This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Clofazimine
catalog :
C8895
citations: 56
Reference
Mulkearns Hubert E, Torre Healy L, Silver D, Eurich J, Bayık D, Serbinowski E, et al. Development of a Cx46 Targeting Strategy for Cancer Stem Cells. Cell Rep. 2019;27:1062-1072.e5 pubmed publisher
Ajmal M, Almutairi F, Zaidi N, Alam P, Siddiqi M, Khan M, et al. Biophysical insights into the interaction of clofazimine with human alpha 1-acid glycoprotein: a multitechnique approach. J Biomol Struct Dyn. 2019;37:1390-1401 pubmed publisher
Murashov M, Lalone V, Rzeczycki P, Keswani R, Yoon G, Sud S, et al. The Physicochemical Basis of Clofazimine-Induced Skin Pigmentation. J Invest Dermatol. 2018;138:697-703 pubmed publisher
Officioso A, Alzoubi K, Manna C, Lang F. Clofazimine Induced Suicidal Death of Human Erythrocytes. Cell Physiol Biochem. 2015;37:331-41 pubmed publisher
Faouzi M, Starkus J, Penner R. State-dependent blocking mechanism of Kv 1.3 channels by the antimycobacterial drug clofazimine. Br J Pharmacol. 2015;172:5161-73 pubmed publisher
Kaiser M, Maser P, Tadoori L, Ioset J, Brun R. Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning. PLoS ONE. 2015;10:e0135556 pubmed publisher
Panić G, Vargas M, Scandale I, Keiser J. Activity Profile of an FDA-Approved Compound Library against Schistosoma mansoni. PLoS Negl Trop Dis. 2015;9:e0003962 pubmed publisher
Shimokawa Y, Yoda N, Kondo S, Yamamura Y, Takiguchi Y, Umehara K. Inhibitory Potential of Twenty Five Anti-tuberculosis Drugs on CYP Activities in Human Liver Microsomes. Biol Pharm Bull. 2015;38:1425-9 pubmed publisher
Vocat A, Hartkoorn R, Lechartier B, Zhang M, Dhar N, Cole S, et al. Bioluminescence for assessing drug potency against nonreplicating Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2015;59:4012-9 pubmed publisher
Koot D, Cromarty D. Anticancer efficacy and toxicokinetics of a novel paclitaxel-clofazimine nanoparticulate co-formulation. Drug Deliv Transl Res. 2015;5:257-67 pubmed publisher
Tyagi S, Ammerman N, Li S, Adamson J, Converse P, Swanson R, et al. Clofazimine shortens the duration of the first-line treatment regimen for experimental chemotherapy of tuberculosis. Proc Natl Acad Sci U S A. 2015;112:869-74 pubmed publisher
Grossman T, Shoen C, Jones S, Jones P, Cynamon M, Locher C. The efflux pump inhibitor timcodar improves the potency of antimycobacterial agents. Antimicrob Agents Chemother. 2015;59:1534-41 pubmed publisher
Marcos L, Conerly S, Walker S. Leprosy. Am J Trop Med Hyg. 2014;91:216 pubmed publisher
Srikanth C, Joshi P, Bikkasani A, Porwal K, Gayen J. Bone distribution study of anti leprotic drug clofazimine in rat bone marrow cells by a sensitive reverse phase liquid chromatography method. J Chromatogr B Analyt Technol Biomed Life Sci. 2014;960:82-6 pubmed publisher
Adams K, Szumowski J, Ramakrishnan L. Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs. J Infect Dis. 2014;210:456-66 pubmed publisher
Oh C, Moon C, Park O, Kwon S, Jang J. Novel drug combination for Mycobacterium abscessus disease therapy identified in a Drosophila infection model. J Antimicrob Chemother. 2014;69:1599-607 pubmed publisher
Yoo J, Lyu J, Lee S, Kim W, Kim D, Shim T. Clinical experience of using clofazimine to treat multidrug-resistant tuberculosis [Correspondence]. Int J Tuberc Lung Dis. 2013;17:1243-4 pubmed publisher
Grosset J, Tyagi S, Almeida D, Converse P, Li S, Ammerman N, et al. Assessment of clofazimine activity in a second-line regimen for tuberculosis in mice. Am J Respir Crit Care Med. 2013;188:608-12 pubmed publisher
Hossain D. Using methotrexate to treat patients with ENL unresponsive to steroids and clofazimine: a report on 9 patients. Lepr Rev. 2013;84:105-12 pubmed
Gopal M, Padayatchi N, Metcalfe J, O Donnell M. Systematic review of clofazimine for the treatment of drug-resistant tuberculosis. Int J Tuberc Lung Dis. 2013;17:1001-7 pubmed publisher
Bhaumik S. Clofazimine should be used in all cases of leprosy, says Indian research council. BMJ. 2013;346:f1963 pubmed publisher
Paniz Mondolfi A, Cressey B, Ahmad A, Tapia Centola B, Cohen L, Mahmoodi M. Granulomatous alopecia: a variant of alopecia areata?. J Cutan Pathol. 2013;40:357-60 pubmed publisher
Tirhazouine I, Chiheb S, Hali F, Rifki A, Benchikhi H. [Histoid leprosy]. Ann Dermatol Venereol. 2013;140:244-5 pubmed publisher
Weberschock T, Göttig S. A young man with livid facial nodules and a loss of eyebrows. Lancet Infect Dis. 2013;13:276 pubmed publisher
Massone C, Clapasson A, Nunzi E. Borderline lepromatous leprosy in an Italian man. Am J Trop Med Hyg. 2013;88:211 pubmed publisher
Deps P, Guerra P, Nasser S, Simon M. Hemolytic anemia in patients receiving daily dapsone for the treatment of leprosy. Lepr Rev. 2012;83:305-7 pubmed
Cunha M, Virmond M, Schettini A, Cruz R, Ura S, Ghuidella C, et al. OFLOXACIN multicentre trial in MB leprosy FUAM-Manaus and ILSL-Bauru, Brazil. Lepr Rev. 2012;83:261-8 pubmed
Lockwood D, Cunha M. Developing new MDT regimens for MB patients; time to test ROM 12 month regimens globally. Lepr Rev. 2012;83:241-4 pubmed
Wu X, Cherian P, Lee R, Hurdle J. The membrane as a target for controlling hypervirulent Clostridium difficile infections. J Antimicrob Chemother. 2013;68:806-15 pubmed publisher
Baik J, Stringer K, Mane G, Rosania G. Multiscale distribution and bioaccumulation analysis of clofazimine reveals a massive immune system-mediated xenobiotic sequestration response. Antimicrob Agents Chemother. 2013;57:1218-30 pubmed publisher
Degang Y, Akama T, Hara T, Tanigawa K, Ishido Y, Gidoh M, et al. Clofazimine modulates the expression of lipid metabolism proteins in Mycobacterium leprae-infected macrophages. PLoS Negl Trop Dis. 2012;6:e1936 pubmed publisher
Rodríguez G, Abaúnza M, Vargas E, Lopez F. [Leprosy and the testis]. Biomedica. 2012;32:13-22 pubmed publisher
Verma R, Germishuizen W, Motheo M, Agrawal A, Singh A, Mohan M, et al. Inhaled microparticles containing clofazimine are efficacious in treatment of experimental tuberculosis in mice. Antimicrob Agents Chemother. 2013;57:1050-2 pubmed publisher
Bailly N, Thomas M, Klumperman B. Poly(N-vinylpyrrolidone)-block-poly(vinyl acetate) as a drug delivery vehicle for hydrophobic drugs. Biomacromolecules. 2012;13:4109-17 pubmed publisher
Baik J, Rosania G. Macrophages sequester clofazimine in an intracellular liquid crystal-like supramolecular organization. PLoS ONE. 2012;7:e47494 pubmed publisher
Dey T, Brigden G, Cox H, Shubber Z, Cooke G, Ford N. Outcomes of clofazimine for the treatment of drug-resistant tuberculosis: a systematic review and meta-analysis. J Antimicrob Chemother. 2013;68:284-93 pubmed publisher
van Ingen J, Totten S, Helstrom N, Heifets L, Boeree M, Daley C. In vitro synergy between clofazimine and amikacin in treatment of nontuberculous mycobacterial disease. Antimicrob Agents Chemother. 2012;56:6324-7 pubmed publisher
Wang T, Lee M, Choi E, Pardo Villamizar C, Lee S, Yang I, et al. Granzyme B-induced neurotoxicity is mediated via activation of PAR-1 receptor and Kv1.3 channel. PLoS ONE. 2012;7:e43950 pubmed publisher
Zhang D, Lu Y, Liu K, Liu B, Wang J, Zhang G, et al. Identification of less lipophilic riminophenazine derivatives for the treatment of drug-resistant tuberculosis. J Med Chem. 2012;55:8409-17 pubmed publisher
Zhang M, Sala C, Hartkoorn R, Dhar N, Mendoza Losana A, Cole S. Streptomycin-starved Mycobacterium tuberculosis 18b, a drug discovery tool for latent tuberculosis. Antimicrob Agents Chemother. 2012;56:5782-9 pubmed publisher
Adar T, Tayer Shifman O, Mizrahi M, Tavdi S, Barak O, Shalit M. Dapsone induced eosinophilic pneumonia. Eur Ann Allergy Clin Immunol. 2012;44:144-6 pubmed
Grant S, Kaufmann B, Chand N, Haseley N, Hung D. Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals. Proc Natl Acad Sci U S A. 2012;109:12147-52 pubmed publisher
Madke B, Ghia D, Gadkari R, Nayak C. Cheilitis granulomatosa (Miescher granulomatous macrocheilitis) with trisomy 21. Dermatol Online J. 2012;18:7 pubmed
Xu J, Lu Y, Fu L, Zhu H, Wang B, Mdluli K, et al. In vitro and in vivo activity of clofazimine against Mycobacterium tuberculosis persisters. Int J Tuberc Lung Dis. 2012;16:1119-25 pubmed publisher
Cholo M, Steel H, Fourie P, Germishuizen W, Anderson R. Clofazimine: current status and future prospects. J Antimicrob Chemother. 2012;67:290-8 pubmed publisher
Gurfinkel P, Pina J, Ramos e Silva M. Use of clofazimine in dermatology. J Drugs Dermatol. 2009;8:846-51 pubmed
. Clofazimine. Tuberculosis (Edinb). 2008;88:96-9 pubmed publisher
Pais A, Pereira S, Garg I, Stephen J, Antony M, Inchara Y. Intra-abdominal, crystal-storing histiocytosis due to clofazimine in a patient with lepromatous leprosy and concurrent carcinoma of the colon. Lepr Rev. 2004;75:171-6 pubmed
Ridder G, Fradis M, Lohle E. Cheilitis granulomatosa Miescher: treatment with clofazimine and review of the literature. Ann Otol Rhinol Laryngol. 2001;110:964-7 pubmed
Sanchez M. Miscellaneous treatments: thalidomide, potassium iodide, levamisole, clofazimine, colchicine, and D-penicillamine. Clin Dermatol. 2000;18:131-45 pubmed
O CONNOR R, O Sullivan J, O Kennedy R. The pharmacology, metabolism, and chemistry of clofazimine. Drug Metab Rev. 1995;27:591-614 pubmed
Arbiser J, Moschella S. Clofazimine: a review of its medical uses and mechanisms of action. J Am Acad Dermatol. 1995;32:241-7 pubmed
Holdiness M. Clinical pharmacokinetics of clofazimine. A review. Clin Pharmacokinet. 1989;16:74-85 pubmed
Garrelts J. Clofazimine: a review of its use in leprosy and Mycobacterium avium complex infection. DICP. 1991;25:525-31 pubmed
Kumar B. Clofazimine--a review. Indian J Lepr. 1991;63:78-92 pubmed
Freerksen E, Seydel J. Critical comments on the treatment of leprosy and other mycobacterial infections with clofazimine. Arzneimittelforschung. 1992;42:1243-5 pubmed
product information
Catalog Number :
C8895
Product Name :
Clofazimine
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA