This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
2-Chloro-N 6 -cyclopentyladenosine
catalog :
C7938
citations: 72
Reference
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Odagaki Y, Kinoshita M, Ota T, Meana J, Callado L, Matsuoka I, et al. Functional coupling between adenosine A1 receptors and G-proteins in rat and postmortem human brain membranes determined with conventional guanosine-5'-O-(3-[35S]thio)triphosphate ([35S]GTPγS) binding or [35S]GTPγS/immunoprecipitation assay. Purinergic Signal. 2018;14:177-190 pubmed publisher
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Mei H, Poonit N, Zhang Y, Ye C, Cai H, Yu C, et al. Activating adenosine A1 receptor accelerates PC12 cell injury via ADORA1/PKC/KATP pathway after intermittent hypoxia exposure. Mol Cell Biochem. 2018;446:161-170 pubmed publisher
Labazi H, Teng B, Mustafa S. Functional changes in vascular reactivity to adenosine receptor activation in type I diabetic mice. Eur J Pharmacol. 2018;820:191-197 pubmed publisher
Soni H, Peixoto Neves D, Buddington R, Adebiyi A. Adenosine A1 receptor-operated calcium entry in renal afferent arterioles is dependent on postnatal maturation of TRPC3 channels. Am J Physiol Renal Physiol. 2017;313:F1216-F1222 pubmed publisher
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Zuccarini M, Giuliani P, Buccella S, Di Liberto V, Mudo G, Belluardo N, et al. Modulation of the TGF-β1-induced epithelial to mesenchymal transition (EMT) mediated by P1 and P2 purine receptors in MDCK cells. Purinergic Signal. 2017;13:429-442 pubmed publisher
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Jackson E, Zhang Y, Cheng D. Alkaline Phosphatase Inhibitors Attenuate Renovascular Responses to Norepinephrine. Hypertension. 2017;69:484-493 pubmed publisher
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Cheng P, Zuo X, Ren Y, Bai S, Tang W, Chen X, et al. Adenosine A1-Receptors Modulate mTOR Signaling to Regulate White Matter Inflammatory Lesions Induced by Chronic Cerebral Hypoperfusion. Neurochem Res. 2016;41:3272-3277 pubmed
Vincenzi F, Ravani A, Pasquini S, Merighi S, Gessi S, Romagnoli R, et al. Positive allosteric modulation of A1 adenosine receptors as a novel and promising therapeutic strategy for anxiety. Neuropharmacology. 2016;111:283-292 pubmed publisher
Koszałka P, Gołuńska M, Urban A, Stasiłojć G, Stanisławowski M, Majewski M, et al. Specific Activation of A3, A2A and A1 Adenosine Receptors in CD73-Knockout Mice Affects B16F10 Melanoma Growth, Neovascularization, Angiogenesis and Macrophage Infiltration. PLoS ONE. 2016;11:e0151420 pubmed publisher
Almeida R, Comasseto D, Ramos D, Hansel G, Zimmer E, Loureiro S, et al. Guanosine Anxiolytic-Like Effect Involves Adenosinergic and Glutamatergic Neurotransmitter Systems. Mol Neurobiol. 2017;54:423-436 pubmed publisher
Searl T, Dynda D, Alanee S, El Zawahry A, McVary K, Silinsky E. A1 Adenosine Receptor-Mediated Inhibition of Parasympathetic Neuromuscular Transmission in Human and Murine Urinary Bladder. J Pharmacol Exp Ther. 2016;356:116-22 pubmed publisher
Romagnoli R, Baraldi P, Lopez Cara C, Cruz Lopez O, Moorman A, Massink A, et al. Synthesis and biological evaluation of a new series of 2-amino-3-aroyl thiophene derivatives as agonist allosteric modulators of the A1 adenosine receptor. A position-dependent effect study. Eur J Med Chem. 2015;101:185-204 pubmed publisher
Santafe M, Priego M, Obis T, Garcia N, Tomas M, Lanuza M, et al. Adenosine receptors and muscarinic receptors cooperate in acetylcholine release modulation in the neuromuscular synapse. Eur J Neurosci. 2015;42:1775-87 pubmed publisher
Hughes S, Cravetchi X, Vilas G, Hammond J. Adenosine A1 receptor activation modulates human equilibrative nucleoside transporter 1 (hENT1) activity via PKC-mediated phosphorylation of serine-281. Cell Signal. 2015;27:1008-18 pubmed publisher
Booker S, Pires N, Cobb S, Soares da Silva P, Vida I. Carbamazepine and oxcarbazepine, but not eslicarbazepine, enhance excitatory synaptic transmission onto hippocampal CA1 pyramidal cells through an antagonist action at adenosine A1 receptors. Neuropharmacology. 2015;93:103-15 pubmed publisher
Zhang X, Xia J, Qian D, Wang Y, Lin Y, Huang X, et al. An adenosine A1 agonist 2-chloro-N6 cyclopentyladenosine inhibits the angiotensin II-induced cardiomyocyte hypertrophy through the calcineurin pathway. Cardiology. 2014;129:153-62 pubmed publisher
Smith N, Bromley M, Denning D, Simpson A, Bowyer P. Elevated levels of the neutrophil chemoattractant pro-platelet basic protein in macrophages from individuals with chronic and allergic aspergillosis. J Infect Dis. 2015;211:651-60 pubmed publisher
Guo D, Venhorst S, Massink A, van Veldhoven J, Vauquelin G, Ijzerman A, et al. Molecular mechanism of allosteric modulation at GPCRs: insight from a binding kinetics study at the human A1 adenosine receptor. Br J Pharmacol. 2014;171:5295-312 pubmed publisher
Smith N, Hankinson J, Simpson A, Denning D, Bowyer P. Reduced expression of TLR3, TLR10 and TREM1 by human macrophages in Chronic cavitary pulmonary aspergillosis, and novel associations of VEGFA, DENND1B and PLAT. Clin Microbiol Infect. 2014;20:O960-8 pubmed publisher
Gao X, Lu Q, Chou G, Wang Z, Pan R, Xia Y, et al. Norisoboldine attenuates inflammatory pain via the adenosine A1 receptor. Eur J Pain. 2014;18:939-48 pubmed publisher
Yang Z, Tian Y, Liu Y, Hennessy S, Kron I, French B. Acute hyperglycemia abolishes ischemic preconditioning by inhibiting Akt phosphorylation: normalizing blood glucose before ischemia restores ischemic preconditioning. Oxid Med Cell Longev. 2013;2013:329183 pubmed publisher
Smith N, Hankinson J, Simpson A, Bowyer P, Denning D. A prominent role for the IL1 pathway and IL15 in susceptibility to chronic cavitary pulmonary aspergillosis. Clin Microbiol Infect. 2014;20:O480-8 pubmed publisher
Jackson E, Cheng D, Mi Z, Verrier J, Janesko Feldman K, Kochanek P. Role of CD73 in Renal Sympathetic Neurotransmission in the Mouse Kidney. Physiol Rep. 2013;1: pubmed
Kim J, Kim M, Ham A, Brown K, Greene R, D Agati V, et al. IL-11 is required for A1 adenosine receptor-mediated protection against ischemic AKI. J Am Soc Nephrol. 2013;24:1558-70 pubmed publisher
Langemeijer E, Verzijl D, Dekker S, IJzerman A. Functional selectivity of adenosine A1 receptor ligands?. Purinergic Signal. 2013;9:91-100 pubmed publisher
Crawford D, Jiang X, Taylor A, Mennerick S. Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro. J Neurosci. 2012;32:13100-10 pubmed
Hinze A, Mayer P, Harst A, von Kugelgen I. Adenosine A(3) receptor-induced proliferation of primary human coronary smooth muscle cells involving the induction of early growth response genes. J Mol Cell Cardiol. 2012;53:639-45 pubmed publisher
Tabor Godwin J, Tsueng G, Sayen M, Gottlieb R, Feuer R. The role of autophagy during coxsackievirus infection of neural progenitor and stem cells. Autophagy. 2012;8:938-53 pubmed publisher
Park S, Kim M, Kim J, Brown K, Haase V, D Agati V, et al. Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia. Kidney Int. 2012;82:878-91 pubmed publisher
Hu S, Dong H, Zhang H, Wang S, Hou L, Chen S, et al. Noninvasive limb remote ischemic preconditioning contributes neuroprotective effects via activation of adenosine A1 receptor and redox status after transient focal cerebral ischemia in rats. Brain Res. 2012;1459:81-90 pubmed publisher
Prakasam H, Herrington H, Roppolo J, Jackson E, Apodaca G. Modulation of bladder function by luminal adenosine turnover and A1 receptor activation. Am J Physiol Renal Physiol. 2012;303:F279-92 pubmed publisher
Luca M, Liuni A, Muxel S, Munzel T, Forconi S, Gori T, et al. Chronic pharmacological preconditioning against ischemia. Clin Hemorheol Microcirc. 2011;49:287-93 pubmed publisher
Hamil N, Cock H, Walker M. Acute down-regulation of adenosine A(1) receptor activity in status epilepticus. Epilepsia. 2012;53:177-88 pubmed publisher
Komatsu S, Dobson J, Ikebe M, Shea L, Fenton R. Crosstalk between adenosine A1 and ?1-adrenergic receptors regulates translocation of PKC? in isolated rat cardiomyocytes. J Cell Physiol. 2012;227:3201-7 pubmed publisher
Dacho A, Lyutenski S, Aust G, Dietz A. Highly selective A(1) -adenosine-agonist (2-chloro-N6-cyclopentyladenosine) and reduction of flap necrosis in adipocutaneous flaps in rats. Head Neck. 2012;34:1100-5 pubmed publisher
Teng B, Mustafa S. A(2A) adenosine receptor-mediated increase in coronary flow in hyperlipidemic APOE-knockout mice. J Exp Pharmacol. 2011;2011:59-68 pubmed
Bott Flügel L, Bernshausen A, Schneider H, Luppa P, Zimmermann K, Albrecht Küpper B, et al. Selective attenuation of norepinephrine release and stress-induced heart rate increase by partial adenosine A1 agonism. PLoS ONE. 2011;6:e18048 pubmed publisher
Littwitz C, Timpert M, Bender K, Pott L, Kienitz M. Autocrine signaling via A(1) adenosine receptors causes downregulation of M(2) receptors in adult rat atrial myocytes in vitro. Pflugers Arch. 2011;461:165-76 pubmed publisher
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Leshem Lev D, Hochhauser E, Chanyshev B, Isak A, Shainberg A. Adenosine A(1) and A (3) receptor agonists reduce hypoxic injury through the involvement of P38 MAPK. Mol Cell Biochem. 2010;345:153-60 pubmed publisher
Ponnoth D, Nadeem A, Tilley S, Mustafa S. Involvement of A1 adenosine receptors in altered vascular responses and inflammation in an allergic mouse model of asthma. Am J Physiol Heart Circ Physiol. 2010;299:H81-7 pubmed publisher
Wong A, Guo C, Gupta R, Housley G, Thorne P, Vlajkovic S. Post exposure administration of A(1) adenosine receptor agonists attenuates noise-induced hearing loss. Hear Res. 2010;260:81-8 pubmed publisher
Yang Z, Sun W, Hu K. Adenosine A(1) receptors selectively target protein kinase C isoforms to the caveolin-rich plasma membrane in cardiac myocytes. Biochim Biophys Acta. 2009;1793:1868-75 pubmed publisher
Fukuda M, Suzuki Y, Hino H, Kuzume K, Morimoto T, Ishii E. Adenosine A1 receptor blockage mediates theophylline-associated seizures. Epilepsia. 2010;51:483-7 pubmed publisher
Pritchett C, Pardee A, McGuirk S, Will M. The role of nucleus accumbens adenosine-opioid interaction in mediating palatable food intake. Brain Res. 2010;1306:85-92 pubmed publisher
Bozarov A, Wang Y, Yu J, Wunderlich J, Hassanain H, Alhaj M, et al. Activation of adenosine low-affinity A3 receptors inhibits the enteric short interplexus neural circuit triggered by histamine. Am J Physiol Gastrointest Liver Physiol. 2009;297:G1147-62 pubmed publisher
Xie C, Ran K, Liu J, Xu J, Chang Y. [Metallothionein mediates cardioprotection induced by delayed preconditioning with adenosine A1 receptor agonist in rabbits]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009;34:603-7 pubmed
Balakumar P, Singh H, Reddy K, Anand Srivastava M. Adenosine-A1 receptors activation restores the suppressed cardioprotective effects of ischemic preconditioning in hyperhomocysteinemic rat hearts. J Cardiovasc Pharmacol. 2009;54:204-12 pubmed publisher
Fenton R, Komatsu S, Ikebe M, Shea L, Dobson J. Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKC-epsilon to RACK2 in adult rat and mouse. Am J Physiol Heart Circ Physiol. 2009;297:H718-25 pubmed publisher
Kang E, Vedantham K, Long X, Dadarlat M, Dadara M, Kwon I, et al. Drug-eluting stent for delivery of signal pathway-specific 1,3-dipropyl-8-cyclopentyl xanthine. Mol Pharm. 2009;6:1110-7 pubmed publisher
Gao Z, Ye K, Göblyös A, Ijzerman A, Jacobson K. Flexible modulation of agonist efficacy at the human A3 adenosine receptor by the imidazoquinoline allosteric enhancer LUF6000. BMC Pharmacol. 2008;8:20 pubmed publisher
Narimatsu E, Niiya T, Kawamata M, Namiki A. Adenosine and adenosine uptake inhibitors potentiate the neuromuscular blocking action of rocuronium mediated by adenosine A(1) receptors in isolated rat diaphragms. Acta Anaesthesiol Scand. 2008;52:1415-22 pubmed publisher
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Romagnoli R, Baraldi P, Carrion M, Cara C, Cruz Lopez O, Iaconinoto M, et al. Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[N-(substituted) piperazin-1-yl]thiophenes as potent allosteric enhancers of the A1 adenosine receptor. J Med Chem. 2008;51:5875-9 pubmed publisher
Cappellacci L, Franchetti P, Vita P, Petrelli R, Lavecchia A, Jayaram H, et al. Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3'-C-methyladenosine derivatives. J Med Chem. 2008;51:4260-9 pubmed publisher
Jolly L, March J, Kemp P, Bennett T, Gardiner S. Regional haemodynamic responses to adenosine receptor activation vary across time following lipopolysaccharide treatment in conscious rats. Br J Pharmacol. 2008;154:1600-10 pubmed publisher
Nakav S, Chaimovitz C, Sufaro Y, Lewis E, Shaked G, Czeiger D, et al. Anti-inflammatory preconditioning by agonists of adenosine A1 receptor. PLoS ONE. 2008;3:e2107 pubmed publisher
Cappellacci L, Franchetti P, Vita P, Petrelli R, Lavecchia A, Costa B, et al. 5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 receptor from different species. Bioorg Med Chem. 2008;16:336-53 pubmed
Deaglio S, Dwyer K, Gao W, Friedman D, Usheva A, Erat A, et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med. 2007;204:1257-65 pubmed
Jacobson K, Gao Z, Tchilibon S, Duong H, Joshi B, Sonin D, et al. Semi-rational design of (north)-methanocarba nucleosides as dual acting A(1) and A(3) adenosine receptor agonists: novel prototypes for cardioprotection. J Med Chem. 2005;48:8103-7 pubmed
product information
Catalog Number :
C7938
Product Name :
2-Chloro-N 6 -cyclopentyladenosine
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
adenosine receptor agonist
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA