This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
protein
product name :
Acetylcholinesterase from human erythrocytes
catalog :
C0663
citations: 75
Reference
Zhou Y, Lu X, Yang H, Chen Y, Wang F, Li J, et al. Discovery of Selective Butyrylcholinesterase (BChE) Inhibitors through a Combination of Computational Studies and Biological Evaluations. Molecules. 2019;24: pubmed publisher
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Mohamed T, Rao P. 2,4-Disubstituted quinazolines as amyloid-? aggregation inhibitors with dual cholinesterase inhibition and antioxidant properties: Development and structure-activity relationship (SAR) studies. Eur J Med Chem. 2017;126:823-843 pubmed publisher
Chen L, Ye R, Xu Y, Gao Z, Au D, Qian P. Comparative safety of the antifouling compound butenolide and 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) to the marine medaka (Oryzias melastigma). Aquat Toxicol. 2014;149:116-25 pubmed publisher
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Tariq S, Khan H, Popalzai A, Niazi I, Safiullah -. Attenuation of erythrocytic acetyl cholinesterase by paracetamol and chloroquine: evidence in an in vitro study. Pak J Pharm Sci. 2014;27:261-4 pubmed
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Tonin A, Da Silva A, Schafer A, Aires A, Oliveira C, Zanini D, et al. Influence of experimental infection by Haemonchus contortus on acetylcholinesterase activity in lymphocytes of lambs. Exp Parasitol. 2014;139:19-23 pubmed publisher
Shukor M, Tham L, Halmi M, Khalid I, Begum G, Syed M. Development of an inhibitive assay using commercial Electrophorus electricus acetylcholinesterase for heavy metal detection. J Environ Biol. 2013;34:967-70 pubmed
Mataqueiro M, Nakaghi L, Yamada P, de Camargo Ferraz G, de Queiroz Neto A, Deoliveira G. Degradation, residual determination, and cholinesterase activity of triclorfon in Piaractus mesopotamicus Holmberg (PACU) 1887. J Toxicol Environ Health A. 2014;77:125-32 pubmed publisher
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Biradar S, Joshi H, Tarak K. Cerebroprotective effect of isolated harmine alkaloids extracts of seeds of Peganum harmala L. on sodium nitrite-induced hypoxia and ethanol-induced neurodegeneration in young mice. Pak J Biol Sci. 2013;16:1687-97 pubmed
Kumar A, Rinwa P, Dhar H. Possible nitric oxide modulation in the protective effects of rutin against experimental head trauma-induced cognitive deficits: behavioral, biochemical, and molecular correlates. J Surg Res. 2014;188:268-79 pubmed publisher
Jackson C, Carville A, Ward J, Mansfield K, Ollis D, Khurana T, et al. Use of OpdA, an organophosphorus (OP) hydrolase, prevents lethality in an African green monkey model of acute OP poisoning. Toxicology. 2014;317:1-5 pubmed publisher
Cahlíková L, Hrabinova M, Kulhánková A, Benesová N, Chlebek J, Jun D, et al. Alkaloids from Chlidanthus fragrans and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase activities. Nat Prod Commun. 2013;8:1541-4 pubmed
D Andrea V, Bianchi E, Taurone S, Mignini F, Cavallotti C, Artico M. Cholinergic innervation of human mesenteric lymphatic vessels. Folia Morphol (Warsz). 2013;72:322-7 pubmed
Podolska M, Nadolna K, Szostakowska B. Acetylcholinesterase activity in the host-parasite system of the cod Gadus morhua and acanthocephalan Echinorhynchus gadi from the southern Baltic Sea. Mar Pollut Bull. 2014;79:100-6 pubmed publisher
ROSENBERG Y, Gearhart J, Mao L, Jiang X, Hernandez Abanto S. Protection against paraoxon toxicity by an intravenous pretreatment with polyethylene-glycol-conjugated recombinant butyrylcholinesterase in macaques. Chem Biol Interact. 2014;210:20-5 pubmed publisher
Suzuki H, Ito Y, Noro Y, Koketsu M, Kamijima M, Tomizawa M. Organophosphate agents induce plasma hypertriglyceridemia in mouse via single or dual inhibition of the endocannabinoid hydrolyzing enzyme(s). Toxicol Lett. 2014;225:153-7 pubmed publisher
Sharma R, Gupta B, Acharya J, Kaushik M, Ghosh K. Interactions between xylene-linked carbamoyl bis-pyridinium mono-oximes and organophosphates inhibited-AChE: a kinetic study. Toxicology. 2014;316:1-8 pubmed publisher
Pizzurro D, Dao K, Costa L. Diazinon and diazoxon impair the ability of astrocytes to foster neurite outgrowth in primary hippocampal neurons. Toxicol Appl Pharmacol. 2014;274:372-82 pubmed publisher
Garcia Reyero N, Escalon B, Prats E, Stanley J, Thienpont B, Melby N, et al. Effects of BDE-209 contaminated sediments on zebrafish development and potential implications to human health. Environ Int. 2014;63:216-23 pubmed publisher
Gutierres J, Carvalho F, Schetinger M, Marisco P, Agostinho P, Rodrigues M, et al. Anthocyanins restore behavioral and biochemical changes caused by streptozotocin-induced sporadic dementia of Alzheimer's type. Life Sci. 2014;96:7-17 pubmed publisher
Laetz C, Baldwin D, Hebert V, Stark J, Scholz N. Elevated temperatures increase the toxicity of pesticide mixtures to juvenile coho salmon. Aquat Toxicol. 2014;146:38-44 pubmed publisher
Tsymbaliuk V, Vasyl ieva I, Oleksenko N, Chopyk N, Tsiubko O, Halanta O. [Stimulation of cholinogenesis in the human fetal nerve cells culture]. Tsitol Genet. 2013;47:54-9 pubmed
Sarikaya B, Somer N, Kaya G, Onur M, Bastida J, Berkov S. GC-MS investigation and acetylcholinesterase inhibitory activity of Galanthus rizehensis. Z Naturforsch C J Biosci. 2013;68:118-24 pubmed
Shen Y, Li B, Xu H, Zhang G. Design, synthesis, and biological evaluation of acetophenone derivatives as dual binding acetylcholinesterase inhibitors. Pharmazie. 2013;68:307-10 pubmed
Nam Y, Lee D. Ameliorating effect of zhizi (Fructus gardeniae) extract and its glycosides on scopolamine-induced memory impairment. J Tradit Chin Med. 2013;33:223-7 pubmed
Temiz Arpaci O, Eylem Cifcioglu Goztepe B, Kaynak Onurdağ F, Ozgen S, Senol F, Erdogan Orhan I. Synthesis and different biological activities of novel benzoxazoles. Acta Biol Hung. 2013;64:249-61 pubmed publisher
Nikitashina A, Petrov K, Zobov V, Reznik V, Nikol skiĭ E. Specific inhibitory effects of the alkylammonium derivative 6-methyluracil on acetylcholinesterase of smooth and striated muscles in rats. Dokl Biol Sci. 2013;449:82-4 pubmed publisher
Iudin M, Chepur S, Bykov V, Kurpiakova A, Subbotina S, Nikiforov A, et al. [Specific features of the anticonvulsant effect of memantine in mice intoxicated with a model organic phosphate]. Eksp Klin Farmakol. 2013;76:3-5 pubmed
Wang L, Lv H, Zhang L, Hua H, Wang J, Hu Z, et al. [Screening of endophytic fungi from Huperzia serrata for acetylcholinesterase inhibitory activity and its taxonomic identification]. Zhongguo Zhong Yao Za Zhi. 2012;37:3701-5 pubmed
Almasieh M, Macintyre J, Pouliot M, Casanova C, Vaucher E, Kelly M, et al. Acetylcholinesterase inhibition promotes retinal vasoprotection and increases ocular blood flow in experimental glaucoma. Invest Ophthalmol Vis Sci. 2013;54:3171-83 pubmed publisher
Greenfield S. Discovering and targeting the basic mechanism of neurodegeneration: the role of peptides from the C-terminus of acetylcholinesterase: non-hydrolytic effects of ache: the actions of peptides derived from the C-terminal and their relevance to neurodege. Chem Biol Interact. 2013;203:543-6 pubmed publisher
van der Kamp M, Mulholland A. Combined quantum mechanics/molecular mechanics (QM/MM) methods in computational enzymology. Biochemistry. 2013;52:2708-28 pubmed publisher
Ikoma N, Itano O, Fuchimoto Y, Du W, Kitagawa Y. Colonic perforation in a case of adult Hirschsprung's disease with acetylcholinesterase-negative neuronal fibers. Am Surg. 2013;79:E130-2 pubmed
Iudin M, Lantukhov D, Vengerovich N. [Studying kinetics of oxime-induced reactivation of malathion-inhibited cholinesterase]. Eksp Klin Farmakol. 2013;76:21-4 pubmed
Rehman A, Fatima A, Abbas N, Abbasi M, Khan K, Ashraf M, et al. Synthesis, characterization and biological screening of 5-substituted-1,3,4-oxadiazole-2yl-N-(2-methoxy-5-chlorophenyl)-2-sulfanyl acetamide. Pak J Pharm Sci. 2013;26:345-52 pubmed
Ye L, Fu F, Liu W, Sun K, Li Y, He J, et al. Preparation and in vitro and in vivo evaluation of HupA PLGA microsphere. Pak J Pharm Sci. 2013;26:315-22 pubmed
Bai F, Xu Y, Chen J, Liu Q, Gu J, Wang X, et al. Free energy landscape for the binding process of Huperzine A to acetylcholinesterase. Proc Natl Acad Sci U S A. 2013;110:4273-8 pubmed publisher
Reddy M, Godoy A, Dion K, Matias A, Callender K, Kiszewski A, et al. Insecticide resistance allele frequencies in Anopheles gambiae before and after anti-vector interventions in continental Equatorial Guinea. Am J Trop Med Hyg. 2013;88:897-907 pubmed publisher
Spilovská K, Korabecny J, Kral J, Horova A, Musilek K, Soukup O, et al. 7-Methoxytacrine-adamantylamine heterodimers as cholinesterase inhibitors in Alzheimer's disease treatment--synthesis, biological evaluation and molecular modeling studies. Molecules. 2013;18:2397-418 pubmed publisher
Luo H, Li C, Kim J, Liu Y, Jung J, Koh Y, et al. Biruloquinone, an acetylcholinesterase inhibitor produced by lichen-forming fungus Cladonia macilenta. J Microbiol Biotechnol. 2013;23:161-6 pubmed
Mineur Y, Obayemi A, Wigestrand M, Fote G, Calarco C, Li A, et al. Cholinergic signaling in the hippocampus regulates social stress resilience and anxiety- and depression-like behavior. Proc Natl Acad Sci U S A. 2013;110:3573-8 pubmed publisher
Scott M, McAllister J. Comparison of biochemical and molecular tests for detecting insecticide resistance due to insensitive acetylcholinesterase in Culex quinquefasciatus. J Am Mosq Control Assoc. 2012;28:323-6 pubmed
Garcia Ratés S, Lewis M, Worrall R, Greenfield S. Additive toxicity of β-amyloid by a novel bioactive peptide in vitro: possible implications for Alzheimer's disease. PLoS ONE. 2013;8:e54864 pubmed publisher
Scriba G, Abromeit H, Hense M, Fan Y. Capillary electrophoretic enzyme assays. Methods Mol Biol. 2013;984:285-308 pubmed publisher
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Artursson E, Andersson P, Akfur C, Linusson A, Börjegren S, Ekström F. Catalytic-site conformational equilibrium in nerve-agent adducts of acetylcholinesterase: possible implications for the HI-6 antidote substrate specificity. Biochem Pharmacol. 2013;85:1389-97 pubmed publisher
Ghadimi S, Valmoozi A, Pourayoubi M, Samani K. Structure-activity study of phosphoramido acid esters as acetylcholinesterase inhibitors. J Enzyme Inhib Med Chem. 2008;23:556-61 pubmed
Dvir H, Harel M, Bon S, Liu W, Vidal M, Garbay C, et al. The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix. EMBO J. 2004;23:4394-405 pubmed
Gerhard D, Wagner L, Feingold E, Shenmen C, Grouse L, Schuler G, et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004;14:2121-7 pubmed
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ZITTLE C, Dellamonica E, CUSTER J, Krikorian R. Purification of human red cell acetylcholinesterase by electrophoresis, ultracentrifugation and gradient extraction. Arch Biochem Biophys. 1955;56:469-75 pubmed
Bergmann F, Rimon S, Segal R. Effect of pH on the activity of eel esterase towards different substrates. Biochem J. 1958;68:493-9 pubmed
Hillier L, Fulton R, Fulton L, Graves T, Pepin K, Wagner McPherson C, et al. The DNA sequence of human chromosome 7. Nature. 2003;424:157-64 pubmed
Yang L, He H, Zhang X. Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells. Neurosci Res. 2002;42:261-8 pubmed
Wilson M, Riemer C, Martindale D, Schnupf P, Boright A, Cheung T, et al. Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. Nucleic Acids Res. 2001;29:1352-65 pubmed
Kryger G, Harel M, Giles K, Toker L, Velan B, Lazar A, et al. Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II. Acta Crystallogr D Biol Crystallogr. 2000;56:1385-94 pubmed
Felder C, Botti S, Lifson S, Silman I, Sussman J. External and internal electrostatic potentials of cholinesterase models. J Mol Graph Model. 1997;15:318-27, 335-7 pubmed
Bartels C, Zelinski T, Lockridge O. Mutation at codon 322 in the human acetylcholinesterase (ACHE) gene accounts for YT blood group polymorphism. Am J Hum Genet. 1993;52:928-36 pubmed
Karpel R, Ben Aziz Aloya R, Sternfeld M, Ehrlich G, Ginzberg D, Tarroni P, et al. Expression of three alternative acetylcholinesterase messenger RNAs in human tumor cell lines of different tissue origins. Exp Cell Res. 1994;210:268-77 pubmed
Leuzinger W, Baker A, Cauvin E. Acetylcholinesterase. II. Crystallization, absorption spectra, isoionic point. Proc Natl Acad Sci U S A. 1968;59:620-3 pubmed
Ciliv G, Ozand P. Human erythrocyte acetylcholinesterase purification, properties and kinetic behavior. Biochim Biophys Acta. 1972;284:136-56 pubmed
Chhajlani V, Derr D, Earles B, Schmell E, August T. Purification and partial amino acid sequence analysis of human erythrocyte acetylcholinesterase. FEBS Lett. 1989;247:279-82 pubmed
Soreq H, Ben Aziz R, Prody C, Seidman S, Gnatt A, Neville L, et al. Molecular cloning and construction of the coding region for human acetylcholinesterase reveals a G + C-rich attenuating structure. Proc Natl Acad Sci U S A. 1990;87:9688-92 pubmed
Velan B, Grosfeld H, Kronman C, Leitner M, Gozes Y, Lazar A, et al. The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant. J Biol Chem. 1991;266:23977-84 pubmed
Shafferman A, Kronman C, Flashner Y, Leitner M, Grosfeld H, Ordentlich A, et al. Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding. J Biol Chem. 1992;267:17640-8 pubmed
product information
Catalog Number :
C0663
Product Name :
Acetylcholinesterase from human erythrocytes
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
buffered aqueous solution, ?500 units/mg protein (BCA)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA