This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Cerulenin
catalog :
C2389
citations: 99
Reference
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Schütter M, Giavalisco P, Brodesser S, Graef M. Local Fatty Acid Channeling into Phospholipid Synthesis Drives Phagophore Expansion during Autophagy. Cell. 2020;180:135-149.e14 pubmed publisher
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van der Heijden C, Keating S, Groh L, Joosten L, Netea M, Riksen N. Aldosterone induces trained immunity: the role of fatty acid synthesis. Cardiovasc Res. 2020;116:317-328 pubmed publisher
Kassab E, Mehlmer N, Brueck T. GFP Scaffold-Based Engineering for the Production of Unbranched Very Long Chain Fatty Acids in Escherichia coli With Oleic Acid and Cerulenin Supplementation. Front Bioeng Biotechnol. 2019;7:408 pubmed publisher
Acheampong K, Kokona B, Braun G, Jacobsen D, Johnson K, Charkoudian L. Colorimetric Assay Reports on Acyl Carrier Protein Interactions. Sci Rep. 2019;9:15589 pubmed publisher
Lu Y, Zheng Y, Coyaud E, Zhang C, Selvabaskaran A, Yu Y, et al. Palmitoylation of NOD1 and NOD2 is required for bacterial sensing. Science. 2019;366:460-467 pubmed publisher
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Lou J, Iyer K, Hasan S, Cowen L, Mazhab Jafari M. Electron cryomicroscopy observation of acyl carrier protein translocation in type I fungal fatty acid synthase. Sci Rep. 2019;9:12987 pubmed publisher
Gouw A, Margulis K, Liu N, Raman S, Mancuso A, Toal G, et al. The MYC Oncogene Cooperates with Sterol-Regulated Element-Binding Protein to Regulate Lipogenesis Essential for Neoplastic Growth. Cell Metab. 2019;30:556-572.e5 pubmed publisher
Kim Y, Lee S, Kim S, Jang H, Hwang I, Jin S, et al. Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation. Nat Chem Biol. 2019;15:907-916 pubmed publisher
Dabirian Y, Li X, Chen Y, David F, Nielsen J, Siewers V. Expanding the Dynamic Range of a Transcription Factor-Based Biosensor in Saccharomyces cerevisiae. ACS Synth Biol. 2019;8:1968-1975 pubmed publisher
Pereira M, Chen T, Buang N, Olona A, Ko J, Prendecki M, et al. Acute Iron Deprivation Reprograms Human Macrophage Metabolism and Reduces Inflammation In Vivo. Cell Rep. 2019;28:498-511.e5 pubmed publisher
Xiong X, Lee C, Li W, Yu J, Zhu L, Kim Y, et al. Acid Sphingomyelinase regulates the localization and trafficking of palmitoylated proteins. Biol Open. 2019;: pubmed publisher
Kalkreuter E, Keeler A, Malico A, Bingham K, Gayen A, Williams G. Development of a Genetically Encoded Biosensor for Detection of Polyketide Synthase Extender Units in Escherichia coli. ACS Synth Biol. 2019;8:1391-1400 pubmed publisher
Thomas R, Srivastava S, Katreddy R, Sobieski J, Weihua Z. Kinase-Inactivated EGFR Is Required for the Survival of Wild-Type EGFR-Expressing Cancer Cells Treated with Tyrosine Kinase Inhibitors. Int J Mol Sci. 2019;20: pubmed publisher
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Bermeo S, Al Saedi A, Vidal C, Khalil M, Pang M, Troen B, et al. Treatment with an inhibitor of fatty acid synthase attenuates bone loss in ovariectomized mice. Bone. 2019;: pubmed publisher
Umekita K, Miyauchi S, Nomura H, Umeki K, Okayama A. Neutrophil-derived lactoferrin induces the inflammatory responses of rheumatoid arthritis synovial fibroblasts via Toll-like receptor 4. Clin Exp Rheumatol. 2019;: pubmed
Ganesan S, Sosa Ponce M, Tavassoli M, Shabits B, Mahadeo M, Prenner E, et al. Metabolic control of cytosolic-facing pools of diacylglycerol in budding yeast. Traffic. 2019;20:226-245 pubmed publisher
Jin H, Du C, Wang C, Yuan C, Du W. Ginseng metabolite protopanaxadiol interferes with lipid metabolism and induces endoplasmic reticulum stress and p53 activation to promote cancer cell death. Phytother Res. 2019;33:610-617 pubmed publisher
Zhang N, Zhao H, Zhang L. Fatty Acid Synthase Promotes the Palmitoylation of Chikungunya Virus nsP1. J Virol. 2019;93: pubmed publisher
Walters A, Amoateng K, Wang R, Chen J, McDermott G, Larabell C, et al. Nuclear envelope expansion in budding yeast is independent of cell growth and does not determine nuclear volume. Mol Biol Cell. 2019;30:131-145 pubmed publisher
Dumoulin A, Dagane A, Dittmar G, Rathjen F. S-palmitoylation Is Required for the Control of Growth Cone Morphology of DRG Neurons by CNP-Induced cGMP Signaling. Front Mol Neurosci. 2018;11:345 pubmed publisher
Wong D, Amarasinghe R, Pichersky E, Peakall R. Evidence for the Involvement of Fatty Acid Biosynthesis and Degradation in the Formation of Insect Sex Pheromone-Mimicking Chiloglottones in Sexually Deceptive Chiloglottis Orchids. Front Plant Sci. 2018;9:839 pubmed publisher
Giner Robles L, Lázaro B, de la Cruz F, Moncalian G. fabH deletion increases DHA production in Escherichia coli expressing Pfa genes. Microb Cell Fact. 2018;17:88 pubmed publisher
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Rahman H, Carneglia J, Lausten M, Robertello M, Choy J, Golin J. Robust, pleiotropic drug resistance 5 (Pdr5)-mediated multidrug resistance is vigorously maintained in Saccharomyces cerevisiae cells during glucose and nitrogen limitation. FEMS Yeast Res. 2018;18: pubmed publisher
Singh K, Kim S, Hahm E, Pore S, Jacobs B, Singh S. Prostate cancer chemoprevention by sulforaphane in a preclinical mouse model is associated with inhibition of fatty acid metabolism. Carcinogenesis. 2018;39:826-837 pubmed publisher
Liu C, Pan Z, An F, Lu Y. Co-addition Strategy for Enhancement of Chaetominine from Submerged Fermentation of Aspergillus fumigatus CY018. Appl Biochem Biotechnol. 2018;186:384-399 pubmed publisher
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Stoiber K, Nagło O, Pernpeintner C, Zhang S, Koeberle A, Ulrich M, et al. Targeting de novo lipogenesis as a novel approach in anti-cancer therapy. Br J Cancer. 2018;118:43-51 pubmed publisher
Luu T, Bard J, Carbonnelle D, Chaillou C, Huvelin J, Bobin Dubigeon C, et al. Lithocholic bile acid inhibits lipogenesis and induces apoptosis in breast cancer cells. Cell Oncol (Dordr). 2018;41:13-24 pubmed publisher
Chen T, Zhou L, Li H, Tian Y, Li J, Dong L, et al. Fatty acid synthase affects expression of ErbB receptors in epithelial to mesenchymal transition of breast cancer cells and invasive ductal carcinoma. Oncol Lett. 2017;14:5934-5946 pubmed publisher
Katre G, Ajmera N, Zinjarde S, Ravikumar A. Mutants of Yarrowia lipolytica NCIM 3589 grown on waste cooking oil as a biofactory for biodiesel production. Microb Cell Fact. 2017;16:176 pubmed publisher
Parisi L, Li N, Atilla Gokcumen G. Very Long Chain Fatty Acids Are Functionally Involved in Necroptosis. Cell Chem Biol. 2017;24:1445-1454.e8 pubmed publisher
Gao Q, Binns D, Kinch L, Grishin N, Ortiz N, Chen X, et al. Pet10p is a yeast perilipin that stabilizes lipid droplets and promotes their assembly. J Cell Biol. 2017;216:3199-3217 pubmed publisher
Sun W, Kato H, Kitajima S, Lee K, Gradin K, Okamoto T, et al. Interaction between von Hippel-Lindau Protein and Fatty Acid Synthase Modulates Hypoxia Target Gene Expression. Sci Rep. 2017;7:7190 pubmed publisher
Wei H, Shi Y, Ma X, Pan Y, Hu H, Li Y, et al. A type-I diacylglycerol acyltransferase modulates triacylglycerol biosynthesis and fatty acid composition in the oleaginous microalga, Nannochloropsis oceanica. Biotechnol Biofuels. 2017;10:174 pubmed publisher
Ferrari E, Bruhn C, Peretti M, Cassani C, Carotenuto W, Elgendy M, et al. PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response. Mol Cell. 2017;67:266-281.e4 pubmed publisher
Nickels J, Chatterjee S, Stanley C, Qian S, Cheng X, Myles D, et al. The in vivo structure of biological membranes and evidence for lipid domains. PLoS Biol. 2017;15:e2002214 pubmed publisher
Dacquay L, Flint A, Butcher J, Salem D, Kennedy M, Kaern M, et al. NuA4 Lysine Acetyltransferase Complex Contributes to Phospholipid Homeostasis in Saccharomyces cerevisiae. G3 (Bethesda). 2017;7:1799-1809 pubmed publisher
Cui Y, Xing P, Wang Y, Liu M, Qiu L, Ying G, et al. NADPH accumulation is responsible for apoptosis in breast cancer cells induced by fatty acid synthase inhibition. Oncotarget. 2017;8:32576-32585 pubmed publisher
Lee K, Lee M, Cha E, Sul J, Lee J, Kim J, et al. Inhibitory effect of emodin on fatty acid synthase, colon cancer proliferation and apoptosis. Mol Med Rep. 2017;15:2163-2173 pubmed publisher
Schmidt E, Fee B, Henry S, Nichols A, Shinohara M, Rathmell J, et al. Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages. J Biol Chem. 2017;292:4651-4662 pubmed publisher
Vos M, Geens A, Böhm C, Deaulmerie L, Swerts J, Rossi M, et al. Cardiolipin promotes electron transport between ubiquinone and complex I to rescue PINK1 deficiency. J Cell Biol. 2017;216:695-708 pubmed publisher
Bozaquel Morais B, Madeira J, Venancio T, Pacheco Rosa T, Masuda C, Montero Lomeli M. A Chemogenomic Screen Reveals Novel Snf1p/AMPK Independent Regulators of Acetyl-CoA Carboxylase. PLoS ONE. 2017;12:e0169682 pubmed publisher
Bastos D, Paupert J, Maillard C, Seguin F, Carvalho M, Agostini M, et al. Effects of fatty acid synthase inhibitors on lymphatic vessels: an in vitro and in vivo study in a melanoma model. Lab Invest. 2017;97:194-206 pubmed publisher
Qiu Y, Hassaninasab A, Han G, Carman G. Phosphorylation of Dgk1 Diacylglycerol Kinase by Casein Kinase II Regulates Phosphatidic Acid Production in Saccharomyces cerevisiae. J Biol Chem. 2016;291:26455-26467 pubmed
Brandi J, Dando I, Pozza E, Biondani G, Jenkins R, Elliott V, et al. Proteomic analysis of pancreatic cancer stem cells: Functional role of fatty acid synthesis and mevalonate pathways. J Proteomics. 2017;150:310-322 pubmed publisher
Thangamani S, Mohammad H, Abushahba M, Sobreira T, Hedrick V, PAUL L, et al. Antibacterial activity and mechanism of action of auranofin against multi-drug resistant bacterial pathogens. Sci Rep. 2016;6:22571 pubmed publisher
Guo L, Chen X, Li L, Tang W, Pan Y, Kong J. Transcriptome-enabled discovery and functional characterization of enzymes related to (2S)-pinocembrin biosynthesis from Ornithogalum caudatum and their application for metabolic engineering. Microb Cell Fact. 2016;15:27 pubmed publisher
Kangwan N, Kim Y, Han Y, Jeong M, Park J, Go E, et al. Sonic hedgehog inhibitors prevent colitis-associated cancer via orchestrated mechanisms of IL-6/gp130 inhibition, 15-PGDH induction, Bcl-2 abrogation, and tumorsphere inhibition. Oncotarget. 2016;7:7667-82 pubmed publisher
Bollu L, Katreddy R, Blessing A, Pham N, Zheng B, Wu X, et al. Intracellular activation of EGFR by fatty acid synthase dependent palmitoylation. Oncotarget. 2015;6:34992-5003 pubmed publisher
Zhou L, Yu Y, Chen X, Diab A, Ruan L, He J, et al. The Multiple DSF-family QS Signals are Synthesized from Carbohydrate and Branched-chain Amino Acids via the FAS Elongation Cycle. Sci Rep. 2015;5:13294 pubmed publisher
Grau R, de Oña P, Kunert M, Leñini C, Gallegos Monterrosa R, Mhatre E, et al. A Duo of Potassium-Responsive Histidine Kinases Govern the Multicellular Destiny of Bacillus subtilis. MBio. 2015;6:e00581 pubmed publisher
Wang W, Snyder N, Worth A, Blair I, Witze E. Regulation of lipid synthesis by the RNA helicase Mov10 controls Wnt5a production. Oncogenesis. 2015;4:e154 pubmed publisher
Chen Q, Chong T, Yin J, Luo P, Deng A. Molecular events are associated with resistance to vinblastine in bladder cancer. Cell Mol Biol (Noisy-le-grand). 2015;61:33-8 pubmed
Tenagy -, Park J, Iwama R, Kobayashi S, Ohta A, Horiuchi H, et al. Involvement of acyl-CoA synthetase genes in n-alkane assimilation and fatty acid utilization in yeast Yarrowia lipolytica. FEMS Yeast Res. 2015;15:fov031 pubmed publisher
Bauerschlag D, Maass N, Leonhardt P, Verburg F, Pecks U, Zeppernick F, et al. Fatty acid synthase overexpression: target for therapy and reversal of chemoresistance in ovarian cancer. J Transl Med. 2015;13:146 pubmed publisher
Tamura H, Okada H, Kume K, Koyano T, Goshima T, Nakamura R, et al. Isolation of a spontaneous cerulenin-resistant sake yeast with both high ethyl caproate-producing ability and normal checkpoint integrity. Biosci Biotechnol Biochem. 2015;79:1191-9 pubmed publisher
Hashimoto M, Komatsu K, Iwai R, Keima T, Maejima K, Shiraishi T, et al. Cell Death Triggered by a Putative Amphipathic Helix of Radish mosaic virus Helicase Protein Is Tightly Correlated With Host Membrane Modification. Mol Plant Microbe Interact. 2015;28:675-88 pubmed publisher
Moon J, Lee S, Park M, Siempos I, Haslip M, Lee P, et al. UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis. J Clin Invest. 2015;125:665-80 pubmed publisher
Martínez de Morentin P, Lage R, González García I, Ruíz Pino F, Martins L, Fernández Mallo D, et al. Pregnancy induces resistance to the anorectic effect of hypothalamic malonyl-CoA and the thermogenic effect of hypothalamic AMPK inhibition in female rats. Endocrinology. 2015;156:947-60 pubmed publisher
Malvi P, Chaube B, Pandey V, Vijayakumar M, Boreddy P, Mohammad N, et al. Obesity induced rapid melanoma progression is reversed by orlistat treatment and dietary intervention: role of adipokines. Mol Oncol. 2015;9:689-703 pubmed publisher
Bollu L, Ren J, Blessing A, Katreddy R, Gao G, Xu L, et al. Involvement of de novo synthesized palmitate and mitochondrial EGFR in EGF induced mitochondrial fusion of cancer cells. Cell Cycle. 2014;13:2415-30 pubmed publisher
Rossato F, Zecchin K, La Guardia P, Ortega R, Alberici L, Costa R, et al. Fatty acid synthase inhibitors induce apoptosis in non-tumorigenic melan-a cells associated with inhibition of mitochondrial respiration. PLoS ONE. 2014;9:e101060 pubmed publisher
Perera V, Newton G, Parnell J, Komives E, Pogliano K. Purification and characterization of the Staphylococcus aureus bacillithiol transferase BstA. Biochim Biophys Acta. 2014;1840:2851-61 pubmed publisher
Dridi S, Decuypere E, Buyse J. Cerulenin upregulates heat shock protein-70 gene expression in chicken muscle. Poult Sci. 2013;92:2745-53 pubmed publisher
Degtyar V, Hafez I, Bray C, Zucker R. Dance of the SNAREs: assembly and rearrangements detected with FRET at neuronal synapses. J Neurosci. 2013;33:5507-23 pubmed publisher
Ciana A, Achilli C, Hannoush R, Risso A, Balduini C, Minetti G. Freely turning over palmitate in erythrocyte membrane proteins is not responsible for the anchoring of lipid rafts to the spectrin skeleton: a study with bio-orthogonal chemical probes. Biochim Biophys Acta. 2013;1828:924-31 pubmed publisher
Banas W, Furmanek T, Banas A. Effect of haloxyfop and cerulenin on de novo biosynthesis of lipids in roots of wheat and maize. Acta Biochim Pol. 2012;59:567-73 pubmed
Tian D, Qiu Y, Zhan Y, Li X, Zhi X, Wang X, et al. Overexpression of steroidogenic acute regulatory protein in rat aortic endothelial cells attenuates palmitic acid-induced inflammation and reduction in nitric oxide bioavailability. Cardiovasc Diabetol. 2012;11:144 pubmed publisher
Santolla M, Lappano R, De Marco P, Pupo M, Vivacqua A, Sisci D, et al. G protein-coupled estrogen receptor mediates the up-regulation of fatty acid synthase induced by 17?-estradiol in cancer cells and cancer-associated fibroblasts. J Biol Chem. 2012;287:43234-45 pubmed publisher
Yitzhaki S, Rostron J, Xu Y, Rideout M, Authement R, Barlow S, et al. Similarities between exogenously- and endogenously-induced envelope stress: the effects of a new antibacterial molecule, TPI1609-10. PLoS ONE. 2012;7:e44896 pubmed publisher
Tirado Vélez J, Joumady I, Sáez Benito A, Cozar Castellano I, Perdomo G. Inhibition of fatty acid metabolism reduces human myeloma cells proliferation. PLoS ONE. 2012;7:e46484 pubmed publisher
Zara G, Goffrini P, Lodi T, Zara S, Mannazzu I, Budroni M. FLO11 expression and lipid biosynthesis are required for air-liquid biofilm formation in a Saccharomyces cerevisiae flor strain. FEMS Yeast Res. 2012;12:864-6 pubmed publisher
Nishiuchi H, Tabira Y, Yamagishi K. A combination of flow cytometry and traditional screening using chemicals to isolate high glutathione-producing yeast mutants. Biosci Biotechnol Biochem. 2012;76:1085-90 pubmed
Liu Z, Zhou Y, Luo Q, Hu M, Wang G, Huang S, et al. Inhibition of fatty acid synthase supresses osteosarcoma cell invasion and migration. Indian J Pathol Microbiol. 2012;55:163-9 pubmed publisher
Jiang B, Li E, Lu Y, Jiang Q, Cui D, Jing Y, et al. Inhibition of fatty-acid synthase suppresses P-AKT and induces apoptosis in bladder cancer. Urology. 2012;80:484.e9-15 pubmed publisher
Goblirsch B, Frias J, Wackett L, Wilmot C. Crystal structures of Xanthomonas campestris OleA reveal features that promote head-to-head condensation of two long-chain fatty acids. Biochemistry. 2012;51:4138-46 pubmed publisher
Theodorou E, Theodorou M, Kyriakidis D. Involvement of the AtoSCDAEB regulon in the high molecular weight poly-(R)-3-hydroxybutyrate biosynthesis in phaCAB(+)Escherichia coli. Metab Eng. 2012;14:354-65 pubmed publisher
Jeong N, Yoo Y. Cerulenin-induced apoptosis is mediated by disrupting the interaction between AIF and hexokinase II. Int J Oncol. 2012;40:1949-56 pubmed publisher
Sakai K, Koyama N, Fukuda T, Mori Y, Onaka H, Tomoda H. Search method for inhibitors of Staphyloxanthin production by methicillin-resistant Staphylococcus aureus. Biol Pharm Bull. 2012;35:48-53 pubmed
Deepa P, Vandhana S, Jayanthi U, Krishnakumar S. Therapeutic and toxicologic evaluation of anti-lipogenic agents in cancer cells compared with non-neoplastic cells. Basic Clin Pharmacol Toxicol. 2012;110:494-503 pubmed publisher
Liu Z, Wang G, Shu Y, Zou P, Zhou Y, Yin Q. Enhanced antitumor activity of epirubicin combined with cerulenin in osteosarcoma. Mol Med Rep. 2012;5:326-30 pubmed publisher
Nguyen L, Nosanchuk J. Lipid droplet formation protects against gluco/lipotoxicity in Candida parapsilosis: an essential role of fatty acid desaturase Ole1. Cell Cycle. 2011;10:3159-67 pubmed
Hu N, Li Y, Zhao Y, Wang Q, You J, Zhang X, et al. A novel positive feedback loop involving FASN/p-ERK1/2/5-LOX/LTB4/FASN sustains high growth of breast cancer cells. Acta Pharmacol Sin. 2011;32:921-9 pubmed publisher
Gao S, Zhu G, Gao X, Wu D, Carrasco P, Casals N, et al. Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding. Proc Natl Acad Sci U S A. 2011;108:9691-6 pubmed publisher
Gao S, Keung W, Serra D, Wang W, Carrasco P, Casals N, et al. Malonyl-CoA mediates leptin hypothalamic control of feeding independent of inhibition of CPT-1a. Am J Physiol Regul Integr Comp Physiol. 2011;301:R209-17 pubmed publisher
Schubert S, Barker K, Znaidi S, Schneider S, Dierolf F, Dunkel N, et al. Regulation of efflux pump expression and drug resistance by the transcription factors Mrr1, Upc2, and Cap1 in Candida albicans. Antimicrob Agents Chemother. 2011;55:2212-23 pubmed publisher
Theodorou E, Theodorou M, Kyriakidis D. AtoSC two-component system is involved in cPHB biosynthesis through fatty acid metabolism in E. coli. Biochim Biophys Acta. 2011;1810:561-8 pubmed publisher
Mao L, Inoue K, Tao Y, Montelione G, McDermott A, Inouye M. Suppression of phospholipid biosynthesis by cerulenin in the condensed Single-Protein-Production (cSPP) system. J Biomol NMR. 2011;49:131-7 pubmed publisher
Fakas S, Konstantinou C, Carman G. DGK1-encoded diacylglycerol kinase activity is required for phospholipid synthesis during growth resumption from stationary phase in Saccharomyces cerevisiae. J Biol Chem. 2011;286:1464-74 pubmed publisher
Nakajima T, Tanaka N, Kanbe H, Hara A, Kamijo Y, Zhang X, et al. Bezafibrate at clinically relevant doses decreases serum/liver triglycerides via down-regulation of sterol regulatory element-binding protein-1c in mice: a novel peroxisome proliferator-activated receptor alpha-independent mechanism. Mol Pharmacol. 2009;75:782-92 pubmed publisher
Goodrich Tanrikulu M, Jacobson D, Stafford A, Lin J, McKeon T. Characterization of Neurospora crassa mutants isolated following repeat-induced point mutation of the beta subunit of fatty acid synthase. Curr Genet. 1999;36:147-52 pubmed
Pereira H, Rebello M. Inhibition of Mayaro virus replication by cerulenin in Aedes albopictus cells. Acta Virol. 1998;42:383-8 pubmed
Tomoda H, Kawaguchi A, Okuda S. [Mechanism of action of cerulenin on fatty acid synthetase and cerulenin resistance in a cerulenin-producing fungus]. Seikagaku. 1985;57:190-201 pubmed
product information
Catalog Number :
C2389
Product Name :
Cerulenin
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC), from Cephalosporium caerulens
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA