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product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Carboplatin
catalog :
C2538
citations: 210
Reference
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Ji J, Zuo P, Wang Y. Enhanced Antiproliferative Effect of Carboplatin in Cervical Cancer Cells Utilizing Folate-Grafted Polymeric Nanoparticles. Nanoscale Res Lett. 2015;10:453 pubmed publisher
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Yang L, Guo J, Shen Y, Cai J, Xiong Z, Dong W, et al. Clinical efficacy and safety of paclitaxel plus carboplatin as neoadjuvant chemotherapy prior to radical hysterectomy and pelvic lymphadenectomy for Stage IB2-IIB cervical cancer. Int J Clin Exp Med. 2015;8:13690-8 pubmed
Rohnalter V, Roth K, Finkernagel F, Adhikary T, Obert J, Dorzweiler K, et al. A multi-stage process including transient polyploidization and EMT precedes the emergence of chemoresistent ovarian carcinoma cells with a dedifferentiated and pro-inflammatory secretory phenotype. Oncotarget. 2015;6:40005-25 pubmed publisher
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Tonsing Carter E, Bailey B, Saadatzadeh M, Ding J, Wang H, Sinn A, et al. Potentiation of Carboplatin-Mediated DNA Damage by the Mdm2 Modulator Nutlin-3a in a Humanized Orthotopic Breast-to-Lung Metastatic Model. Mol Cancer Ther. 2015;14:2850-63 pubmed publisher
Meker S, Braitbard O, Margulis Goshen K, Magdassi S, Hochman J, Tshuva E. Highly Stable Tetra-Phenolato Titanium(IV) Agent Formulated into Nanoparticles Demonstrates Anti-Tumoral Activity and Selectivity. Molecules. 2015;20:18526-38 pubmed publisher
Jiang N, Chen W, Zhang J, Li Y, Zeng X, Zhang T, et al. Aberrantly regulated dysadherin and B-cell lymphoma 2/B-cell lymphoma 2-associated X enhances tumorigenesis and DNA targeting drug resistance of liver cancer stem cells. Mol Med Rep. 2015;12:7239-46 pubmed publisher
Cui L, Hu Y, Bai B, Zhang S. Serum miR-335 Level is Associated with the Treatment Response to Trans-Arterial Chemoembolization and Prognosis in Patients with Hepatocellular Carcinoma. Cell Physiol Biochem. 2015;37:276-83 pubmed publisher
Mao D, Che J, Han S, Zhao H, Zhu Y, Zhu H. RNAi-mediated knockdown of the CLN3 gene inhibits proliferation and promotes apoptosis in drug-resistant ovarian cancer cells. Mol Med Rep. 2015;12:6635-41 pubmed publisher
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Antonissen G, Devreese M, De Baere S, Hellebuyck T, Van de Maele I, Rouffaer L, et al. Comparative Pharmacokinetics and Allometric Scaling of Carboplatin in Different Avian Species. PLoS ONE. 2015;10:e0134177 pubmed publisher
Massey A. Multiparametric Cell Cycle Analysis Using the Operetta High-Content Imager and Harmony Software with PhenoLOGIC. PLoS ONE. 2015;10:e0134306 pubmed publisher
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Zhang N, Zhang L, Liu Z, Huang G, Zhang L, Yi J, et al. Therapeutic efficacy of paclitaxel and carboplatin via arterial or venous perfusion in rabbits with VX-2 tongue cancer. Int J Clin Exp Med. 2015;8:4979-88 pubmed
Mohell N, Alfredsson J, Fransson Ã, Uustalu M, Byström S, Gullbo J, et al. APR-246 overcomes resistance to cisplatin and doxorubicin in ovarian cancer cells. Cell Death Dis. 2015;6:e1794 pubmed publisher
Vallo S, Michaelis M, Rothweiler F, Bartsch G, Gust K, Limbart D, et al. Drug-Resistant Urothelial Cancer Cell Lines Display Diverse Sensitivity Profiles to Potential Second-Line Therapeutics. Transl Oncol. 2015;8:210-6 pubmed publisher
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Tang Y, Wang Y, Deosarkar S, Soroush F, Kiani M, Wang B. Fast, Stable Induction of P-Glycoprotein-mediated Drug Resistance in BT-474 Breast Cancer Cells by Stable Transfection of ABCB1 Gene. Anticancer Res. 2015;35:2531-8 pubmed
Yang M, Xu Z, Wang Q, Zhang A, Min J. A hyposensitive anticancer drug induces higher surface expression and release of heat shock proteins in a human hepatocellular carcinoma cell line. Mol Med Rep. 2015;12:2879-85 pubmed publisher
Ito Y, Kikuchi E, Tanaka N, Kosaka T, Suzuki E, Mizuno R, et al. Down-regulation of NF kappa B activation is an effective therapeutic modality in acquired platinum-resistant bladder cancer. BMC Cancer. 2015;15:324 pubmed publisher
Zarogoulidis P, Petanidis S, Kioseoglou E, Domvri K, Anestakis D, Zarogoulidis K. MiR-205 and miR-218 expression is associated with carboplatin chemoresistance and regulation of apoptosis via Mcl-1 and Survivin in lung cancer cells. Cell Signal. 2015;27:1576-88 pubmed publisher
Biswas R, Mondal A, Ahn J. Deregulation of EGFR/PI3K and activation of PTEN by photodynamic therapy combined with carboplatin in human anaplastic thyroid cancer cells and xenograft tumors in nude mice. J Photochem Photobiol B. 2015;148:118-127 pubmed publisher
Andrei A, Hall A, Smith A, Bascuñana C, Malina A, Connor A, et al. Increased in vitro and in vivo sensitivity of BRCA2-associated pancreatic cancer to the poly(ADP-ribose) polymerase-1/2 inhibitor BMN 673. Cancer Lett. 2015;364:8-16 pubmed publisher
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Karginova O, Siegel M, Van Swearingen A, Deal A, Adamo B, Sambade M, et al. Efficacy of Carboplatin Alone and in Combination with ABT888 in Intracranial Murine Models of BRCA-Mutated and BRCA-Wild-Type Triple-Negative Breast Cancer. Mol Cancer Ther. 2015;14:920-30 pubmed publisher
Chen S, Kuo C, Pan H, Tsou T, Yeh S, Chang J. Mechanistic basis of a combination D-penicillamine and platinum drugs synergistically inhibits tumor growth in oxaliplatin-resistant human cervical cancer cells in vitro and in vivo. Biochem Pharmacol. 2015;95:28-37 pubmed publisher
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Zhang B, Wang Y, Gong H, Zhao H, Lv X, Yuan G, et al. Isorhamnetin flavonoid synergistically enhances the anticancer activity and apoptosis induction by cis-platin and carboplatin in non-small cell lung carcinoma (NSCLC). Int J Clin Exp Pathol. 2015;8:25-37 pubmed
Winterhoff B, Freyer L, Hammond E, Giri S, Mondal S, Roy D, et al. PG545 enhances anti-cancer activity of chemotherapy in ovarian models and increases surrogate biomarkers such as VEGF in preclinical and clinical plasma samples. Eur J Cancer. 2015;51:879-892 pubmed publisher
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Kang J, Kang H, Kim I, Lee H, Ha J, Yeo C, et al. Curcumin sensitizes human lung cancer cells to apoptosis and metastasis synergistically combined with carboplatin. Exp Biol Med (Maywood). 2015;240:1416-25 pubmed publisher
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Yanagihara N, Kobayashi D, Kuribayashi K, Tanaka M, Hasegawa T, Watanabe N. Significance of SALL4 as a drug‑resistant factor in lung cancer. Int J Oncol. 2015;46:1527-34 pubmed publisher
Hosokawa Y, Takahashi H, Inoue A, Kawabe Y, Funahashi Y, Kameda K, et al. Oct-3/4 modulates the drug-resistant phenotype of glioblastoma cells through expression of ATP binding cassette transporter G2. Biochim Biophys Acta. 2015;1850:1197-205 pubmed publisher
Eppler S, Gordon M, Redfern C, Trudeau C, Xu N, Han K, et al. Lack of a pharmacokinetic interaction between trastuzumab and carboplatin in the presence of docetaxel: results from a phase Ib study in patients with HER2-positive metastatic or locally advanced inoperable solid tumors. Anticancer Drugs. 2015;26:448-55 pubmed publisher
Laemmle A, Hahn D, Hu L, Rüfenacht V, Gautschi M, Leibundgut K, et al. Fatal hyperammonemia and carbamoyl phosphate synthetase 1 (CPS1) deficiency following high-dose chemotherapy and autologous hematopoietic stem cell transplantation. Mol Genet Metab. 2015;114:438-44 pubmed publisher
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Moraleja I, Moreno Gordaliza E, Esteban Fernández D, Mena M, Linscheid M, Gomez Gomez M. A shotgun approach for the identification of platinum-protein complexes. Anal Bioanal Chem. 2015;407:2393-403 pubmed publisher
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Patel S, Kusano A, Truong A, Stelzer K, Laramore G. Fast neutron radiotherapy in the treatment of malignant pleural mesothelioma. Am J Clin Oncol. 2015;38:47-50 pubmed publisher
Spigel D, Patel J, Reynolds C, Garon E, Hermann R, Govindan R, et al. Quality of life analyses from the randomized, open-label, phase III PointBreak study of pemetrexed-carboplatin-bevacizumab followed by maintenance pemetrexed-bevacizumab versus paclitaxel-carboplatin-bevacizumab followed by maintenance bevacizumab in. J Thorac Oncol. 2015;10:353-9 pubmed publisher
Kondo R, Watanabe S, Ishikawa D, Tanaka T, Ohshima Y, Asakawa K, et al. [A case of thymic cancer effectively treated by weekly paclitaxel combined with carboplatin]. Gan To Kagaku Ryoho. 2014;41:2607-9 pubmed
Teng P, Bateman N, Darcy K, Hamilton C, Maxwell G, Bakkenist C, et al. Pharmacologic inhibition of ATR and ATM offers clinically important distinctions to enhancing platinum or radiation response in ovarian, endometrial, and cervical cancer cells. Gynecol Oncol. 2015;136:554-61 pubmed publisher
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Makharza S, Vittorio O, Cirillo G, Oswald S, Hinde E, Kavallaris M, et al. Graphene oxide - gelatin nanohybrids as functional tools for enhanced Carboplatin activity in neuroblastoma cells. Pharm Res. 2015;32:2132-43 pubmed publisher
Meier J, Haendler B, Seidel H, Groth P, Adams R, Ziegelbauer K, et al. Knockdown of platinum-induced growth differentiation factor 15 abrogates p27-mediated tumor growth delay in the chemoresistant ovarian cancer model A2780cis. Cancer Med. 2015;4:253-67 pubmed publisher
Connolly R, Leal J, Goetz M, Zhang Z, Zhou X, Jacobs L, et al. TBCRC 008: early change in 18F-FDG uptake on PET predicts response to preoperative systemic therapy in human epidermal growth factor receptor 2-negative primary operable breast cancer. J Nucl Med. 2015;56:31-7 pubmed publisher
Keitel U, Scheel A, Thomale J, Halpape R, Kaulfuß S, Scheel C, et al. Bcl-xL mediates therapeutic resistance of a mesenchymal breast cancer cell subpopulation. Oncotarget. 2014;5:11778-91 pubmed
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Shinde A, Zhai J, Yu K, Frankel P, Yim J, Luu T, et al. Pathologic complete response rates in triple-negative, HER2-positive, and hormone receptor-positive breast cancers after anthracycline-free neoadjuvant chemotherapy with carboplatin and paclitaxel with or without trastuzumab. Breast. 2015;24:18-23 pubmed publisher
Reddy Ammakkanavar N, Matei D, Abonour R, Einhorn L. High-dose chemotherapy for recurrent ovarian germ cell tumors. J Clin Oncol. 2015;33:226-7 pubmed publisher
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Rithirangsriroj K, Manchana T, Akkayagorn L. Efficacy of acupuncture in prevention of delayed chemotherapy induced nausea and vomiting in gynecologic cancer patients. Gynecol Oncol. 2015;136:82-6 pubmed publisher
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Doebele R, Spigel D, Tehfe M, Thomas S, Reck M, Verma S, et al. Phase 2, randomized, open-label study of ramucirumab in combination with first-line pemetrexed and platinum chemotherapy in patients with nonsquamous, advanced/metastatic non-small cell lung cancer. Cancer. 2015;121:883-92 pubmed publisher
Cummings C, Linger R, Cohen R, Sather S, Kirkpatrick G, Davies K, et al. Mer590, a novel monoclonal antibody targeting MER receptor tyrosine kinase, decreases colony formation and increases chemosensitivity in non-small cell lung cancer. Oncotarget. 2014;5:10434-45 pubmed
Wang H, Zhu L, Gao J, Hu Z, Lin B. Promotive role of recombinant HE4 protein in proliferation and carboplatin resistance in ovarian cancer cells. Oncol Rep. 2015;33:403-12 pubmed publisher
O Shaughnessy J, Schwartzberg L, Danso M, Miller K, Rugo H, Neubauer M, et al. Phase III study of iniparib plus gemcitabine and carboplatin versus gemcitabine and carboplatin in patients with metastatic triple-negative breast cancer. J Clin Oncol. 2014;32:3840-7 pubmed publisher
Xu N, Redfern C, Gordon M, Eppler S, Lum B, Trudeau C. Trastuzumab, in combination with carboplatin and docetaxel, does not prolong the QT interval of patients with HER2-positive metastatic or locally advanced inoperable solid tumors: results from a phase Ib study. Cancer Chemother Pharmacol. 2014;74:1251-60 pubmed publisher
Eba J, Shimokawa T, Nakamura K, Shibata T, Misumi Y, Okamoto H, et al. A Phase II/III study comparing carboplatin and irinotecan with carboplatin and etoposide for the treatment of elderly patients with extensive-disease small-cell lung cancer (JCOG1201). Jpn J Clin Oncol. 2015;45:115-8 pubmed publisher
Kenicer J, Spears M, Lyttle N, Taylor K, Liao L, Cunningham C, et al. Molecular characterisation of isogenic taxane resistant cell lines identify novel drivers of drug resistance. BMC Cancer. 2014;14:762 pubmed publisher
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Shimizu R, Fujimoto D, Kato R, Otoshi T, Kawamura T, Tamai K, et al. The safety and efficacy of paclitaxel and carboplatin with or without bevacizumab for treating patients with advanced nonsquamous non-small cell lung cancer with interstitial lung disease. Cancer Chemother Pharmacol. 2014;74:1159-66 pubmed publisher
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Okuma Y, Saito M, Hosomi Y, Sakuyama T, Okamura T. Key components of chemotherapy for thymic malignancies: a systematic review and pooled analysis for anthracycline-, carboplatin- or cisplatin-based chemotherapy. J Cancer Res Clin Oncol. 2015;141:323-31 pubmed publisher
Yagi Y, Maeda T, Yoshimitsu Y, Sakuma H. [A case of malignant peritoneal mesothelioma diagnosed with laparoscopic biopsy]. Gan To Kagaku Ryoho. 2014;41:995-7 pubmed
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Zhang Z, Zhang H, Hu Z, Wang P, Wan J, Li B. Synergy of 1,25-dihydroxyvitamin D3 and carboplatin in growth suppression of SKOV-3 cells. Oncol Lett. 2014;8:1348-1354 pubmed
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Utku S, Ozçelik A, Gumus F, Yilmaz S, Arsoy T, Açik L, et al. Synthesis, in-vitro cytotoxic activity and DNA interactions of new dicarboxylatoplatinum(II) complexes with 2-hydroxymethylbenzimidazole as carrier ligands. J Pharm Pharmacol. 2014;66:1593-605 pubmed publisher
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Saba N, Hurwitz S, Magliocca K, Kim S, Owonikoko T, Harvey D, et al. Phase 1 and pharmacokinetic study of everolimus in combination with cetuximab and carboplatin for recurrent/metastatic squamous cell carcinoma of the head and neck. Cancer. 2014;120:3940-51 pubmed publisher
Sullivan I, Salazar J, Majem M, Pallares C, del Rio E, Paez D, et al. Pharmacogenetics of the DNA repair pathways in advanced non-small cell lung cancer patients treated with platinum-based chemotherapy. Cancer Lett. 2014;353:160-6 pubmed publisher
Johnson C, Green D, Zoon K. Human monocytes in the presence of interferons alpha2a and gamma are potent killers of serous ovarian cancer cell lines in combination with paclitaxel and carboplatin. J Interferon Cytokine Res. 2015;35:55-62 pubmed publisher
Lheureux S, N Diaye M, Blanc Fournier C, Dugué A, Clarisse B, Dutoit S, et al. Identification of predictive factors of response to the BH3-mimetic molecule ABT-737: an ex vivo experiment in human serous ovarian carcinoma. Int J Cancer. 2015;136:E340-50 pubmed publisher
Yamasaki S, Tanimoto K, Kohno K, Kadowaki M, Takase K, Kondo S, et al. UGT1A1 *6 polymorphism predicts outcome in elderly patients with relapsed or refractory diffuse large B-cell lymphoma treated with carboplatin, dexamethasone, etoposide and irinotecan. Ann Hematol. 2015;94:65-9 pubmed publisher
Najjar F, Alammar M, Bachour M, Almalla N, Altahan M, Alali A, et al. Predictive and prognostic value of circulating endothelial cells in non-small cell lung cancer patients treated with standard chemotherapy. J Cancer Res Clin Oncol. 2015;141:119-25 pubmed publisher
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Takase N, Matsumoto K, Onoe T, Kitao A, Tanioka M, Kikukawa Y, et al. 4-step 4-h carboplatin desensitization protocol for patients with gynecological malignancies showing platinum hypersensitivity: a retrospective study. Int J Clin Oncol. 2015;20:566-73 pubmed publisher
Ortolan E, Giacomino A, Martinetto F, Morone S, Lo Buono N, Ferrero E, et al. CD157 enhances malignant pleural mesothelioma aggressiveness and predicts poor clinical outcome. Oncotarget. 2014;5:6191-205 pubmed
Tzeng T, Cao L, Fu Y, Zeng H, Cheng W. Methylseleninic acid sensitizes Notch3-activated OVCA429 ovarian cancer cells to carboplatin. PLoS ONE. 2014;9:e101664 pubmed publisher
Tsubamoto H, Sonoda T, Inoue K. Impact of itraconazole on the survival of heavily pre-treated patients with triple-negative breast cancer. Anticancer Res. 2014;34:3839-44 pubmed
Tirmazy S, Barthakur U, El Modir A, Anwar S, Fernando I. Chemotherapy for advanced endometrial cancer with carboplatin and epirubicin. Anticancer Res. 2014;34:3793-8 pubmed
Petrillo M, Zannoni G, Tortorella L, Pedone Anchora L, Salutari V, Ercoli A, et al. Prognostic role and predictors of complete pathologic response to neoadjuvant chemotherapy in primary unresectable ovarian cancer. Am J Obstet Gynecol. 2014;211:632.e1-8 pubmed publisher
Ishikura H, Kumihashi Y, Kimura S, Matsuoka Y, Matsumoto D. [Clinical experience of the use of pemetrexed (PEM) combined with cisplatin (CDDP)/Carboplatin (CBDCA) followed by long-term maintenance PEM in patients with non-squamous non-small cell lung cancer]. Gan To Kagaku Ryoho. 2014;41:623-6 pubmed
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product information
Catalog Number :
C2538
Product Name :
Carboplatin
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA