Michailidis E, Vercauteren K, Mancio Silva L, Andrus L, Jahan C, Ricardo Lax I, et al. Expansion, in vivo-ex vivo cycling, and genetic manipulation of primary human hepatocytes. Proc Natl Acad Sci U S A. 2020;117:1678-1688 pubmed publisher

Hellman K, Ohlsson J, Malo M, Olsson R, Ek F. Discovery of Procognitive Antipsychotics by Combining Muscarinic M1 Receptor Structure-Activity Relationship with Systems Response Profiles in Zebrafish Larvae. ACS Chem Neurosci. 2020;11:173-183 pubmed publisher

Prasad A, Xie C, Chaichim C, Nguyen J, McClusky H, Killcross S, et al. Complementary roles for ventral pallidum cell types and their projections in relapse. J Neurosci. 2019;: pubmed publisher

Randlett O, Haesemeyer M, Forkin G, Shoenhard H, Schier A, Engert F, et al. Distributed Plasticity Drives Visual Habituation Learning in Larval Zebrafish. Curr Biol. 2019;29:1337-1345.e4 pubmed publisher

Zhang W, Zhang C, Liu F, Mao Y, Xu W, Fan T, et al. Antiproliferative activities of the second-generation antipsychotic drug sertindole against breast cancers with a potential application for treatment of breast-to-brain metastases. Sci Rep. 2018;8:15753 pubmed publisher

Wang Z, Maunze B, Wang Y, Tsoulfas P, Blackmore M. Global Connectivity and Function of Descending Spinal Input Revealed by 3D Microscopy and Retrograde Transduction. J Neurosci. 2018;38:10566-10581 pubmed publisher

Anderson S, Livingston M, Couchman L, Smith D, Connolly M, Miller J, et al. Sex differences in plasma clozapine and norclozapine concentrations in clinical practice and in relation to body mass index and plasma glucose concentrations: a retrospective survey. Ann Gen Psychiatry. 2015;14:39 pubmed publisher

Canfrán Duque A, Pastor O, Reina M, Lerma M, Cruz Jentoft A, Lasunción M, et al. Curcumin Mitigates the Intracellular Lipid Deposit Induced by Antipsychotics In Vitro. PLoS ONE. 2015;10:e0141829 pubmed publisher

Yamaoka T, Kitamura Y. Characterization of a highly sensitive and selective novel trapping reagent, stable isotope labeled glutathione ethyl ester, for the detection of reactive metabolites. J Pharmacol Toxicol Methods. 2015;76:83-95 pubmed publisher

Rossmann J, Gurke R, Renner L, Oertel R, Kirch W. Evaluation of the matrix effect of different sample matrices for 33 pharmaceuticals by post-column infusion. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;1000:84-94 pubmed publisher

Alves V, Gonçalves J, Conceição C, Teixeira H, Câmara J. An improved analytical strategy combining microextraction by packed sorbent combined with ultra high pressure liquid chromatography for the determination of fluoxetine, clomipramine and their active metabolites in human urine. J Chromatogr A. 2015;1408:30-40 pubmed publisher

Ma J, Domicevica L, Schnell J, Biggin P. Position and orientational preferences of drug-like compounds in lipid membranes: a computational and NMR approach. Phys Chem Chem Phys. 2015;17:19766-76 pubmed publisher

Reuss B, Schroten H, Ishikawa H, Asif A. Cross-reactivity of Antibodies Directed to the Gram-Negative Bacterium Neisseria gonorrhoeae With Heat Shock Protein 60 and ATP-Binding Protein Correlates to Reduced Mitochondrial Activity in HIBCPP Choroid Plexus Papilloma Cells. J Mol Neurosci. 2015;57:123-38 pubmed publisher

de Souza I, Domingues D, Queiroz M. Hybrid silica monolith for microextraction by packed sorbent to determine drugs from plasma samples by liquid chromatography-tandem mass spectrometry. Talanta. 2015;140:166-175 pubmed publisher

Qin A, Liang X, Deng Y, Dean B, Shahidi Latham S. Collagenase as an effective tool for drug quantitation in tissues. Bioanalysis. 2015;7:1069-79 pubmed publisher

Domingues D, Souza I, Queiroz M. Analysis of drugs in plasma samples from schizophrenic patients by column-switching liquid chromatography-tandem mass spectrometry with organic-inorganic hybrid cyanopropyl monolithic column. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;993-994:26-35 pubmed publisher

Olianas M, Dedoni S, Onali P. Antidepressants activate the lysophosphatidic acid receptor LPA(1) to induce insulin-like growth factor-I receptor transactivation, stimulation of ERK1/2 signaling and cell proliferation in CHO-K1 fibroblasts. Biochem Pharmacol. 2015;95:311-23 pubmed publisher

Goda S, Olszewski M, Piasecka J, Rejniak K, Whittington M, Kasicki S, et al. Aberrant high frequency oscillations recorded in the rat nucleus accumbens in the methylazoxymethanol acetate neurodevelopmental model of schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2015;61:44-51 pubmed publisher

Rajji T, Mulsant B, Davies S, Kalache S, Tsoutsoulas C, Pollock B, et al. Prediction of working memory performance in schizophrenia by plasma ratio of clozapine to N-desmethylclozapine. Am J Psychiatry. 2015;172:579-85 pubmed publisher

Gurke R, Rossmann J, Schubert S, Sandmann T, Rößler M, Oertel R, et al. Development of a SPE-HPLC-MS/MS method for the determination of most prescribed pharmaceuticals and related metabolites in urban sewage samples. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;990:23-30 pubmed publisher

Quiason C, Shahidi Latham S. Imaging MALDI MS of Dosed Brain Tissues Utilizing an Alternative Analyte Pre-extraction Approach. J Am Soc Mass Spectrom. 2015;26:967-73 pubmed publisher

Elmorsy E, Smith P. Bioenergetic disruption of human micro-vascular endothelial cells by antipsychotics. Biochem Biophys Res Commun. 2015;460:857-62 pubmed publisher

Kishi T, Matsuda Y, Mukai T, Matsunaga S, Yasue I, Fujita K, et al. A cross-sectional survey to investigate the prevalence of pain in Japanese patients with major depressive disorder and schizophrenia. Compr Psychiatry. 2015;59:91-7 pubmed publisher

Matongo S, Birungi G, Moodley B, Ndungu P. Occurrence of selected pharmaceuticals in water and sediment of Umgeni River, KwaZulu-Natal, South Africa. Environ Sci Pollut Res Int. 2015;22:10298-308 pubmed publisher

Zhang N, Zhong P, Shin S, Metallo J, Danielson E, Olsen C, et al. S-SCAM, a rare copy number variation gene, induces schizophrenia-related endophenotypes in transgenic mouse model. J Neurosci. 2015;35:1892-904 pubmed publisher

Chen M, Wu S, Tsai T, Wang L, Tsai F. Regulation of neutrophil phagocytosis of Escherichia coli by antipsychotic drugs. Int Immunopharmacol. 2014;23:550-7 pubmed publisher

Citraro R, Leo A, Aiello R, Pugliese M, Russo E, De Sarro G. Comparative analysis of the treatment of chronic antipsychotic drugs on epileptic susceptibility in genetically epilepsy-prone rats. Neurotherapeutics. 2015;12:250-62 pubmed publisher

Baker T, Florczynski M, Beninger R. Differential effects of clozapine, metoclopramide, haloperidol and risperidone on acquisition and performance of operant responding in rats. Psychopharmacology (Berl). 2015;232:1535-43 pubmed publisher

Park S, Lee M. Successful electroconvulsive therapy and improvement of negative symptoms in refractory schizophrenia with clozapine-induced seizures: a case report. Psychiatr Danub. 2014;26:360-2 pubmed

Wichniak A, Okruszek Ł, Linke M, Jarkiewicz M, Jędrasik Styła M, Ciołkiewicz A, et al. Electroencephalographic theta activity and cognition in schizophrenia: preliminary results. World J Biol Psychiatry. 2015;16:206-10 pubmed publisher

Baier P, Brzózka M, Shahmoradi A, Reinecke L, Kroos C, Wichert S, et al. Mice lacking the circadian modulators SHARP1 and SHARP2 display altered sleep and mixed state endophenotypes of psychiatric disorders. PLoS ONE. 2014;9:e110310 pubmed publisher

Ashby D, Lapish C, Phillips A. Stability of avoidance behaviour following repeated intermittent treatment with clozapine, olanzapine or D,L-govadine. Behav Pharmacol. 2015;26:133-8 pubmed publisher

Versace F, Déglon J, Mangin P, Staub C. Application of direct-infusion ESI-MS/MS for toxicological screening. Bioanalysis. 2014;6:2043-55 pubmed publisher

Kawaura K, Koike H, Kinoshita K, Kambe D, Kaku A, Karasawa J, et al. Effects of a glycine transporter-1 inhibitor and D-serine on MK-801-induced immobility in the forced swimming test in rats. Behav Brain Res. 2015;278:186-92 pubmed publisher

Wu C, Wang S, Liu S. Clozapine use reduced psychiatric hospitalization and emergency room visits in patients with bipolar disorder independent of improved treatment regularity in a three-year follow-up period. Bipolar Disord. 2015;17:415-23 pubmed publisher

Chen X, Wang Z, Liu M, Liao M, Wang X, Du H, et al. Determination of sunitinib and its active metabolite, N-desethyl sunitinib in mouse plasma and tissues by UPLC-MS/MS: assay development and application to pharmacokinetic and tissue distribution studies. Biomed Chromatogr. 2015;29:679-88 pubmed publisher

Konopaske G, Lange N, Coyle J, Benes F. Prefrontal cortical dendritic spine pathology in schizophrenia and bipolar disorder. JAMA Psychiatry. 2014;71:1323-31 pubmed publisher

Tylutki Z, Jawień W, Ciszowski K, Wilimowska J, Anand J. Abnormal olanzapine toxicokinetic profiles--population pharmacokinetic analysis. Toxicol Mech Methods. 2015;25:1-12 pubmed publisher

Popik P, Holuj M, Nikiforuk A, Kos T, Trullas R, Skolnick P. 1-aminocyclopropanecarboxylic acid (ACPC) produces procognitive but not antipsychotic-like effects in rats. Psychopharmacology (Berl). 2015;232:1025-38 pubmed publisher

Rahmani A, Mohammadpour A, Sahebnasagh A, Mohajeri S. Haloperidol imprinted polymer: preparation, evaluation, and application for drug assay in brain tissue. Anal Bioanal Chem. 2014;406:7729-39 pubmed publisher

Jeon S, Kim Y, Chung I, Kim Y. Clozapine induces chloride channel-4 expression through PKA activation and modulates CDK5 expression in SH-SY5Y and U87 cells. Prog Neuropsychopharmacol Biol Psychiatry. 2015;56:168-73 pubmed publisher

Sempio C, Morini L, Vignali C, Groppi A. Simple and sensitive screening and quantitative determination of 88 psychoactive drugs and their metabolites in blood through LC-MS/MS: application on postmortem samples. J Chromatogr B Analyt Technol Biomed Life Sci. 2014;970:1-7 pubmed publisher

Petrides G, Malur C, Braga R, Bailine S, Schooler N, Malhotra A, et al. Electroconvulsive therapy augmentation in clozapine-resistant schizophrenia: a prospective, randomized study. Am J Psychiatry. 2015;172:52-8 pubmed publisher

Patteet L, Maudens K, Stove C, Lambert W, Morrens M, Sabbe B, et al. The use of dried blood spots for quantification of 15 antipsychotics and 7 metabolites with ultra-high performance liquid chromatography - tandem mass spectrometry. Drug Test Anal. 2015;7:502-11 pubmed publisher

O Callaghan M, Bay Richter C, O Tuathaigh C, Heery D, Waddington J, Moran P. Potentiation of latent inhibition by haloperidol and clozapine is attenuated in Dopamine D2 receptor (Drd-2)-deficient mice: do antipsychotics influence learning to ignore irrelevant stimuli via both Drd-2 and non-Drd-2 mechanisms?. J Psychopharmacol. 2014;28:973-7 pubmed publisher

Wang H, Zrada M, Anderson K, Katwaru R, Harradine P, Choi B, et al. Understanding and reducing the experimental variability of in vitro plasma protein binding measurements. J Pharm Sci. 2014;103:3302-9 pubmed publisher

Cai B, Chen X, Liu F, Li J, Gu L, Liu J, et al. A cell-based functional assay using a green fluorescent protein-based calcium indicator dCys-GCaMP. Assay Drug Dev Technol. 2014;12:342-51 pubmed publisher

von Wilmsdorff M, Bouvier M, Henning U, Schmitt A, Schneider Axmann T, Gaebel W. Sex-dependent metabolic alterations of rat liver after 12-week exposition to haloperidol or clozapine. Horm Metab Res. 2014;46:782-8 pubmed publisher

Trasi N, Baird J, Kestur U, Taylor L. Factors influencing crystal growth rates from undercooled liquids of pharmaceutical compounds. J Phys Chem B. 2014;118:9974-82 pubmed publisher

Mielnik C, Horsfall W, Ramsey A. Diazepam improves aspects of social behaviour and neuron activation in NMDA receptor-deficient mice. Genes Brain Behav. 2014;13:592-602 pubmed publisher

Brami Cherrier K, Anzalone A, Ramos M, Forne I, Macciardi F, Imhof A, et al. Epigenetic reprogramming of cortical neurons through alteration of dopaminergic circuits. Mol Psychiatry. 2014;19:1193-200 pubmed publisher

Lobach A, Uetrecht J. Clozapine promotes the proliferation of granulocyte progenitors in the bone marrow leading to increased granulopoiesis and neutrophilia in rats. Chem Res Toxicol. 2014;27:1109-19 pubmed publisher

Ng W, Kennar R, Uetrecht J. Effect of clozapine and olanzapine on neutrophil kinetics: implications for drug-induced agranulocytosis. Chem Res Toxicol. 2014;27:1104-8 pubmed publisher

Hoffman K, Basurto E. Clozapine and glycinamide prevent MK-801-induced deficits in the novel object recognition (NOR) test in the domestic rabbit (Oryctolagus cuniculus). Behav Brain Res. 2014;271:203-11 pubmed publisher

Wifling D, Löffel K, Nordemann U, Strasser A, Bernhardt G, Dove S, et al. Molecular determinants for the high constitutive activity of the human histamine H4 receptor: functional studies on orthologues and mutants. Br J Pharmacol. 2015;172:785-98 pubmed publisher

Zhong P, Liu X, Zhang Z, Hu Y, Liu S, Lezama Ruiz M, et al. Cyclin-dependent kinase 5 in the ventral tegmental area regulates depression-related behaviors. J Neurosci. 2014;34:6352-66 pubmed publisher

Park J, Rhau B, Hermann A, McNally K, Zhou C, Gong D, et al. Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal. Proc Natl Acad Sci U S A. 2014;111:5896-901 pubmed publisher

Abdel Wahab B, Metwally M, El khawanki M, Hashim A. Protective effect of captopril against clozapine-induced myocarditis in rats: role of oxidative stress, proinflammatory cytokines and DNA damage. Chem Biol Interact. 2014;216:43-52 pubmed publisher

Driver D, Anvari A, Peroutka C, Kataria R, Overman J, Lang D, et al. Management of clozapine-induced fever in a child. Am J Psychiatry. 2014;171:398-402 pubmed publisher

Riga M, Soria G, Tudela R, Artigas F, Celada P. The natural hallucinogen 5-MeO-DMT, component of Ayahuasca, disrupts cortical function in rats: reversal by antipsychotic drugs. Int J Neuropsychopharmacol. 2014;17:1269-82 pubmed publisher

Hill A, Perrin M, Heide J, Campbell T, Mann S, Vandenberg J. Kinetics of drug interaction with the Kv11.1 potassium channel. Mol Pharmacol. 2014;85:769-76 pubmed publisher

Merenlender Wagner A, Malishkevich A, Shemer Z, Udawela M, Gibbons A, Scarr E, et al. Autophagy has a key role in the pathophysiology of schizophrenia. Mol Psychiatry. 2015;20:126-32 pubmed publisher

Tsermpini E, Assimakopoulos K, Bartsakoulia M, Iconomou G, Papadima E, Mitropoulos K, et al. Individualizing clozapine and risperidone treatment for schizophrenia patients. Pharmacogenomics. 2014;15:95-110 pubmed publisher

Sankaranarayanan A, Mulchandani M, Tirupati S. Clozapine, cancer chemotherapy and neutropenia - dilemmas in management. Psychiatr Danub. 2013;25:419-22 pubmed

Spencer B, Prainsack B, Rujescu D, Giegling I, Collier D, Gaughran F, et al. Opening Pandora's box in the UK: a hypothetical pharmacogenetic test for clozapine. Pharmacogenomics. 2013;14:1907-14 pubmed publisher

Michaelides M, Anderson S, Ananth M, Smirnov D, Thanos P, Neumaier J, et al. Whole-brain circuit dissection in free-moving animals reveals cell-specific mesocorticolimbic networks. J Clin Invest. 2013;123:5342-50 pubmed publisher

Anderson S, Michaelides M, Zarnegar P, Ren Y, Fagergren P, Thanos P, et al. Impaired periamygdaloid-cortex prodynorphin is characteristic of opiate addiction and depression. J Clin Invest. 2013;123:5334-41 pubmed publisher

Silva B, Mattucci C, Krzywkowski P, Murana E, Illarionova A, Grinevich V, et al. Independent hypothalamic circuits for social and predator fear. Nat Neurosci. 2013;16:1731-3 pubmed publisher

Eriksen J, Rosenborg S. [No given alternatives to clozapine in treatment-resistant schizophrenia]. Lakartidningen. 2013;110:1809 pubmed

Dragovic S, Venkataraman H, Begheijn S, Vermeulen N, Commandeur J. Effect of human glutathione S-transferase hGSTP1-1 polymorphism on the detoxification of reactive metabolites of clozapine, diclofenac and acetaminophen. Toxicol Lett. 2014;224:272-81 pubmed publisher

Kohlrausch F. Pharmacogenetics in schizophrenia: a review of clozapine studies. Braz J Psychiatry. 2013;35:305-17 pubmed publisher

Yamamori H, Hashimoto R, Ishima T, Kishi F, Yasuda Y, Ohi K, et al. Plasma levels of mature brain-derived neurotrophic factor (BDNF) and matrix metalloproteinase-9 (MMP-9) in treatment-resistant schizophrenia treated with clozapine. Neurosci Lett. 2013;556:37-41 pubmed publisher

Makkos Z. [Combination of second generation antipsychotics -- case report]. Neuropsychopharmacol Hung. 2013;15:173-6 pubmed

Vila Rodriguez F, Tsang P, Barr A. Chronic benign neutropenia/agranulocytosis associated with non-clozapine antipsychotics. Am J Psychiatry. 2013;170:1213-4 pubmed publisher

Wenthur C, Lindsley C. Classics in chemical neuroscience: clozapine. ACS Chem Neurosci. 2013;4:1018-25 pubmed publisher

Haas S, de Andrade C, Sansone P, Guterres S, Dalla Costa T. Development of innovative oil-core self-organized nanovesicles prepared with chitosan and lecithin using a 2(3) full-factorial design. Pharm Dev Technol. 2014;19:769-78 pubmed publisher

Najim H, Heath D, Singh P. Antipsychotic prescribing before clozapine in a community psychiatric hospital: a case note review. Psychiatr Danub. 2013;25 Suppl 2:S165-70 pubmed

Batanero B, Barba F, Martín A. One-pot formation of 1,3,4-oxadiazol-2(3H)-ones and dibenzo[c,e]azepines by concomitant cathodic reduction of diazonium salts and phenanthrenequinones. J Org Chem. 2013;78:9477-81 pubmed publisher

. Quetiapine and cardiac muscle disorders. Prescrire Int. 2013;22:184 pubmed

Vredenburg G, Vassell K, Commandeur J, Vermeulen N, Vos J. Reconstitution of the interplay between cytochrome P450 and human glutathione S-transferases in clozapine metabolism in yeast. Toxicol Lett. 2013;222:247-56 pubmed publisher

Sanz Fuentenebro J, Taboada D, Palomo T, Aragües M, Ovejero S, Del Alamo C, et al. Randomized trial of clozapine vs. risperidone in treatment-naïve first-episode schizophrenia: results after one year. Schizophr Res. 2013;149:156-61 pubmed publisher

Stevens K, Zheng L, Abrams D. Intermittent versus continuous central administration of clozapine in DBA/2 mice, improvement in sensory inhibition deficits. Schizophr Res. 2013;149:121-6 pubmed publisher

Nielsen J, Correll C, Manu P, Kane J. Termination of clozapine treatment due to medical reasons: when is it warranted and how can it be avoided?. J Clin Psychiatry. 2013;74:603-13; quiz 613 pubmed publisher

Idris A, Elgorashe R. Sequential injection chromatography for separation and quantification of chlorpromazine in human urine and pharmaceutical formulations. J AOAC Int. 2013;96:282-9 pubmed

Chen C, Huang M, Kao C, Lin S, Kuo P, Chiu C, et al. Effects of adjunctive metformin on metabolic traits in nondiabetic clozapine-treated patients with schizophrenia and the effect of metformin discontinuation on body weight: a 24-week, randomized, double-blind, placebo-controlled study. J Clin Psychiatry. 2013;74:e424-30 pubmed publisher

Ikai S, Suzuki T, Uchida H, Mimura M, Fujii Y. Reintroduction of clozapine after perforation of the large intestine--a case report and review of the literature. Ann Pharmacother. 2013;47:e31 pubmed publisher

Szota A, Ogłodek E, Araszkiewicz A. Fever development in neuroleptic malignant syndrome during treatment with olanzapine and clozapine. Pharmacol Rep. 2013;65:279-87 pubmed

Ishøy P, Knop F, Vilsbøll T, Glenthøj B, Ebdrup B. Sustained weight loss after treatment with a glucagon-like peptide-1 receptor agonist in an obese patient with schizophrenia and type 2 diabetes. Am J Psychiatry. 2013;170:681-2 pubmed publisher

Inada K, Ishigooka J. [Clozapine]. Nihon Rinsho. 2013;71:678-83 pubmed

Nagai N, Watanabe K. [Olanzapine]. Nihon Rinsho. 2013;71:666-72 pubmed

Wigard M, Van Gool A, Schulte P. [Reaction on 'Addition of fluvoxamine to clozapine: theory and practice'. Reply to Sommer]. Tijdschr Psychiatr. 2013;55:310-2 pubmed

Bonito Oliva A, Pallottino S, Bertran Gonzalez J, Girault J, Valjent E, Fisone G. Haloperidol promotes mTORC1-dependent phosphorylation of ribosomal protein S6 via dopamine- and cAMP-regulated phosphoprotein of 32 kDa and inhibition of protein phosphatase-1. Neuropharmacology. 2013;72:197-203 pubmed publisher

Kaur H, Bassi P, Monif T, Khuroo A, Kaur G. Development and validation of high performance liquid chromatographic method for analysis of clozapine. Pak J Pharm Sci. 2013;26:465-72 pubmed

Sommer I. [Reaction on 'Addition of fluvoxamine to clozapine: theory and practice']. Tijdschr Psychiatr. 2013;55:309-10 pubmed

Archie A, Persoons P, Vandenbulcke M. [The use of clozapine and levodopa for the treatment of persistent visual hallucinations and parkinsonism in Lewy body dementia]. Tijdschr Psychiatr. 2013;55:287-91 pubmed

Moisan J, Turgeon M, Desjardins O, Grégoire J. Comparative safety of antipsychotics: another look at the risk of diabetes. Can J Psychiatry. 2013;58:218-24 pubmed

Cohen D, Monden M. White blood cell monitoring during long-term clozapine treatment. Am J Psychiatry. 2013;170:366-9 pubmed publisher

Ishak R, Awad G, Zaki N, El Shamy A, Mortada N. A comparative study of chitosan shielding effect on nano-carriers hydrophilicity and biodistribution. Carbohydr Polym. 2013;94:669-76 pubmed publisher

Bock R, Shin J, Kaplan A, Dobi A, Markey E, Kramer P, et al. Strengthening the accumbal indirect pathway promotes resilience to compulsive cocaine use. Nat Neurosci. 2013;16:632-8 pubmed publisher

Gopalakrishnan R, Subhalakshmi T, Kuruvilla A, Jacob K. Clozapine re-challenge under the cover of Filgrastim. J Postgrad Med. 2013;59:54-5 pubmed publisher

Shulman M, Jennifer Njoku I, Manu P. Thrombotic complications of treatment with antipsychotic drugs. Minerva Med. 2013;104:175-84 pubmed

Maher K, Tan M, Tossell J, Weisinger B, Gochman P, Miller R, et al. Risk factors for neutropenia in clozapine-treated children and adolescents with childhood-onset schizophrenia. J Child Adolesc Psychopharmacol. 2013;23:110-6 pubmed publisher

Howes O, Taylor D. Authors' reply. Br J Psychiatry. 2013;202:155 pubmed

Piccinni A, Veltri A, Marazziti D, Moroni I, Dell osso L. Effectiveness of a clozapine-aripiprazole combination in Tourette syndrome and bipolar spectrum disorder. J Neuropsychiatry Clin Neurosci. 2013;25:E45 pubmed publisher

Wilson M, Offenberger J. Intermittent neutropenia and leucopenia unrelated to clozapine in a 12-year-old girl with schizophrenia. J Child Adolesc Psychopharmacol. 2013;23:136-8 pubmed publisher

Jain S, Ruiz de Azua I, Lu H, White M, Guettier J, Wess J. Chronic activation of a designer G(q)-coupled receptor improves ? cell function. J Clin Invest. 2013;123:1750-62 pubmed publisher

Olmez S, Vural I, Sahin S, Ertugrul A, Capan Y. Formulation and evaluation of clozapine orally disintegrating tablets prepared by direct compression. Pharmazie. 2013;68:110-6 pubmed

Saur T, Demarco S, Ortiz A, Sliwoski G, Hao L, Wang X, et al. A genome-wide RNAi screen in Caenorhabditis elegans identifies the nicotinic acetylcholine receptor subunit ACR-7 as an antipsychotic drug target. PLoS Genet. 2013;9:e1003313 pubmed publisher

Kumar T, Kathpal A, Longshore C. Dose dependent stuttering with clozapine: a case report. Asian J Psychiatr. 2013;6:178-9 pubmed publisher

Xenitidis K, Campbell C, Mortimer A. Identifying treatment-resistant schizophrenia. Br J Psychiatry. 2013;202:238 pubmed publisher

Lin C, Chiu H, Chen J, Liou Y, Wang Y, Chen T, et al. Switching from clozapine to zotepine in patients with schizophrenia: a 12-week prospective, randomized, rater blind, and parallel study. J Clin Psychopharmacol. 2013;33:211-4 pubmed publisher

Hu Q, Zhang C, Zhu S. Fatal multisystem venous thrombosis associated with clozapine. J Clin Psychopharmacol. 2013;33:256-8 pubmed publisher

Yang S, Liao Y, Liu H, Chen W, Chen C, Kuo C. Antipsychotic drugs, mood stabilizers, and risk of pneumonia in bipolar disorder: a nationwide case-control study. J Clin Psychiatry. 2013;74:e79-86 pubmed publisher

Wigard M, Van Gool A, Schulte P. [Addition of fluvoxamine to clozapine: theory and practice]. Tijdschr Psychiatr. 2013;55:113-21 pubmed

Basta Kaim A, Szczęsny E, Leśkiewicz M, Głombik K, Slusarczyk J, Budziszewska B, et al. Maternal immune activation leads to age-related behavioral and immunological changes in male rat offspring - the effect of antipsychotic drugs. Pharmacol Rep. 2012;64:1400-10 pubmed

Hill M, Freudenreich O. Clozapine: key discussion points for prescribers. Clin Schizophr Relat Psychoses. 2013;6:177-85 pubmed publisher

Mustafa F. Schizophrenia past clozapine: what works?. J Clin Psychopharmacol. 2013;33:63-8 pubmed publisher

Souza J, Kayo M, Tassell I, Martins C, Elkis H. Efficacy of olanzapine in comparison with clozapine for treatment-resistant schizophrenia: evidence from a systematic review and meta-analyses. CNS Spectr. 2013;18:82-9 pubmed publisher

Bobb V, Weinberg M, Gabel S, Kranzler H, Olfson M. Use of clozapine in a state child and adolescent psychiatric hospital. Psychiatr Q. 2013;84:343-9 pubmed publisher

Remington G, Agid O, Foussias G, Ferguson L, McDonald K, Powell V. Clozapine and therapeutic drug monitoring: is there sufficient evidence for an upper threshold?. Psychopharmacology (Berl). 2013;225:505-18 pubmed publisher

Cohen D, Bogers J, van Dijk D, Bakker B, Schulte P. Beyond white blood cell monitoring: screening in the initial phase of clozapine therapy. J Clin Psychiatry. 2012;73:1307-12 pubmed publisher

Vera I, Rezende L, Molina V, Sanz Fuentenebro J. Clozapine as treatment of first choice in first psychotic episodes. What do we know?. Actas Esp Psiquiatr. 2012;40:281-9 pubmed

Meltzer H. Clozapine: balancing safety with superior antipsychotic efficacy. Clin Schizophr Relat Psychoses. 2012;6:134-44 pubmed

Munitz H. [Clozapine--the neglected potential]. Harefuah. 2012;151:298-300, 318, 317 pubmed

Røge R, Møller B, Andersen C, Correll C, Nielsen J. Immunomodulatory effects of clozapine and their clinical implications: what have we learned so far?. Schizophr Res. 2012;140:204-13 pubmed publisher

Diem O, Schäffner M, Seifarth W, Leib Mösch C. Influence of antipsychotic drugs on human endogenous retrovirus (HERV) transcription in brain cells. PLoS ONE. 2012;7:e30054 pubmed publisher

Robertson S, Matthies H, Owens W, Sathananthan V, Christianson N, Kennedy J, et al. Insulin reveals Akt signaling as a novel regulator of norepinephrine transporter trafficking and norepinephrine homeostasis. J Neurosci. 2010;30:11305-16 pubmed publisher

Kiss A, Bundzikova J, Pirnik Z, Mikkelsen J. Different antipsychotics elicit different effects on magnocellular oxytocinergic and vasopressinergic neurons as revealed by Fos immunohistochemistry. J Neurosci Res. 2010;88:677-85 pubmed publisher

Feifel D, Mexal S, Melendez G, Liu P, Goldenberg J, Shilling P. The brattleboro rat displays a natural deficit in social discrimination that is restored by clozapine and a neurotensin analog. Neuropsychopharmacology. 2009;34:2011-8 pubmed publisher

Linck V, Herrmann A, Piato A, Detanico B, Figueiró M, Flório J, et al. Alstonine as an antipsychotic: effects on brain amines and metabolic changes. Evid Based Complement Alternat Med. 2011;2011:418597 pubmed publisher

Zhukovskaya N, Neumaier J. Clozapine downregulates 5-hydroxytryptamine6 (5-HT6) and upregulates 5-HT7 receptors in HeLa cells. Neurosci Lett. 2000;288:236-40 pubmed

Bergqvist P, Dong J, Blier P. Effect of atypical antipsychotic drugs on 5-HT2 receptors in the rat orbito-frontal cortex: an in vivo electrophysiological study. Psychopharmacology (Berl). 1999;143:89-96 pubmed

Hermann B, Wetzel C, Pestel E, Zieglgansberger W, Holsboer F, Rupprecht R. Functional antagonistic properties of clozapine at the 5-HT3 receptor. Biochem Biophys Res Commun. 1996;225:957-60 pubmed

Kuoppamaki M, Syvalahti E, Hietala J. Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonists. Eur J Pharmacol. 1993;245:179-82 pubmed

Van Tol H, Bunzow J, Guan H, Sunahara R, Seeman P, Niznik H, et al. Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature. 1991;350:610-4 pubmed