This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
8-(4-Chlorophenylthio)-2′-O-methyladenosine 3′,5′-cyclic monophosphate monosodium hydrate
catalog :
C8988
citations: 14
Reference
Chen Y, Huang G, Wang Y, Cheng M, Zhu F, Zhong J, et al. Exchange protein directly activated by cAMP (Epac) protects against airway inflammation and airway remodeling in asthmatic mice. Respir Res. 2019;20:285 pubmed publisher
Wiejak J, van Basten B, Luchowska Stańska U, Hamilton G, Yarwood S. The novel exchange protein activated by cyclic AMP 1 (EPAC1) agonist, I942, regulates inflammatory gene expression in human umbilical vascular endothelial cells (HUVECs). Biochim Biophys Acta Mol Cell Res. 2019;1866:264-276 pubmed publisher
Dale P, Head V, Dowling M, Taylor C. Selective inhibition of histamine-evoked Ca2+ signals by compartmentalized cAMP in human bronchial airway smooth muscle cells. Cell Calcium. 2018;71:53-64 pubmed publisher
Nuamnaichati N, Sato V, Moongkarndi P, Parichatikanond W, Mangmool S. Sustained ?-AR stimulation induces synthesis and secretion of growth factors in cardiac myocytes that affect on cardiac fibroblast activation. Life Sci. 2018;193:257-269 pubmed publisher
Dominguez Soto A, Usategui A, Casas Engel M, Simón Fuentes M, Nieto C, Cuevas V, et al. Serotonin drives the acquisition of a profibrotic and anti-inflammatory gene profile through the 5-HT7R-PKA signaling axis. Sci Rep. 2017;7:14761 pubmed publisher
Li M, Hothi S, Salvage S, Jeevaratnam K, Grace A, Huang C. Arrhythmic effects of Epac-mediated ryanodine receptor activation in Langendorff-perfused murine hearts are associated with reduced conduction velocity. Clin Exp Pharmacol Physiol. 2017;44:686-692 pubmed publisher
Sun W, Jiao W, Huang Y, Li R, Zhang Z, Wang J, et al. Exchange proteins directly activated by cAMP induce the proliferation of rat anterior pituitary GH3 cells via the activation of extracellular signal-regulated kinase. Biochem Biophys Res Commun. 2017;485:355-359 pubmed publisher
Blackwood B, Wood D, Yuan C, Nicolas J, De Plaen I, Farrow K, et al. A Role for cAMP and Protein Kinase A in Experimental Necrotizing Enterocolitis. Am J Pathol. 2017;187:401-417 pubmed publisher
Fogli S, Stefanelli F, Battolla B, Bianchi F, Breschi M, Mattii L. Salbutamol inhibits RhoA activation in normal but not in desensitized bronchial smooth muscle cells. J Pharm Pharmacol. 2015;67:1416-20 pubmed publisher
Yao Y, Cui X, Al Ramahi I, Sun X, Li B, Hou J, et al. A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity. elife. 2015;4: pubmed publisher
Ruete M, Lucchesi O, Bustos M, Tomes C. Epac, Rap and Rab3 act in concert to mobilize calcium from sperm's acrosome during exocytosis. Cell Commun Signal. 2014;12:43 pubmed publisher
CHRUSCINSKI A, Singh H, Chan S, Utz P. Broad-scale phosphoprotein profiling of beta adrenergic receptor (?-AR) signaling reveals novel phosphorylation and dephosphorylation events. PLoS ONE. 2013;8:e82164 pubmed publisher
Huang H, Chikazu D, Voznesensky O, Herschman H, Kream B, Drissi H, et al. Parathyroid hormone induction of cyclooxygenase-2 in murine osteoblasts: role of the calcium-calcineurin-NFAT pathway. J Bone Miner Res. 2010;25:819-29 pubmed publisher
Roscioni S, Kistemaker L, Menzen M, Elzinga C, Gosens R, Halayko A, et al. PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells. Respir Res. 2009;10:88 pubmed publisher
product information
Catalog Number :
C8988
Product Name :
8-(4-Chlorophenylthio)-2′-O-methyladenosine 3′,5′-cyclic monophosphate monosodium hydrate
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA