This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
protein
product name :
Calpain 1 human
catalog :
C6108
citations: 26
Reference
Liu W, Ruiz Velasco A, Wang S, Khan S, Zi M, Jungmann A, et al. Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling. Nat Commun. 2017;8:494 pubmed publisher
Su W, Kowalczyk A. The VE-cadherin cytoplasmic domain undergoes proteolytic processing during endocytosis. Mol Biol Cell. 2017;28:76-84 pubmed publisher
Okoro E, Guo Z, Yang H. Akt isoform-dependent regulation of ATP-Binding cassette A1 expression by apolipoprotein E. Biochem Biophys Res Commun. 2016;477:123-128 pubmed publisher
Trillsch F, Kuerti S, Eulenburg C, Burandt E, Woelber L, Prieske K, et al. E-Cadherin fragments as potential mediators for peritoneal metastasis in advanced epithelial ovarian cancer. Br J Cancer. 2016;114:213-20 pubmed publisher
Pawlinski R. Inhibit the calpain to climb the mountain. Blood. 2014;123:1123-4 pubmed publisher
Tyagi T, Ahmad S, Gupta N, Sahu A, Ahmad Y, Nair V, et al. Altered expression of platelet proteins and calpain activity mediate hypoxia-induced prothrombotic phenotype. Blood. 2014;123:1250-60 pubmed publisher
Cataldo F, Peche L, Klaric E, Brancolini C, Myers M, Demarchi F, et al. CAPNS1 regulates USP1 stability and maintenance of genome integrity. Mol Cell Biol. 2013;33:2485-96 pubmed publisher
Zhang C, Bai D, Huang X, Shi G, Ke A, Yang L, et al. Prognostic significance of Capn4 overexpression in intrahepatic cholangiocarcinoma. PLoS ONE. 2013;8:e54619 pubmed publisher
Velma V, Broome H, Hebert M. Regulated specific proteolysis of the Cajal body marker protein coilin. Chromosoma. 2012;121:629-42 pubmed publisher
Kulkarni S, Saju L, Farver C, Tubbs R. Calpain4 is required for activation of HER2 in breast cancer cells exposed to trastuzumab and its suppression decreases survival and enhances response. Int J Cancer. 2012;131:2420-32 pubmed publisher
Zhang X, You X, Wang Q, Zhang T, Du Y, Lv N, et al. Hepatitis B virus X protein drives multiple cross-talk cascade loops involving NF-?B, 5-LOX, OPN and Capn4 to promote cell migration. PLoS ONE. 2012;7:e31458 pubmed publisher
Gutowska Owsiak D, Schaupp A, Salimi M, Selvakumar T, McPherson T, Taylor S, et al. IL-17 downregulates filaggrin and affects keratinocyte expression of genes associated with cellular adhesion. Exp Dermatol. 2012;21:104-10 pubmed publisher
Letavernier E, Dansou B, Lochner M, Perez J, Bellocq A, Lindenmeyer M, et al. Critical role of the calpain/calpastatin balance in acute allograft rejection. Eur J Immunol. 2011;41:473-84 pubmed publisher
Zhang F, Wang Q, Ye L, Feng Y, Zhang X. Hepatitis B virus X protein upregulates expression of calpain small subunit 1 via nuclear factor-kappaB/p65 in hepatoma cells. J Med Virol. 2010;82:920-8 pubmed publisher
Peterson D, Ando D, Taketa D, Zhou H, Dahlquist F, Lew J. No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro. Proc Natl Acad Sci U S A. 2010;107:2884-9 pubmed publisher
Fairfax B, Vannberg F, Radhakrishnan J, Hakonarson H, Keating B, Hill A, et al. An integrated expression phenotype mapping approach defines common variants in LEP, ALOX15 and CAPNS1 associated with induction of IL-6. Hum Mol Genet. 2010;19:720-30 pubmed publisher
Bai D, Dai Z, Zhou J, Liu Y, Qiu S, Tan C, et al. Capn4 overexpression underlies tumor invasion and metastasis after liver transplantation for hepatocellular carcinoma. Hepatology. 2009;49:460-70 pubmed publisher
Pamonsinlapatham P, Gril B, Dufour S, Hadj Slimane R, Gigoux V, Pethe S, et al. Capns1, a new binding partner of RasGAP-SH3 domain in K-Ras(V12) oncogenic cells: modulation of cell survival and migration. Cell Signal. 2008;20:2119-26 pubmed publisher
Jones M, Morton J, Coxon J, McNabb S, Lee H, Aitken S, et al. Synthesis, biological evaluation and molecular modelling of N-heterocyclic dipeptide aldehydes as selective calpain inhibitors. Bioorg Med Chem. 2008;16:6911-23 pubmed publisher
Spengler D. The protein kinase Aurora C phosphorylates TRF2. Cell Cycle. 2007;6:2579-80 pubmed
Asangani I, Rasheed S, Leupold J, Post S, Allgayer H. NRF-1, and AP-1 regulate the promoter of the human calpain small subunit 1 (CAPNS1) gene. Gene. 2008;410:197-206 pubmed publisher
Davis T, Walker J, Finerty P, MacKenzie F, Newman E, Dhe Paganon S. The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition. J Mol Biol. 2007;366:216-29 pubmed
Dutt P, Spriggs C, Davies P, Jia Z, Elce J. Origins of the difference in Ca2+ requirement for activation of mu- and m-calpain. Biochem J. 2002;367:263-9 pubmed
Squier M, Cohen J. Calpain, an upstream regulator of thymocyte apoptosis. J Immunol. 1997;158:3690-7 pubmed
Wagner B, Fu S, Margolis J, Fleshman K. A synthetic endopeptidase substrate hydrolyzed by the bovine lens neutral proteinase preparation. Exp Eye Res. 1984;38:477-83 pubmed
Zolfaghari R, Baker C, Canizaro P, Amirgholami A, Behal F. A high-molecular-mass neutral endopeptidase-24.5 from human lung. Biochem J. 1987;241:129-35 pubmed
product information
Catalog Number :
C6108
Product Name :
Calpain 1 human
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
aqueous glycerol solution
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA