This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Charybdotoxin
catalog :
C7802
citations: 35
Reference
Lazzari Dean J, Gest A, Miller E. Optical estimation of absolute membrane potential using fluorescence lifetime imaging. elife. 2019;8: pubmed publisher
Albuquerque J, Assis V, Almeida A, Basílio I, Luciano M, Meireles B, et al. Antioxidant and vasorelaxant activities induced by northeastern Brazilian fermented grape skins. BMC Complement Altern Med. 2017;17:376 pubmed publisher
Behringer E, Shaw R, Westcott E, Socha M, Segal S. Aging impairs electrical conduction along endothelium of resistance arteries through enhanced Ca2+-activated K+ channel activation. Arterioscler Thromb Vasc Biol. 2013;33:1892-901 pubmed publisher
Banerjee A, Lee A, CAMPBELL E, MacKinnon R. Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel. elife. 2013;2:e00594 pubmed publisher
MacKenzie A, Dunning L, Ferrell W, Lockhart J. Angiotensin II Type 1 receptor blockade protects endothelium-derived hyperpolarising factor-mediated relaxation in a rat model of monoarthritis. Life Sci. 2013;92:1131-7 pubmed publisher
Feng J, Hu Y, Yi H, Yin S, Han S, Hu J, et al. Two conserved arginine residues from the SK3 potassium channel outer vestibule control selectivity of recognition by scorpion toxins. J Biol Chem. 2013;288:12544-53 pubmed publisher
Hua Z, Kobertz W. Chemical derivatization and purification of peptide-toxins for probing ion channel complexes. Methods Mol Biol. 2013;995:19-30 pubmed publisher
Stoneking C, Shivakumar O, Thomas D, Colledge W, Mason M. Voltage dependence of the Ca(2+)-activated K(+) channel K(Ca)3.1 in human erythroleukemia cells. Am J Physiol Cell Physiol. 2013;304:C858-72 pubmed publisher
Chen Z, Han S, Cao Z, Wu Y, Zhuo R, Li W. Fusion expression and purification of four disulfide-rich peptides reveals enterokinase secondary cleavage sites in animal toxins. Peptides. 2013;39:145-51 pubmed publisher
Bergeron Z, Bingham J. Scorpion toxins specific for potassium (K+) channels: a historical overview of peptide bioengineering. Toxins (Basel). 2012;4:1082-119 pubmed publisher
Nakamura K, Shimizu T, Tanaka K, Taniuchi K, Yokotani K. Involvement of presynaptic voltage-dependent Kv3 channel in endothelin-1-induced inhibition of noradrenaline release from rat gastric sympathetic nerves. Eur J Pharmacol. 2012;694:98-103 pubmed publisher
Pulkkinen V, Manson M, Säfholm J, Adner M, Dahlen S. The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea. Am J Physiol Lung Cell Mol Physiol. 2012;303:L956-66 pubmed publisher
Failli P, Vannacci A, Di Cesare Mannelli L, Motterlini R, Masini E. Relaxant effect of a water soluble carbon monoxide-releasing molecule (CORM-3) on spontaneously hypertensive rat aortas. Cardiovasc Drugs Ther. 2012;26:285-92 pubmed publisher
Baranowska Kuczko M, MacLean M, Kozłowska H, Malinowska B. Endothelium-dependent mechanisms of the vasodilatory effect of the endocannabinoid, anandamide, in the rat pulmonary artery. Pharmacol Res. 2012;66:251-9 pubmed publisher
Moretti M, Budni J, Ribeiro C, Rodrigues A. Involvement of different types of potassium channels in the antidepressant-like effect of ascorbic acid in the mouse tail suspension test. Eur J Pharmacol. 2012;687:21-7 pubmed publisher
Nikouee A, Khabiri M, Grissmer S, Ettrich R. Charybdotoxin and margatoxin acting on the human voltage-gated potassium channel hKv1.3 and its H399N mutant: an experimental and computational comparison. J Phys Chem B. 2012;116:5132-40 pubmed publisher
Gordon D, Chung S. Permeation and block of the Kv1.2 channel examined using brownian and molecular dynamics. Biophys J. 2011;101:2671-8 pubmed publisher
Chen R, Robinson A, Gordon D, Chung S. Modeling the binding of three toxins to the voltage-gated potassium channel (Kv1.3). Biophys J. 2011;101:2652-60 pubmed publisher
Gordon D, Chen R, Ho J, Coote M, Chung S. Rigid body Brownian dynamics as a tool for studying ion channel blockers. J Phys Chem B. 2012;116:1933-41 pubmed publisher
Chen Y, Hou L, Zhou X, Qiu D, Yuan W, Zhu L, et al. Inspiratory-activated and inspiratory-inhibited airway vagal preganglionic neurons in the ventrolateral medulla of neonatal rat are different in intrinsic electrophysiological properties. Respir Physiol Neurobiol. 2012;180:323-30 pubmed publisher
Budni J, Freitas A, Binfaré R, Rodrigues A. Role of potassium channels in the antidepressant-like effect of folic acid in the forced swimming test in mice. Pharmacol Biochem Behav. 2012;101:148-54 pubmed publisher
Chen X, Li Y, Hollenberg M, Triggle C, Ding H. The contribution of d-tubocurarine-sensitive and apamin-sensitive K-channels to EDHF-mediated relaxation of mesenteric arteries from eNOS-/- mice. J Cardiovasc Pharmacol. 2012;59:413-25 pubmed publisher
Jang J, Park J, Kim S, Lee S, Hong S, Ryu P. Property of large conductance Ca(2+)-activated K+ channels from Fasciola hepatica incorporated into planar lipid bilayer. Vet Parasitol. 2012;186:281-8 pubmed publisher
Liu W, Liu Y, Lai X, Kuang S. Intramuscular adipose is derived from a non-Pax3 lineage and required for efficient regeneration of skeletal muscles. Dev Biol. 2012;361:27-38 pubmed publisher
Wang K, Terrenoire C, Sampson K, Iyer V, Osteen J, Lu J, et al. Biophysical properties of slow potassium channels in human embryonic stem cell derived cardiomyocytes implicate subunit stoichiometry. J Physiol. 2011;589:6093-104 pubmed publisher
Kawanai T. Triclosan, an environmental pollutant from health care products, evokes charybdotoxin-sensitive hyperpolarization in rat thymocytes. Environ Toxicol Pharmacol. 2011;32:417-22 pubmed publisher
Mandala M, Gokina N, Barron C, Osol G. Endothelial-derived hyperpolarization factor (EDHF) contributes to PlGF-induced dilation of mesenteric resistance arteries from pregnant rats. J Vasc Res. 2012;49:43-9 pubmed publisher
Mustafa A, Sikka G, Gazi S, Steppan J, Jung S, Bhunia A, et al. Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels. Circ Res. 2011;109:1259-68 pubmed publisher
Khabiri M, Nikouee A, Cwiklik L, Grissmer S, Ettrich R. Charybdotoxin unbinding from the mKv1.3 potassium channel: a combined computational and experimental study. J Phys Chem B. 2011;115:11490-500 pubmed publisher
Laohapitakworn S, Thongbunchoo J, Nakkrasae L, Krishnamra N, Charoenphandhu N. Parathyroid hormone (PTH) rapidly enhances CFTR-mediated HCO?? secretion in intestinal epithelium-like Caco-2 monolayer: a novel ion regulatory action of PTH. Am J Physiol Cell Physiol. 2011;301:C137-49 pubmed publisher
Tenenholz T, Klenk K, Matteson D, Blaustein M, Weber D. Structural determinants of scorpion toxin affinity: the charybdotoxin (alpha-KTX) family of K(+)-channel blocking peptides. Rev Physiol Biochem Pharmacol. 2000;140:135-85 pubmed
Doughty J, Plane F, Langton P. Charybdotoxin and apamin block EDHF in rat mesenteric artery if selectively applied to the endothelium. Am J Physiol. 1999;276:H1107-12 pubmed publisher
Hanner M, Vianna Jorge R, Kamassah A, Schmalhofer W, Knaus H, Kaczorowski G, et al. The beta subunit of the high conductance calcium-activated potassium channel. Identification of residues involved in charybdotoxin binding. J Biol Chem. 1998;273:16289-96 pubmed
Garcia M, Knaus H, Munujos P, Slaughter R, Kaczorowski G. Charybdotoxin and its effects on potassium channels. Am J Physiol. 1995;269:C1-10 pubmed
Miller C. The charybdotoxin family of K+ channel-blocking peptides. Neuron. 1995;15:5-10 pubmed
product information
Catalog Number :
C7802
Product Name :
Charybdotoxin
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
≥90% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA