This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
antibody
product name :
Monoclonal Anti-Ceramide antibody produced in mouse
catalog :
C8104
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
MID 15B4
reactivity :
human, mouse
application :
western blot, immunocytochemistry, flow cytometry
citations: 16
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; fig 1
Corcelle Termeau E, Vindeløv S, Hämälistö S, Mograbi B, Keldsbo A, Bräsen J, et al. Excess sphingomyelin disturbs ATG9A trafficking and autophagosome closure. Autophagy. 2016;12:833-49 pubmed publisher
  • flow cytometry; mouse; fig 4
Apostolidis S, Rodríguez Rodríguez N, Suárez Fueyo A, Dioufa N, Ozcan E, Crispín J, et al. Phosphatase PP2A is requisite for the function of regulatory T cells. Nat Immunol. 2016;17:556-64 pubmed publisher
  • western blot; mouse
Wang W, Fromm M. Sphingolipids are required for efficient triacylglycerol loss in conjugated linoleic Acid treated adipocytes. PLoS ONE. 2015;10:e0119005 pubmed publisher
  • immunocytochemistry; human; 1:500; fig 1
Patwardhan G, Hosain S, Liu D, Khiste S, Zhao Y, Bielawski J, et al. Ceramide modulates pre-mRNA splicing to restore the expression of wild-type tumor suppressor p53 in deletion-mutant cancer cells. Biochim Biophys Acta. 2014;1841:1571-80 pubmed publisher
Chen J, Liang B, Bian D, Luo Y, Yang J, Li Z, et al. Knockout of neutrophil elastase protects against western diet induced nonalcoholic steatohepatitis in mice by regulating hepatic ceramides metabolism. Biochem Biophys Res Commun. 2019;518:691-697 pubmed publisher
Torralba D, Baixauli F, Villarroya Beltri C, Fernandez Delgado I, Latorre Pellicer A, Acin Perez R, et al. Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts. Nat Commun. 2018;9:2658 pubmed publisher
Marshall M, Issa Y, Jakubauskas B, Stoskute M, Elackattu V, Marshall J, et al. Long-Term Improvement of Neurological Signs and Metabolic Dysfunction in a Mouse Model of Krabbe's Disease after Global Gene Therapy. Mol Ther. 2018;26:874-889 pubmed publisher
Kady N, Liu X, Lydic T, Syed M, Navitskaya S, Wang Q, et al. ELOVL4-Mediated Production of Very Long-Chain Ceramides Stabilizes Tight Junctions and Prevents Diabetes-Induced Retinal Vascular Permeability. Diabetes. 2018;67:769-781 pubmed publisher
Panda P, Naik P, Meher B, Das D, Mukhopadhyay S, Praharaj P, et al. PUMA dependent mitophagy by Abrus agglutinin contributes to apoptosis through ceramide generation. Biochim Biophys Acta Mol Cell Res. 2018;1865:480-495 pubmed publisher
Gabriel B, Al Tarrah M, Alhindi Y, Kilikevicius A, Venckunas T, Gray S, et al. H55N polymorphism is associated with low citrate synthase activity which regulates lipid metabolism in mouse muscle cells. PLoS ONE. 2017;12:e0185789 pubmed publisher
Shin K, Hwang I, Choe S, Park J, Ji Y, Kim J, et al. Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation. Nat Commun. 2017;8:1087 pubmed publisher
Singh R, Haka A, Brumfield A, Grosheva I, Bhardwaj P, Chin H, et al. Ceramide activation of RhoA/Rho kinase impairs actin polymerization during aggregated LDL catabolism. J Lipid Res. 2017;58:1977-1987 pubmed publisher
Jung W, Liu C, Yu Y, Chang Y, Lien W, Chao H, et al. Lipophagy prevents activity-dependent neurodegeneration due to dihydroceramide accumulation in vivo. EMBO Rep. 2017;18:1150-1165 pubmed publisher
Corriden R, Hollands A, Olson J, Derieux J, Lopez J, Chang J, et al. Tamoxifen augments the innate immune function of neutrophils through modulation of intracellular ceramide. Nat Commun. 2015;6:8369 pubmed publisher
Du T, Wang L, Duan C, Lu L, Zhang J, Gao G, et al. GBA deficiency promotes SNCA/α-synuclein accumulation through autophagic inhibition by inactivated PPP2A. Autophagy. 2015;11:1803-20 pubmed publisher
Sharma N, Mani P, Nandwani N, Mishra R, Rana A, Sarkar D. Reciprocal regulation of AKT and MAP kinase dictates virus-host cell fusion. J Virol. 2010;84:4366-82 pubmed publisher
product information
Catalog Number :
C8104
Product Name :
Monoclonal Anti-Ceramide antibody produced in mouse
Product Type :
ANTIBODIES - SIAL
Product Group :
Protein & Pathway Technologies
Host Species :
mouse
Clonality :
monoclonal
Conjugation :
unconjugated
Clone Name :
MID 15B4
Isotype :
IgM
Product Description :
clone MID 15B4, purified immunoglobulin, buffered aqueous solution
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA