This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Cordycepin
catalog :
C3394
citations: 74
Reference
Hawley S, Ross F, Russell F, Atrih A, Lamont D, Hardie D. Mechanism of Activation of AMPK by Cordycepin. Cell Chem Biol. 2020;27:214-222.e4 pubmed publisher
Cebrià Costa J, Pascual Reguant L, Gonzalez Perez A, Serra Bardenys G, Querol J, Cosín M, et al. LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells. Oncogene. 2020;39:79-121 pubmed publisher
Salas Armenteros I, Barroso S, Rondon A, Perez M, Andújar E, Luna R, et al. Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability. Cell Rep. 2019;28:1551-1563.e7 pubmed publisher
Jiang Q, Lou Z, Wang H, Chen C. Antimicrobial effect and proposed action mechanism of cordycepin against Escherichia coli and Bacillus subtilis. J Microbiol. 2019;57:288-297 pubmed publisher
Tumini E, Herrera Moyano E, San Martín Alonso M, Barroso S, Galmarini C, Aguilera A. The Antitumor Drugs Trabectedin and Lurbinectedin Induce Transcription-Dependent Replication Stress and Genome Instability. Mol Cancer Res. 2019;17:773-782 pubmed publisher
Fong P, Ao C, Tou K, Huang K, Cheong C, Meng L. Experimental and In Silico Analysis of Cordycepin and its Derivatives as Endometrial Cancer Treatment. Oncol Res. 2019;27:237-251 pubmed publisher
Bonath F, Domingo Prim J, Tarbier M, Friedländer M, Visa N. Next-generation sequencing reveals two populations of damage-induced small RNAs at endogenous DNA double-strand breaks. Nucleic Acids Res. 2018;46:11869-11882 pubmed publisher
Knop K, Stepien A, Barciszewska Pacak M, Taube M, Bielewicz D, Michalak M, et al. Active 5' splice sites regulate the biogenesis efficiency of Arabidopsis microRNAs derived from intron-containing genes. Nucleic Acids Res. 2016;: pubmed
Chan J, Barseghyan G, Asatiani M, Wasser S. Chemical Composition and Medicinal Value of Fruiting Bodies and Submerged Cultured Mycelia of Caterpillar Medicinal Fungus Cordyceps militaris CBS-132098 (Ascomycetes). Int J Med Mushrooms. 2015;17:649-59 pubmed
Liu X, Musser D, Lee C, Yang X, Arnold J, Cameron C, et al. Nucleobase but not Sugar Fidelity is Maintained in the Sabin I RNA-Dependent RNA Polymerase. Viruses. 2015;7:5571-86 pubmed publisher
Wang F, Yin P, Lu Y, Zhou Z, Jiang C, Liu Y, et al. Cordycepin prevents oxidative stress-induced inhibition of osteogenesis. Oncotarget. 2015;6:35496-508 pubmed publisher
Ye J, Yang J, Sun Y, Zhao P, Gao S, Jung C, et al. Geminivirus Activates ASYMMETRIC LEAVES 2 to Accelerate Cytoplasmic DCP2-Mediated mRNA Turnover and Weakens RNA Silencing in Arabidopsis. PLoS Pathog. 2015;11:e1005196 pubmed publisher
Kang F, Chen P, Pan B, Lai M, Chen Y, Huang B. Apoptotic effect of cordycepin combined with cisplatin and/or paclitaxel on MA-10 mouse Leydig tumor cells. Onco Targets Ther. 2015;8:2345-60 pubmed publisher
Meristoudis C, Trangas T, Lambrianidou A, Papadopoulos V, Dimitriadis E, Courtis N, et al. Systematic analysis of the contribution of c-myc mRNA constituents upon cap and IRES mediated translation. Biol Chem. 2015;396:1301-13 pubmed publisher
Pan B, Wang Y, Lai M, Mu Y, Huang B. Cordycepin induced MA-10 mouse Leydig tumor cell apoptosis by regulating p38 MAPKs and PI3K/AKT signaling pathways. Sci Rep. 2015;5:13372 pubmed publisher
Pizzolato J, Mukherjee S, Schärer O, Jiricny J. FANCD2-associated nuclease 1, but not exonuclease 1 or flap endonuclease 1, is able to unhook DNA interstrand cross-links in vitro. J Biol Chem. 2015;290:22602-11 pubmed publisher
Chen X, Wang Y, Liu J, Xu P, Zhang X, Tian Y, et al. Synergistic effect of HMGB1 knockdown and cordycepin in the K562 human chronic myeloid leukemia cell line. Mol Med Rep. 2015;12:4462-4468 pubmed publisher
Sonoki H, Sato T, Endo S, Matsunaga T, Yamaguchi M, Yamazaki Y, et al. Quercetin Decreases Claudin-2 Expression Mediated by Up-Regulation of microRNA miR-16 in Lung Adenocarcinoma A549 Cells. Nutrients. 2015;7:4578-92 pubmed publisher
Abeldenov S, Talhaoui I, Zharkov D, Ishchenko A, Ramanculov E, Saparbaev M, et al. Characterization of DNA substrate specificities of apurinic/apyrimidinic endonucleases from Mycobacterium tuberculosis. DNA Repair (Amst). 2015;33:1-16 pubmed publisher
Peng J, Wang P, Ge H, Qu X, Jin X. Effects of cordycepin on the microglia-overactivation-induced impairments of growth and development of hippocampal cultured neurons. PLoS ONE. 2015;10:e0125902 pubmed publisher
Charlier J, Polese C, Nouet C, Carnol M, Bosman B, Krämer U, et al. Zinc triggers a complex transcriptional and post-transcriptional regulation of the metal homeostasis gene FRD3 in Arabidopsis relatives. J Exp Bot. 2015;66:3865-78 pubmed publisher
Ferrari L, Araldi D, Levine J. Distinct terminal and cell body mechanisms in the nociceptor mediate hyperalgesic priming. J Neurosci. 2015;35:6107-16 pubmed publisher
Chen J, Shi Q, Wang Y, Li Z, Wang S. Dereplication of known nucleobase and nucleoside compounds in natural product extracts by capillary electrophoresis-high resolution mass spectrometry. Molecules. 2015;20:5423-37 pubmed publisher
Kim J, Lee H, Kang K, Chun K, Hwang G. Cordyceps militaris mushroom and cordycepin inhibit RANKL-induced osteoclast differentiation. J Med Food. 2015;18:446-52 pubmed publisher
Zhang J, Wu D, Jiang K, Zhang D, Zheng X, Wan C, et al. Preparation, spectroscopy and molecular modelling studies of the inclusion complex of cordycepin with cyclodextrins. Carbohydr Res. 2015;406:55-64 pubmed publisher
Yamamoto K, Shichiri H, Uda A, Yamashita K, Nishioka T, Kume M, et al. Apoptotic Effects of the Extracts of Cordyceps militaris via Erk Phosphorylation in a Renal Cell Carcinoma Cell Line. Phytother Res. 2015;29:707-13 pubmed publisher
Ryu E, Son M, Lee M, Lee K, Cho J, Cho S, et al. Cordycepin is a novel chemical suppressor of Epstein-Barr virus replication. Oncoscience. 2014;1:866-881 pubmed
Ferrari L, Bogen O, Reichling D, Levine J. Accounting for the delay in the transition from acute to chronic pain: axonal and nuclear mechanisms. J Neurosci. 2015;35:495-507 pubmed publisher
Kim Y, Kim E, Hwang J, Han Y, Kim S, Jeong J, et al. Radical Scavenging Activities of Undaria pinnatifida Extracts Fermented with Cordyceps militaris Mycelia. J Microbiol Biotechnol. 2015;25:820-7 pubmed
Hu P, Chen W, Bao J, Jiang L, Wu L. Cordycepin modulates inflammatory and catabolic gene expression in interleukin-1beta-induced human chondrocytes from advanced-stage osteoarthritis: an in vitro study. Int J Clin Exp Pathol. 2014;7:6575-84 pubmed
Dong C, Vashisht A, Hegde A. Proteasome regulates the mediators of cytoplasmic polyadenylation signaling during late-phase long-term potentiation. Neurosci Lett. 2014;583:199-204 pubmed publisher
Lee H, Kim S, Kim G, Moon S, Kim W, Jeong Y, et al. Involvement of autophagy in cordycepin-induced apoptosis in human prostate carcinoma LNCaP cells. Environ Toxicol Pharmacol. 2014;38:239-50 pubmed publisher
Potenski C, Niu H, Sung P, Klein H. Avoidance of ribonucleotide-induced mutations by RNase H2 and Srs2-Exo1 mechanisms. Nature. 2014;511:251-4 pubmed publisher
Ruma I, Putranto E, Kondo E, Watanabe R, Saito K, Inoue Y, et al. Extract of Cordyceps militaris inhibits angiogenesis and suppresses tumor growth of human malignant melanoma cells. Int J Oncol. 2014;45:209-18 pubmed publisher
Prasad R, Horton J, Chastain P, Gassman N, Freudenthal B, Hou E, et al. Suicidal cross-linking of PARP-1 to AP site intermediates in cells undergoing base excision repair. Nucleic Acids Res. 2014;42:6337-51 pubmed publisher
Zhou F, Roy B, Dunlap J, Enganti R, von Arnim A. Translational control of Arabidopsis meristem stability and organogenesis by the eukaryotic translation factor eIF3h. PLoS ONE. 2014;9:e95396 pubmed publisher
Ueda Y, Mori K, Satoh S, Dansako H, Ikeda M, Kato N. Anti-HCV activity of the Chinese medicinal fungus Cordyceps militaris. Biochem Biophys Res Commun. 2014;447:341-5 pubmed publisher
Chen Y, Yang S, Hueng D, Syu J, Liao C, Wu Y. Cordycepin induces apoptosis of C6 glioma cells through the adenosine 2A receptor-p53-caspase-7-PARP pathway. Chem Biol Interact. 2014;216:17-25 pubmed publisher
Vodnala S, Lundbäck T, Yeheskieli E, Sjöberg B, Gustavsson A, Svensson R, et al. Structure-activity relationships of synthetic cordycepin analogues as experimental therapeutics for African trypanosomiasis. J Med Chem. 2013;56:9861-73 pubmed publisher
Tuli H, Sharma A, Sandhu S, Kashyap D. Cordycepin: a bioactive metabolite with therapeutic potential. Life Sci. 2013;93:863-9 pubmed publisher
Dalla Rosa L, Da Silva A, Ruchel J, Gressler L, Oliveira C, França R, et al. Influence of treatment with 3'-deoxyadenosine associated deoxycoformycin on hematological parameters and activity of adenosine deaminase in infected mice with Trypanosoma evansi. Exp Parasitol. 2013;135:357-62 pubmed publisher
Xiong Y, Zhang S, Xu L, Song B, Huang G, Lu J, et al. Suppression of T-cell activation in vitro and in vivo by cordycepin from Cordyceps militaris. J Surg Res. 2013;185:912-22 pubmed publisher
Wu F, Chen Y, Chang S, Shih I. Cultivation of medicinal caterpillar fungus, Cordyceps militaris (Ascomycetes), and production of cordycepin using the spent medium from levan fermentation. Int J Med Mushrooms. 2013;15:393-405 pubmed
Gu L, Johno H, Nakajima S, Kato H, Takahashi S, Katoh R, et al. Blockade of Smad signaling by 3'-deoxyadenosine: a mechanism for its anti-fibrotic potential. Lab Invest. 2013;93:450-61 pubmed publisher
Seo M, Kim M, Lee H, Park J, Kang B, Kim G, et al. Effect of cordycepin on the expression of the inflammatory cytokines TNF-alpha, IL-6, and IL-17A in C57BL/6 mice. J Microbiol Biotechnol. 2013;23:156-60 pubmed
Dalla Rosa L, Da Silva A, Gressler L, Oliveira C, Dambrós M, Miletti L, et al. Cordycepin (3'-deoxyadenosine) pentostatin (deoxycoformycin) combination treatment of mice experimentally infected with Trypanosoma evansi. Parasitology. 2013;140:663-71 pubmed publisher
Lee H, Park C, Jeong J, Kim M, Seo M, Kang B, et al. Apoptosis induction of human prostate carcinoma cells by cordycepin through reactive oxygen species‑mediated mitochondrial death pathway. Int J Oncol. 2013;42:1036-44 pubmed publisher
Zhao Z, Song G, Tian H, Yu Y, Tian X, Liu J, et al. Triacetyl-3-hydroxyphenyladenosine, a derivative of cordycepin, attenuates atherosclerosis in apolipoprotein E-knockout mice. Exp Biol Med (Maywood). 2012;237:1262-72 pubmed publisher
Chiba Y, Mineta K, Hirai M, Suzuki Y, Kanaya S, Takahashi H, et al. Changes in mRNA stability associated with cold stress in Arabidopsis cells. Plant Cell Physiol. 2013;54:180-94 pubmed publisher
Li C, Yan A, Cai C, Liu Z. [Fast determination of adenosine and cordycepin in Cordyceps and its deserted solid medium]. Se Pu. 2012;30:711-5 pubmed
Su W, Slepenkov S, Slevin M, Lyons S, Ziemniak M, Kowalska J, et al. mRNAs containing the histone 3' stem-loop are degraded primarily by decapping mediated by oligouridylation of the 3' end. RNA. 2013;19:1-16 pubmed publisher
Kondrashov A, Meijer H, Barthet Barateig A, Parker H, Khurshid A, Tessier S, et al. Inhibition of polyadenylation reduces inflammatory gene induction. RNA. 2012;18:2236-50 pubmed publisher
Ren Z, Cui J, Huo Z, Xue J, Cui H, Luo B, et al. Cordycepin suppresses TNF-?-induced NF-?B activation by reducing p65 transcriptional activity, inhibiting I?B? phosphorylation, and blocking IKK? ubiquitination. Int Immunopharmacol. 2012;14:698-703 pubmed publisher
Ramesh T, Yoo S, Kim S, Hwang S, Sohn S, Kim I, et al. Cordycepin (3'-deoxyadenosine) attenuates age-related oxidative stress and ameliorates antioxidant capacity in rats. Exp Gerontol. 2012;47:979-87 pubmed publisher
Sohn S, Lee S, Hwang S, Kim S, Kim I, Ye M, et al. Effect of long-term administration of cordycepin from Cordyceps militaris on testicular function in middle-aged rats. Planta Med. 2012;78:1620-5 pubmed publisher
Lee H, Burger P, Vogel M, Friese K, Brüning A. The nucleoside antagonist cordycepin causes DNA double strand breaks in breast cancer cells. Invest New Drugs. 2012;30:1917-25 pubmed publisher
Chen M, Cheung F, Chan M, Hui P, Ip S, Ling Y, et al. Protective roles of Cordyceps on lung fibrosis in cellular and rat models. J Ethnopharmacol. 2012;143:448-54 pubmed publisher
Jeong M, Seo M, Park J, Kang B, Kim K, Lee J, et al. Effect of cordycepin purified from Cordyceps militaris on Th1 and Th2 cytokines in mouse splenocytes. J Microbiol Biotechnol. 2012;22:1161-4 pubmed
Baik J, Kwon H, Kim K, Jeong Y, Cho Y, Lee Y. Cordycepin induces apoptosis in human neuroblastoma SK-N-BE(2)-C and melanoma SK-MEL-2 cells. Indian J Biochem Biophys. 2012;49:86-91 pubmed
Takahashi S, Tamai M, Nakajima S, Kato H, Johno H, Nakamura T, et al. Blockade of adipocyte differentiation by cordycepin. Br J Pharmacol. 2012;167:561-75 pubmed publisher
Kadomatsu M, Nakajima S, Kato H, Gu L, Chi Y, Yao J, et al. Cordycepin as a sensitizer to tumour necrosis factor (TNF)-α-induced apoptosis through eukaryotic translation initiation factor 2α (eIF2α)- and mammalian target of rapamycin complex 1 (mTORC1)-mediated inhibition of nuclear factor (NF)-κB. Clin Exp Immunol. 2012;168:325-32 pubmed publisher
Pao H, Pan B, Leu S, Huang B. Cordycepin stimulated steroidogenesis in MA-10 mouse Leydig tumor cells through the protein kinase C Pathway. J Agric Food Chem. 2012;60:4905-13 pubmed publisher
Lim L, Lee C, Chang E. Optimization of solid state culture conditions for the production of adenosine, cordycepin, and D-mannitol in fruiting bodies of medicinal caterpillar fungus Cordyceps militaris (L.:Fr.) Link (Ascomycetes). Int J Med Mushrooms. 2012;14:181-7 pubmed
Chen Y, Chou P, Chien Y, Wu C, Wu T, Sheu M. Ethanol extracts of fruiting bodies of Antrodia cinnamomea exhibit anti-migration action in human adenocarcinoma CL1-0 cells through the MAPK and PI3K/AKT signaling pathways. Phytomedicine. 2012;19:768-78 pubmed publisher
Dong J, Liu M, Lei C, Zheng X, Wang Y. Effects of selenium and light wavelengths on liquid culture of Cordyceps militaris Link. Appl Biochem Biotechnol. 2012;166:2030-6 pubmed publisher
Jung S, Park S, Kim W, Moon S. Ras/ERK1 pathway regulation of p27KIP1-mediated G1-phase cell-cycle arrest in cordycepin-induced inhibition of the proliferation of vascular smooth muscle cells. Eur J Pharmacol. 2012;681:15-22 pubmed publisher
Brzezinski K, Dauter Z, Jaskolski M. High-resolution structures of complexes of plant S-adenosyl-L-homocysteine hydrolase (Lupinus luteus). Acta Crystallogr D Biol Crystallogr. 2012;68:218-31 pubmed publisher
Fourches D, Barnes J, Day N, Bradley P, Reed J, Tropsha A. Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chem Res Toxicol. 2010;23:171-83 pubmed publisher
Martin S, Shisler J. Early viral protein synthesis is necessary for NF-kappaB activation in modified vaccinia Ankara (MVA)-infected 293 T fibroblast cells. Virology. 2009;390:298-306 pubmed publisher
Lloyd A, Henderson T, Vigil P, Mobley H. Genomic islands of uropathogenic Escherichia coli contribute to virulence. J Bacteriol. 2009;191:3469-81 pubmed publisher
Wei H, Ye X, Chen Z, Zhong Y, Li P, Pu S, et al. Synthesis and pharmacokinetic evaluation of novel N-acyl-cordycepin derivatives with a normal alkyl chain. Eur J Med Chem. 2009;44:665-9 pubmed publisher
Kodama E, McCaffrey R, Yusa K, Mitsuya H. Antileukemic activity and mechanism of action of cordycepin against terminal deoxynucleotidyl transferase-positive (TdT+) leukemic cells. Biochem Pharmacol. 2000;59:273-81 pubmed
Ioannidis P, Courtis N, Havredaki M, Michailakis E, Tsiapalis C, Trangas T. The polyadenylation inhibitor cordycepin (3'dA) causes a decline in c-MYC mRNA levels without affecting c-MYC protein levels. Oncogene. 1999;18:117-25 pubmed
Duncan R. Cordycepin blocks recovery of non-heat-shock mRNA translation following heat shock in Drosophila. Eur J Biochem. 1995;233:784-92 pubmed
product information
Catalog Number :
C3394
Product Name :
Cordycepin
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
from Cordyceps militaris
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA