This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Ciglitizone
catalog :
C3974
citations: 48
Reference
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Dasgupta S, Vliet S, Cheng V, Mitchell C, Kirkwood J, Vollaro A, et al. Complex Interplay Among Nuclear Receptor Ligands, Cytosine Methylation, and the Metabolome in Driving Tris(1,3-dichloro-2-propyl)phosphate-Induced Epiboly Defects in Zebrafish. Environ Sci Technol. 2019;53:10497-10505 pubmed publisher
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Choe S, Choi E, Hyeon J, Keum B, Choi I, Kim S. Telmisartan, an angiotensin II receptor blocker, attenuates Prevotella intermedia lipopolysaccharide-induced production of nitric oxide and interleukin-1β in murine macrophages. Int Immunopharmacol. 2019;75:105750 pubmed publisher
Castillo J, Wu E, Lowe C, Srinivasan S, McCord R, Wagle M, et al. CBP/p300 drives the differentiation of Regulatory T cells through transcriptional and non-transcriptional mechanisms. Cancer Res. 2019;: pubmed publisher
Levick S, Brower G, Janicki J. Substance P-mediated cardiac mast cell activation: An in vitro study. Neuropeptides. 2019;74:52-59 pubmed publisher
Fukano K, Tsukuda S, Oshima M, Suzuki R, Aizaki H, Ohki M, et al. Troglitazone Impedes the Oligomerization of Sodium Taurocholate Cotransporting Polypeptide and Entry of Hepatitis B Virus Into Hepatocytes. Front Microbiol. 2018;9:3257 pubmed publisher
Nor Effa S, Yaacob N, Mohd Nor N. Crosstalk between PPARγ Ligands and Inflammatory-Related Pathways in Natural T-Regulatory Cells from Type 1 Diabetes Mouse Model. Biomolecules. 2018;8: pubmed publisher
Cho R, Yang C, Tseng H, Hsiao L, Lin C, Yang C. Haem oxygenase-1 up-regulation by rosiglitazone via ROS-dependent Nrf2-antioxidant response elements axis or PPARγ attenuates LPS-mediated lung inflammation. Br J Pharmacol. 2018;175:3928-3946 pubmed publisher
Zhong W, Tsai Y, Chin L, Tseng J, Tang L, Horng S, et al. A Synergistic Anti-Cancer Effect of Troglitazone and Lovastatin in a Human Anaplastic Thyroid Cancer Cell Line and in a Mouse Xenograft Model. Int J Mol Sci. 2018;19: pubmed publisher
Chistyakov D, Grabeklis S, Goriainov S, Chistyakov V, Sergeeva M, Reiser G. Astrocytes synthesize primary and cyclopentenone prostaglandins that are negative regulators of their proliferation. Biochem Biophys Res Commun. 2018;500:204-210 pubmed publisher
Mitchell C, Dasgupta S, Zhang S, Stapleton H, Volz D. Disruption of Nuclear Receptor Signaling Alters Triphenyl Phosphate-Induced Cardiotoxicity in Zebrafish Embryos. Toxicol Sci. 2018;163:307-318 pubmed publisher
Chang T, Yang C, Lee Y, Wu S. Stimulatory Action of Telmisartan, an Antagonist of Angiotensin II Receptor, on Voltage-Gated Na⁺ Current: Experimental and Theoretical Studies. Chin J Physiol. 2018;61:1-13 pubmed publisher
Haj Yasein N, Berg O, Jernerén F, Refsum H, Nebb H, Dalen K. Cysteine deprivation prevents induction of peroxisome proliferator-activated receptor gamma-2 and adipose differentiation of 3T3-L1 cells. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862:623-635 pubmed publisher
Liu Y, Zhang Y, Zhang Y, Zhang J, Liu Y, Feng P, et al. Obesity-induced endoplasmic reticulum stress suppresses nuclear factor-Y expression. Mol Cell Biochem. 2017;426:47-54 pubmed publisher
Wright S, Wuertz B, Harris G, Abu Ghazallah R, Miller W, Gaffney P, et al. Functional activation of PPARγ in human upper aerodigestive cancer cell lines. Mol Carcinog. 2017;56:149-162 pubmed publisher
Choong E, Guo J, Persson A, Virding S, Johansson I, Mkrtchian S, et al. Developmental regulation and induction of cytochrome P450 2W1, an enzyme expressed in colon tumors. PLoS ONE. 2015;10:e0122820 pubmed publisher
Kim D, Ihn H, Moon C, Oh S, Park S, Kim S, et al. Ciglitazone, a peroxisome proliferator-activated receptor gamma ligand, inhibits proliferation and differentiation of th17 cells. Biomol Ther (Seoul). 2015;23:71-6 pubmed publisher
Baron D, Kaindl U, Haudek Prinz V, Bayer E, Röhrl C, Gerner C, et al. Autonomous inhibition of apoptosis correlates with responsiveness of colon carcinoma cell lines to ciglitazone. PLoS ONE. 2014;9:e114158 pubmed publisher
Rappocciolo G, Jais M, Piazza P, Reinhart T, Berendam S, García Expósito L, et al. Alterations in cholesterol metabolism restrict HIV-1 trans infection in nonprogressors. MBio. 2014;5:e01031-13 pubmed publisher
Lebovic D, Kavoussi S, Lee J, Banu S, Arosh J. PPAR? activation inhibits growth and survival of human endometriotic cells by suppressing estrogen biosynthesis and PGE2 signaling. Endocrinology. 2013;154:4803-13 pubmed publisher
Han E, Im C, Park S, Moon E, Hong S. Combined treatment with peroxisome proliferator-activated receptor (PPAR) gamma ligands and gamma radiation induces apoptosis by PPAR?-independent up-regulation of reactive oxygen species-induced deoxyribonucleic acid damage signals in non-small cell. Int J Radiat Oncol Biol Phys. 2013;85:e239-48 pubmed publisher
Terrasi M, Bazan V, Caruso S, Insalaco L, Amodeo V, Fanale D, et al. Effects of PPAR? agonists on the expression of leptin and vascular endothelial growth factor in breast cancer cells. J Cell Physiol. 2013;228:1368-74 pubmed publisher
Kanakasabai S, Pestereva E, Chearwae W, Gupta S, Ansari S, Bright J. PPAR? agonists promote oligodendrocyte differentiation of neural stem cells by modulating stemness and differentiation genes. PLoS ONE. 2012;7:e50500 pubmed publisher
Paulitschke V, Gruber S, Hofstätter E, Haudek Prinz V, Klepeisz P, Schicher N, et al. Proteome analysis identified the PPAR? ligand 15d-PGJ2 as a novel drug inhibiting melanoma progression and interfering with tumor-stroma interaction. PLoS ONE. 2012;7:e46103 pubmed publisher
Liu H, Wang S, Sun A, Huang D, Wang W, Zhang C, et al. Danhong inhibits oxidized low-density lipoprotein-induced immune maturation of dentritic cells via a peroxisome proliferator activated receptor ?-mediated pathway. J Pharmacol Sci. 2012;119:1-9 pubmed
Jun H, Lim H, Choi J, Jung H, Chae S. Ciglitazone inhibits cigarette smoke solution-induced inflammatory responses in human middle ear epithelial cells. Int J Pediatr Otorhinolaryngol. 2012;76:1136-9 pubmed publisher
Liu X, Yu H, Yang L, Li C, Li L. 15-Deoxy-?(12,14)-prostaglandin J(2) attenuates the biological activities of monocyte/macrophage cell lines. Eur J Cell Biol. 2012;91:654-61 pubmed publisher
Norazmi M, Mohamed R, Nurul A, Yaacob N. The modulation of PPARγ1 and PPARγ2 mRNA expression by ciglitazone in CD3/CD28-activated naïve and memory CD4+ T cells. Clin Dev Immunol. 2012;2012:849195 pubmed publisher
Sampath S, McLean L, Buono C, Moulin P, Wolf A, Chibout S, et al. The use of rat lens explant cultures to study the mechanism of drug-induced cataractogenesis. Toxicol Sci. 2012;126:128-39 pubmed publisher
McKinnon B, Bersinger N, Mueller M. Peroxisome proliferating activating receptor gamma-independent attenuation of interleukin 6 and interleukin 8 secretion from primary endometrial stromal cells by thiazolidinediones. Fertil Steril. 2012;97:657-64 pubmed publisher
Lee M, Kim D, Kim H, Kim H, Yang J, Ryu S, et al. Cell death is induced by ciglitazone, a peroxisome proliferator-activated receptor ? (PPAR?) agonist, independently of PPAR? in human glioma cells. Biochem Biophys Res Commun. 2012;417:552-7 pubmed publisher
Plissonnier M, Fauconnet S, Bittard H, Lascombe I. The antidiabetic drug ciglitazone induces high grade bladder cancer cells apoptosis through the up-regulation of TRAIL. PLoS ONE. 2011;6:e28354 pubmed publisher
Mo Z, Chen X, Long Z, Zeng Y, Zhang Q, Yi G. [Effect of ciglitazone on THP-1 macrophage CD36 expression and cholesterol influx]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2011;27:685-7 pubmed
Rusinova R, Herold K, Sanford R, Greathouse D, Hemmings H, Andersen O. Thiazolidinedione insulin sensitizers alter lipid bilayer properties and voltage-dependent sodium channel function: implications for drug discovery. J Gen Physiol. 2011;138:249-70 pubmed publisher
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Yokoyama Y, Xin B, Shigeto T, Mizunuma H. Combination of ciglitazone, a peroxisome proliferator-activated receptor gamma ligand, and cisplatin enhances the inhibition of growth of human ovarian cancers. J Cancer Res Clin Oncol. 2011;137:1219-28 pubmed publisher
Hofnagel O, Engel T, Severs N, Robenek H, Buers I. SR-PSOX at sites predisposed to atherosclerotic lesion formation mediates monocyte-endothelial cell adhesion. Atherosclerosis. 2011;217:371-8 pubmed publisher
Tuinman P, Gerards M, Jongsma G, Vlaar A, Boon L, Juffermans N. Lack of evidence of CD40 ligand involvement in transfusion-related acute lung injury. Clin Exp Immunol. 2011;165:278-84 pubmed publisher
Lai L, Ho T. Pigment epithelial-derived factor inhibits c-FLIP expression and assists ciglitazone-induced apoptosis in hepatocellular carcinoma. Anticancer Res. 2011;31:1173-80 pubmed
Jiang Y, Kim P, Lu Y, Feingold K. PPARgamma activators stimulate aquaporin 3 expression in keratinocytes/epidermis. Exp Dermatol. 2011;20:595-9 pubmed publisher
Wang J, Mak O. Induction of apoptosis by 15d-PGJ2 via ROS formation: an alternative pathway without PPAR? activation in non-small cell lung carcinoma A549 cells. Prostaglandins Other Lipid Mediat. 2011;94:104-11 pubmed publisher
Lin T, Tang C, Wu K, Fong Y, Yang R, Fu W. 15-deoxy-?(12,14) -prostaglandin-J2 and ciglitazone inhibit TNF-?-induced matrix metalloproteinase 13 production via the antagonism of NF-?B activation in human synovial fibroblasts. J Cell Physiol. 2011;226:3242-50 pubmed publisher
Al Alem L, Southard R, Kilgore M, Curry T. Specific thiazolidinediones inhibit ovarian cancer cell line proliferation and cause cell cycle arrest in a PPAR? independent manner. PLoS ONE. 2011;6:e16179 pubmed publisher
Chen C, Huang P, Chu P, Chen M, Chou C, Wang D, et al. Energy restriction-mimetic agents induce apoptosis in prostate cancer cells in part through epigenetic activation of KLF6 tumor suppressor gene expression. J Biol Chem. 2011;286:9968-76 pubmed publisher
Han J, Crowe D. Steroid receptor coactivator 1 deficiency increases MMTV-neu mediated tumor latency and differentiation specific gene expression, decreases metastasis, and inhibits response to PPAR ligands. BMC Cancer. 2010;10:629 pubmed publisher
Willson T, Cobb J, Cowan D, Wiethe R, Correa I, Prakash S, et al. The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones. J Med Chem. 1996;39:665-8 pubmed
Cantello B, Cawthorne M, Cottam G, Duff P, Haigh D, Hindley R, et al. [[omega-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents. J Med Chem. 1994;37:3977-85 pubmed
product information
Catalog Number :
C3974
Product Name :
Ciglitizone
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA