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product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Carbamoylcholine chloride
catalog :
C4382
citations: 203
Reference
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Nøhr A, Shehata M, Palmer D, Pokhrel R, Vallianou M, Foster S, et al. Identification of a novel scaffold for a small molecule GPR139 receptor agonist. Sci Rep. 2019;9:3802 pubmed publisher
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Durand de Cuttoli R, Mondoloni S, Marti F, Lemoine D, Nguyen C, Naudé J, et al. Manipulating midbrain dopamine neurons and reward-related behaviors with light-controllable nicotinic acetylcholine receptors. elife. 2018;7: pubmed publisher
Hannanta Anan P, Chow B. Optogenetic Inhibition of Gαq Protein Signaling Reduces Calcium Oscillation Stochasticity. ACS Synth Biol. 2018;7:1488-1495 pubmed publisher
Kanai S, Edwards A, Rurik J, Osei Owusu P, Blumer K. Proteolytic degradation of regulator of G protein signaling 2 facilitates temporal regulation of Gq/11 signaling and vascular contraction. J Biol Chem. 2017;292:19266-19278 pubmed publisher
Sangoi M, Lamothe S, Guo J, Yang T, Li W, Avery E, et al. ?-Arrestin-Mediated Regulation of the Human Ether-a-go-go-Related Gene Potassium Channel. Mol Pharmacol. 2017;92:162-174 pubmed publisher
de Sousa D, Mesquita R, de Araújo Ribeiro L, de Lima J. Spasmolytic Activity of Carvone and Limonene Enantiomers. Nat Prod Commun. 2015;10:1893-6 pubmed
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Al Suleimani Y, Al Mahruqi A, Hiley C. Mechanisms of vasorelaxation induced by the cannabidiol analogue compound O-1602 in the rat small mesenteric artery. Eur J Pharmacol. 2015;765:107-14 pubmed publisher
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Heusler P, Cussac D, Naline E, Tardif S, Clerc T, Devillier P. Characterization of V0162, a new long-acting antagonist at human M3 muscarinic acetylcholine receptors. Pharmacol Res. 2015;100:117-26 pubmed publisher
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Kovacevic I, Müller M, Kojonazarov B, Ehrke A, Randriamboavonjy V, Kohlstedt K, et al. The F-BAR Protein NOSTRIN Dictates the Localization of the Muscarinic M3 Receptor and Regulates Cardiovascular Function. Circ Res. 2015;117:460-9 pubmed publisher
Wang S, Iring A, Strilic B, Albarrán Juárez J, Kaur H, Troidl K, et al. P2Y₂ and Gq/G₁₁ control blood pressure by mediating endothelial mechanotransduction. J Clin Invest. 2015;125:3077-86 pubmed publisher
Hodeify R, Selvaraj S, Wen J, Arredouani A, Hubrack S, Dib M, et al. A STIM1-dependent 'trafficking trap' mechanism regulates Orai1 plasma membrane residence and Ca²⁺ influx levels. J Cell Sci. 2015;128:3143-54 pubmed publisher
Goswami C, Shimada Y, Yoshimura M, Mondal A, Oda S, Tanaka T, et al. Motilin Stimulates Gastric Acid Secretion in Coordination with Ghrelin in Suncus murinus. PLoS ONE. 2015;10:e0131554 pubmed publisher
Wan M, Zhang W, Tian Y, Xu C, Xu T, Liu J, et al. Unraveling a molecular determinant for clathrin-independent internalization of the M2 muscarinic acetylcholine receptor. Sci Rep. 2015;5:11408 pubmed publisher
Yamanishi T, Kaga K, Fuse M, Shibata C, Kamai T, Uchiyama T. The role of muscarinic receptor subtypes on carbachol-induced contraction of normal human detrusor and overactive detrusor associated with benign prostatic hyperplasia. J Pharmacol Sci. 2015;128:65-70 pubmed publisher
Joseph N, Tom Esther N, Télesphore Benoît N, Paul Désiré D, Oumarou Bibi Farouck A, Théophile D, et al. Effects of the aqueous extract of Pittosporum mannii Hook. f. (Pittosporaceae) stem barks on spontaneous and spasmogen-induced contractile activity of isolated rat duodenum. J Ethnopharmacol. 2015;172:1-9 pubmed publisher
Mastropaolo M, Zizzo M, Auteri M, Caldara G, Liotta R, Mule F, et al. Activation of angiotensin II type 1 receptors and contractile activity in human sigmoid colon in vitro. Acta Physiol (Oxf). 2015;215:37-45 pubmed publisher
Loong B, Tan J, Lim K, Mbaki Y, Ting K. Contractile function of smooth muscle retained after overnight storage. Naunyn Schmiedebergs Arch Pharmacol. 2015;388:1061-7 pubmed publisher
Glykos V, Whittington M, LeBeau F. Subregional differences in the generation of fast network oscillations in the rat medial prefrontal cortex (mPFC) in vitro. J Physiol. 2015;593:3597-615 pubmed publisher
Moradi M, Fatahi Z, Haghparast A. Blockade of D1-like dopamine receptors within the ventral tegmental area and nucleus accumbens attenuates antinociceptive responses induced by chemical stimulation of the lateral hypothalamus. Neurosci Lett. 2015;599:61-6 pubmed publisher
Binker M, Richards D, Gaisano H, Cosen Binker L. ER stress-associated CTRC mutants decrease stimulated pancreatic zymogen secretion through SIRT2-mediated microtubule dysregulation. Biochem Biophys Res Commun. 2015;463:329-35 pubmed publisher
Kaneda T, Saito E, Kanda H, Urakawa N, Shimizu K. Effects of papaverine on carbachol- and high K+ -induced contraction in the bovine abomasum. J Vet Med Sci. 2015;77:1269-74 pubmed publisher
Gillespie J, Rouget C, Palea S, Granato C, Birder L, Korstanje C. The characteristics of intrinsic complex micro-contractile activity in isolated strips of the rat bladder. Naunyn Schmiedebergs Arch Pharmacol. 2015;388:709-18 pubmed publisher
Goswami C, Tanaka T, Jogahara T, Sakai T, Sakata I. Motilin stimulates pepsinogen secretion in Suncus murinus. Biochem Biophys Res Commun. 2015;462:263-8 pubmed publisher
Cernecka H, Kersten K, Maarsingh H, Elzinga C, de Jong I, Korstanje C, et al. β3-Adrenoceptor-mediated relaxation of rat and human urinary bladder: roles of BKCa channels and Rho kinase. Naunyn Schmiedebergs Arch Pharmacol. 2015;388:749-59 pubmed publisher
Dooley L, Abdalmula A, Washington E, Kaufman C, Tudor E, Ghosh P, et al. Effect of mesenchymal precursor cells on the systemic inflammatory response and endothelial dysfunction in an ovine model of collagen-induced arthritis. PLoS ONE. 2015;10:e0124144 pubmed publisher
Rhodes J, Saxena D, Zhang G, Gittes G, Potoka D. Defective parasympathetic innervation is associated with airway branching abnormalities in experimental CDH. Am J Physiol Lung Cell Mol Physiol. 2015;309:L168-74 pubmed publisher
Hadigal S, Agelidis A, Karasneh G, Antoine T, Yakoub A, Ramani V, et al. Heparanase is a host enzyme required for herpes simplex virus-1 release from cells. Nat Commun. 2015;6:6985 pubmed publisher
Ibáñez Sandoval O, Xenias H, Tepper J, Koós T. Dopaminergic and cholinergic modulation of striatal tyrosine hydroxylase interneurons. Neuropharmacology. 2015;95:468-76 pubmed publisher
Brodarac A, Šarić T, Oberwallner B, Mahmoodzadeh S, Neef K, Albrecht J, et al. Susceptibility of murine induced pluripotent stem cell-derived cardiomyocytes to hypoxia and nutrient deprivation. Stem Cell Res Ther. 2015;6:83 pubmed publisher
Ohi Y, Kato D, Mizuno M, Sato T, Ueki Y, Borlongan C, et al. Enhancement of long-term potentiation via muscarinic modulation in the hippocampus of HCNP precursor transgenic mice. Neurosci Lett. 2015;597:1-6 pubmed publisher
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Macêdo C, Vasconcelos L, Correia A, Martins I, Lira D, Santos B, et al. Mechanisms underlying the relaxant effect of Galetin 3,6- dimethyl ether, from Piptadenia stipulacea (Benth.) Ducke, on guinea-pig trachea. Z Naturforsch C J Biosci. 2014;69:434-42 pubmed publisher
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Ciciora S, Williams K, Gariepy C. Effects of Amoxicillin and Clavulanic Acid on the Spontaneous Mechanical Activity of Juvenile Rat Duodenum. J Pediatr Gastroenterol Nutr. 2015;61:340-5 pubmed publisher
Jardí F, Aguilera M, Vergara P, Martinez V. Lipopolysaccharides facilitate colonic motor alterations associated to the sensitization to a luminal antigen in rats. J Neurogastroenterol Motil. 2015;21:222-35 pubmed publisher
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Bocian R, Kazmierska P, Kłos Wojtczak P, Kowalczyk T, Konopacki J. Orexinergic theta rhythm in the rat hippocampal formation: In vitro and in vivo findings. Hippocampus. 2015;25:1393-406 pubmed publisher
Paparini D, Gori S, Grasso E, Scordo W, Calo G, Perez Leiros C, et al. Acetylcholine contributes to control the physiological inflammatory response during the peri-implantation period. Acta Physiol (Oxf). 2015;214:237-47 pubmed publisher
Zhu Y, Lu Y, Qu C, Miller M, Tian J, Thakur D, et al. Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. Br J Pharmacol. 2015;172:3495-509 pubmed publisher
Amonyingcharoen S, Suriyo T, Thiantanawat A, Watcharasit P, Satayavivad J. Taurolithocholic acid promotes intrahepatic cholangiocarcinoma cell growth via muscarinic acetylcholine receptor and EGFR/ERK1/2 signaling pathway. Int J Oncol. 2015;46:2317-26 pubmed publisher
Wada Y, Baba S, Kamimura S. Effects of the dynein inhibitor ciliobrevin on the flagellar motility of sea urchin spermatozoa. Cytoskeleton (Hoboken). 2015;72:182-92 pubmed publisher
Tang Y, Yang W, Wang Y, Gong Y, Jiang L, Lin L. Estrogen regulates the expression of small-conductance Ca-activated K+ channels in colonic smooth muscle cells. Digestion. 2015;91:187-96 pubmed publisher
Zhao Q, Gu X, Zhang C, Lu Q, Chen H, Xu L. Blocking M2 muscarinic receptor signaling inhibits tumor growth and reverses epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC). Cancer Biol Ther. 2015;16:634-43 pubmed publisher
Cerina M, Szkudlarek H, Coulon P, Meuth P, Kanyshkova T, Nguyen X, et al. Thalamic Kv 7 channels: pharmacological properties and activity control during noxious signal processing. Br J Pharmacol. 2015;172:3126-40 pubmed publisher
Kang S, McDermott C, Farr S, Chess Williams R. Enhanced urothelial ATP release and contraction following intravesical treatment with the cytotoxic drug, doxorubicin. Naunyn Schmiedebergs Arch Pharmacol. 2015;388:773-80 pubmed publisher
Granja M, Braga L, Carpi Santos R, de Araújo Martins L, Nunes Tavares N, Calaza K, et al. IL-4 Induces Cholinergic Differentiation of Retinal Cells In Vitro. Cell Mol Neurobiol. 2015;35:689-701 pubmed publisher
Riahi E, Arezoomandan R, Fatahi Z, Haghparast A. The electrical activity of hippocampal pyramidal neuron is subjected to descending control by the brain orexin/hypocretin system. Neurobiol Learn Mem. 2015;119:93-101 pubmed publisher
Wei F, Wei M, Murakami M. Mechanism involved in Danshen-induced fluid secretion in salivary glands. World J Gastroenterol. 2015;21:1444-56 pubmed publisher
AlSuleimani Y, Hiley C. The GPR55 agonist lysophosphatidylinositol relaxes rat mesenteric resistance artery and induces Ca(2+) release in rat mesenteric artery endothelial cells. Br J Pharmacol. 2015;172:3043-57 pubmed publisher
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St Laurent C, St Laurent K, Mathison R, Befus A. Calcium-binding protein, spermatid-specific 1 is expressed in human salivary glands and contains an anti-inflammatory motif. Am J Physiol Regul Integr Comp Physiol. 2015;308:R569-75 pubmed publisher
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Terra S, Cardoso J, Félix R, Martins L, Souza D, Guma F, et al. STC1 interference on calcitonin family of receptors signaling during osteoblastogenesis via adenylate cyclase inhibition. Mol Cell Endocrinol. 2015;403:78-87 pubmed publisher
Tomankova H, Valuskova P, Varejkova E, Rotkova J, Benes J, Myslivecek J. The M2 muscarinic receptors are essential for signaling in the heart left ventricle during restraint stress in mice. Stress. 2015;18:208-20 pubmed publisher
Ezzatpanah S, Babapour V, Sadeghi B, Haghparast A. Chemical stimulation of the lateral hypothalamus by carbachol attenuated the formalin-induced pain behaviors in rats. Pharmacol Biochem Behav. 2015;129:105-10 pubmed publisher
Cheah E, Mann T, Burcham P, Henry P. Influenza A infection attenuates relaxation responses of mouse tracheal smooth muscle evoked by acrolein. Biochem Pharmacol. 2015;93:519-26 pubmed publisher
Janbaz K, Qayyum A, Saqib F, Imran I, Zia Ul Haq M, De Feo V. Bronchodilator, vasodilator and spasmolytic activities of Cymbopogon martinii. J Physiol Pharmacol. 2014;65:859-66 pubmed
Mutihac R, Alegre Abarrategui J, Gordon D, Farrimond L, Yamasaki Mann M, Talbot K, et al. TARDBP pathogenic mutations increase cytoplasmic translocation of TDP-43 and cause reduction of endoplasmic reticulum Ca²⁺ signaling in motor neurons. Neurobiol Dis. 2015;75:64-77 pubmed publisher
Shukla M, Htoo H, Wintachai P, Hernandez J, Dubois C, Postina R, et al. Melatonin stimulates the nonamyloidogenic processing of βAPP through the positive transcriptional regulation of ADAM10 and ADAM17. J Pineal Res. 2015;58:151-65 pubmed publisher
Rashidy Pour A, Moradi M, Fatahi Z, Haghparast A, Haghparast A. Role of intra-hippocampal orexin 1 and orexin 2 receptors in conditioned place preference induced by chemical stimulation of the lateral hypothalamus. Behav Brain Res. 2015;279:106-11 pubmed publisher
Palla A, Khan N, Bashir S, Ur Rehman N, Iqbal J, Gilani A. Pharmacological basis for the medicinal use of Linum usitatissimum (Flaxseed) in infectious and non-infectious diarrhea. J Ethnopharmacol. 2015;160:61-8 pubmed publisher
Hill G, Headon D, Harris Z, Huttner K, Limesand K. Pharmacological activation of the EDA/EDAR signaling pathway restores salivary gland function following radiation-induced damage. PLoS ONE. 2014;9:e112840 pubmed publisher
Fonseca B, Martínez Águila A, Díaz Hernández M, Pintor J. Diadenosine tetraphosphate contributes to carbachol-induced tear secretion. Purinergic Signal. 2015;11:87-93 pubmed publisher
Lee C, Rho S, Sung G, Kim N, Yang J, Lee N, et al. Effect of Goniosynechialysis During Phacoemulsification on IOP in Patients With Medically Well-controlled Chronic Angle-Closure Glaucoma. J Glaucoma. 2015;24:405-9 pubmed publisher
Evcim A, Micili S, Karaman M, Erbil G, Guneli E, Gidener S, et al. The Role of Rac1 on Carbachol-induced Contractile Activity in Detrusor Smooth Muscle from Streptozotocin-induced Diabetic Rats. Basic Clin Pharmacol Toxicol. 2015;116:476-84 pubmed publisher
Ramos Filho A, Shah A, Augusto T, Barbosa G, Leiria L, de Carvalho H, et al. Menthol inhibits detrusor contractility independently of TRPM8 activation. PLoS ONE. 2014;9:e111616 pubmed publisher
Leong R, Xing H, Braekman J, Kem W. Non-competitive Inhibition of Nicotinic Acetylcholine Receptors by Ladybird Beetle Alkaloids. Neurochem Res. 2015;40:2078-86 pubmed publisher
Grace K, Vanstone L, Horner R. Endogenous cholinergic input to the pontine REM sleep generator is not required for REM sleep to occur. J Neurosci. 2014;34:14198-209 pubmed publisher
Omar B, Sörhede Winzell M, Ahrén B. Conditional glucagon receptor overexpression has multi-faceted consequences for beta-cell function. Metabolism. 2014;63:1568-76 pubmed publisher
Nishiyama K, Azuma Y, Shintaku K, Yoshida N, Nakajima H, Takeuchi T. Evidence that nitric oxide is a non-adrenergic non-cholinergic inhibitory neurotransmitter in the circular muscle of the mouse distal colon: a study on the mechanism of nitric oxide-induced relaxation. Pharmacology. 2014;94:99-108 pubmed publisher
Bijos D, Drake M, Vahabi B. Anoctamin-1 in the juvenile rat urinary bladder. PLoS ONE. 2014;9:e106190 pubmed publisher
Wu C, Sui G, Archer S, Sassone Corsi P, Aitken K, Bagli D, et al. Local receptors as novel regulators for peripheral clock expression. FASEB J. 2014;28:4610-6 pubmed publisher
Guan N, Thor A, Hallén K, Wiklund N, Gustafsson L. Cascade bioassay evidence for the existence of urothelium-derived inhibitory factor in Guinea pig urinary bladder. PLoS ONE. 2014;9:e103932 pubmed publisher
Nuche Berenguer B, Moreno P, Jensen R. Elucidation of the roles of the Src kinases in pancreatic acinar cell signaling. J Cell Biochem. 2015;116:22-36 pubmed publisher
Mori D, Watanabe N, Kaminuma O, Murata T, Hiroi T, Ozaki H, et al. IL-17A induces hypo-contraction of intestinal smooth muscle via induction of iNOS in muscularis macrophages. J Pharmacol Sci. 2014;125:394-405 pubmed
Blackmore H, Niu Y, Fernandez Twinn D, Tarry Adkins J, Giussani D, Ozanne S. Maternal diet-induced obesity programs cardiovascular dysfunction in adult male mouse offspring independent of current body weight. Endocrinology. 2014;155:3970-80 pubmed publisher
Hubert F, Belacel Ouari M, Manoury B, Zhai K, Domergue Dupont V, Mateo P, et al. Alteration of vascular reactivity in heart failure: role of phosphodiesterases 3 and 4. Br J Pharmacol. 2014;171:5361-75 pubmed publisher
Bhatia V, Rastellini C, Han S, Aronson J, Greeley G, Falzon M. Acinar cell-specific knockout of the PTHrP gene decreases the proinflammatory and profibrotic responses in pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2014;307:G533-49 pubmed publisher
Lima Fernandes E, Misticone S, Boularan C, Paradis J, Enslen H, Roux P, et al. A biosensor to monitor dynamic regulation and function of tumour suppressor PTEN in living cells. Nat Commun. 2014;5:4431 pubmed publisher
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Gavaldá A, Ramos I, Carcasona C, Calama E, Otal R, Montero J, et al. The in vitro and in vivo profile of aclidinium bromide in comparison with glycopyrronium bromide. Pulm Pharmacol Ther. 2014;28:114-21 pubmed publisher
Bläuer M, Sand J, Nordback I, Laukkarinen J. A novel 2-step culture model for long-term in vitro maintenance of human pancreatic acinar cells. Pancreas. 2014;43:762-7 pubmed publisher
Luis J, Aquino T, Lira B, Filho P, Scotti M, Scotti L, et al. Synthesis and preliminary ex vivo evaluation of the spasmolytic activity of 1,3-thiazolium- and 1,3,4-thiadiazolium-5-methylthio- and 5-thioacetate derivatives. Acta Pharm. 2014;64:233-45 pubmed publisher
Sibaev A, Yuece B, Allescher H, Saur D, Storr M, Kurjak M. The endocannabinoid anandamide regulates the peristaltic reflex by reducing neuro-neuronal and neuro-muscular neurotransmission in ascending myenteric reflex pathways in rats. Pharmacol Rep. 2014;66:256-63 pubmed publisher
Hammad F, Stephen B, Lubbad L, Morrison J, Lammers W. Macroscopic electrical propagation in the guinea pig urinary bladder. Am J Physiol Renal Physiol. 2014;307:F172-82 pubmed publisher
Lies B, Gil V, Groneberg D, Seidler B, Saur D, Wischmeyer E, et al. Interstitial cells of Cajal mediate nitrergic inhibitory neurotransmission in the murine gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol. 2014;307:G98-106 pubmed publisher
Ruggieri M, Braverman A, Vegesna A, Miller L. Nicotinic receptor subtypes mediating relaxation of the normal human clasp and sling fibers of the upper gastric sphincter. Neurogastroenterol Motil. 2014;26:1015-25 pubmed publisher
Karakhanova S, Golovastova M, Philippov P, Werner J, Bazhin A. Interlude of cGMP and cGMP/protein kinase G type 1 in pancreatic adenocarcinoma cells. Pancreas. 2014;43:784-94 pubmed publisher
Michal P, El Fakahany E, Dolezal V. Changes in Membrane Cholesterol Differentially Influence Preferential and Non-preferential Signaling of the M1 and M3 Muscarinic Acetylcholine Receptors. Neurochem Res. 2015;40:2068-77 pubmed publisher
Hao C, Huang Z, Song S, Shi Y, Cheng X, Murohara T, et al. Arterial baroreflex dysfunction impairs ischemia-induced angiogenesis. J Am Heart Assoc. 2014;3:e000804 pubmed publisher
Zarepour L, Fatahi Z, Sarihi A, Haghparast A. Blockade of orexin-1 receptors in the ventral tegmental area could attenuate the lateral hypothalamic stimulation-induced potentiation of rewarding properties of morphine. Neuropeptides. 2014;48:179-85 pubmed publisher
Lee M, Cho K, Park H, Sung H, Choi S, Im W. Pharmacological profile of DA-6886, a novel 5-HT4 receptor agonist to accelerate colonic motor activity in mice. Eur J Pharmacol. 2014;735:115-22 pubmed publisher
Ruzza C, Rizzi A, Malfacini D, Cerlesi M, Ferrari F, Marzola E, et al. Pharmacological characterization of tachykinin tetrabranched derivatives. Br J Pharmacol. 2014;171:4125-37 pubmed publisher
Pekel G, Yagci R, Acer S, Cetin E, Cevik A, Kaşıkçı A. Effect of intracameral carbachol in phacoemulsification surgery on macular morphology and retinal vessel caliber. Cutan Ocul Toxicol. 2015;34:42-5 pubmed publisher
La Fuente J, Fernández A, Cuevas P, Gonzalez Corrochano R, Chen M, Angulo J. Stimulation of large-conductance calcium-activated potassium channels inhibits neurogenic contraction of human bladder from patients with urinary symptoms and reverses acetic acid-induced bladder hyperactivity in rats. Eur J Pharmacol. 2014;735:68-76 pubmed publisher
Del Fiacco M, Quartu M, Ekstrom J, Melis T, Boi M, Isola M, et al. Effect of the neuropeptides vasoactive intestinal peptide, peptide histidine methionine and substance P on human major salivary gland secretion. Oral Dis. 2015;21:216-23 pubmed publisher
Wang T, Hogan Cann A, Kang Y, Cui Z, Guo J, Yang T, et al. Muscarinic receptor activation increases hERG channel expression through phosphorylation of ubiquitin ligase Nedd4-2. Mol Pharmacol. 2014;85:877-86 pubmed publisher
Violato N, Rafacho A, Boschero A, Bosqueiro J. Higher insulin sensitivity and impaired insulin secretion in cachetic solid ehrlich tumour-bearing mice. Horm Metab Res. 2014;46:615-20 pubmed publisher
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product information
Catalog Number :
C4382
Product Name :
Carbamoylcholine chloride
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (titration), crystalline
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
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