21-mediated cell-cycle arrest. Oncogene. 2011;30:2679-90 pubmed publisher

Zan U, Topaktas M, Istifli E. In vitro genotoxicity of rocuronium bromide in human peripheral lymphocytes. Cytotechnology. 2011;63:239-45 pubmed publisher

Shetty R, Lee Y, Liu B, Husain A, Joseph R, Lu Y, et al. Synthesis and pharmacological evaluation of N-(3-(1H-indol-4-yl)-5-(2-methoxyisonicotinoyl)phenyl)methanesulfonamide (LP-261), a potent antimitotic agent. J Med Chem. 2011;54:179-200 pubmed publisher

Yamazaki Y, Kido Y, Hidaka K, Yasui H, Kiso Y, Yakushiji F, et al. Tubulin photoaffinity labeling study with a plinabulin chemical probe possessing a biotin tag at the oxazole. Bioorg Med Chem. 2011;19:595-602 pubmed publisher

Qian Y, Zhang H, Lv P, Zhu H. Synthesis, molecular modeling and biological evaluation of guanidine derivatives as novel antitubulin agents. Bioorg Med Chem. 2010;18:8218-25 pubmed publisher

Chen J, Wang Z, Li C, Lu Y, Vaddady P, Meibohm B, et al. Discovery of novel 2-aryl-4-benzoyl-imidazoles targeting the colchicines binding site in tubulin as potential anticancer agents. J Med Chem. 2010;53:7414-27 pubmed publisher

Ekins S, Williams A, Xu J. A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug Metab Dispos. 2010;38:2302-8 pubmed publisher

Vantikommu J, Palle S, Reddy P, Ramanatham V, Khagga M, Pallapothula V. Synthesis and cytotoxicity evaluation of novel 1,4-disubstituted 1,2,3-triazoles via CuI catalysed 1,3-dipolar cycloaddition. Eur J Med Chem. 2010;45:5044-50 pubmed publisher

Puri N, Prakash O, Manoharlal R, Sharma M, Ghosh I, Prasad R. Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. Eur J Med Chem. 2010;45:4813-26 pubmed publisher

Johansson E, Dubois J, Darbre T, Reymond J. Glycopeptide dendrimer colchicine conjugates targeting cancer cells. Bioorg Med Chem. 2010;18:6589-97 pubmed publisher

Yi M, Hong N, Hong Y. Derivation and characterization of haploid embryonic stem cell cultures in medaka fish. Nat Protoc. 2010;5:1418-30 pubmed publisher

Greene N, Fisk L, Naven R, Note R, Patel M, Pelletier D. Developing structure-activity relationships for the prediction of hepatotoxicity. Chem Res Toxicol. 2010;23:1215-22 pubmed publisher

Surkau G, Böhm K, Muller K, Prinz H. Synthesis, antiproliferative activity and inhibition of tubulin polymerization by anthracenone-based oxime derivatives. Eur J Med Chem. 2010;45:3354-64 pubmed publisher

Kozaka T, Nakagawa Goto K, Shi Q, Lai C, Hamel E, Bastow K, et al. Antitumor agents 273. Design and synthesis of N-alkyl-thiocolchicinoids as potential antitumor agents. Bioorg Med Chem Lett. 2010;20:4091-4 pubmed publisher

Nickel H, Schmidt P, Böhm K, Baasner S, Muller K, Gerlach M, et al. Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety. Eur J Med Chem. 2010;45:3420-38 pubmed publisher

Yang B, Zhu Z, Goodson H, Miller M. Syntheses and biological evaluation of ring-C modified colchicine analogs. Bioorg Med Chem Lett. 2010;20:3831-3 pubmed publisher

Qian Y, Ma G, Yang Y, Cheng K, Zheng Q, Mao W, et al. Synthesis, molecular modeling and biological evaluation of dithiocarbamates as novel antitubulin agents. Bioorg Med Chem. 2010;18:4310-6 pubmed publisher

Ibanez Sandoval O, Tecuapetla F, Unal B, Shah F, Koos T, Tepper J. Electrophysiological and morphological characteristics and synaptic connectivity of tyrosine hydroxylase-expressing neurons in adult mouse striatum. J Neurosci. 2010;30:6999-7016 pubmed publisher

Leslie B, Holaday C, Nguyen T, Hergenrother P. Phenylcinnamides as novel antimitotic agents. J Med Chem. 2010;53:3964-72 pubmed publisher

Xiong J, Taniguchi M, Kashiwada Y, Sekiya M, Yamagishi T, Takaishi Y. Papyriferic acid derivatives as reversal agents of multidrug resistance in cancer cells. Bioorg Med Chem. 2010;18:2964-75 pubmed publisher

Stefely J, Palchaudhuri R, Miller P, Peterson R, Moraski G, Hergenrother P, et al. N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a new scaffold that provides rapid access to antimicrotubule agents: synthesis and evaluation of antiproliferative activity against select cancer cell lines. J Med Chem. 2010;53:3389-95 pubmed publisher

Lee K. Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach. J Nat Prod. 2010;73:500-16 pubmed publisher

Li W, Hwang D, Song J, Chen C, Chuu J, Hu C, et al. Synthesis and biological activities of 2-amino-1-arylidenamino imidazoles as orally active anticancer agents. J Med Chem. 2010;53:2409-17 pubmed publisher

Nien C, Chen Y, Kuo C, Hsieh H, Chang C, Wu J, et al. 5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors. J Med Chem. 2010;53:2309-13 pubmed publisher

Uehara T, Ono A, Maruyama T, Kato I, Yamada H, Ohno Y, et al. The Japanese toxicogenomics project: application of toxicogenomics. Mol Nutr Food Res. 2010;54:218-27 pubmed publisher

Abdel Bar F, Khanfar M, Elnagar A, Badria F, Zaghloul A, Ahmad K, et al. Design and pharmacophore modeling of biaryl methyl eugenol analogs as breast cancer invasion inhibitors. Bioorg Med Chem. 2010;18:496-507 pubmed publisher

Fourches D, Barnes J, Day N, Bradley P, Reed J, Tropsha A. Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chem Res Toxicol. 2010;23:171-83 pubmed publisher

. Guide to Receptors and Channels (GRAC), 4th Edition. Br J Pharmacol. 2009;158 Suppl 1:S1-254 pubmed publisher

Ducki S, Mackenzie G, Greedy B, Armitage S, Chabert J, Bennett E, et al. Combretastatin-like chalcones as inhibitors of microtubule polymerisation. Part 2: Structure-based discovery of alpha-aryl chalcones. Bioorg Med Chem. 2009;17:7711-22 pubmed publisher

Yuan J, Johnson R, Huang R, Wichterman J, Jiang H, Hayton K, et al. Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nat Chem Biol. 2009;5:765-71 pubmed publisher

Wu Y, Coumar M, Chang J, Sun H, Kuo F, Kuo C, et al. Synthesis and evaluation of 3-aroylindoles as anticancer agents: metabolite approach. J Med Chem. 2009;52:4941-5 pubmed publisher

Messaoudi S, Tréguier B, Hamze A, Provot O, Peyrat J, De Losada J, et al. Isocombretastatins a versus combretastatins a: the forgotten isoCA-4 isomer as a highly promising cytotoxic and antitubulin agent. J Med Chem. 2009;52:4538-42 pubmed publisher

Fan T, Wang D, Zhao J, Wang J, Fu Y, Guo R. Establishment and characterization of a novel untransfected corneal endothelial cell line from New Zealand white rabbits. Mol Vis. 2009;15:1070-8 pubmed

Chang D, Yoon E, Lee G, Kim S, Kim W, Kim Y, et al. Design, synthesis and identification of novel colchicine-derived immunosuppressant. Bioorg Med Chem Lett. 2009;19:4416-20 pubmed publisher

Kemnitzer W, Kuemmerle J, Zhang H, Kasibhatla S, Tseng B, Drewe J, et al. Discovery of 3-aryl-5-aryl-1,2,4-oxadiazoles as a new series of apoptosis inducers. 2. Identification of more aqueous soluble analogs as potential anticancer agents. Bioorg Med Chem Lett. 2009;19:4410-5 pubmed publisher

Kemnitzer W, Sirisoma N, May C, Tseng B, Drewe J, Cai S. Discovery of 4-anilino-N-methylthieno[3,2-d]pyrimidines and 4-anilino-N-methylthieno[2,3-d]pyrimidines as potent apoptosis inducers. Bioorg Med Chem Lett. 2009;19:3536-40 pubmed publisher

Kemnitzer W, Sirisoma N, Nguyen B, Jiang S, Kasibhatla S, Crogan Grundy C, et al. Discovery of N-aryl-9-oxo-9H-fluorene-1-carboxamides as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure-activity relationships of the carboxamide group. Bioorg Med Chem Lett. 2009;19:3045-9 pubmed publisher

Barta T, Barabasz A, Foley B, Geng L, Hall S, Hanson G, et al. Novel carbazole and acyl-indole antimitotics. Bioorg Med Chem Lett. 2009;19:3078-80 pubmed publisher

Karapidaki I, Bakopoulou A, Papageorgiou A, Iakovidou Z, Mioglou E, Nikolaropoulos S, et al. Genotoxic, cytostatic, antineoplastic and apoptotic effects of newly synthesized antitumour steroidal esters. Mutat Res. 2009;675:51-9 pubmed publisher

Sirisoma N, Pervin A, Drewe J, Tseng B, Cai S. Discovery of substituted N'-(2-oxoindolin-3-ylidene)benzohydrazides as new apoptosis inducers using a cell- and caspase-based HTS assay. Bioorg Med Chem Lett. 2009;19:2710-3 pubmed publisher

Zhang H, Crogan Grundy C, May C, Drewe J, Tseng B, Cai S. Discovery and structure-activity relationships of (2-(arylthio)benzylideneamino)guanidines as a novel series of potent apoptosis inducers. Bioorg Med Chem. 2009;17:2852-8 pubmed publisher

Lu Y, Li C, Wang Z, Ross C, Chen J, Dalton J, et al. Discovery of 4-substituted methoxybenzoyl-aryl-thiazole as novel anticancer agents: synthesis, biological evaluation, and structure-activity relationships. J Med Chem. 2009;52:1701-11 pubmed publisher

Frackenpohl J, Adelt I, Antonicek H, Arnold C, Behrmann P, Blaha N, et al. Insecticidal heterolignans--tubuline polymerization inhibitors with activity against chewing pests. Bioorg Med Chem. 2009;17:4160-84 pubmed publisher

Prinz H, Schmidt P, Böhm K, Baasner S, Muller K, Unger E, et al. 10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2009;52:1284-94 pubmed publisher

Davis R, Barnes E, Longden J, Avery V, Healy P. Isolation, structure elucidation and cytotoxic evaluation of endiandrin B from the Australian rainforest plant Endiandra anthropophagorum. Bioorg Med Chem. 2009;17:1387-92 pubmed publisher

Gaspar I, Szabad J. In vivo analysis of MT-based vesicle transport by confocal reflection microscopy. Cell Motil Cytoskeleton. 2009;66:68-79 pubmed publisher

Simoni D, Invidiata F, Eleopra M, Marchetti P, Rondanin R, Baruchello R, et al. Design, synthesis and biological evaluation of novel stilbene-based antitumor agents. Bioorg Med Chem. 2009;17:512-22 pubmed publisher

Nolan L, Levy A. Prolonged oestrogen treatment does not correlate with a sustained increase in anterior pituitary mitotic index in ovariectomized Wistar rats. J Endocrinol. 2009;200:301-9 pubmed publisher

Reddy G, Kuo C, Tan U, Coumar M, Chang C, Chiang Y, et al. Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents. J Med Chem. 2008;51:8163-7 pubmed publisher

Chia E, Pearce A, Berridge M, Larsen L, Perry N, Sansom C, et al. Synthesis and anti-inflammatory structure-activity relationships of thiazine-quinoline-quinones: inhibitors of the neutrophil respiratory burst in a model of acute gouty arthritis. Bioorg Med Chem. 2008;16:9432-42 pubmed publisher

Santana L, González Díaz H, Quezada E, Uriarte E, Yáñez M, Viña D, et al. Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. J Med Chem. 2008;51:6740-51 pubmed publisher

Ahlin G, Karlsson J, Pedersen J, Gustavsson L, Larsson R, Matsson P, et al. Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. J Med Chem. 2008;51:5932-42 pubmed publisher

Simoni D, Romagnoli R, Baruchello R, Rondanin R, Grisolia G, Eleopra M, et al. Novel A-ring and B-ring modified combretastatin A-4 (CA-4) analogues endowed with interesting cytotoxic activity. J Med Chem. 2008;51:6211-5 pubmed publisher

Anchoori R, Kortenhorst M, Hidalgo M, Sarkar T, Hallur G, Bai R, et al. Novel microtubule-interacting phenoxy pyridine and phenyl sulfanyl pyridine analogues for cancer therapy. J Med Chem. 2008;51:5953-7 pubmed publisher

Craig D, Owen C, Conway W, Walsh M, Downey C, Basson M. Colchicine inhibits pressure-induced tumor cell implantation within surgical wounds and enhances tumor-free survival in mice. J Clin Invest. 2008;118:3170-80 pubmed publisher

Arnold L, Ranaivo P, Guy R. Synthesis and characterization of BODIPY-labeled colchicine. Bioorg Med Chem Lett. 2008;18:5867-70 pubmed publisher

Nussbaumer P, Winiski A. Structure-activity relationship studies on a novel class of antiproliferative agents derived from Lavendustin A. Part I: Ring A modifications. Bioorg Med Chem. 2008;16:7552-60 pubmed publisher

Guo Z, Moazzami A, Tjen A Looi S, Longhurst J. Responses of opioid and serotonin containing medullary raphe neurons to electroacupuncture. Brain Res. 2008;1229:125-36 pubmed publisher

Sirisoma N, Kasibhatla S, Pervin A, Zhang H, Jiang S, Willardsen J, et al. Discovery of 2-chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine (EP128265, MPI-0441138) as a potent inducer of apoptosis with high in vivo activity. J Med Chem. 2008;51:4771-9 pubmed publisher

Fortin J, Côté M, Lacroix J, Desjardins M, Petitclerc E, C Gaudreault R. Selective alkylation of beta(II)-tubulin and thioredoxin-1 by structurally related subsets of aryl chloroethylureas leading to either anti-microtubules or redox modulating agents. Bioorg Med Chem. 2008;16:7277-90 pubmed publisher

Liou J, Wu Z, Kuo C, Chang C, Lu P, Chen C, et al. Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors. J Med Chem. 2008;51:4351-5 pubmed publisher

Ty N, Dupeyre G, Chabot G, Seguin J, Tillequin F, Scherman D, et al. Synthesis and biological evaluation of new disubstituted analogues of 6-methoxy-3-(3',4',5'-trimethoxybenzoyl)-1H-indole (BPR0L075), as potential antivascular agents. Bioorg Med Chem. 2008;16:7494-503 pubmed publisher

Fortin J, Côté M, Lacroix J, Petitclerc E, C Gaudreault R. Aromatic 2-chloroethyl urea derivatives and bioisosteres. Part 2: Cytocidal activity and effects on the nuclear translocation of thioredoxin-1, and the cell cycle progression. Bioorg Med Chem. 2008;16:7477-88 pubmed publisher

Vogel S, Kaufmann D, Pojarova M, Muller C, Pfaller T, Kühne S, et al. Aroyl hydrazones of 2-phenylindole-3-carbaldehydes as novel antimitotic agents. Bioorg Med Chem. 2008;16:6436-47 pubmed publisher

Keller L, Beaumont S, Liu J, Thoret S, Bignon J, Wdzieczak Bakala J, et al. New C5-alkylated indolobenzazepinones acting as inhibitors of tubulin polymerization: cytotoxic and antitumor activities. J Med Chem. 2008;51:3414-21 pubmed publisher

Fortin J, Côté M, Lacroix J, Patenaude A, Petitclerc E, C Gaudreault R. Cycloalkyl-substituted aryl chloroethylureas inhibiting cell cycle progression in G0/G1 phase and thioredoxin-1 nuclear translocation. Bioorg Med Chem Lett. 2008;18:3526-31 pubmed publisher

Pedersen J, Matsson P, Bergström C, Norinder U, Hoogstraate J, Artursson P. Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). J Med Chem. 2008;51:3275-87 pubmed publisher

Na S, Collin O, Chowdhury F, Tay B, Ouyang M, Wang Y, et al. Rapid signal transduction in living cells is a unique feature of mechanotransduction. Proc Natl Acad Sci U S A. 2008;105:6626-31 pubmed publisher

Tseng K, Lin C, Lo Y, Hu Y, Chen L, Yang S, et al. Synthesis and biological evaluation of novel symmetry bis-enediynes. Eur J Med Chem. 2009;44:35-41 pubmed publisher

Obach R, Lombardo F, Waters N. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug Metab Dispos. 2008;36:1385-405 pubmed publisher

Lo Y, Lin C, Lin C, Lin Y, Duh T, Hong Y, et al. 2-(6-aryl-3(Z)-hexen-1,5-diynyl)anilines as a new class of potent antitubulin agents. J Med Chem. 2008;51:2682-8 pubmed publisher

Diana P, Martorana A, Barraja P, Montalbano A, Dattolo G, Cirrincione G, et al. Isoindolo[2,1-a]quinoxaline derivatives, novel potent antitumor agents with dual inhibition of tubulin polymerization and topoisomerase I. J Med Chem. 2008;51:2387-99 pubmed publisher

Jain H, Zhang C, Zhou S, Zhou H, Ma J, Liu X, et al. Synthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein. Bioorg Med Chem. 2008;16:4626-51 pubmed publisher

Kemnitzer W, Drewe J, Jiang S, Zhang H, Crogan Grundy C, Labreque D, et al. Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. 4. Structure-activity relationships of N-alkyl substituted pyrrole fused at the 7,8-positions. J Med Chem. 2008;51:417-23 pubmed publisher

Cullen M, Sarkar T, Hamel E, Hartman T, Watson K, Buckheit R, et al. Inhibition of tubulin polymerization by select alkenyldiarylmethanes. Bioorg Med Chem Lett. 2008;18:469-73 pubmed

Tripathi A, Fornabaio M, Kellogg G, Gupton J, Gewirtz D, Yeudall W, et al. Docking and hydropathic scoring of polysubstituted pyrrole compounds with antitubulin activity. Bioorg Med Chem. 2008;16:2235-42 pubmed

Henriquez F, Ingram P, Muench S, Rice D, Roberts C. Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds. Antimicrob Agents Chemother. 2008;52:1133-5 pubmed

Zuse A, Schmidt P, Baasner S, Böhm K, Muller K, Gerlach M, et al. Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2007;50:6059-66 pubmed

Magedov I, Manpadi M, Slambrouck S, Steelant W, Rozhkova E, Przheval skii N, et al. Discovery and investigation of antiproliferative and apoptosis-inducing properties of new heterocyclic podophyllotoxin analogues accessible by a one-step multicomponent synthesis. J Med Chem. 2007;50:5183-92 pubmed

Randhawa P, Farasati N, Huang Y. BK Virus replication in vitro: limited effect of drugs interfering with viral uptake and intracellular transport. Antimicrob Agents Chemother. 2007;51:4492-4 pubmed

Müller H, Klinkhammer W, Globisch C, Kassack M, Pajeva I, Wiese M. New functional assay of P-glycoprotein activity using Hoechst 33342. Bioorg Med Chem. 2007;15:7470-9 pubmed

Pojarova M, Kaufmann D, Gastpar R, Nishino T, Reszka P, Bednarski P, et al. [(2-Phenylindol-3-yl)methylene]propanedinitriles inhibit the growth of breast cancer cells by cell cycle arrest in G(2)/M phase and apoptosis. Bioorg Med Chem. 2007;15:7368-79 pubmed

Liou J, Wu C, Hsieh H, Chang C, Chen C, Kuo C, et al. 4- and 5-aroylindoles as novel classes of potent antitubulin agents. J Med Chem. 2007;50:4548-52 pubmed

Hoet S, Pieters L, Muccioli G, Habib Jiwan J, Opperdoes F, Quetin Leclercq J. Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds. J Nat Prod. 2007;70:1360-3 pubmed

Ben Amor N, Bouaziz A, Romera Castillo C, Salido S, Linares Palomino P, Bartegi A, et al. Characterization of the intracellular mechanisms involved in the antiaggregant properties of cinnamtannin B-1 from bay wood in human platelets. J Med Chem. 2007;50:3937-44 pubmed

Gangjee A, Yu J, Copper J, Smith C. Discovery of novel antitumor antimitotic agents that also reverse tumor resistance. J Med Chem. 2007;50:3290-301 pubmed

Magedov I, Manpadi M, Evdokimov N, Elias E, Rozhkova E, Ogasawara M, et al. Antiproliferative and apoptosis inducing properties of pyrano[3,2-c]pyridones accessible by a one-step multicomponent synthesis. Bioorg Med Chem Lett. 2007;17:3872-6 pubmed

Fortin J, Lacroix J, Desjardins M, Patenaude A, Petitclerc E, C Gaudreault R. Alkylation potency and protein specificity of aromatic urea derivatives and bioisosteres as potential irreversible antagonists of the colchicine-binding site. Bioorg Med Chem. 2007;15:4456-69 pubmed

La Regina G, Edler M, Brancale A, Kandil S, Coluccia A, Piscitelli F, et al. Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies. J Med Chem. 2007;50:2865-74 pubmed

Pelletier D, Gehlhaar D, Tilloy Ellul A, Johnson T, Greene N. Evaluation of a published in silico model and construction of a novel Bayesian model for predicting phospholipidosis inducing potential. J Chem Inf Model. 2007;47:1196-205 pubmed

Diamandis P, Wildenhain J, Clarke I, Sacher A, Graham J, Bellows D, et al. Chemical genetics reveals a complex functional ground state of neural stem cells. Nat Chem Biol. 2007;3:268-73 pubmed

Duan J, Cai X, Meng F, Lan L, Hart C, Matteucci M. Potent antitubulin tumor cell cytotoxins based on 3-aroyl indazoles. J Med Chem. 2007;50:1001-6 pubmed

Metwally K, Aly O, Aly E, Banerjee A, Ravindra R, Bane S. Synthesis and biological activity of 2,5-diaryl-3-methylpyrimido[4,5-c]quinolin-1(2H)-one derivatives. Bioorg Med Chem. 2007;15:2434-40 pubmed

Zhang Q, Peng Y, Wang X, Keenan S, Arora S, Welsh W. Highly potent triazole-based tubulin polymerization inhibitors. J Med Chem. 2007;50:749-54 pubmed

Zhang N, Ayral Kaloustian S, Nguyen T, Afragola J, Hernandez R, Lucas J, et al. Synthesis and SAR of [1,2,4]triazolo[1,5-a]pyrimidines, a class of anticancer agents with a unique mechanism of tubulin inhibition. J Med Chem. 2007;50:319-27 pubmed

Zuse A, Schmidt P, Baasner S, Böhm K, Muller K, Gerlach M, et al. 9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2006;49:7816-25 pubmed

Chang J, Hsieh H, Chang C, Hsu K, Chiang Y, Chen C, et al. 7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents. J Med Chem. 2006;49:6656-9 pubmed

Chang J, Yang M, Chang C, Chen C, Kuo C, Liou J. 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents. J Med Chem. 2006;49:6412-5 pubmed

Mahboobi S, Sellmer A, Höcher H, Eichhorn E, Bär T, Schmidt M, et al. [4-(imidazol-1-yl)thiazol-2-yl]phenylamines. A novel class of highly potent colchicine site binding tubulin inhibitors: synthesis and cytotoxic activity on selected human cancer cell lines. J Med Chem. 2006;49:5769-76 pubmed

Yanagawa T, Noguchi T, Miyachi H, Kobayashi H, Hashimoto Y. Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide. Bioorg Med Chem Lett. 2006;16:4748-51 pubmed

Hallur G, Jimeno A, Dalrymple S, Zhu T, Jung M, Hidalgo M, et al. Benzoylphenylurea sulfur analogues with potent antitumor activity. J Med Chem. 2006;49:2357-60 pubmed

Huang R, Wallqvist A, Covell D. Assessment of in vitro and in vivo activities in the National Cancer Institute's anticancer screen with respect to chemical structure, target specificity, and mechanism of action. J Med Chem. 2006;49:1964-79 pubmed

Cifuentes M, Schilling B, Ravindra R, Winter J, Janik M. Synthesis and biological evaluation of B-ring modified colchicine and isocolchicine analogs. Bioorg Med Chem Lett. 2006;16:2761-4 pubmed

Anderson J, Ting A, Boozer S, Brunden K, Crumrine C, Danzig J, et al. Identification of novel and improved antimitotic agents derived from noscapine. J Med Chem. 2005;48:7096-8 pubmed

Ouyang X, Chen X, Piatnitski E, Kiselyov A, He H, Mao Y, et al. Synthesis and structure-activity relationships of 1,2,4-triazoles as a novel class of potent tubulin polymerization inhibitors. Bioorg Med Chem Lett. 2005;15:5154-9 pubmed

Wang Y, Li Y, Li Y, Yang S, Yang L. Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism. Bioorg Med Chem Lett. 2005;15:4076-84 pubmed

Székelyhidi Z, Pato J, Wáczek F, Banhegyi P, Hegymegi Barakonyi B, Eros D, et al. Synthesis of selective SRPK-1 inhibitors: novel tricyclic quinoxaline derivatives. Bioorg Med Chem Lett. 2005;15:3241-6 pubmed

Anderson J, Ting A, Boozer S, Brunden K, Danzig J, Dent T, et al. Discovery of S-phase arresting agents derived from noscapine. J Med Chem. 2005;48:2756-8 pubmed

Fang X, Shao L, Zhang H, Wang S. CHMIS-C: a comprehensive herbal medicine information system for cancer. J Med Chem. 2005;48:1481-8 pubmed

Alali F, El Elimat T, Li C, Qandil A, Alkofahi A, Tawaha K, et al. New colchicinoids from a native Jordanian meadow saffron, colchicum brachyphyllum: isolation of the first naturally occurring dextrorotatory colchicinoid. J Nat Prod. 2005;68:173-8 pubmed

Inatsuki S, Noguchi T, Miyachi H, Oda S, Iguchi T, Kizaki M, et al. Tubulin-polymerization inhibitors derived from thalidomide. Bioorg Med Chem Lett. 2005;15:321-5 pubmed

Suzuki Y. Cell death, phagocytosis, and neurogenesis in mouse olfactory epithelium and vomeronasal organ after colchicine treatment. Ann N Y Acad Sci. 1998;855:252-4 pubmed

Jordan A, Hadfield J, Lawrence N, McGown A. Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle. Med Res Rev. 1998;18:259-96 pubmed

Andreu J, Perez Ramirez B, Gorbunoff M, Ayala D, Timasheff S. Role of the colchicine ring A and its methoxy groups in the binding to tubulin and microtubule inhibition. Biochemistry. 1998;37:8356-68 pubmed

Wang T, Wang H, Ichijo H, Giannakakou P, Foster J, Fojo T, et al. Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways. J Biol Chem. 1998;273:4928-36 pubmed

De Vincenzo R, Scambia G, Ferlini C, Distefano M, Filippini P, Riva A, et al. Antiproliferative activity of colchicine analogues on MDR-positive and MDR-negative human cancer cell lines. Anticancer Drug Des. 1998;13:19-33 pubmed

Ceccatelli S, Ahlbom E, Diana A, Zhivotovsky B. Apoptosis in rat hippocampal dentate gyrus after intraventricular colchicine. Neuroreport. 1997;8:3779-83 pubmed

Banerjee A. Differential effects of colchicine and its B-ring modified analog MTPT on the assembly-independent GTPase activity of purified beta-tubulin isoforms from bovine brain. Biochem Biophys Res Commun. 1997;231:698-700 pubmed

Luduena R, Banerjee A, Khan I. Tubulin structure and biochemistry. Curr Opin Cell Biol. 1992;4:53-7 pubmed