This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Concanamycin A
catalog :
C9705
citations: 45
Reference
Tsao L, Crosby E, Trotter T, Agarwal P, Hwang B, Acharya C, et al. CD47 blockade augmentation of trastuzumab antitumor efficacy dependent on antibody-dependent cellular phagocytosis. JCI Insight. 2019;4: pubmed publisher
Duan T, Smith A, Verkman A. Complement-independent bystander injury in AQP4-IgG seropositive neuromyelitis optica produced by antibody-dependent cellular cytotoxicity. Acta Neuropathol Commun. 2019;7:112 pubmed publisher
Li M, Zhang C, Zong Y, Feng J, Ma T, Hu M, et al. Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK. Cell Metab. 2019;: pubmed publisher
Murphy J, Liu H, Ma X, Shaver A, Egan B, Oh C, et al. Simple nutrients bypass the requirement for HLH-30 in coupling lysosomal nutrient sensing to survival. PLoS Biol. 2019;17:e3000245 pubmed publisher
Hu W, Zhang L, Li M, Shen J, Liu X, Xiao Z, et al. Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through the PDIA3 receptor in gastric epithelial cells. Autophagy. 2019;:1-19 pubmed publisher
Prasad H, Rao R. Histone deacetylase-mediated regulation of endolysosomal pH. J Biol Chem. 2018;293:6721-6735 pubmed publisher
Han C, Sim S, Kim S, Singh R, Hwang S, Kim Y, et al. Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression. Nat Commun. 2018;9:468 pubmed publisher
Zheng P, Wu J, Sahu S, Zeng H, Huang L, Liu Z, et al. Loss of alkaline ceramidase inhibits autophagy in Arabidopsis and plays an important role during environmental stress response. Plant Cell Environ. 2018;41:837-849 pubmed publisher
Hong Z, Pedersen N, Wang L, Torgersen M, Stenmark H, Raiborg C. PtdIns3P controls mTORC1 signaling through lysosomal positioning. J Cell Biol. 2017;216:4217-4233 pubmed publisher
Kwong L, Bijlsma M, Roelink H. Shh-mediated degradation of Hhip allows cell autonomous and non-cell autonomous Shh signalling. Nat Commun. 2014;5:4849 pubmed publisher
Colas C, Menezes S, Gutiérrez Martínez E, Péan C, Dionne M, Guermonprez P. An improved flow cytometry assay to monitor phagosome acidification. J Immunol Methods. 2014;412:1-13 pubmed publisher
Alves M, Oliveira P. 2,4-Dichlorophenoxyacetic acid alters intracellular pH and ion transport in the outer mantle epithelium of the bivalve Anodonta cygnea. Aquat Toxicol. 2014;154:12-8 pubmed publisher
Capecci J, Forgac M. The function of vacuolar ATPase (V-ATPase) a subunit isoforms in invasiveness of MCF10a and MCF10CA1a human breast cancer cells. J Biol Chem. 2013;288:32731-41 pubmed publisher
Sanchez Felipe L, Villar E, Muñoz Barroso I. Entry of Newcastle Disease Virus into the host cell: role of acidic pH and endocytosis. Biochim Biophys Acta. 2014;1838:300-9 pubmed publisher
Horova V, Hradilova N, Jelínková I, Koc M, Svadlenka J, Brazina J, et al. Inhibition of vacuolar ATPase attenuates the TRAIL-induced activation of caspase-8 and modulates the trafficking of TRAIL receptosomes. FEBS J. 2013;280:3436-50 pubmed publisher
Tao W, Higgs M, Spain W, Ransom C. Postsynaptic GABAB receptors enhance extrasynaptic GABAA receptor function in dentate gyrus granule cells. J Neurosci. 2013;33:3738-43 pubmed publisher
Saheb E, Trzyna W, Bush J. An Acanthamoeba castellanii metacaspase associates with the contractile vacuole and functions in osmoregulation. Exp Parasitol. 2013;133:314-26 pubmed publisher
Aravena C, Beltrán A, Cornejo M, Torres V, Diaz E, Guzman Gutierrez E, et al. Potential role of sodium-proton exchangers in the low concentration arsenic trioxide-increased intracellular pH and cell proliferation. PLoS ONE. 2012;7:e51451 pubmed publisher
Somamoto T, Nakanishi T, Nakao M. Identification of anti-viral cytotoxic effector cells in the ginbuna crucian carp, Carassius auratus langsdorfii. Dev Comp Immunol. 2013;39:370-7 pubmed publisher
Nujić K, Banjanac M, Munić V, Polancec D, Erakovic Haber V. Impairment of lysosomal functions by azithromycin and chloroquine contributes to anti-inflammatory phenotype. Cell Immunol. 2012;279:78-86 pubmed publisher
Beck M, Zhou J, Faulkner C, Maclean D, Robatzek S. Spatio-temporal cellular dynamics of the Arabidopsis flagellin receptor reveal activation status-dependent endosomal sorting. Plant Cell. 2012;24:4205-19 pubmed publisher
Yokomakura A, Hong J, Ohuchi K, Oh S, Lee J, Mano N, et al. Increased production of reactive oxygen species by the vacuolar-type (H(+))-ATPase inhibitors bafilomycin A1 and concanamycin A in RAW 264 cells. J Toxicol Sci. 2012;37:1045-8 pubmed
Nordenfelt P, Grinstein S, Bjorck L, Tapper H. V-ATPase-mediated phagosomal acidification is impaired by Streptococcus pyogenes through Mga-regulated surface proteins. Microbes Infect. 2012;14:1319-29 pubmed publisher
Kuzinski J, Zitnan R, Albrecht E, Viergutz T, Schweigel Röntgen M. Modulation of vH+-ATPase is part of the functional adaptation of sheep rumen epithelium to high-energy diet. Am J Physiol Regul Integr Comp Physiol. 2012;303:R909-20 pubmed publisher
Michel V, Licon Munoz Y, Trujillo K, Bisoffi M, Parra K. Inhibitors of vacuolar ATPase proton pumps inhibit human prostate cancer cell invasion and prostate-specific antigen expression and secretion. Int J Cancer. 2013;132:E1-10 pubmed publisher
Sagiv A, Biran A, Yon M, Simon J, Lowe S, Krizhanovsky V. Granule exocytosis mediates immune surveillance of senescent cells. Oncogene. 2013;32:1971-7 pubmed publisher
Papakrivos J, Sa J, Wellems T. Functional characterization of the Plasmodium falciparum chloroquine-resistance transporter (PfCRT) in transformed Dictyostelium discoideum vesicles. PLoS ONE. 2012;7:e39569 pubmed publisher
Sun S, Tepp W, Johnson E, Chapman E. Botulinum neurotoxins B and E translocate at different rates and exhibit divergent responses to GT1b and low pH. Biochemistry. 2012;51:5655-62 pubmed
Dengjel J, Høyer Hansen M, Nielsen M, Eisenberg T, Harder L, Schandorff S, et al. Identification of autophagosome-associated proteins and regulators by quantitative proteomic analysis and genetic screens. Mol Cell Proteomics. 2012;11:M111.014035 pubmed publisher
Glauser D, Kratz A, Stevenson P. Herpesvirus glycoproteins undergo multiple antigenic changes before membrane fusion. PLoS ONE. 2012;7:e30152 pubmed publisher
Ramirez D, Khvotchev M, Trauterman B, Kavalali E. Vti1a identifies a vesicle pool that preferentially recycles at rest and maintains spontaneous neurotransmission. Neuron. 2012;73:121-34 pubmed publisher
Boardman T, Warner C, Ramírez Gómez F, Matrisciano J, Bromage E. Characterization of an anti-rainbow trout (Oncorhynchus mykiss) CD3? monoclonal antibody. Vet Immunol Immunopathol. 2012;145:511-5 pubmed publisher
Kopic S, Wagner M, Griessenauer C, Socrates T, Ritter M, Geibel J. Vacuolar-type H+-ATPase-mediated proton transport in the rat parietal cell. Pflugers Arch. 2012;463:419-27 pubmed publisher
Dyve Lingelem A, Bergan J, Sandvig K. Inhibitors of intravesicular acidification protect against Shiga toxin in a pH-independent manner. Traffic. 2012;13:443-54 pubmed publisher
Wagner C, Mohebbi N, Uhlig U, Giebisch G, Breton S, Brown D, et al. Angiotensin II stimulates H⁺-ATPase activity in intercalated cells from isolated mouse connecting tubules and cortical collecting ducts. Cell Physiol Biochem. 2011;28:513-20 pubmed publisher
Leitz J, Kavalali E. Ca²⁺ influx slows single synaptic vesicle endocytosis. J Neurosci. 2011;31:16318-26 pubmed publisher
Zhang L, Zhang H, Liu P, Hao H, Jin J, Lin J. Arabidopsis R-SNARE proteins VAMP721 and VAMP722 are required for cell plate formation. PLoS ONE. 2011;6:e26129 pubmed publisher
van der Poel S, Wolthoorn J, van den Heuvel D, Egmond M, Groux Degroote S, Neumann S, et al. Hyperacidification of trans-Golgi network and endo/lysosomes in melanocytes by glucosylceramide-dependent V-ATPase activity. Traffic. 2011;12:1634-47 pubmed publisher
Koivusalo M, Steinberg B, Mason D, Grinstein S. In situ measurement of the electrical potential across the lysosomal membrane using FRET. Traffic. 2011;12:972-82 pubmed publisher
Bartoletti T, Thoreson W. Quantal amplitude at the cone ribbon synapse can be adjusted by changes in cytosolic glutamate. Mol Vis. 2011;17:920-31 pubmed
Gendre D, Oh J, Boutté Y, Best J, Samuels L, Nilsson R, et al. Conserved Arabidopsis ECHIDNA protein mediates trans-Golgi-network trafficking and cell elongation. Proc Natl Acad Sci U S A. 2011;108:8048-53 pubmed publisher
Hong S, Qian J, Yang J, Li H, Kwak L, Yi Q. Roles of idiotype-specific t cells in myeloma cell growth and survival: Th1 and CTL cells are tumoricidal while Th2 cells promote tumor growth. Cancer Res. 2008;68:8456-64 pubmed publisher
Voelkl S, Moore T, Rehli M, Nishimura M, Mackensen A, Fischer K. Characterization of MHC class-I restricted TCRalphabeta+ CD4- CD8- double negative T cells recognizing the gp100 antigen from a melanoma patient after gp100 vaccination. Cancer Immunol Immunother. 2009;58:709-18 pubmed publisher
Dröse S, Bindseil K, Bowman E, Siebers A, Zeeck A, Altendorf K. Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases. Biochemistry. 1993;32:3902-6 pubmed
Nishihara T, Akifusa S, Koseki T, Kato S, Muro M, Hanada N. Specific inhibitors of vacuolar type H(+)-ATPases induce apoptotic cell death. Biochem Biophys Res Commun. 1995;212:255-62 pubmed
product information
Catalog Number :
C9705
Product Name :
Concanamycin A
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥70% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA