Kang J, Lago C, Lee J, Park J, Donnelly M, Starost M, et al. A Mouse Homolog of a Human TP53 Germline Mutation Reveals a Lipolytic Activity of p53. Cell Rep. 2020;30:783-792.e5 pubmed publisher

Nguyen H, Yi D, Lin F, Viscarra J, Tabuchi C, Ngo K, et al. Aifm2, a NADH Oxidase, Supports Robust Glycolysis and Is Required for Cold- and Diet-Induced Thermogenesis. Mol Cell. 2020;77:600-617.e4 pubmed publisher

Périé L, Verma N, Xu L, Ma X, Mueller E. Transcriptional Regulation of ZNF638 in Thermogenic Cells by the cAMP Response Element Binding Protein in Male Mice. J Endocr Soc. 2019;3:2326-2340 pubmed publisher

Helsley R, Varadharajan V, Brown A, Gromovsky A, Schugar R, Ramachandiran I, et al. Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease. elife. 2019;8: pubmed publisher

Qiao X, Kim D, Jun H, Ma Y, Knights A, Park M, et al. Protein Arginine Methyltransferase 1 Interacts With PGC1α and Modulates Thermogenic Fat Activation. Endocrinology. 2019;160:2773-2786 pubmed publisher

Zhao Y, Pan J, Wang Y, Zou Y, Guo L, Tang Q, et al. Stimulation of histamine H4 receptor participates in cold-induced browning of subcutaneous white adipose tissue. Am J Physiol Endocrinol Metab. 2019;317:E1158-E1171 pubmed publisher

He P, Hou B, Li Y, Xu C, Ma P, Lam S, et al. Lipid Profiling Reveals Browning Heterogeneity of White Adipose Tissue by Β3-Adrenergic Stimulation. Biomolecules. 2019;9: pubmed publisher

Kim S, Lee E, Lee S, Kim Y, Lee C, Jo D, et al. Site-specific impairment of perivascular adipose tissue on advanced atherosclerotic plaques using multimodal nonlinear optical imaging. Proc Natl Acad Sci U S A. 2019;116:17765-17774 pubmed publisher

Hurtado del Pozo C, Ruiz H, Arivazhagan L, Aranda J, Shim C, Daya P, et al. A Receptor of the Immunoglobulin Superfamily Regulates Adaptive Thermogenesis. Cell Rep. 2019;28:773-791.e7 pubmed publisher

Wang W, Ishibashi J, Trefely S, Shao M, Cowan A, Sakers A, et al. A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate. Cell Metab. 2019;: pubmed publisher

Li J, Gong L, Liu S, Zhang Y, Zhang C, Tian M, et al. Adipose HuR protects against diet-induced obesity and insulin resistance. Nat Commun. 2019;10:2375 pubmed publisher

Kurita K, Ishikawa K, Takeda K, Fujimoto M, Ono H, Kumagai J, et al. CXCL12-CXCR4 pathway activates brown adipocytes and induces insulin resistance in CXCR4-deficient mice under high-fat diet. Sci Rep. 2019;9:6165 pubmed publisher

Cervone D, Sheremeta J, Kraft E, Dyck D. Acylated and unacylated ghrelin directly regulate ß-3 stimulated lipid turnover in rodent subcutaneous and visceral adipose tissue ex vivo but not in vivo. Adipocyte. 2019;8:1-15 pubmed publisher

Shrestha S, Sunaga H, Hanaoka H, Yamaguchi A, Kuwahara S, Umbarawan Y, et al. Circulating FABP4 is eliminated by the kidney via glomerular filtration followed by megalin-mediated reabsorption. Sci Rep. 2018;8:16451 pubmed publisher

Ju L, Chen S, Alimujiang M, Bai N, Yan H, Fang Q, et al. A novel role for Bcl2l13 in promoting beige adipocyte biogenesis. Biochem Biophys Res Commun. 2018;506:485-491 pubmed publisher

Santos R, Frank A, Fátima L, Palmer B, Oz O, Clegg D. Activation of estrogen receptor alpha induces beiging of adipocytes. Mol Metab. 2018;18:51-59 pubmed publisher

Drareni K, Ballaire R, Barilla S, Mathew M, Toubal A, Fan R, et al. GPS2 Deficiency Triggers Maladaptive White Adipose Tissue Expansion in Obesity via HIF1A Activation. Cell Rep. 2018;24:2957-2971.e6 pubmed publisher

Hagberg C, Li Q, Kutschke M, Bhowmick D, Kiss E, Shabalina I, et al. Flow Cytometry of Mouse and Human Adipocytes for the Analysis of Browning and Cellular Heterogeneity. Cell Rep. 2018;24:2746-2756.e5 pubmed publisher

Jun H, Yu H, Gong J, Jiang J, Qiao X, Perkey E, et al. An immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling. Nat Med. 2018;24:814-822 pubmed publisher

Yuan F, Zhang L, Cao Y, Gao W, Zhao C, Fang Y, et al. Spermidine/spermine N1-acetyltransferase-mediated polyamine catabolism regulates beige adipocyte biogenesis. Metabolism. 2018;85:298-304 pubmed publisher

Mendes N, Gaspar J, Lima Junior J, Donato J, Velloso L, Araujo E. TGF-β1 down-regulation in the mediobasal hypothalamus attenuates hypothalamic inflammation and protects against diet-induced obesity. Metabolism. 2018;85:171-182 pubmed publisher

Banfi S, Gusarova V, Gromada J, Cohen J, Hobbs H. Increased thermogenesis by a noncanonical pathway in ANGPTL3/8-deficient mice. Proc Natl Acad Sci U S A. 2018;115:E1249-E1258 pubmed publisher

Williams J, Elvington A, Ivanov S, Kessler S, Luehmann H, Baba O, et al. Thermoneutrality but Not UCP1 Deficiency Suppresses Monocyte Mobilization Into Blood. Circ Res. 2017;121:662-676 pubmed publisher

Doig C, Fletcher R, Morgan S, McCabe E, Larner D, Tomlinson J, et al. 11β-HSD1 Modulates the Set Point of Brown Adipose Tissue Response to Glucocorticoids in Male Mice. Endocrinology. 2017;158:1964-1976 pubmed publisher

Boutant M, Kulkarni S, Joffraud M, Ratajczak J, Valera Alberni M, Combe R, et al. Mfn2 is critical for brown adipose tissue thermogenic function. EMBO J. 2017;36:1543-1558 pubmed publisher

Di Salvo J, Nagabukuro H, Wickham L, Abbadie C, DeMartino J, Fitzmaurice A, et al. Pharmacological Characterization of a Novel Beta 3 Adrenergic Agonist, Vibegron: Evaluation of Antimuscarinic Receptor Selectivity for Combination Therapy for Overactive Bladder. J Pharmacol Exp Ther. 2017;360:346-355 pubmed publisher

Yang H, Wu J, Wang S, Severi I, Sartini L, Frizzell N, et al. Adipose-Specific Deficiency of Fumarate Hydratase in Mice Protects Against Obesity, Hepatic Steatosis, and Insulin Resistance. Diabetes. 2016;65:3396-3409 pubmed

Boutant M, Joffraud M, Kulkarni S, García Casarrubios E, García Roves P, Ratajczak J, et al. SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function. Mol Metab. 2015;4:118-31 pubmed publisher

Park J, Jung K, Lee J, Quach C, Moon S, Cho Y, et al. 18F-FDG PET/CT monitoring of β3 agonist-stimulated brown adipocyte recruitment in white adipose tissue. J Nucl Med. 2015;56:153-8 pubmed publisher

Bartelt A, Weigelt C, Cherradi M, Niemeier A, Tödter K, Heeren J, et al. Effects of adipocyte lipoprotein lipase on de novo lipogenesis and white adipose tissue browning. Biochim Biophys Acta. 2013;1831:934-42 pubmed publisher

Ghorbani M, Shafiee Ardestani M, Gigloo S, Cohan R, Inanlou D, Ghorbani P. Anti diabetic effect of CL 316,243 (a ?3-adrenergic agonist) by down regulation of tumour necrosis factor (TNF-?) expression. PLoS ONE. 2012;7:e45874 pubmed publisher

Oikawa F, Nakahara T, Akanuma K, Ueda K, Mori A, Sakamoto K, et al. Protective effects of the β3-adrenoceptor agonist CL316243 against N-methyl-D-aspartate-induced retinal neurotoxicity. Naunyn Schmiedebergs Arch Pharmacol. 2012;385:1077-81 pubmed publisher

Sato M, Hutchinson D, Halls M, Furness S, Bengtsson T, Evans B, et al. Interaction with caveolin-1 modulates G protein coupling of mouse ?3-adrenoceptor. J Biol Chem. 2012;287:20674-88 pubmed publisher

Chen Y, Cypess A, Sass C, Brownell A, Jokivarsi K, Kahn C, et al. Anatomical and functional assessment of brown adipose tissue by magnetic resonance imaging. Obesity (Silver Spring). 2012;20:1519-26 pubmed publisher

Ferguson R, Novosyadlyy R, Fierz Y, Alikhani N, Sun H, Yakar S, et al. Hyperinsulinemia enhances c-Myc-mediated mammary tumor development and advances metastatic progression to the lung in a mouse model of type 2 diabetes. Breast Cancer Res. 2012;14:R8 pubmed

Kaya T, Karadas B, Altun A, Sarac I, Bagcivan I. Effects and selectivity of CL 316243, beta-3-adrenoceptor agonist, in term-pregnant rat myometrium. Gynecol Obstet Invest. 2012;73:63-9 pubmed publisher

Kitao N, Hashimoto M. Increased thermogenic capacity of brown adipose tissue under low temperature and its contribution to arousal from hibernation in Syrian hamsters. Am J Physiol Regul Integr Comp Physiol. 2012;302:R118-25 pubmed publisher

Okamatsu Ogura Y, Nio Kobayashi J, Iwanaga T, Terao A, Kimura K, Saito M. Possible involvement of uncoupling protein 1 in appetite control by leptin. Exp Biol Med (Maywood). 2011;236:1274-81 pubmed publisher

Wanajo I, Tomiyama Y, Yamazaki Y, Kojima M. Ureteral selectivity of intravenous β-adrenoceptor agonists in pig model of acute ureteral obstruction: comparison of KUL-7211, a selective β2/β3 agonist, with isoproterenol, terbutaline, and CL-316243. Urology. 2011;77:1266.e1-6 pubmed publisher

Chartoumpekis D, Habeos I, Ziros P, Psyrogiannis A, Kyriazopoulou V, Papavassiliou A. Brown adipose tissue responds to cold and adrenergic stimulation by induction of FGF21. Mol Med. 2011;17:736-40 pubmed publisher

Bundgaard H, Liu C, Garcia A, Hamilton E, Huang Y, Chia K, et al. ?(3) adrenergic stimulation of the cardiac Na+-K+ pump by reversal of an inhibitory oxidative modification. Circulation. 2010;122:2699-708 pubmed publisher

Deiuliis J, Liu L, Belury M, Rim J, Shin S, Lee K. Beta(3)-adrenergic signaling acutely down regulates adipose triglyceride lipase in brown adipocytes. Lipids. 2010;45:479-89 pubmed publisher

Mori A, Miwa T, Sakamoto K, Nakahara T, Ishii K. Pharmacological evidence for the presence of functional beta(3)-adrenoceptors in rat retinal blood vessels. Naunyn Schmiedebergs Arch Pharmacol. 2010;382:119-26 pubmed publisher

Fukui H, Miwa E, Iwachido T, Kitaura H, Furukawa H. Various emetogens increase the secretion of salivary amylase in rats: a potential model in emesis research. J Pharmacol Sci. 2010;113:143-52 pubmed

Vegiopoulos A, Muller Decker K, Strzoda D, Schmitt I, Chichelnitskiy E, Ostertag A, et al. Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes. Science. 2010;328:1158-61 pubmed publisher

Pang Z, Wu N, Zhang X, Avallone R, Croci T, Dressler H, et al. GPR40 is partially required for insulin secretion following activation of beta3-adrenergic receptors. Mol Cell Endocrinol. 2010;325:18-25 pubmed publisher

Mattsson C, Andersson E, Nedergaard J. Differential involvement of caveolin-1 in brown adipocyte signaling: impaired beta3-adrenergic, but unaffected LPA, PDGF and EGF receptor signaling. Biochim Biophys Acta. 2010;1803:983-9 pubmed publisher

Barbatelli G, Murano I, Madsen L, Hao Q, Jimenez M, Kristiansen K, et al. The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation. Am J Physiol Endocrinol Metab. 2010;298:E1244-53 pubmed publisher

Nagabukuro H, Degenhardt A, Villa K, Mistry S, Gichuru L, Jochnowitz N, et al. Correlation between pharmacologically-induced changes in cystometric parameters and spinal c-Fos expression in rats. Auton Neurosci. 2010;156:19-26 pubmed publisher

Fierz Y, Novosyadlyy R, Vijayakumar A, Yakar S, LeRoith D. Insulin-sensitizing therapy attenuates type 2 diabetes-mediated mammary tumor progression. Diabetes. 2010;59:686-93 pubmed publisher

Kanshin E, Wang S, Ashmarina L, Fedjaev M, Nifant ev I, Mitchell G, et al. The stoichiometry of protein phosphorylation in adipocyte lipid droplets: analysis by N-terminal isotope tagging and enzymatic dephosphorylation. Proteomics. 2009;9:5067-77 pubmed publisher

Aizawa N, Igawa Y, Nishizawa O, Wyndaele J. Effects of CL316,243, a beta 3-adrenoceptor agonist, and intravesical prostaglandin E2 on the primary bladder afferent activity of the rat. Neurourol Urodyn. 2010;29:771-6 pubmed publisher

Martin S, Okano S, Kistler C, Fernandez Rojo M, Hill M, Parton R. Spatiotemporal regulation of early lipolytic signaling in adipocytes. J Biol Chem. 2009;284:32097-107 pubmed publisher

Ahmad F, Lindh R, Tang Y, Ruishalme I, Ost A, Sahachartsiri B, et al. Differential regulation of adipocyte PDE3B in distinct membrane compartments by insulin and the beta3-adrenergic receptor agonist CL316243: effects of caveolin-1 knockdown on formation/maintenance of macromolecular signalling complexes. Biochem J. 2009;424:399-410 pubmed publisher

Chaudhry A, Granneman J. Differential regulation of functional responses by beta-adrenergic receptor subtypes in brown adipocytes. Am J Physiol. 1999;277:R147-53 pubmed publisher

Soeder K, Snedden S, Cao W, Della Rocca G, Daniel K, Luttrell L, et al. The beta3-adrenergic receptor activates mitogen-activated protein kinase in adipocytes through a Gi-dependent mechanism. J Biol Chem. 1999;274:12017-22 pubmed

Igawa Y, Yamazaki Y, Takeda H, Hayakawa K, Akahane M, Ajisawa Y, et al. Functional and molecular biological evidence for a possible beta3-adrenoceptor in the human detrusor muscle. Br J Pharmacol. 1999;126:819-25 pubmed

Ohsaka Y, Murakami T, Yoshida T, Tokumitsu Y. Comparison of atypical beta3-adrenoceptor agonists with their respective metabolic activities in rat white adipocytes. Jpn J Pharmacol. 1998;77:41-51 pubmed

Umekawa T, Yoshida T, Sakane N, Kondo M. Effect of CL316,243, a highly specific beta 3-adrenoceptor agonist, on lipolysis of human and rat adipocytes. Horm Metab Res. 1996;28:394-6 pubmed