This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
protein
product name :
Complement component C1q from human serum
catalog :
C1740
citations: 58
Reference
Sahu S, Stiller C, Cavallaro S, Karlström A, Linnros J, Dev A. Influence of molecular size and zeta potential in electrokinetic biosensing. Biosens Bioelectron. 2020;152:112005 pubmed publisher
Yoshimura N, Yokoyama Y, Sako M, Aoyama N, Hirai F, Sawada K, et al. Development of a C1q-immobilized (Cim) assay to measure total antibodies to infliximab and its clinical relevance in patients with inflammatory bowel disease. Cytokine. 2019;120:54-61 pubmed publisher
Martini F, Eckmair B, Stefanic S, Jin C, Garg M, Yan S, et al. Highly modified and immunoactive N-glycans of the canine heartworm. Nat Commun. 2019;10:75 pubmed publisher
Wada R, Matsui M, Kawasaki N. Influence of N-glycosylation on effector functions and thermal stability of glycoengineered IgG1 monoclonal antibody with homogeneous glycoforms. MAbs. 2019;11:350-372 pubmed publisher
Marusic C, Pioli C, Stelter S, Novelli F, Lonoce C, Morrocchi E, et al. N-glycan engineering of a plant-produced anti-CD20-hIL-2 immunocytokine significantly enhances its effector functions. Biotechnol Bioeng. 2017;: pubmed publisher
Cai Y, Teo B, Yeo J, Lu J. C1q protein binds to the apoptotic nucleolus and causes C1 protease degradation of nucleolar proteins. J Biol Chem. 2015;290:22570-80 pubmed publisher
Cresci G, Allende D, McMullen M, Nagy L. Alternative complement pathway component Factor D contributes to efficient clearance of tissue debris following acute CClâ‚„-induced injury. Mol Immunol. 2015;64:9-17 pubmed publisher
Arduin E, Arora S, Bamert P, Kuiper T, Popp S, Geisse S, et al. Highly reduced binding to high and low affinity mouse Fc gamma receptors by L234A/L235A and N297A Fc mutations engineered into mouse IgG2a. Mol Immunol. 2015;63:456-63 pubmed publisher
Clarke E, Weist B, Walsh C, Tenner A. Complement protein C1q bound to apoptotic cells suppresses human macrophage and dendritic cell-mediated Th17 and Th1 T cell subset proliferation. J Leukoc Biol. 2015;97:147-60 pubmed publisher
Miao H, Jia Y, Xie S, Wang X, Zhao J, Chu Y, et al. Structural insights into the C1q domain of Caprin-2 in canonical Wnt signaling. J Biol Chem. 2014;289:34104-13 pubmed publisher
Gao Z, Li M, Ma J, Zhang S. An amphioxus gC1q protein binds human IgG and initiates the classical pathway: Implications for a C1q-mediated complement system in the basal chordate. Eur J Immunol. 2014;44:3680-95 pubmed publisher
Peerschke E, Ghebrehiwet B. cC1qR/CR and gC1qR/p33: observations in cancer. Mol Immunol. 2014;61:100-9 pubmed publisher
Mayer A, Johnson J, Parks G. The neutralizing capacity of antibodies elicited by parainfluenza virus infection of African Green Monkeys is dependent on complement. Virology. 2014;460-461:23-33 pubmed publisher
Greenhalgh A, David S. Differences in the phagocytic response of microglia and peripheral macrophages after spinal cord injury and its effects on cell death. J Neurosci. 2014;34:6316-22 pubmed publisher
Sosoniuk E, Vallejos G, Kenawy H, Gaboriaud C, Thielens N, Fujita T, et al. Trypanosoma cruzi calreticulin inhibits the complement lectin pathway activation by direct interaction with L-Ficolin. Mol Immunol. 2014;60:80-5 pubmed publisher
HIATT A, Bohorova N, Bohorov O, Goodman C, Kim D, Pauly M, et al. Glycan variants of a respiratory syncytial virus antibody with enhanced effector function and in vivo efficacy. Proc Natl Acad Sci U S A. 2014;111:5992-7 pubmed publisher
Schiering I, de Haan T, Niermeijer J, Koelman J, Majoie C, Reneman L, et al. Correlation between clinical and histologic findings in the human neonatal hippocampus after perinatal asphyxia. J Neuropathol Exp Neurol. 2014;73:324-34 pubmed publisher
Lobsiger C, Cleveland D. Reply to Woodruff et al.: C1q and C3-dependent complement pathway activation does not contribute to disease in SOD1 mutant ALS mice. Proc Natl Acad Sci U S A. 2014;111:E5 pubmed
Liu G, Pang Y, Liu X, Li Q. [Structure, distribution, classification, and function of C1q protein family: a review]. Yi Chuan. 2013;35:1072-80 pubmed
Woodruff T, Lee J, Noakes P. Role for terminal complement activation in amyotrophic lateral sclerosis disease progression. Proc Natl Acad Sci U S A. 2014;111:E3-4 pubmed publisher
Derecki N, Kipnis J. From neurons to microglia, with complements. Nat Neurosci. 2013;16:1712-3 pubmed publisher
Zhang Z, Pinto A, Wan L, Wang W, Berg M, Oliva I, et al. Dysregulation of synaptogenesis genes antecedes motor neuron pathology in spinal muscular atrophy. Proc Natl Acad Sci U S A. 2013;110:19348-53 pubmed publisher
Lobsiger C, Boillée S, Pozniak C, Khan A, McAlonis Downes M, Lewcock J, et al. C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice. Proc Natl Acad Sci U S A. 2013;110:E4385-92 pubmed publisher
Bialas A, Stevens B. TGF-? signaling regulates neuronal C1q expression and developmental synaptic refinement. Nat Neurosci. 2013;16:1773-82 pubmed publisher
López Lera A, Torres Canizales J, Garrido S, Morales A, Lopez Trascasa M. Rothmund-Thomson syndrome and glomerulonephritis in a homozygous C1q-deficient patient due to a Gly164Ser C1qC mutation. J Invest Dermatol. 2014;134:1152-1154 pubmed publisher
Agarwal V, Ahl J, Riesbeck K, Blom A. An alternative role of C1q in bacterial infections: facilitating Streptococcus pneumoniae adherence and invasion of host cells. J Immunol. 2013;191:4235-45 pubmed publisher
Arkwright P, Riley P, Hughes S, Alachkar H, Wynn R. Successful cure of C1q deficiency in human subjects treated with hematopoietic stem cell transplantation. J Allergy Clin Immunol. 2014;133:265-7 pubmed publisher
Kubal C, Mangus R, Saxena R, Lobashevsky A, Higgins N, Agarwal A, et al. Crossmatch-positive liver transplantation in patients receiving thymoglobulin-rituximab induction. Transplantation. 2014;97:56-63 pubmed publisher
Luo H, Li W, Yang F, Zhou L, Wen P, Zhou J. [Expressions of complement C1q and C3c in rat brain tissues with cerebral ischemia/reperfusion injury]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013;29:897-900 pubmed
Zotova E, Bharambe V, Cheaveau M, Morgan W, Holmes C, Harris S, et al. Inflammatory components in human Alzheimer's disease and after active amyloid-?42 immunization. Brain. 2013;136:2677-96 pubmed publisher
Farrera C, Fadeel B. Macrophage clearance of neutrophil extracellular traps is a silent process. J Immunol. 2013;191:2647-56 pubmed publisher
Ramirez Ortiz Z, Pendergraft W, Prasad A, Byrne M, Iram T, Blanchette C, et al. The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity. Nat Immunol. 2013;14:917-26 pubmed publisher
Tsanyan M, Torgashina A, Aleksandrova E, Soloviev S, Nasonov E. [Anti-C1q antibodies in patients with systemic lupus erythematosus treated by rituximab]. Ter Arkh. 2013;85:53-9 pubmed
Bally I, Ancelet S, Moriscot C, Gonnet F, Mantovani A, Daniel R, et al. Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites. Proc Natl Acad Sci U S A. 2013;110:8650-5 pubmed publisher
Ma Y, Ramachandran A, Ford N, Parada I, Prince D. Remodeling of dendrites and spines in the C1q knockout model of genetic epilepsy. Epilepsia. 2013;54:1232-9 pubmed publisher
Trouw L, Daha N, Kurreeman F, Böhringer S, Goulielmos G, Westra H, et al. Genetic variants in the region of the C1q genes are associated with rheumatoid arthritis. Clin Exp Immunol. 2013;173:76-83 pubmed publisher
Byrne J, Ní Gabhann J, Stacey K, Coffey B, McCarthy E, Thomas W, et al. Bruton's tyrosine kinase is required for apoptotic cell uptake via regulating the phosphorylation and localization of calreticulin. J Immunol. 2013;190:5207-15 pubmed publisher
Lee H, Choi S, Jeong K, Sung J, Moon S, Moon J, et al. Association of C1q deposition with renal outcomes in IgA nephropathy. Clin Nephrol. 2013;80:98-104 pubmed publisher
Kogan A, Filatov V, Kolosova O, Katrukha I, Mironova E, Zhuravleva N, et al. Oligomeric adiponectin forms and their complexes in the blood of healthy donors and patients with type 2 diabetes mellitus. J Immunoassay Immunochem. 2013;34:180-96 pubmed publisher
Freitas M, Rebellato L, Ozawa M, Nguyen A, Sasaki N, Everly M, et al. The role of immunoglobulin-G subclasses and C1q in de novo HLA-DQ donor-specific antibody kidney transplantation outcomes. Transplantation. 2013;95:1113-9 pubmed publisher
Joseph K, Kulik L, Coughlin B, Kunchithapautham K, Bandyopadhyay M, Thiel S, et al. Oxidative stress sensitizes retinal pigmented epithelial (RPE) cells to complement-mediated injury in a natural antibody-, lectin pathway-, and phospholipid epitope-dependent manner. J Biol Chem. 2013;288:12753-65 pubmed publisher
Brookes C, Kuisma E, Alexander F, Allen L, Tipton T, Ram S, et al. Development of a large scale human complement source for use in bacterial immunoassays. J Immunol Methods. 2013;391:39-49 pubmed publisher
Broyer L, Goetsch L, Broussas M. Evaluation of complement-dependent cytotoxicity using ATP measurement and C1q/C4b binding. Methods Mol Biol. 2013;988:319-29 pubmed publisher
Kishida K, Kishida N, Arima M, Nakatsuji H, Kobayashi H, Funahashi T, et al. Serum C1q- binding adiponectin in maintenance hemodialysis patients. BMC Nephrol. 2013;14:50 pubmed publisher
Ghebrehiwet B, Jesty J, Vinayagasundaram R, Vinayagasundaram U, Ji Y, Valentino A, et al. Targeting gC1qR domains for therapy against infection and inflammation. Adv Exp Med Biol. 2013;735:97-110 pubmed
Daponte A, Deligeoroglou E, Pournaras S, Hadjichristodoulou C, Garas A, Anastasiadou F, et al. Interleukin-15 (IL-15) and anti-C1q antibodies as serum biomarkers for ectopic pregnancy and missed abortion. Clin Dev Immunol. 2013;2013:637513 pubmed publisher
Lachmann N, Todorova K, Schulze H, Schonemann C. Systematic comparison of four cell- and Luminex-based methods for assessment of complement-activating HLA antibodies. Transplantation. 2013;95:694-700 pubmed publisher
Ma C, Wang Y, Zhang G, Chen Z, Qiu Y, Li J, et al. Immunoglobulin G expression and its potential role in primary and metastatic breast cancers. Curr Mol Med. 2013;13:429-37 pubmed
Wu F, Chen L, Liu X, Wang H, Su P, Han Y, et al. Lamprey variable lymphocyte receptors mediate complement-dependent cytotoxicity. J Immunol. 2013;190:922-30 pubmed publisher
Tait B, Süsal C, Gebel H, Nickerson P, Zachary A, Claas F, et al. Consensus guidelines on the testing and clinical management issues associated with HLA and non-HLA antibodies in transplantation. Transplantation. 2013;95:19-47 pubmed publisher
Rayner L, Kadkhodayi Kholghi N, Heenan R, Gor J, Dalby P, Perkins S. The solution structure of rabbit IgG accounts for its interactions with the Fc receptor and complement C1q and its conformational stability. J Mol Biol. 2013;425:506-23 pubmed publisher
Benoit M, Hernandez M, Dinh M, Benavente F, Vasquez O, Tenner A. C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-? neurotoxicity. J Biol Chem. 2013;288:654-65 pubmed publisher
Llorente S, Boix F, Eguia J, Lopez M, Bosch A, Martinez H, et al. C1q-fixing human leukocyte antigen assay in immunized renal patients: correlation between Luminex SAB-C1q and SAB-IgG. Transplant Proc. 2012;44:2535-7 pubmed publisher
Zeevi A, Lunz J, Feingold B, Shullo M, Bermudez C, Teuteberg J, et al. Persistent strong anti-HLA antibody at high titer is complement binding and associated with increased risk of antibody-mediated rejection in heart transplant recipients. J Heart Lung Transplant. 2013;32:98-105 pubmed publisher
Nakatsuji H, Kishida K, Kobayashi H, Funahashi T, Shimomura I. Three-month treatment with pioglitazone reduces circulating C1q-binding adiponectin complex to total-adiponectin ratio, without changes in body mass index, in people with type 2 diabetes. Diabetes Res Clin Pract. 2013;99:e14-7 pubmed publisher
Son M, Santiago Schwarz F, Al Abed Y, Diamond B. C1q limits dendritic cell differentiation and activation by engaging LAIR-1. Proc Natl Acad Sci U S A. 2012;109:E3160-7 pubmed publisher
Terrasse R, Tacnet Delorme P, Moriscot C, Perard J, Schoehn G, Vernet T, et al. Human and pneumococcal cell surface glyceraldehyde-3-phosphate dehydrogenase (GAPDH) proteins are both ligands of human C1q protein. J Biol Chem. 2012;287:42620-33 pubmed publisher
Peerschke E, Reid K, Ghebrehiwet B. Platelet activation by C1q results in the induction of alpha IIb/beta 3 integrins (GPIIb-IIIa) and the expression of P-selectin and procoagulant activity. J Exp Med. 1993;178:579-87 pubmed
product information
Catalog Number :
C1740
Product Name :
Complement component C1q from human serum
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
≥95% (SDS-PAGE)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA