This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
protein
product name :
Cytochrome P450 Reductase human
catalog :
C8113
citations: 60
Reference
Minerdi D, Sadeghi S, Pautasso L, Morra S, Aigotti R, Medana C, et al. Expression and role of CYP505A1 in pathogenicity of Fusarium oxysporum f. sp. lactucae. Biochim Biophys Acta Proteins Proteom. 2020;1868:140268 pubmed publisher
Froeling F, Swamynathan M, Deschênes A, Chio I, Brosnan E, Yao M, et al. Bioactivation of Napabucasin Triggers Reactive Oxygen Species-Mediated Cancer Cell Death. Clin Cancer Res. 2019;25:7162-7174 pubmed publisher
Sun X, Wu C, Qiu Y, Wu Y, Chen J, Huang J, et al. Heme oxygenase-1 attenuates seawater drowning-induced acute lung injury through a reduction in inflammation and oxidative stress. Int Immunopharmacol. 2019;74:105634 pubmed publisher
Kadowaki T, Yukitake H, Naito M, Sato K, Kikuchi Y, Kondo Y, et al. A two-component system regulates gene expression of the type IX secretion component proteins via an ECF sigma factor. Sci Rep. 2016;6:23288 pubmed publisher
Meints C, Parke S, Wolthers K. Proximal FAD histidine residue influences interflavin electron transfer in cytochrome P450 reductase and methionine synthase reductase. Arch Biochem Biophys. 2014;547:18-26 pubmed publisher
Sugishima M, Sato H, Higashimoto Y, Harada J, Wada K, Fukuyama K, et al. Structural basis for the electron transfer from an open form of NADPH-cytochrome P450 oxidoreductase to heme oxygenase. Proc Natl Acad Sci U S A. 2014;111:2524-9 pubmed publisher
Cankar K, van Houwelingen A, Goedbloed M, Renirie R, de Jong R, Bouwmeester H, et al. Valencene oxidase CYP706M1 from Alaska cedar (Callitropsis nootkatensis). FEBS Lett. 2014;588:1001-7 pubmed publisher
Stiborova M, Moserova M, Cerná V, Indra R, Dracinsky M, Sulc M, et al. Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions. Toxicology. 2014;318:1-12 pubmed publisher
Oguro A, Koyama C, Xu J, Imaoka S. A cellular stress response (CSR) that interacts with NADPH-P450 reductase (NPR) is a new regulator of hypoxic response. Biochem Biophys Res Commun. 2014;445:43-7 pubmed publisher
Simtchouk S, Eng J, Meints C, Makins C, Wolthers K. Kinetic analysis of cytochrome P450 reductase from Artemisia annua reveals accelerated rates of NADH-dependent flavin reduction. FEBS J. 2013;280:6627-42 pubmed publisher
Su J, Gu Y, Pruijn F, Smaill J, Patterson A, Guise C, et al. Zinc finger nuclease knock-out of NADPH:cytochrome P450 oxidoreductase (POR) in human tumor cell lines demonstrates that hypoxia-activated prodrugs differ in POR dependence. J Biol Chem. 2013;288:37138-53 pubmed publisher
Zhu Y, Ding X, Fang C, Zhang Q. Regulation of intestinal cytochrome P450 expression by hepatic cytochrome P450: possible involvement of fibroblast growth factor 15 and impact on systemic drug exposure. Mol Pharmacol. 2014;85:139-47 pubmed publisher
Weightman P, Smith C, Convery J, Harrison P, Khara B, Scrutton N. Conformational change induced by electron transfer in a monolayer of cytochrome P450 reductase adsorbed at the Au(110)-phosphate buffer interface. Phys Rev E Stat Nonlin Soft Matter Phys. 2013;88:032715 pubmed
Elens L, Sombogaard F, Hesselink D, van Schaik R, van Gelder T. Single-nucleotide polymorphisms in P450 oxidoreductase and peroxisome proliferator-activated receptor-α are associated with the development of new-onset diabetes after transplantation in kidney transplant recipients treated with tacrolimus. Pharmacogenet Genomics. 2013;23:649-57 pubmed publisher
Tran N, Nguyen D, Dwaraknath S, Mahadevan S, Chavez G, Nguyen A, et al. An efficient light-driven P450 BM3 biocatalyst. J Am Chem Soc. 2013;135:14484-7 pubmed publisher
Huang W, Ellis J, Moody P, Raven E, Roberts G. Redox-linked domain movements in the catalytic cycle of cytochrome p450 reductase. Structure. 2013;21:1581-9 pubmed publisher
Lee C, Ding X, Riddick D. Downregulation of mouse hepatic CYP3A protein by 3-methylcholanthrene does not require cytochrome P450-dependent metabolism. Drug Metab Dispos. 2013;41:1782-6 pubmed publisher
Chandor Proust A, Bibby J, Régent Kloeckner M, Roux J, Guittard Crilat E, Poupardin R, et al. The central role of mosquito cytochrome P450 CYP6Zs in insecticide detoxification revealed by functional expression and structural modelling. Biochem J. 2013;455:75-85 pubmed publisher
Arendse L, Blundell T, Blackburn J. Combining in silico protein stability calculations with structure-function relationships to explore the effect of polymorphic variation on cytochrome P450 drug metabolism. Curr Drug Metab. 2013;14:745-63 pubmed
Nishida C, Everett S, Ortiz de Montellano P. Specificity determinants of CYP1B1 estradiol hydroxylation. Mol Pharmacol. 2013;84:451-8 pubmed publisher
Pengpai Z, Sheng H, Lehe M, Yinlin L, Zhihua J, Guixiang H. Improving the activity of cytochrome P450 BM-3 catalyzing indole hydroxylation by directed evolution. Appl Biochem Biotechnol. 2013;171:93-103 pubmed publisher
Jiang D, Tu R, Bai P, Wang Q. Directed evolution of cytochrome P450 for sterol epoxidation. Biotechnol Lett. 2013;35:1663-8 pubmed publisher
van de Waterbeemd B, Zomer G, Kaaijk P, Ruiterkamp N, Wijffels R, van den Dobbelsteen G, et al. Improved production process for native outer membrane vesicle vaccine against Neisseria meningitidis. PLoS ONE. 2013;8:e65157 pubmed publisher
Liu S, Yao Y, Lu S, ALDOUS K, Ding X, Mei C, et al. The role of renal proximal tubule P450 enzymes in chloroform-induced nephrotoxicity: utility of renal specific P450 reductase knockout mouse models. Toxicol Appl Pharmacol. 2013;272:230-7 pubmed publisher
Xie Z, Liu W, Xu Y, Chen S. [Optimization of tri-expression of human CYP3A4 with POR and cyt b5 in Sf 9 cells]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2013;42:38-44 pubmed
Su J, Guise C, Wilson W. FSL-61 is a 6-nitroquinolone fluorogenic probe for one-electron reductases in hypoxic cells. Biochem J. 2013;452:79-86 pubmed publisher
Nambu S, Matsui T, Goulding C, Takahashi S, Ikeda Saito M. A new way to degrade heme: the Mycobacterium tuberculosis enzyme MhuD catalyzes heme degradation without generating CO. J Biol Chem. 2013;288:10101-9 pubmed publisher
Marchenko M, Ketsa O. [Generation of superoxide anion-radical in the liver monooxygenase system of preliminary radiation-exposed tumor-bearing rats]. Ukr Biokhim Zh (1999). 2012;84:101-8 pubmed
Stiborova M, Cechova T, Bořek Dohalská L, Moserova M, Frei E, Schmeiser H, et al. Activation and detoxification metabolism of urban air pollutants 2-nitrobenzanthrone and carcinogenic 3-nitrobenzanthrone by rat and mouse hepatic microsomes. Neuro Endocrinol Lett. 2012;33 Suppl 3:8-15 pubmed
Meints C, Simtchouk S, Wolthers K. Aromatic substitution of the FAD-shielding tryptophan reveals its differential role in regulating electron flux in methionine synthase reductase and cytochrome P450 reductase. FEBS J. 2013;280:1460-74 pubmed publisher
Haque M, Bayachou M, Fadlalla M, Durra D, Stuehr D. Charge-pairing interactions control the conformational setpoint and motions of the FMN domain in neuronal nitric oxide synthase. Biochem J. 2013;450:607-17 pubmed publisher
Sideri A, Goyal A, Di Nardo G, Tsotsou G, Gilardi G. Hydroxylation of non-substituted polycyclic aromatic hydrocarbons by cytochrome P450 BM3 engineered by directed evolution. J Inorg Biochem. 2013;120:1-7 pubmed publisher
Lee C, Ding X, Riddick D. The role of cytochrome P450-dependent metabolism in the regulation of mouse hepatic growth hormone signaling components and target genes by 3-methylcholanthrene. Drug Metab Dispos. 2013;41:457-65 pubmed publisher
Zhang P, Jia K, Fang C, Zhou X, Ding X, Zhang Q. Dietary regulation of mouse intestinal P450 expression and drug metabolism. Drug Metab Dispos. 2013;41:529-35 pubmed publisher
Araki N, Tsuruoka S, Hasegawa G, Yanagihara H, Omasa T, Enosawa S, et al. Inhibition of CYP3A4 by 6',7'-dihydroxybergamottin in human CYP3A4 over-expressed hepG2 cells. J Pharm Pharmacol. 2012;64:1715-21 pubmed publisher
Schuckel J, Rylott E, Grogan G, Bruce N. A gene-fusion approach to enabling plant cytochromes p450 for biocatalysis. Chembiochem. 2012;13:2758-63 pubmed publisher
Miller W. P450 oxidoreductase deficiency: a disorder of steroidogenesis with multiple clinical manifestations. Sci Signal. 2012;5:pt11 pubmed publisher
Riddick D, Ding X, Wolf C, Porter T, Pandey A, Zhang Q, et al. NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology. Drug Metab Dispos. 2013;41:12-23 pubmed publisher
Shen Q, Chen Y, Wang T, Wu S, Lu X, Zhang L, et al. Overexpression of the cytochrome P450 monooxygenase (cyp71av1) and cytochrome P450 reductase (cpr) genes increased artemisinin content in Artemisia annua (Asteraceae). Genet Mol Res. 2012;11:3298-309 pubmed publisher
Hu L, Zhuo W, He Y, Zhou H, Fan L. Pharmacogenetics of P450 oxidoreductase: implications in drug metabolism and therapy. Pharmacogenet Genomics. 2012;22:812-9 pubmed publisher
Kenaan C, Shea E, Lin H, Zhang H, Pratt Hyatt M, Hollenberg P. Interactions between CYP2E1 and CYP2B4: effects on affinity for NADPH-cytochrome P450 reductase and substrate metabolism. Drug Metab Dispos. 2013;41:101-10 pubmed publisher
Lin H, Kenaan C, Zhang H, Hollenberg P. Reaction of human cytochrome P450 3A4 with peroxynitrite: nitrotyrosine formation on the proximal side impairs its interaction with NADPH-cytochrome P450 reductase. Chem Res Toxicol. 2012;25:2642-53 pubmed publisher
Zhao Y, Vanhoutte P, Leung S. Endothelial nitric oxide synthase-independent release of nitric oxide in the aorta of the spontaneously hypertensive rat. J Pharmacol Exp Ther. 2013;344:15-22 pubmed publisher
Convery J, Smith C, Khara B, Scrutton N, Harrison P, Farrell T, et al. Controlling the formation of a monolayer of cytochrome P450 reductase onto Au surfaces. Phys Rev E Stat Nonlin Soft Matter Phys. 2012;86:011903 pubmed
Pottier M, Bozzolan F, Chertemps T, Jacquin Joly E, Lalouette L, Siaussat D, et al. Cytochrome P450s and cytochrome P450 reductase in the olfactory organ of the cotton leafworm Spodoptera littoralis. Insect Mol Biol. 2012;21:568-80 pubmed publisher
Iyanagi T, Xia C, KIM J. NADPH-cytochrome P450 oxidoreductase: prototypic member of the diflavin reductase family. Arch Biochem Biophys. 2012;528:72-89 pubmed publisher
Lee C, Riddick D. Aryl hydrocarbon receptor-dependence of dioxin's effects on constitutive mouse hepatic cytochromes P450 and growth hormone signaling components. Can J Physiol Pharmacol. 2012;90:1354-63 pubmed publisher
Dudka J, Burdan F, Korga A, Iwan M, Madej Czerwonka B, Cendrowska Pinkosz M, et al. Intensification of doxorubicin-related oxidative stress in the heart by hypothyroidism is not related to the expression of cytochrome P450 NADPH-reductase and inducible nitric oxide synthase, as well as activity of xanthine oxidase. Oxid Med Cell Longev. 2012;2012:139327 pubmed publisher
Geier M, Braun A, Emmerstorfer A, Pichler H, Glieder A. Production of human cytochrome P450 2D6 drug metabolites with recombinant microbes--a comparative study. Biotechnol J. 2012;7:1346-58 pubmed publisher
Vincent B, Morellet N, Fatemi F, Aigrain L, Truan G, Guittet E, et al. The closed and compact domain organization of the 70-kDa human cytochrome P450 reductase in its oxidized state as revealed by NMR. J Mol Biol. 2012;420:296-309 pubmed publisher
Fredenhagen A, Kittelmann M, Oberer L, Kuhn A, Kühnöl J, Délémonté T, et al. Biocatalytic synthesis and structure elucidation of cyclized metabolites of the deacetylase inhibitor panobinostat (LBH589). Drug Metab Dispos. 2012;40:1041-50 pubmed publisher
Pudney C, Khara B, Johannissen L, Scrutton N. Coupled motions direct electrons along human microsomal P450 Chains. PLoS Biol. 2011;9:e1001222 pubmed publisher
Penketh P, Baumann R, Shyam K, Williamson H, Ishiguro K, Zhu R, et al. 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119): a cytotoxic prodrug with two stable conformations differing in biological and physical properties. Chem Biol Drug Des. 2011;78:513-26 pubmed publisher
Masters B, Kamin H, Gibson Q, Williams C. STUDIES ON THE MECHANISM OF MICROSOMAL TRIPHOSPHOPYRIDINE NUCLEOTIDE-CYTOCHROME C REDUCTASE. J Biol Chem. 1965;240:921-31 pubmed
Williams C, Kamin H. Microsomal triphosphopyridine nucleotide-cytochrome c reductase of liver. J Biol Chem. 1962;237:587-95 pubmed
Gutierrez A, Grunau A, Paine M, Munro A, Wolf C, Roberts G, et al. Electron transfer in human cytochrome P450 reductase. Biochem Soc Trans. 2003;31:497-501 pubmed
Munro A, Noble M, Robledo L, Daff S, Chapman S. Determination of the redox properties of human NADPH-cytochrome P450 reductase. Biochemistry. 2001;40:1956-63 pubmed
Sevrioukova I, Peterson J. NADPH-P-450 reductase: structural and functional comparisons of the eukaryotic and prokaryotic isoforms. Biochimie. 1995;77:562-72 pubmed
Lu A, Junk K, Coon M. Resolution of the cytochrome P-450-containing omega-hydroxylation system of liver microsomes into three components. J Biol Chem. 1969;244:3714-21 pubmed
Masters B, Bilimoria M, Kamin H, Gibson Q. The mechanism of 1- and 2-electron transfers catalyzed by reduced triphosphopyridine nucleotide-cytochrome c reductase. J Biol Chem. 1965;240:4081-8 pubmed
product information
Catalog Number :
C8113
Product Name :
Cytochrome P450 Reductase human
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
recombinant, expressed in baculovirus infected insect cells
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA