This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
protein
product name :
Cathepsin L from human liver
catalog :
C6854
citations: 60
Reference
Dean D, Lee J. pH-Dependent fibril maturation of a Pmel17 repeat domain isoform revealed by tryptophan fluorescence. Biochim Biophys Acta Proteins Proteom. 2019;: pubmed publisher
de Novais L, de Arueira C, Ferreira L, Ribeiro T, Sousa P, Jacinto M, et al. 4'-Hydroxy-6,7-methylenedioxy-3-methoxyflavone: A novel flavonoid from Dulacia egleri with potential inhibitory activity against cathepsins B and L. Fitoterapia. 2019;132:26-29 pubmed publisher
Flynn J, McGlinchey R, Walker R, Lee J. Structural features of α-synuclein amyloid fibrils revealed by Raman spectroscopy. J Biol Chem. 2018;293:767-776 pubmed publisher
Chauhan S, Tomar R. Efficient expression and purification of biologically active human cystatin proteins. Protein Expr Purif. 2016;118:10-7 pubmed publisher
Fujii T, Kamiya M, Urano Y. In vivo imaging of intraperitoneally disseminated tumors in model mice by using activatable fluorescent small-molecular probes for activity of cathepsins. Bioconjug Chem. 2014;25:1838-46 pubmed publisher
Wang D, Zhang M, Bian H, Dong H, Xu W, Xu X, et al. Proteolysis and cathepsin activities in the processing of dry-cured duck. Poult Sci. 2014;93:687-94 pubmed publisher
Minton K. Innate immunity: The inside story on complement activation. Nat Rev Immunol. 2014;14:61 pubmed publisher
Miller B, Friedman A, Choi H, Hogan J, McCammon J, Hook V, et al. The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L. J Nat Prod. 2014;77:92-9 pubmed publisher
Lajoie S, Wills Karp M. New twist on an ancient innate immune pathway. Immunity. 2013;39:1000-2 pubmed publisher
Liszewski M, Kolev M, Le Friec G, Leung M, Bertram P, Fara A, et al. Intracellular complement activation sustains T cell homeostasis and mediates effector differentiation. Immunity. 2013;39:1143-57 pubmed publisher
Laskar A, Eilertsen J, Li W, Yuan X. SPION primes THP1 derived M2 macrophages towards M1-like macrophages. Biochem Biophys Res Commun. 2013;441:737-42 pubmed publisher
Cui Z, Hwang S, Gomes A. Identification of the immunoproteasome as a novel regulator of skeletal muscle differentiation. Mol Cell Biol. 2014;34:96-109 pubmed publisher
Du X, Chen N, Wong A, Craik C, Bromme D. Elastin degradation by cathepsin V requires two exosites. J Biol Chem. 2013;288:34871-81 pubmed publisher
Tardif N, Klaude M, Lundell L, Thorell A, Rooyackers O. Autophagic-lysosomal pathway is the main proteolytic system modified in the skeletal muscle of esophageal cancer patients. Am J Clin Nutr. 2013;98:1485-92 pubmed publisher
Serra C, Sandor N, Jang H, Lee D, Toraldo G, Guarneri T, et al. The effects of testosterone deprivation and supplementation on proteasomal and autophagy activity in the skeletal muscle of the male mouse: differential effects on high-androgen responder and low-androgen responder muscle groups. Endocrinology. 2013;154:4594-606 pubmed publisher
Česen M, Repnik U, Turk V, Turk B. Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Cell Death Dis. 2013;4:e818 pubmed publisher
Wang Y, Qin S, Han R, Wu J, Liang Z, Qin Z, et al. Cathepsin L plays a role in quinolinic acid-induced NF-Κb activation and excitotoxicity in rat striatal neurons. PLoS ONE. 2013;8:e75702 pubmed publisher
Gonzales Santana B, Dalton J, Vasquez Camargo F, Parkinson M, Ndao M. The diagnosis of human fascioliasis by enzyme-linked immunosorbent assay (ELISA) using recombinant cathepsin L protease. PLoS Negl Trop Dis. 2013;7:e2414 pubmed publisher
Müller S, Faulhaber A, Sieber C, Pfeifer D, Hochberg T, Gansz M, et al. The endolysosomal cysteine cathepsins L and K are involved in macrophage-mediated clearance of Staphylococcus aureus and the concomitant cytokine induction. FASEB J. 2014;28:162-75 pubmed publisher
Gan X, Zhao G, Huang C, Rowe A, Purdham D, Karmazyn M. Identification of fat mass and obesity associated (FTO) protein expression in cardiomyocytes: regulation by leptin and its contribution to leptin-induced hypertrophy. PLoS ONE. 2013;8:e74235 pubmed publisher
Joshi S, Kim H, Feeley B, Liu X. Differential ubiquitin-proteasome and autophagy signaling following rotator cuff tears and suprascapular nerve injury. J Orthop Res. 2014;32:138-44 pubmed publisher
Primon M, Huszthy P, Motaln H, Talasila K, Torkar A, Bjerkvig R, et al. Cathepsin L silencing enhances arsenic trioxide mediated in vitro cytotoxicity and apoptosis in glioblastoma U87MG spheroids. Exp Cell Res. 2013;319:2637-48 pubmed publisher
Lv B, Lindholt J, Wang J, Cheng X, Shi G. Plasma levels of cathepsins L, K, and V and risks of abdominal aortic aneurysms: a randomized population-based study. Atherosclerosis. 2013;230:100-105 pubmed publisher
Sansri V, Changklungmoa N, Chaichanasak P, Sobhon P, Meemon K. Molecular cloning, characterization and functional analysis of a novel juvenile-specific cathepsin L of Fasciola gigantica. Acta Trop. 2013;128:76-84 pubmed publisher
Tholen S, Biniossek M, Gansz M, Ahrens T, Schlimpert M, Kizhakkedathu J, et al. Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis. Cell Mol Life Sci. 2014;71:899-916 pubmed publisher
Du L, Gao J, Bi F, Wang L, Liu C. A polarizable ellipsoidal force field for halogen bonds. J Comput Chem. 2013;34:2032-40 pubmed publisher
Wang D, Dong H, Zhang M, Liu F, Bian H, Zhu Y, et al. Changes in actomyosin dissociation and endogenous enzyme activities during heating and their relationship with duck meat tenderness. Food Chem. 2013;141:675-9 pubmed publisher
Huai J, Vögtle F, Jöckel L, Li Y, Kiefer T, Ricci J, et al. TNFα-induced lysosomal membrane permeability is downstream of MOMP and triggered by caspase-mediated NDUFS1 cleavage and ROS formation. J Cell Sci. 2013;126:4015-25 pubmed publisher
Sudhan D, Siemann D. Cathepsin L inhibition by the small molecule KGP94 suppresses tumor microenvironment enhanced metastasis associated cell functions of prostate and breast cancer cells. Clin Exp Metastasis. 2013;30:891-902 pubmed publisher
Arockiaraj J, Gnanam A, Muthukrishnan D, Thirumalai M, Pasupuleti M, Milton J, et al. Macrobrachium rosenbergii cathepsin L: molecular characterization and gene expression in response to viral and bacterial infections. Microbiol Res. 2013;168:569-79 pubmed publisher
Mullins S, Sameni M, Blum G, Bogyo M, Sloane B, Moin K. Three-dimensional cultures modeling premalignant progression of human breast epithelial cells: role of cysteine cathepsins. Biol Chem. 2012;393:1405-16 pubmed
Zhang Y, Lu Y, Liu J, Yang C, Feng Q, Xu W. A regulatory pathway, ecdysone-transcription factor relish-cathepsin L, is involved in insect fat body dissociation. PLoS Genet. 2013;9:e1003273 pubmed publisher
Marques C, Oliveira C, Alves S, Chaves S, Coutinho O, Corte Real M, et al. Acetate-induced apoptosis in colorectal carcinoma cells involves lysosomal membrane permeabilization and cathepsin D release. Cell Death Dis. 2013;4:e507 pubmed publisher
Pazgier M, Ericksen B, Ling M, Toth E, Shi J, Li X, et al. Structural and functional analysis of the pro-domain of human cathelicidin, LL-37. Biochemistry. 2013;52:1547-58 pubmed publisher
Duan Y, Liu P, Li J, Li J, Gao B, Chen P. [Cloning and expression analysis of Cathepsin L cDNA of Exopalaemon carinicauda]. Dongwuxue Yanjiu. 2013;34:39-46 pubmed publisher
Grotsky D, Gonzalez Suarez I, Novell A, Neumann M, Yaddanapudi S, Croke M, et al. BRCA1 loss activates cathepsin L-mediated degradation of 53BP1 in breast cancer cells. J Cell Biol. 2013;200:187-202 pubmed publisher
Dev A, Byrne S, Verma R, Ashton Rickardt P, Wojchowski D. Erythropoietin-directed erythropoiesis depends on serpin inhibition of erythroblast lysosomal cathepsins. J Exp Med. 2013;210:225-32 pubmed publisher
Kolypetri P, Jiang H, Carayanniotis G. Identification of pathogenic T cell epitopes near cathepsin cleavage sites in thyroglobulin. J Immunol. 2013;190:1466-71 pubmed publisher
Dou Z, Coppens I, Carruthers V. Non-canonical maturation of two papain-family proteases in Toxoplasma gondii. J Biol Chem. 2013;288:3523-34 pubmed publisher
Marzi A, Reinheckel T, Feldmann H. Cathepsin B & L are not required for ebola virus replication. PLoS Negl Trop Dis. 2012;6:e1923 pubmed publisher
Lee A, Bak H, Kim N, Kim M, Go H, Han J, et al. Cloning, heterologous expression, and enzymatic characterization of cathepsin L from starfish (Asterina pectinifera). Biosci Biotechnol Biochem. 2012;76:2342-6 pubmed
Chavarria G, Horsman M, Arispe W, Kumar G, Chen S, Strecker T, et al. Initial evaluation of the antitumour activity of KGP94, a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L. Eur J Med Chem. 2012;58:568-72 pubmed publisher
Arampatzidou M, Schütte A, Hansson G, Saftig P, Brix K. Effects of cathepsin K deficiency on intercellular junction proteins, luminal mucus layers, and extracellular matrix constituents in the mouse colon. Biol Chem. 2012;393:1391-403 pubmed publisher
Morin V, Sanchez Rubio A, Aze A, Iribarren C, Fayet C, Desdevises Y, et al. The protease degrading sperm histones post-fertilization in sea urchin eggs is a nuclear cathepsin L that is further required for embryo development. PLoS ONE. 2012;7:e46850 pubmed publisher
Torkar A, Bregant S, Devel L, Novinec M, Lenarcic B, Lah T, et al. A novel photoaffinity-based probe for selective detection of cathepsin L active form. Chembiochem. 2012;13:2616-21 pubmed publisher
Irwin L, Byers D. Novel odors affect gene expression for cytokines and proteinases in the rat amygdala and hippocampus. Brain Res. 2012;1489:1-7 pubmed publisher
Kanbak G, Kartkaya K, Ozcelik E, Guvenal A, Kabay S, Arslan G, et al. The neuroprotective effect of acute moderate alcohol consumption on caspase-3 mediated neuroapoptosis in traumatic brain injury: the role of lysosomal cathepsin L and nitric oxide. Gene. 2013;512:492-5 pubmed publisher
Yin M, Soikkeli J, Jahkola T, Virolainen S, Saksela O, Hölttä E. TGF-? signaling, activated stromal fibroblasts, and cysteine cathepsins B and L drive the invasive growth of human melanoma cells. Am J Pathol. 2012;181:2202-16 pubmed publisher
Kanbak G, Canbek M, Oğlakçı A, Kartkaya K, Senturk H, Bayramoglu G, et al. Preventive role of gallic acid on alcohol dependent and cysteine protease-mediated pancreas injury. Mol Biol Rep. 2012;39:10249-55 pubmed publisher
Mallinson J, Constantin Teodosiu D, Glaves P, Martin E, Davies W, Westwood F, et al. Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents. J Physiol. 2012;590:6389-402 pubmed publisher
He K, Zhou H, Pestka J. Mechanisms for ribotoxin-induced ribosomal RNA cleavage. Toxicol Appl Pharmacol. 2012;265:10-8 pubmed publisher
Reif M, Mach L, Oostenbrink C. Molecular insight into propeptide-protein interactions in cathepsins L and O. Biochemistry. 2012;51:8636-53 pubmed publisher
Hamet P. Future needs in exploration of gene-environment interactions. J Hypertens. 2012;30:1915-6 pubmed publisher
Sprawka I, Goławska S, Goławski A, Czerniewicz P, Sytykiewicz H. Antimetabolic effect of phytohemagglutinin to the grain aphid Sitobion avenae fabricius. Acta Biol Hung. 2012;63:342-53 pubmed publisher
Nakashima T, Yasumatsu R, Masuda M, Clayman G, Komune S. Prognostic value of cathepsin L and its inhibitor headpin in oral squamous cell carcinoma. J Laryngol Otol. 2012;126:1134-7 pubmed publisher
Biswas N, Rodriguez Flores J, Courel M, Gayen J, Vaingankar S, Mahata M, et al. Cathepsin L colocalizes with chromogranin a in chromaffin vesicles to generate active peptides. Endocrinology. 2009;150:3547-57 pubmed publisher
Taggart C, Lowe G, Greene C, Mulgrew A, O Neill S, Levine R, et al. Cathepsin B, L, and S cleave and inactivate secretory leucoprotease inhibitor. J Biol Chem. 2001;276:33345-52 pubmed
Barrett A, Kirschke H. Cathepsin B, Cathepsin H, and cathepsin L. Methods Enzymol. 1981;80 Pt C:535-61 pubmed
Kirschke H, Wikstrom P, Shaw E. Active center differences between cathepsins L and B: the S1 binding region. FEBS Lett. 1988;228:128-30 pubmed
Joseph L, Chang L, Stamenkovich D, Sukhatme V. Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts. J Clin Invest. 1988;81:1621-9 pubmed
product information
Catalog Number :
C6854
Product Name :
Cathepsin L from human liver
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
?0.5 units/mg protein, solution
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA