This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
protein
product name :
Complement factor H from human plasma
catalog :
C5813
citations: 81
Reference
Ghosh K, Prakash A, Dhara A, Hussain M, Shrivastav P, Kumar P, et al. Role of Supramolecule ErpY-Like Lipoprotein of Leptospira in Thrombin-Catalyzed Fibrin Clot Inhibition and Binding to Complement Factors H and I, and Its Diagnostic Potential. Infect Immun. 2019;87: pubmed publisher
Wittes J, Musch D. Should we test for genotype in deciding on age-related eye disease study supplementation?. Ophthalmology. 2015;122:3-5 pubmed publisher
Chew E, Klein M, Clemons T, Agrón E, Abecasis G. Genetic testing in persons with age-related macular degeneration and the use of the AREDS supplements: to test or not to test?. Ophthalmology. 2015;122:212-5 pubmed publisher
Blaum B, Hannan J, Herbert A, Kavanagh D, Uhrin D, Stehle T. Structural basis for sialic acid-mediated self-recognition by complement factor H. Nat Chem Biol. 2015;11:77-82 pubmed publisher
Achila D, Liu A, Banerjee R, Li Y, Martinez Hackert E, Zhang J, et al. Structural determinants of host specificity of complement Factor H recruitment by Streptococcus pneumoniae. Biochem J. 2015;465:325-35 pubmed publisher
Shen L, FRAZER ABEL A, Reynolds P, Giclas P, Chappell A, Pangburn M, et al. Mechanistic understanding for the greater sensitivity of monkeys to antisense oligonucleotide-mediated complement activation compared with humans. J Pharmacol Exp Ther. 2014;351:709-17 pubmed publisher
Cai L, Zhu J, Yin D, Chen L, Jin P, Ma F. Identification and characterization of complement factor H in Branchiostoma belcheri. Gene. 2014;553:42-8 pubmed publisher
Loeven M, Rops A, Berden J, Daha M, Rabelink T, van der Vlag J. The role of heparan sulfate as determining pathogenic factor in complement factor H-associated diseases. Mol Immunol. 2015;63:203-8 pubmed publisher
Awh C, Hawken S, Zanke B. Treatment response to antioxidants and zinc based on CFH and ARMS2 genetic risk allele number in the Age-Related Eye Disease Study. Ophthalmology. 2015;122:162-9 pubmed publisher
Saade C, Ganti B, Marmor M, Freund K, Smith R. Risk characteristics of the combined geographic atrophy and choroidal neovascularisation phenotype in age-related macular degeneration. Br J Ophthalmol. 2014;98:1729-32 pubmed publisher
Land M, Cooper R, Young J, Berg E, Kitchner T, Xiang Q, et al. Cone structure in subjects with known genetic relative risk for AMD. Optom Vis Sci. 2014;91:939-49 pubmed publisher
Myers C, Klein B, Gangnon R, Sivakumaran T, Iyengar S, Klein R. Cigarette smoking and the natural history of age-related macular degeneration: the Beaver Dam Eye Study. Ophthalmology. 2014;121:1949-55 pubmed publisher
Matar D, Naqvi F, Racusen L, Carter Monroe N, Montgomery R, Alachkar N. Atypical hemolytic uremic syndrome recurrence after kidney transplantation. Transplantation. 2014;98:1205-12 pubmed publisher
Valoti E, Alberti M, Tortajada A, García Fernández J, Gastoldi S, Besso L, et al. A novel atypical hemolytic uremic syndrome-associated hybrid CFHR1/CFH gene encoding a fusion protein that antagonizes factor H-dependent complement regulation. J Am Soc Nephrol. 2015;26:209-19 pubmed publisher
Bernhard S, Fleury C, Su Y, Zipfel P, Koske I, Nordstrom T, et al. Outer membrane protein OlpA contributes to Moraxella catarrhalis serum resistance via interaction with factor H and the alternative pathway. J Infect Dis. 2014;210:1306-10 pubmed publisher
Huang L, Li Y, Guo S, Sun Y, Zhang C, Bai Y, et al. Different hereditary contribution of the CFH gene between polypoidal choroidal vasculopathy and age-related macular degeneration in Chinese Han people. Invest Ophthalmol Vis Sci. 2014;55:2534-8 pubmed publisher
Ferluga J, Kishore U, Sim R. A potential anti-coagulant role of complement factor H. Mol Immunol. 2014;59:188-93 pubmed publisher
Wilkes M, Miller D, Mitchell M, Zanke B, Petersen M, Sisk R, et al. Investigation of choroidal neovascularization risk alleles in ocular histoplasmosis. Ophthalmology. 2014;121:1487-8.e1 pubmed publisher
Bonomo J, Palmer N, Hicks P, Lea J, Okusa M, Langefeld C, et al. Complement factor H gene associations with end-stage kidney disease in African Americans. Nephrol Dial Transplant. 2014;29:1409-14 pubmed publisher
Hautamäki A, Kivioja J, Seitsonen S, Savolainen E, Liinamaa M, Luoma A, et al. The IL-8, VEGF, and CFH polymorphisms and bevacizumab in age-related macular degeneration. Ophthalmology. 2014;121:973-973.e1 pubmed publisher
Boddu S, Lee M, Marsiglia M, Marmor M, Freund K, Smith R. Risk factors associated with reticular pseudodrusen versus large soft drusen. Am J Ophthalmol. 2014;157:985-993.e2 pubmed publisher
Grumach A, Ceccon M, Rutz R, Fertig A, Kirschfink M. Complement profile in neonates of different gestational ages. Scand J Immunol. 2014;79:276-81 pubmed publisher
Wang X, Geng P, Zhang Y, Zhang M. Association between complement factor H Val62Ile polymorphism and age-related macular degeneration susceptibility: a meta-analysis. Gene. 2014;538:306-12 pubmed publisher
Liu K, Chen L, Lai T, Tam P, Ho M, Chiang S, et al. Genes in the high-density lipoprotein metabolic pathway in age-related macular degeneration and polypoidal choroidal vasculopathy. Ophthalmology. 2014;121:911-6 pubmed publisher
Nozal P, Garrido S, Alba Domínguez M, Espinosa L, Peña A, Cordoba S, et al. An ELISA assay with two monoclonal antibodies allows the estimation of free factor H and identifies patients with acquired deficiency of this complement regulator. Mol Immunol. 2014;58:194-200 pubmed publisher
Faleri A, Santini L, Brier S, Pansegrau W, Lo Surdo P, Scarselli M, et al. Two cross-reactive monoclonal antibodies recognize overlapping epitopes on Neisseria meningitidis factor H binding protein but have different functional properties. FASEB J. 2014;28:1644-53 pubmed publisher
Rowan S, Weikel K, Chang M, Nagel B, Thinschmidt J, Carey A, et al. Cfh genotype interacts with dietary glycemic index to modulate age-related macular degeneration-like features in mice. Invest Ophthalmol Vis Sci. 2014;55:492-501 pubmed publisher
Del Tordello E, Vacca I, Ram S, Rappuoli R, Serruto D. Neisseria meningitidis NalP cleaves human complement C3, facilitating degradation of C3b and survival in human serum. Proc Natl Acad Sci U S A. 2014;111:427-32 pubmed publisher
Joachim N, Mitchell P, Rochtchina E, Tan A, Wang J. Incidence and progression of reticular drusen in age-related macular degeneration: findings from an older Australian cohort. Ophthalmology. 2014;121:917-25 pubmed publisher
Ardissino G, Tel F, Testa S, Marzano A, Lazzari R, Salardi S, et al. Skin involvement in atypical hemolytic uremic syndrome. Am J Kidney Dis. 2014;63:652-5 pubmed publisher
Schaumberg D, Rose L, DeAngelis M, Semba R, Hageman G, Chasman D. Prospective study of common variants in CX3CR1 and risk of macular degeneration: pooled analysis from 5 long-term studies. JAMA Ophthalmol. 2014;132:84-95 pubmed publisher
Ruseva M, Takahashi M, Fujita T, Pickering M. C3 dysregulation due to factor H deficiency is mannan-binding lectin-associated serine proteases (MASP)-1 and MASP-3 independent in vivo. Clin Exp Immunol. 2014;176:84-92 pubmed publisher
Budzinskaia M, Pogoda T, Generozov E, Chikun E, Gurova I, Shchegoleva I, et al. [Contemporary pharmacogenetic approaches to the treatment of age-related macular degeneration]. Vestn Oftalmol. 2013;129:128-35 pubmed
McLaughlin M, Paglione M, Slakter J, Tolentino M, Ye L, Xu C, et al. Initial exploration of oral pazopanib in healthy participants and patients with age-related macular degeneration. JAMA Ophthalmol. 2013;131:1595-601 pubmed publisher
Cao S, Ko A, Partanen M, Pakzad Vaezi K, Merkur A, Albiani D, et al. Relationship between systemic cytokines and complement factor H Y402H polymorphism in patients with dry age-related macular degeneration. Am J Ophthalmol. 2013;156:1176-83 pubmed publisher
Lotery A, Gibson J, Cree A, Downes S, Harding S, Rogers C, et al. Pharmacogenetic associations with vascular endothelial growth factor inhibition in participants with neovascular age-related macular degeneration in the IVAN Study. Ophthalmology. 2013;120:2637-2643 pubmed publisher
Fujimura Y. [Atypical hemolytic uremic syndrome]. Rinsho Ketsueki. 2013;54:1897-906 pubmed
Chen A, Seifert H. Structure-function studies of the Neisseria gonorrhoeae major outer membrane porin. Infect Immun. 2013;81:4383-91 pubmed publisher
Helgason H, Sulem P, Duvvari M, Luo H, Thorleifsson G, Stefansson H, et al. A rare nonsynonymous sequence variant in C3 is associated with high risk of age-related macular degeneration. Nat Genet. 2013;45:1371-4 pubmed publisher
Zhan X, Larson D, Wang C, Koboldt D, Sergeev Y, Fulton R, et al. Identification of a rare coding variant in complement 3 associated with age-related macular degeneration. Nat Genet. 2013;45:1375-9 pubmed publisher
Rayes J, Roumenina L, Dimitrov J, Repesse Y, Ing M, Christophe O, et al. The interaction between factor H and VWF increases factor H cofactor activity and regulates VWF prothrombotic status. Blood. 2014;123:121-5 pubmed publisher
Nolasco L, Nolasco J, Feng S, Afshar Kharghan V, Moake J. Human complement factor H is a reductase for large soluble von Willebrand factor multimers--brief report. Arterioscler Thromb Vasc Biol. 2013;33:2524-8 pubmed publisher
Neidich A, Neidich E, Lee A, Nicoletta J, Rohrer R, Milner L, et al. Novel use of intravenous immunoglobulin G in complement factor H missense mutation: a case report. Prog Transplant. 2013;23:213-6 pubmed publisher
Awh C, Lane A, Hawken S, Zanke B, Kim I. CFH and ARMS2 genetic polymorphisms predict response to antioxidants and zinc in patients with age-related macular degeneration. Ophthalmology. 2013;120:2317-23 pubmed publisher
Yang M, Lai T, Tam P, Chiang S, Ng T, Rong S, et al. Association of CFH and SERPING1 polymorphisms with anterior uveitis. Br J Ophthalmol. 2013;97:1475-80 pubmed publisher
Agrahari G, Liang Z, Mayfield J, Balsara R, Ploplis V, Castellino F. Complement-mediated opsonization of invasive group A Streptococcus pyogenes strain AP53 is regulated by the bacterial two-component cluster of virulence responder/sensor (CovRS) system. J Biol Chem. 2013;288:27494-504 pubmed publisher
Kraivong R, Vasanawathana S, Limpitikul W, Malasit P, Tangthawornchaikul N, Botto M, et al. Complement alternative pathway genetic variation and Dengue infection in the Thai population. Clin Exp Immunol. 2013;174:326-34 pubmed publisher
Zhang Y, Nester C, Holanda D, Marsh H, Hammond R, Thomas L, et al. Soluble CR1 therapy improves complement regulation in C3 glomerulopathy. J Am Soc Nephrol. 2013;24:1820-9 pubmed publisher
Wilson V, Darlay R, Wong W, Wood K, McFarlane J, Schejbel L, et al. Genotype/phenotype correlations in complement factor H deficiency arising from uniparental isodisomy. Am J Kidney Dis. 2013;62:978-83 pubmed publisher
Sharma N, Sharma S, Gupta A, Prabhakar S, Singh R, Anand A. Predictive model for earlier diagnosis of suspected age-related macular degeneration patients. DNA Cell Biol. 2013;32:549-55 pubmed publisher
Skerka C, Chen Q, Fremeaux Bacchi V, Roumenina L. Complement factor H related proteins (CFHRs). Mol Immunol. 2013;56:170-80 pubmed publisher
Boiko E, Churashov S, Kamilova T. [Molecular genetic basis of age-related macular degeneration]. Vestn Oftalmol. 2013;129:86-90 pubmed
Dragon Durey M, Blanc C, Marinozzi M, van Schaarenburg R, Trouw L. Autoantibodies against complement components and functional consequences. Mol Immunol. 2013;56:213-21 pubmed publisher
Hörl S, Banki Z, Huber G, Ejaz A, Windisch D, Muellauer B, et al. Reduction of complement factor H binding to CLL cells improves the induction of rituximab-mediated complement-dependent cytotoxicity. Leukemia. 2013;27:2200-8 pubmed publisher
Faber C, Singh A, Krüger Falk M, Juel H, Sørensen T, Nissen M. Age-related macular degeneration is associated with increased proportion of CD56(+) T cells in peripheral blood. Ophthalmology. 2013;120:2310-6 pubmed publisher
Ambati J, Atkinson J, Gelfand B. Immunology of age-related macular degeneration. Nat Rev Immunol. 2013;13:438-51 pubmed publisher
Makou E, Herbert A, Barlow P. Functional anatomy of complement factor H. Biochemistry. 2013;52:3949-62 pubmed publisher
Uslu Gokceoglu A, Dogan C, Comak E, Koyun M, Akman S. Atypical hemolytic uremic syndrome due to factor H autoantibody. Turk J Pediatr. 2013;55:86-9 pubmed
Nan R, Tetchner S, Rodriguez E, Pao P, Gor J, Lengyel I, et al. Zinc-induced self-association of complement C3b and Factor H: implications for inflammation and age-related macular degeneration. J Biol Chem. 2013;288:19197-210 pubmed publisher
Chapin J, Eyler S, Smith R, Tsai H, Laurence J. Complement factor H mutations are present in ADAMTS13-deficient, ticlopidine-associated thrombotic microangiopathies. Blood. 2013;121:4012-3 pubmed publisher
Bhattacharjee A, Oeemig J, Kolodziejczyk R, Meri T, Kajander T, Lehtinen M, et al. Structural basis for complement evasion by Lyme disease pathogen Borrelia burgdorferi. J Biol Chem. 2013;288:18685-95 pubmed publisher
Massart A, Golmarvi S, Hachimi Idrissi S, Broeders E, Tournay Y, Nortier J, et al. Complement factor H functional assay may help to monitor atypical haemolytic uraemic syndrome: a pilot study. Acta Clin Belg. 2013;68:9-14 pubmed
Vaillancourt K, Bonifait L, Grignon L, Frenette M, Gottschalk M, Grenier D. Identification and characterization of a new cell surface protein possessing factor H-binding activity in the swine pathogen and zoonotic agent Streptococcus suis. J Med Microbiol. 2013;62:1073-1080 pubmed publisher
Schmidt C, Bai H, Lin Z, Risitano A, Barlow P, Ricklin D, et al. Rational engineering of a minimized immune inhibitor with unique triple-targeting properties. J Immunol. 2013;190:5712-21 pubmed publisher
Wolf Schnurrbusch U, Hess R, Jordi F, Stuck A, Sarra G, Wolf S, et al. Detection of Chlamydia and complement factors in neovascular membranes of patients with age-related macular degeneration. Ocul Immunol Inflamm. 2013;21:36-43 pubmed publisher
Thompson I, Liu B, Sen H, Jiao X, Katamay R, Li Z, et al. Association of complement factor H tyrosine 402 histidine genotype with posterior involvement in sarcoid-related uveitis. Am J Ophthalmol. 2013;155:1068-1074.e1 pubmed publisher
Klein R, Myers C, Meuer S, Gangnon R, Sivakumaran T, Iyengar S, et al. Risk alleles in CFH and ARMS2 and the long-term natural history of age-related macular degeneration: the Beaver Dam Eye Study. JAMA Ophthalmol. 2013;131:383-92 pubmed publisher
Brookes C, Kuisma E, Alexander F, Allen L, Tipton T, Ram S, et al. Development of a large scale human complement source for use in bacterial immunoassays. J Immunol Methods. 2013;391:39-49 pubmed publisher
Yuan D, Yang Q, Liu X, Yuan D, Yuan S, Xie P, et al. Complement factor H Val62Ile variant and risk of age-related macular degeneration: a meta-analysis. Mol Vis. 2013;19:374-83 pubmed
Banda N, Mehta G, Ferreira V, Cortes C, Pickering M, Pangburn M, et al. Essential role of surface-bound complement factor H in controlling immune complex-induced arthritis. J Immunol. 2013;190:3560-9 pubmed publisher
Bresin E, Rurali E, Caprioli J, Sanchez Corral P, Fremeaux Bacchi V, Rodriguez de Cordoba S, et al. Combined complement gene mutations in atypical hemolytic uremic syndrome influence clinical phenotype. J Am Soc Nephrol. 2013;24:475-86 pubmed publisher
Zhang D, Huang X, Wang D, Li Y, Yao Y. Genetic variants of complement genes ficolin-2, mannose-binding lectin and complement factor H are associated with leprosy in Han Chinese from Southwest China. Hum Genet. 2013;132:629-40 pubmed publisher
Seddon J, Reynolds R, Yu Y, Rosner B. Validation of a prediction algorithm for progression to advanced macular degeneration subtypes. JAMA Ophthalmol. 2013;131:448-55 pubmed publisher
Zipfel P, Lauer N. Defective complement action and control defines disease pathology for retinal and renal disorders and provides a basis for new therapeutic approaches. Adv Exp Med Biol. 2013;735:173-87 pubmed
Barata L, Miwa T, Sato S, Kim D, Mohammed I, Song W. Deletion of Crry and DAF on murine platelets stimulates thrombopoiesis and increases factor H-dependent resistance of peripheral platelets to complement attack. J Immunol. 2013;190:2886-95 pubmed publisher
Sofat R, Mangione P, Gallimore J, Hakobyan S, Hughes T, Shah T, et al. Distribution and determinants of circulating complement factor H concentration determined by a high-throughput immunonephelometric assay. J Immunol Methods. 2013;390:63-73 pubmed publisher
Kenney M, Chwa M, Atilano S, Pavlis J, Falatoonzadeh P, Ramirez C, et al. Mitochondrial DNA variants mediate energy production and expression levels for CFH, C3 and EFEMP1 genes: implications for age-related macular degeneration. PLoS ONE. 2013;8:e54339 pubmed publisher
Clark S, Ridge L, Herbert A, Hakobyan S, Mulloy B, Lennon R, et al. Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions. J Immunol. 2013;190:2049-57 pubmed publisher
Le Quintrec M, Zuber J, Moulin B, Kamar N, Jablonski M, Lionet A, et al. Complement genes strongly predict recurrence and graft outcome in adult renal transplant recipients with atypical hemolytic and uremic syndrome. Am J Transplant. 2013;13:663-75 pubmed publisher
Park S, Shin Y, Kim C, Park H, Seong Y, Kim B, et al. Immune evasion of Enterococcus faecalis by an extracellular gelatinase that cleaves C3 and iC3b. J Immunol. 2008;181:6328-36 pubmed
Perez Caballero D, García Laorden I, Cortés G, Wessels M, de Cordoba S, Alberti S. Interaction between complement regulators and Streptococcus pyogenes: binding of C4b-binding protein and factor H/factor H-like protein 1 to M18 strains involves two different cell surface molecules. J Immunol. 2004;173:6899-904 pubmed
product information
Catalog Number :
C5813
Product Name :
Complement factor H from human plasma
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
1 mg/mL in PBS, pH 7.2, ≥90% (SDS-PAGE)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA