Reference |
---|
Rossi A, Rigotto G, Valente G, Giorgio V, Basso E, Filadi R, et al. Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer's Disease-Related Models. Cell Rep. 2020;30:2332-2348.e10 pubmed publisher
|
Cruz Torres I, Backos D, Herson P. Characterization and Optimization of the Novel Transient Receptor Potential Melastatin 2 Antagonist tatM2NX. Mol Pharmacol. 2020;97:102-111 pubmed publisher
|
Chauhan A, Magoski N. Hydrogen Peroxide Gates a Voltage-Dependent Cation Current in Aplysia Neuroendocrine Cells. J Neurosci. 2019;39:9900-9913 pubmed publisher
|
Chan Y, Chu K, Chan K. Ecdysteroid-mimicking compounds act as both agonists and antagonists to the crustacean ecdysone receptor. Chemosphere. 2019;237:124551 pubmed publisher
|
Kočendová J, Vaňková E, Volejníková A, Nešuta O, Budesinsky M, Socha O, et al. Antifungal activity of analogues of antimicrobial peptides isolated from bee venoms against vulvovaginal Candida spp. FEMS Yeast Res. 2019;19: pubmed publisher
|
Perraud A, Rao D, Kosmacek E, Dagunts A, Oberley Deegan R, Gally F. The ion channel, TRPM2, contributes to the pathogenesis of radiodermatitis. Radiat Environ Biophys. 2019;58:89-98 pubmed publisher
|
Hao Y, Cheung C, Yip W, Ko W. Nobiletin Stimulates Chloride Secretion in Human Bronchial Epithelia via a cAMP/PKA-Dependent Pathway. Cell Physiol Biochem. 2015;37:306-20 pubmed publisher
|
Küblbeck J, Anttila T, Pulkkinen J, Honkakoski P. Improved assays for xenosensor activation based on reverse transfection. Toxicol In Vitro. 2015;29:1759-65 pubmed publisher
|
Adinolfi B, Carpi S, Romanini A, Da Pozzo E, Castagna M, Costa B, et al. Analysis of the Antitumor Activity of Clotrimazole on A375 Human Melanoma Cells. Anticancer Res. 2015;35:3781-6 pubmed
|
Marcondes M, Fernandes A, Itabaiana I, De Souza R, Sola Penna M, Zancan P. Nanomicellar Formulation of Clotrimazole Improves Its Antitumor Action toward Human Breast Cancer Cells. PLoS ONE. 2015;10:e0130555 pubmed publisher
|
Nian S, Gan X, Tan X, Yu Z, Wang P, Chen X, et al. Discovery and Synthesis of a Novel Series of Liver X Receptor Antagonists. Chem Pharm Bull (Tokyo). 2015;63:628-35 pubmed publisher
|
Al Abdullah E, Al Tuwaijri H, Hassan H, Al Alshaikh M, Habib E, El Emam A. Synthesis, Antimicrobial and Hypoglycemic Activities of Novel N-(1-Adamantyl)carbothioamide Derivatives. Molecules. 2015;20:8125-43 pubmed publisher
|
Meng F, Wu N, Nerlich A, Herrler G, Valentin Weigand P, Seitz M. Dynamic Virus-Bacterium Interactions in a Porcine Precision-Cut Lung Slice Coinfection Model: Swine Influenza Virus Paves the Way for Streptococcus suis Infection in a Two-Step Process. Infect Immun. 2015;83:2806-15 pubmed publisher
|
Lualdi M, Pedrini E, Rea K, Monti L, Scaldaferri D, Gariboldi M, et al. Pleiotropic modes of action in tumor cells of RNASET2, an evolutionary highly conserved extracellular RNase. Oncotarget. 2015;6:7851-65 pubmed
|
Mizukoshi Y, Takeuchi K, Arutaki M, Takizawa T, Hanzawa H, Takahashi H, et al. Suppression of problematic compound oligomerization by cosolubilization of nondetergent sulfobetaines. ChemMedChem. 2015;10:736-41 pubmed publisher
|
Brown A, Owen S, PETERS J, Zhang Y, Söffker M, Paull G, et al. Climate change and pollution speed declines in zebrafish populations. Proc Natl Acad Sci U S A. 2015;112:E1237-46 pubmed publisher
|
Lille Langøy R, Goldstone J, Rusten M, Milnes M, Male R, Stegeman J, et al. Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently. Toxicol Appl Pharmacol. 2015;284:54-64 pubmed publisher
|
Astarita G, Avanesian A, Grimaldi B, Realini N, Justinova Z, Panlilio L, et al. Methamphetamine accelerates cellular senescence through stimulation of de novo ceramide biosynthesis. PLoS ONE. 2015;10:e0116961 pubmed publisher
|
Carazo Fernández A, Smutny T, Hyrsová L, Berka K, Pavek P. Chrysin, baicalein and galangin are indirect activators of the human constitutive androstane receptor (CAR). Toxicol Lett. 2015;233:68-77 pubmed publisher
|
Sen S, Kaminiski R, Deshmane S, Langford D, Khalili K, Amini S, et al. Role of hexokinase-1 in the survival of HIV-1-infected macrophages. Cell Cycle. 2015;14:980-9 pubmed publisher
|
Al Abdullah E, Al Tuwaijri H, Hassan H, Haiba M, Habib E, El Emam A. Antimicrobial and hypoglycemic activities of novel N-Mannich bases derived from 5-(1-adamantyl)-4-substituted-1,2,4-triazoline-3-thiones. Int J Mol Sci. 2014;15:22995-3010 pubmed publisher
|
Creusot N, Brion F, Piccini B, Budzinski H, Porcher J, Aït Aïssa S. BFCOD activity in fish cell lines and zebrafish embryos and its modulation by chemical ligands of human aryl hydrocarbon and nuclear receptors. Environ Sci Pollut Res Int. 2015;22:16393-404 pubmed publisher
|
Verma P, Ahuja M. Optimization, characterization and evaluation of chitosan-tailored cubic nanoparticles of clotrimazole. Int J Biol Macromol. 2015;73:138-45 pubmed publisher
|
Haslinger K, Maximowitsch E, Brieke C, Koch A, Cryle M. Cytochrome P450 OxyBtei catalyzes the first phenolic coupling step in teicoplanin biosynthesis. Chembiochem. 2014;15:2719-28 pubmed publisher
|
Yan F, Sun M, Hang T, Sun J, Zhou X, Deng X, et al. A rapid and sensitive UPLC-MS/MS method for determination of HZ08 in rat plasma and tissues: application to a pharmacokinetic study of liposome injections. J Pharm Biomed Anal. 2015;102:246-52 pubmed publisher
|
Sherwood C, Daines M, Price T, Vagner J, Boitano S. A highly potent agonist to protease-activated receptor-2 reveals apical activation of the airway epithelium resulting in Ca2+-regulated ion conductance. Am J Physiol Cell Physiol. 2014;307:C718-26 pubmed publisher
|
Yamamiya I, Yoshisue K, Ishii Y, Yamada H, Yoshida K. Species variation in the enantioselective metabolism of tegafur to 5-fluorouracil among rats, dogs and monkeys. J Pharm Pharmacol. 2014;66:1686-97 pubmed publisher
|
Trasi N, Baird J, Kestur U, Taylor L. Factors influencing crystal growth rates from undercooled liquids of pharmaceutical compounds. J Phys Chem B. 2014;118:9974-82 pubmed publisher
|
Tay S, Lotfalikhani A, Sabet N, Ponnampalavanar S, Sulaiman S, Na S, et al. Occurrence and characterization of Candida nivariensis from a culture collection of Candida glabrata clinical isolates in Malaysia. Mycopathologia. 2014;178:307-14 pubmed publisher
|
Hannemann A, Cytlak U, Rees D, Tewari S, Gibson J. Effects of 5-hydroxymethyl-2-furfural on the volume and membrane permeability of red blood cells from patients with sickle cell disease. J Physiol. 2014;592:4039-49 pubmed publisher
|
Gamarra S, Morano S, Dudiuk C, Mancilla E, Nardin M, de Los Angeles Méndez E, et al. Epidemiology and antifungal susceptibilities of yeasts causing vulvovaginitis in a teaching hospital. Mycopathologia. 2014;178:251-8 pubmed publisher
|
Nishanth Kumar S, Nisha G, Sudaresan A, Venugopal V, Sree Kumar M, Lankalapalli R, et al. Synergistic activity of phenazines isolated from Pseudomonas aeruginosa in combination with azoles against Candida species. Med Mycol. 2014;52:482-90 pubmed publisher
|
Wang J, Jia L, Kuang Z, Wu T, Hong Y, Chen X, et al. The in vitro and in vivo antitumor effects of clotrimazole on oral squamous cell carcinoma. PLoS ONE. 2014;9:e98885 pubmed publisher
|
Corcoran J, Lange A, Cumming R, Owen S, Ball J, Tyler C, et al. Bioavailability of the imidazole antifungal agent clotrimazole and its effects on key biotransformation genes in the common carp (Cyprinus carpio). Aquat Toxicol. 2014;152:57-65 pubmed publisher
|
Sharma C, Muralidhar S, Xu J, Meis J, Chowdhary A. Multilocus sequence typing of Candida africana from patients with vulvovaginal candidiasis in New Delhi, India. Mycoses. 2014;57:544-52 pubmed publisher
|
Grössinger E, Weiss L, Zierler S, Rebhandl S, Krenn P, Hinterseer E, et al. Targeting proliferation of chronic lymphocytic leukemia (CLL) cells through KCa3.1 blockade. Leukemia. 2014;28:954-8 pubmed publisher
|
Yuen C, Yip J, Cheung H, Liu L, Luk C, Wai W. Treatment of interdigital-type tinea pedis with a 2-week regimen of wearing hygienic socks loaded with antifungal microcapsules: a randomized, double-blind, placebo-controlled study. J Am Acad Dermatol. 2013;69:495-6 pubmed publisher
|
Goldust M, Rezaee E, Rouhani S. Double blind study of sertaconazole 2% cream vs. clotrimazole 1% cream in treatment of seborrheic dermatitis. Ann Parasitol. 2013;59:25-9 pubmed
|
Ravani L, Esposito E, Bories C, Moal V, Loiseau P, Djabourov M, et al. Clotrimazole-loaded nanostructured lipid carrier hydrogels: thermal analysis and in vitro studies. Int J Pharm. 2013;454:695-702 pubmed publisher
|
Neary C, Pastorino J. Akt inhibition promotes hexokinase 2 redistribution and glucose uptake in cancer cells. J Cell Physiol. 2013;228:1943-8 pubmed publisher
|
Nawaz A, Jan S, Khan N, Hussain A, Khan G. Formulation and in vitro evaluation of clotrimazole gel containing almond oil and tween 80 as penetration enhancer for topical application. Pak J Pharm Sci. 2013;26:617-22 pubmed
|
Basha M, Abd El Alim S, Shamma R, Awad G. Design and optimization of surfactant-based nanovesicles for ocular delivery of Clotrimazole. J Liposome Res. 2013;23:203-10 pubmed publisher
|
Mast N, Zheng W, Stout C, Pikuleva I. Antifungal Azoles: Structural Insights into Undesired Tight Binding to Cholesterol-Metabolizing CYP46A1. Mol Pharmacol. 2013;84:86-94 pubmed publisher
|
Turner K, Sontheimer H. KCa3.1 modulates neuroblast migration along the rostral migratory stream (RMS) in vivo. Cereb Cortex. 2014;24:2388-400 pubmed publisher
|
Nakayama S, Vest R, Traystman R, Herson P. Sexually dimorphic response of TRPM2 inhibition following cardiac arrest-induced global cerebral ischemia in mice. J Mol Neurosci. 2013;51:92-8 pubmed publisher
|
Sassano M, Doak A, Roth B, Shoichet B. Colloidal aggregation causes inhibition of G protein-coupled receptors. J Med Chem. 2013;56:2406-14 pubmed publisher
|
Stoneking C, Shivakumar O, Thomas D, Colledge W, Mason M. Voltage dependence of the Ca(2+)-activated K(+) channel K(Ca)3.1 in human erythroleukemia cells. Am J Physiol Cell Physiol. 2013;304:C858-72 pubmed publisher
|
Horng C, Chiang N, Chen I, Liang W, Chen I, Kuo D, et al. Effect of clotrimazole on cytosolic Ca(2+) rise and viability in HA59T human hepatoma cells. J Recept Signal Transduct Res. 2013;33:89-95 pubmed publisher
|
Miller B, Wang J, Hirschler Laszkiewicz I, Gao E, Song J, Zhang X, et al. The second member of transient receptor potential-melastatin channel family protects hearts from ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2013;304:H1010-22 pubmed publisher
|
Baudiffier D, Hinfray N, Ravaud C, Creusot N, Chadili E, Porcher J, et al. Effect of in vivo chronic exposure to clotrimazole on zebrafish testis function. Environ Sci Pollut Res Int. 2013;20:2747-60 pubmed publisher
|
Warrilow A, Parker J, Kelly D, Kelly S. Azole affinity of sterol 14?-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens. Antimicrob Agents Chemother. 2013;57:1352-60 pubmed publisher
|
Ouedraogo M, Konaté K, Lepengué A, Souza A, M Batchi B, Sawadogo L. Free radical scavenging capacity, anticandicidal effect of bioactive compounds from Sida cordifolia L., in combination with nystatin and clotrimazole and their effect on specific immune response in rats. Ann Clin Microbiol Antimicrob. 2012;11:33 pubmed publisher
|
Tang M, Corti M, Stirnimann R, Pelivani N, Yawalkar N, Borradori L, et al. Severe cutaneous allergic reactions following topical antifungal therapy. Contact Dermatitis. 2013;68:56-7 pubmed publisher
|
Agustí G, Fittipaldi M, Morato J, Codony F. Viable quantitative PCR for assessing the response of Candida albicans to antifungal treatment. Appl Microbiol Biotechnol. 2013;97:341-9 pubmed publisher
|
Lamm M, Simpson A, McNevin M, Frankenfeld C, Nay R, Variankaval N. Probing the effect of drug loading and humidity on the mechanical properties of solid dispersions with nanoindentation: antiplasticization of a polymer by a drug molecule. Mol Pharm. 2012;9:3396-402 pubmed publisher
|
Zhao Y, Vanhoutte P, Leung S. Endothelial nitric oxide synthase-independent release of nitric oxide in the aorta of the spontaneously hypertensive rat. J Pharmacol Exp Ther. 2013;344:15-22 pubmed publisher
|
McFerrin M, Turner K, Cuddapah V, Sontheimer H. Differential role of IK and BK potassium channels as mediators of intrinsic and extrinsic apoptotic cell death. Am J Physiol Cell Physiol. 2012;303:C1070-8 pubmed publisher
|
Perez R, Nazarian Y, Sohmer H, Sichel J. The effect of topically applied antimycotic agents on inner ear vestibular and cochlear function. Laryngoscope. 2013;123:1033-9 pubmed publisher
|
Khon E, Dzhenzhera G, Ovchinnikov A. [Local antibacterial therapy for the inflammatory diseases of the external and middle ear]. Vestn Otorinolaringol. 2012;:92-4 pubmed
|
Osmanagaoglu M, Kesim M, Yulug E, Mentese A, Karahan S. Ovarian-protective effects of clotrimazole on ovarian ischemia/reperfusion injury in a rat ovarian-torsion model. Gynecol Obstet Invest. 2012;74:125-30 pubmed
|
Tre E, Patel C, Aghara S, Yadav C, Stagni G. Optimization of perfusate pH to improve microdialysis recovery of lipophilic compounds. J Pharmacol Toxicol Methods. 2012;66:276-80 pubmed publisher
|
Balakrishnan P, Song C, Cho H, Yang S, Kim D, Yong C, et al. Inclusion complex effect on the bioavailability of clotrimazole from poloxamer-based solid suppository. Arch Pharm Res. 2012;35:1169-75 pubmed publisher
|
Escribano A, Marcel A, Tugores Y, Ruiz J, Redó V, García Trevijano J, et al. Validation of a modified fluorimetric assay for the screening of trichomonacidal drugs. Mem Inst Oswaldo Cruz. 2012;107:637-43 pubmed
|
Gemma S, Camodeca C, Sanna Coccone S, Joshi B, Bernetti M, Moretti V, et al. Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling. J Med Chem. 2012;55:6948-67 pubmed publisher
|
Kaomongkolgit R, Jamdee K, Wongnoi S, Chimnoi N, Techasakul S. Antifungal activity of coronarin D against Candida albicans. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114:61-6 pubmed publisher
|
Betanzos Lara S, Gómez Ruiz C, Barrón Sosa L, Gracia Mora I, Flores Alamo M, Barba Behrens N. Cytotoxic copper(II), cobalt(II), zinc(II), and nickel(II) coordination compounds of clotrimazole. J Inorg Biochem. 2012;114:82-93 pubmed publisher
|
Block T, Munson E. A 19-year-old male with a 3-day history of congestion and ear pain. J Clin Microbiol. 2012;50:2185, 2544 pubmed publisher
|
Rasool B, Salmo H. Development and clinical evaluation of clotrimazole-β-cyclodextrin eyedrops for the treatment of fungal keratitis. AAPS PharmSciTech. 2012;13:883-9 pubmed publisher
|
Bentmann E, Neumann M, Tahirovic S, Rodde R, Dormann D, Haass C. Requirements for stress granule recruitment of fused in sarcoma (FUS) and TAR DNA-binding protein of 43 kDa (TDP-43). J Biol Chem. 2012;287:23079-94 pubmed publisher
|
Telvekar V, Belubbi A, Bairwa V, Satardekar K. Novel N'-benzylidene benzofuran-3-carbohydrazide derivatives as antitubercular and antifungal agents. Bioorg Med Chem Lett. 2012;22:2343-6 pubmed publisher
|
Liu Z, Shi Q, Ding D, Kelly R, Fang H, Tong W. Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS Comput Biol. 2011;7:e1002310 pubmed publisher
|
Meister S, Plouffe D, Kuhen K, Bonamy G, Wu T, Barnes S, et al. Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science. 2011;334:1372-7 pubmed publisher
|
Chitra S, Paul N, Muthusubramanian S, Manisankar P, Yogeeswari P, Sriram D. A facile synthesis of carbocycle-fused mono and bis-1,2,3-selenadiazoles and their antimicrobial and antimycobacterial studies. Eur J Med Chem. 2011;46:5465-72 pubmed publisher
|
Khidre R, Abu Hashem A, El Shazly M. Synthesis and anti-microbial activity of some 1- substituted amino-4,6-dimethyl-2-oxo-pyridine-3-carbonitrile derivatives. Eur J Med Chem. 2011;46:5057-64 pubmed publisher
|
Al Abdullah E, Al Obaid A, Al Deeb O, Habib E, El Emam A. Synthesis of novel 6-phenyl-2,4-disubstituted pyrimidine-5-carbonitriles as potential antimicrobial agents. Eur J Med Chem. 2011;46:4642-7 pubmed publisher
|
Aly H, Saleh N, Elhady H. Design and synthesis of some new thiophene, thienopyrimidine and thienothiadiazine derivatives of antipyrine as potential antimicrobial agents. Eur J Med Chem. 2011;46:4566-72 pubmed publisher
|
Chen M, Vijay V, Shi Q, Liu Z, Fang H, Tong W. FDA-approved drug labeling for the study of drug-induced liver injury. Drug Discov Today. 2011;16:697-703 pubmed publisher
|
Mayer C, Bracher F. Cytotoxic ring A-modified steroid analogues derived from Grundmann's ketone. Eur J Med Chem. 2011;46:3227-36 pubmed publisher
|
Shaala L, Bamane F, Badr J, Youssef D. Brominated arginine-derived alkaloids from the red sea sponge Suberea mollis. J Nat Prod. 2011;74:1517-20 pubmed publisher
|
Rajakumar P, Satheeshkumar C, Mohanraj G, Mathivanan N. Synthesis and antimicrobial activity of some novel dicationic sulphonophanes. Eur J Med Chem. 2011;46:3093-8 pubmed publisher
|
Reddy D, Shekhar V, Prabhakar P, Babu D, Ramesh D, Siddhardha B, et al. Stereoselective first total synthesis, confirmation of the absolute configuration and bioevaluation of botryolide-E. Bioorg Med Chem Lett. 2011;21:997-1000 pubmed publisher
|
Sinha N, Sen S. Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. Eur J Med Chem. 2011;46:618-30 pubmed publisher
|
Kamal A, Radwan S, Zaki R. Synthesis and biological activity of pyrazolothienotetrahydroisoquinoline and [1,2,4]triazolo[3,4-a]thienotetrahydroisoquinoline derivatives. Eur J Med Chem. 2011;46:567-78 pubmed publisher
|
Chimenti F, Bizzarri B, Bolasco A, Secci D, Chimenti P, Granese A, et al. Synthesis and biological evaluation of novel 2,4-disubstituted-1,3-thiazoles as anti-Candida spp. agents. Eur J Med Chem. 2011;46:378-82 pubmed publisher
|
Bekhit A, Fahmy H, Rostom S, El Din A Bekhit A. Synthesis and biological evaluation of some thiazolylpyrazole derivatives as dual anti-inflammatory antimicrobial agents. Eur J Med Chem. 2010;45:6027-38 pubmed publisher
|
Ekins S, Williams A, Xu J. A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug Metab Dispos. 2010;38:2302-8 pubmed publisher
|
Rajanarendar E, Reddy M, Murthy K, Reddy K, Raju S, Srinivas M, et al. Synthesis, antimicrobial, and mosquito larvicidal activity of 1-aryl-4-methyl-3,6-bis-(5-methylisoxazol-3-yl)-2-thioxo-2,3,6,10b-tetrahydro-1H-pyrimido[5,4-c]quinolin-5-ones. Bioorg Med Chem Lett. 2010;20:6052-5 pubmed publisher
|
Kadi A, Al Abdullah E, Shehata I, Habib E, Ibrahim T, El Emam A. Synthesis, antimicrobial and anti-inflammatory activities of novel 5-(1-adamantyl)-1,3,4-thiadiazole derivatives. Eur J Med Chem. 2010;45:5006-11 pubmed publisher
|
Puri N, Prakash O, Manoharlal R, Sharma M, Ghosh I, Prasad R. Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. Eur J Med Chem. 2010;45:4813-26 pubmed publisher
|
Martel C, Parker J, Warrilow A, Rolley N, Kelly S, Kelly D. Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (sterol 14?-demethylase) doxycycline-regulated mutant and screening of the azole sensitivity of Aspergillus fumigatus isoenzymes CYP51A and CYP51B. Antimicrob Agents Chemother. 2010;54:4920-3 pubmed publisher
|
Martel C, Parker J, Bader O, Weig M, Gross U, Warrilow A, et al. Identification and characterization of four azole-resistant erg3 mutants of Candida albicans. Antimicrob Agents Chemother. 2010;54:4527-33 pubmed publisher
|
Reddy D, Shekhar V, Prabhakar P, Chinna Babu B, Siddhardha B, Murthy U, et al. Stereoselective synthesis and biological evaluation of (R)-rugulactone, (6R)-((4R)-hydroxy-6-phenyl-hex-2-enyl)-5,6-dihydro-pyran-2-one and its 4S epimer. Eur J Med Chem. 2010;45:4657-63 pubmed publisher
|
Warrilow A, Melo N, Martel C, Parker J, Nes W, Kelly S, et al. Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B. Antimicrob Agents Chemother. 2010;54:4225-34 pubmed publisher
|
Greene N, Fisk L, Naven R, Note R, Patel M, Pelletier D. Developing structure-activity relationships for the prediction of hepatotoxicity. Chem Res Toxicol. 2010;23:1215-22 pubmed publisher
|
Martel C, Parker J, Bader O, Weig M, Gross U, Warrilow A, et al. A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. Antimicrob Agents Chemother. 2010;54:3578-83 pubmed publisher
|
Muftuoglu Y, Mustata G. Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010;20:3050-64 pubmed publisher
|
Degraw A, Keiser M, Ochocki J, Shoichet B, Distefano M. Prediction and evaluation of protein farnesyltransferase inhibition by commercial drugs. J Med Chem. 2010;53:2464-71 pubmed publisher
|
Ozdemir A, Turan Zitouni G, Asim Kaplancikli Z, Iscan G, Khan S, Demirci F. Synthesis and the selective antifungal activity of 5,6,7,8-tetrahydroimidazo[1,2-a]pyridine derivatives. Eur J Med Chem. 2010;45:2080-4 pubmed publisher
|
Fourches D, Barnes J, Day N, Bradley P, Reed J, Tropsha A. Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chem Res Toxicol. 2010;23:171-83 pubmed publisher
|
Ramalingam P, Ganapaty S, Rao C. In vitro antitubercular and antimicrobial activities of 1-substituted quinoxaline-2,3(1H,4H)-diones. Bioorg Med Chem Lett. 2010;20:406-8 pubmed publisher
|
Miller C, Nisa S, Dempsey S, Jack C, O Toole R. Modifying culture conditions in chemical library screening identifies alternative inhibitors of mycobacteria. Antimicrob Agents Chemother. 2009;53:5279-83 pubmed publisher
|
Yuan J, Johnson R, Huang R, Wichterman J, Jiang H, Hayton K, et al. Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nat Chem Biol. 2009;5:765-71 pubmed publisher
|
Aghatabay N, Bas A, Kircali A, Sen G, Yazicioğlu M, Gucin F, et al. Synthesis, Raman, FT-IR, NMR spectroscopic characterization, antimicrobial activity, cytotoxicity and DNA binding of new mixed aza-oxo-thia macrocyclic compounds. Eur J Med Chem. 2009;44:4681-9 pubmed publisher
|
Vandeputte P, Tronchin G, Rocher F, Renier G, Berges T, Chabasse D, et al. Hypersusceptibility to azole antifungals in a clinical isolate of Candida glabrata with reduced aerobic growth. Antimicrob Agents Chemother. 2009;53:3034-41 pubmed publisher
|
Castagnolo D, Radi M, Dessì F, Manetti F, Saddi M, Meleddu R, et al. Synthesis and biological evaluation of new enantiomerically pure azole derivatives as inhibitors of Mycobacterium tuberculosis. Bioorg Med Chem Lett. 2009;19:2203-5 pubmed publisher
|
Pegoraro S, Lang M, Dreker T, Kraus J, Hamm S, Meere C, et al. Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants. Bioorg Med Chem Lett. 2009;19:2299-304 pubmed publisher
|
Rostom S, Ashour H, El Razik H, El Fattah A, El Din N. Azole antimicrobial pharmacophore-based tetrazoles: synthesis and biological evaluation as potential antimicrobial and anticonvulsant agents. Bioorg Med Chem. 2009;17:2410-22 pubmed publisher
|
Lamani R, Shetty N, Kamble R, Khazi I. Synthesis and antimicrobial studies of novel methylene bridged benzisoxazolyl imidazo[2,1-b][1,3,4]thiadiazole derivatives. Eur J Med Chem. 2009;44:2828-33 pubmed publisher
|
Roy K, Pratim Roy P. Comparative chemometric modeling of cytochrome 3A4 inhibitory activity of structurally diverse compounds using stepwise MLR, FA-MLR, PLS, GFA, G/PLS and ANN techniques. Eur J Med Chem. 2009;44:2913-22 pubmed publisher
|
Gemma S, Campiani G, Butini S, Joshi B, Kukreja G, Coccone S, et al. Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials. J Med Chem. 2009;52:502-13 pubmed publisher
|
Warrilow A, Jackson C, Parker J, Marczylo T, Kelly D, Lamb D, et al. Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae. Antimicrob Agents Chemother. 2009;53:1157-64 pubmed publisher
|
Al Qawasmeh R, Lee Y, Cao M, Gu X, Viau S, Lightfoot J, et al. 11-Phenyl-[b,e]-dibenzazepine compounds: novel antitumor agents. Bioorg Med Chem Lett. 2009;19:104-7 pubmed publisher
|
Jyrkkärinne J, Windshügel B, Ronkko T, Tervo A, Küblbeck J, Lahtela Kakkonen M, et al. Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship. J Med Chem. 2008;51:7181-92 pubmed publisher
|
Repo S, Jyrkkärinne J, Pulkkinen J, Laatikainen R, Honkakoski P, Johnson M. Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis. J Med Chem. 2008;51:7119-31 pubmed publisher
|
Ahlin G, Karlsson J, Pedersen J, Gustavsson L, Larsson R, Matsson P, et al. Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. J Med Chem. 2008;51:5932-42 pubmed publisher
|
Rezaei Z, Khabnadideh S, Pakshir K, Hossaini Z, Amiri F, Assadpour E. Design, synthesis, and antifungal activity of triazole and benzotriazole derivatives. Eur J Med Chem. 2009;44:3064-7 pubmed publisher
|
Nadaraj V, Selvi S, Mohan S. Microwave-induced synthesis and anti-microbial activities of 7,10,11,12-tetrahydrobenzo[c]acridin-8(9H)-one derivatives. Eur J Med Chem. 2009;44:976-80 pubmed publisher
|
Parker J, Merkamm M, Manning N, Pompon D, Kelly S, Kelly D. Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus. Antimicrob Agents Chemother. 2008;52:3597-603 pubmed publisher
|
O Driscoll M, Greenhalgh K, Young A, Turos E, Dickey S, Lim D. Studies on the antifungal properties of N-thiolated beta-lactams. Bioorg Med Chem. 2008;16:7832-7 pubmed publisher
|
Abou Shoer M, Shaala L, Youssef D, Badr J, Habib A. Bioactive brominated metabolites from the red sea sponge Suberea mollis. J Nat Prod. 2008;71:1464-7 pubmed publisher
|
Plouffe D, Brinker A, McNamara C, Henson K, Kato N, Kuhen K, et al. In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. Proc Natl Acad Sci U S A. 2008;105:9059-64 pubmed publisher
|
Pedersen J, Matsson P, Bergström C, Norinder U, Hoogstraate J, Artursson P. Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). J Med Chem. 2008;51:3275-87 pubmed publisher
|
Aghatabay N, Mahmiani Y, Cevik H, Dulger B. Synthesis, Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of mixed aza-oxo-thia macrocyclic compounds. Eur J Med Chem. 2009;44:365-72 pubmed publisher
|
Gemma S, Campiani G, Butini S, Kukreja G, Coccone S, Joshi B, et al. Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: design, synthesis, and biological and structure-activity relationship studies. J Med Chem. 2008;51:1278-94 pubmed publisher
|
McNaughton Smith G, Burns J, Stocker J, Rigdon G, Creech C, Arrington S, et al. Novel inhibitors of the Gardos channel for the treatment of sickle cell disease. J Med Chem. 2008;51:976-82 pubmed publisher
|
Feng B, Toyama B, Wille H, Colby D, Collins S, May B, et al. Small-molecule aggregates inhibit amyloid polymerization. Nat Chem Biol. 2008;4:197-9 pubmed publisher
|
Kumar R, Arunachalam S, Periasamy V, Preethy C, Riyasdeen A, Akbarsha M. DNA binding and biological studies of some novel water-soluble polymer-copper(II)-phenanthroline complexes. Eur J Med Chem. 2008;43:2082-91 pubmed
|
Serfling A, Wohlrab J, Deising H. Treatment of a clinically relevant plant-pathogenic fungus with an agricultural azole causes cross-resistance to medical azoles and potentiates caspofungin efficacy. Antimicrob Agents Chemother. 2007;51:3672-6 pubmed
|
Chimenti F, Bizzarri B, Maccioni E, Secci D, Bolasco A, Fioravanti R, et al. Synthesis and in vitro activity of 2-thiazolylhydrazone derivatives compared with the activity of clotrimazole against clinical isolates of Candida spp. Bioorg Med Chem Lett. 2007;17:4635-40 pubmed
|
Gemma S, Kukreja G, Campiani G, Butini S, Bernetti M, Joshi B, et al. Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling. Bioorg Med Chem Lett. 2007;17:3535-9 pubmed
|
Velu S, Mou L, Luan C, Yang Z, Delucas L, Brouillette C, et al. Antibacterial nicotinamide adenine dinucleotide synthetase inhibitors: amide- and ether-linked tethered dimers with alpha-amino acid end groups. J Med Chem. 2007;50:2612-21 pubmed
|
Feng B, Simeonov A, Jadhav A, Babaoglu K, Inglese J, Shoichet B, et al. A high-throughput screen for aggregation-based inhibition in a large compound library. J Med Chem. 2007;50:2385-90 pubmed
|
Diamandis P, Wildenhain J, Clarke I, Sacher A, Graham J, Bellows D, et al. Chemical genetics reveals a complex functional ground state of neural stem cells. Nat Chem Biol. 2007;3:268-73 pubmed
|
Aghatabay N, Somer M, Senel M, Dulger B, Gucin F. Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of bis[micro2-(benzimidazol-2-yl)-2-ethanethiolato-N,S,S-chloro-palladium(II)] dimer, [(micro2-CH2CH2NHNCC6H4)PdCl]2.C2H5OH complex. Eur J Med Chem. 2007;42:1069-75 pubmed
|
Tekiner Gulbas B, Temiz Arpaci O, Yildiz I, Altanlar N. Synthesis and in vitro antimicrobial activity of new 2-[p-substituted-benzyl]-5-[substituted-carbonylamino]benzoxazoles. Eur J Med Chem. 2007;42:1293-9 pubmed
|
Levy S, Ihmels J, Carmi M, Weinberger A, Friedlander G, Barkai N. Strategy of transcription regulation in the budding yeast. PLoS ONE. 2007;2:e250 pubmed
|
Gemma S, Campiani G, Butini S, Kukreja G, Joshi B, Persico M, et al. Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: exploring an innovative pharmacophore. J Med Chem. 2007;50:595-8 pubmed
|
Isin E, Guengerich F. Multiple sequential steps involved in the binding of inhibitors to cytochrome P450 3A4. J Biol Chem. 2007;282:6863-74 pubmed
|
Ekins S, Mankowski D, Hoover D, Lawton M, Treadway J, Harwood H. Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. Drug Metab Dispos. 2007;35:493-500 pubmed
|
Aghatabay N, Neshat A, Karabiyik T, Somer M, Haciu D, Dulger B. Synthesis, characterization and antimicrobial activity of Fe(II), Zn(II), Cd(II) and Hg(II) complexes with 2,6-bis(benzimidazol-2-yl) pyridine ligand. Eur J Med Chem. 2007;42:205-13 pubmed
|
Vandeputte P, Tronchin G, Berges T, Hennequin C, Chabasse D, Bouchara J. Reduced susceptibility to polyenes associated with a missense mutation in the ERG6 gene in a clinical isolate of Candida glabrata with pseudohyphal growth. Antimicrob Agents Chemother. 2007;51:982-90 pubmed
|
Kadi A, El Brollosy N, Al Deeb O, Habib E, Ibrahim T, El Emam A. Synthesis, antimicrobial, and anti-inflammatory activities of novel 2-(1-adamantyl)-5-substituted-1,3,4-oxadiazoles and 2-(1-adamantylamino)-5-substituted-1,3,4-thiadiazoles. Eur J Med Chem. 2007;42:235-42 pubmed
|
Cunningham F, Lee H, Gantt E. Carotenoid biosynthesis in the primitive red alga Cyanidioschyzon merolae. Eukaryot Cell. 2007;6:533-45 pubmed
|
Singh D, Verma N, Raghuwanshi S, Shukla P, Kulshreshtha D. Antifungal anthraquinones from Saprosma fragrans. Bioorg Med Chem Lett. 2006;16:4512-4 pubmed
|
MacDonald M, Lamerdin J, Owens S, Keon B, Bilter G, Shang Z, et al. Identifying off-target effects and hidden phenotypes of drugs in human cells. Nat Chem Biol. 2006;2:329-37 pubmed
|
El Sayed K, Youssef D, Marchetti D. Bioactive natural and semisynthetic latrunculins. J Nat Prod. 2006;69:219-23 pubmed
|
Kumar A, Sharma P, Gurram V, Rane N. Studies on synthesis and evaluation of quantitative structure-activity relationship of 10-methyl-6-oxo-5-arylazo-6,7-dihydro-5H-[1,3]azaphospholo[1,5-d][1,4]benzodiazepin-2-phospha-3-ethoxycarbonyl-1-phosphorus dichlorides. Bioorg Med Chem Lett. 2006;16:2484-91 pubmed
|
Kedersha N, Stoecklin G, Ayodele M, Yacono P, Lykke Andersen J, Fritzler M, et al. Stress granules and processing bodies are dynamically linked sites of mRNP remodeling. J Cell Biol. 2005;169:871-84 pubmed
|
Sharma P, Kumar A, Sharma S, Rane N. Studies on synthesis and evaluation of quantitative structure-activity relationship of 5-[(3'-chloro-4',4'-disubstituted-2-oxoazetidinyl)(N-nitro)amino]-6-hydroxy-3-alkyl/aryl[1,3]azaphospholo[1,5-a]pyridin-1-yl-phosphorus dichlorides. Bioorg Med Chem Lett. 2005;15:937-43 pubmed
|
McLean K, Marshall K, Richmond A, Hunter I, Fowler K, Kieser T, et al. Azole antifungals are potent inhibitors of cytochrome P450 mono-oxygenases and bacterial growth in mycobacteria and streptomycetes. Microbiology. 2002;148:2937-2949 pubmed publisher
|
Greenberg H, Shwayder T, Bieszk N, Fivenson D. Clotrimazole/betamethasone diproprionate: a review of costs and complications in the treatment of common cutaneous fungal infections. Pediatr Dermatol. 2002;19:78-81 pubmed
|
Jensen B, Strøbaek D, Olesen S, Christophersen P. The Ca2+-activated K+ channel of intermediate conductance: a molecular target for novel treatments?. Curr Drug Targets. 2001;2:401-22 pubmed
|
Schmook F, Meingassner J, Billich A. Comparison of human skin or epidermis models with human and animal skin in in-vitro percutaneous absorption. Int J Pharm. 2001;215:51-6 pubmed
|
Henry K, Nickels J, Edlind T. Upregulation of ERG genes in Candida species by azoles and other sterol biosynthesis inhibitors. Antimicrob Agents Chemother. 2000;44:2693-700 pubmed
|
Shartava A, Shah A, Goodman S. N-acetylcysteine and clotrimazole inhibit sickle erythrocyte dehydration induced by 1-chloro-2,4-dinitrobenzene. Am J Hematol. 1999;62:19-24 pubmed
|
Wu S, Li H, Jan C, Shen A. Inhibition of Ca2+-activated K+ current by clotrimazole in rat anterior pituitary GH3 cells. Neuropharmacology. 1999;38:979-89 pubmed
|
Thomas G, Karmazyn M, Zygmunt A, Antzelevitch C, Narayanan N. The antifungal antibiotic clotrimazole potently inhibits L-type calcium current in guinea-pig ventricular myocytes. Br J Pharmacol. 1999;126:1531-3 pubmed
|
Snajdrova L, Xu A, Narayanan N. Clotrimazole, an antimycotic drug, inhibits the sarcoplasmic reticulum calcium pump and contractile function in heart muscle. J Biol Chem. 1998;273:28032-9 pubmed
|
Coupry I, Armsby C, Alper S, Parini A, Brugnara C. Inhibition of red cell Ca(2+)-activated K+ transport by clotrimazole does not take place via imidazoline binding sites. Ann N Y Acad Sci. 1995;763:287-9 pubmed
|
Brugnara C, de Franceschi L, Armsby C, Saadane N, Trudel M, Beuzard Y, et al. A new therapeutic approach for sickle cell disease. Blockade of the red cell Ca(2+)-activated K+ channel by clotrimazole. Ann N Y Acad Sci. 1995;763:262-71 pubmed
|
Lücker P, Beubler E, Kukovetz W, Ritter W. Retention time and concentration in human skin of bifonazole and clotrimazole. Dermatologica. 1984;169 Suppl 1:51-5 pubmed
|
Vanden Bossche H, Marichal P, Gorrens J, Coene M. Biochemical basis for the activity and selectivity of oral antifungal drugs. Br J Clin Pract Suppl. 1990;71:41-6 pubmed
|
Fan Havard P, Capano D, Smith S, Mangia A, Eng R. Development of resistance in candida isolates from patients receiving prolonged antifungal therapy. Antimicrob Agents Chemother. 1991;35:2302-5 pubmed
|
Sawyer P, Brogden R, Pinder R, Speight T, Avery -. Clotrimazole: a review of its antifungal activity and therapeutic efficacy. Drugs. 1975;9:424-47 pubmed
|