This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Carmustine
catalog :
C0400
citations: 75
Reference
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Burri S, Prabhu R, Sumrall A, Brick W, Blaker B, Heideman B, et al. BCNU wafer placement with temozolomide (TMZ) in the immediate postoperative period after tumor resection followed by radiation therapy with TMZ in patients with newly diagnosed high grade glioma: final results of a prospective, multi-institutional, p. J Neurooncol. 2015;123:259-66 pubmed publisher
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Sukumari Ramesh S, Prasad N, Alleyne C, Vender J, Dhandapani K. Overexpression of Nrf2 attenuates Carmustine-induced cytotoxicity in U87MG human glioma cells. BMC Cancer. 2015;15:118 pubmed publisher
Krishnamurthy N, Liu L, Xiong X, Zhang J, Montano M. Downregulation of hPMC2 imparts chemotherapeutic sensitivity to alkylating agents in breast cancer cells. Cancer Biol Ther. 2015;16:518-27 pubmed publisher
Olszko M, Adair J, Linde I, Rae D, Trobridge P, Hocum J, et al. Foamy viral vector integration sites in SCID-repopulating cells after MGMTP140K-mediated in vivo selection. Gene Ther. 2015;22:591-5 pubmed publisher
Kim J, Jin X, Ham S, Lee S, Seo S, Kim S, et al. IRF7 promotes glioma cell invasion by inhibiting AGO2 expression. Tumour Biol. 2015;36:5561-9 pubmed publisher
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Fan C, Ting C, Chang Y, Wei K, Liu H, Yeh C. Drug-loaded bubbles with matched focused ultrasound excitation for concurrent blood-brain barrier opening and brain-tumor drug delivery. Acta Biomater. 2015;15:89-101 pubmed publisher
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Chai K, Wang C, Liaw H, Fang K, Yang C, Tzeng S. Downregulation of BRCA1-BRCA2-containing complex subunit 3 sensitizes glioma cells to temozolomide. Oncotarget. 2014;5:10901-15 pubmed
Kanamori M, Higa T, Sonoda Y, Murakami S, Dodo M, Kitamura H, et al. Activation of the NRF2 pathway and its impact on the prognosis of anaplastic glioma patients. Neuro Oncol. 2015;17:555-65 pubmed publisher
Sewing A, Caretti V, Lagerweij T, Schellen P, Jansen M, van Vuurden D, et al. Convection enhanced delivery of carmustine to the murine brainstem: a feasibility study. J Neurosci Methods. 2014;238:88-94 pubmed publisher
Agnihotri S, Burrell K, Buczkowicz P, Remke M, Golbourn B, Chornenkyy Y, et al. ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents. Cancer Discov. 2014;4:1198-213 pubmed publisher
Zhao H, Thienpont B, Yesilyurt B, Moisse M, Reumers J, Coenegrachts L, et al. Mismatch repair deficiency endows tumors with a unique mutation signature and sensitivity to DNA double-strand breaks. elife. 2014;3:e02725 pubmed publisher
Ji W, Yang M, Praggastis A, Li Y, Zhou H, He Y, et al. Carbamoylating activity associated with the activation of the antitumor agent laromustine inhibits angiogenesis by inducing ASK1-dependent endothelial cell death. PLoS ONE. 2014;9:e103224 pubmed publisher
Rancea M, Will A, Borchmann P, Monsef I, Engert A, Skoetz N. Sixteenth biannual report of the Cochrane Haematological Malignancies Group: focus on Non-Hodgkin's lymphoma. J Natl Cancer Inst. 2014;106: pubmed publisher
Zhang J, Chen M, Zhang Y, Zhao L, Yan R, Dai K. Carmustine induces platelet apoptosis. Platelets. 2015;26:437-42 pubmed publisher
Phaltane R, Lachmann N, Brennig S, Ackermann M, Modlich U, Moritz T. Lentiviral MGMT(P140K)-mediated in vivo selection employing a ubiquitous chromatin opening element (A2UCOE) linked to a cellular promoter. Biomaterials. 2014;35:7204-13 pubmed publisher
Kim S, Rait A, Kim E, Pirollo K, Nishida M, Farkas N, et al. A nanoparticle carrying the p53 gene targets tumors including cancer stem cells, sensitizes glioblastoma to chemotherapy and improves survival. ACS Nano. 2014;8:5494-514 pubmed publisher
Fan C, Liu H, Ting C, Lee Y, Huang C, Ma Y, et al. Submicron-bubble-enhanced focused ultrasound for blood-brain barrier disruption and improved CNS drug delivery. PLoS ONE. 2014;9:e96327 pubmed publisher
Xie Q, Yan Y, Huang Z, Zhong X, Huang L. MicroRNA-221 targeting PI3-K/Akt signaling axis induces cell proliferation and BCNU resistance in human glioblastoma. Neuropathology. 2014;34:455-64 pubmed publisher
Shankar A, Hayward J, Kirkwood A, McCarthy K, Hewitt M, Morland B, et al. Treatment outcome in children and adolescents with relapsed Hodgkin lymphoma--results of the UK HD3 relapse treatment strategy. Br J Haematol. 2014;165:534-44 pubmed publisher
Olson J, Nayak L, Ormond D, Wen P, Kalkanis S. The role of cytotoxic chemotherapy in the management of progressive glioblastoma : a systematic review and evidence-based clinical practice guideline. J Neurooncol. 2014;118:501-55 pubmed publisher
Kolstad A, Laurell A, Jerkeman M, Grønbæk K, Elonen E, Räty R, et al. Nordic MCL3 study: 90Y-ibritumomab-tiuxetan added to BEAM/C in non-CR patients before transplant in mantle cell lymphoma. Blood. 2014;123:2953-9 pubmed publisher
Rasche L, Strifler S, Duell J, Rosenwald A, Buck A, Maeder U, et al. The lymphoma-like polychemotherapy regimen "Dexa-BEAM" in advanced and extramedullary multiple myeloma. Ann Hematol. 2014;93:1207-14 pubmed publisher
Shah R, Homapour B, Casselden E, Barr J, Grundy P, Brydon H. Delayed post-operative haemorrhage after carmustine wafer implantation: a case series from two UK centres. Br J Neurosurg. 2014;28:488-94 pubmed publisher
Aoki T, Yamada S. [II. Current status of BCNU stent in the brain for treatment of glioma]. Gan To Kagaku Ryoho. 2013;40:708-17 pubmed
Eroglu C, Kaynar L, Orhan O, Keklik M, Sahin C, Yildiz O, et al. Contribution of involved-field radiotherapy to survival in patients with relapsed or refractory Hodgkin lymphoma undergoing autologous stem cell transplantation. Am J Clin Oncol. 2015;38:68-73 pubmed publisher
Gutenberg A, Lumenta C, Braunsdorf W, Sabel M, Mehdorn H, Westphal M, et al. The combination of carmustine wafers and temozolomide for the treatment of malignant gliomas. A comprehensive review of the rationale and clinical experience. J Neurooncol. 2013;113:163-74 pubmed publisher
Mikesch J, Kuhlmann M, Demant A, Krug U, Thoennissen G, Schmidt E, et al. DexaBEAM versus ICE salvage regimen prior to autologous transplantation for relapsed or refractory aggressive peripheral T cell lymphoma: a retrospective evaluation of parallel patient cohorts of one center. Ann Hematol. 2013;92:1041-8 pubmed publisher
Rahmathulla G, Marko N, Weil R. Cerebral radiation necrosis: a review of the pathobiology, diagnosis and management considerations. J Clin Neurosci. 2013;20:485-502 pubmed publisher
Salmaggi A, Milanesi I, Silvani A, Gaviani P, Marchetti M, Fariselli L, et al. Prospective study of carmustine wafers in combination with 6-month metronomic temozolomide and radiation therapy in newly diagnosed glioblastoma: preliminary results. J Neurosurg. 2013;118:821-9 pubmed publisher
Dörner L, Mustafa A, Rohr A, Mehdorn H, Nabavi A. Growth pattern of tumor recurrence following bis-chloroethylnitrosourea (BCNU) wafer implantation in malignant glioma. J Clin Neurosci. 2013;20:429-34 pubmed publisher
Tseng Y, Liao J, Chen W, Kao Y, Liu S. Sustainable release of carmustine from biodegradable poly[((D,L))-lactide-co-glycolide] nanofibrous membranes in the cerebral cavity: in vitro and in vivo studies. Expert Opin Drug Deliv. 2013;10:879-88 pubmed publisher
Fan C, Ting C, Liu H, Huang C, Hsieh H, Yen T, et al. Antiangiogenic-targeting drug-loaded microbubbles combined with focused ultrasound for glioma treatment. Biomaterials. 2013;34:2142-55 pubmed publisher
Huang H, Cheng A, Lin C, Kuo S. Primary central nervous system diffuse large B cell lymphoma transformed from orbital mucosa-associated lymphoid tissue lymphoma: complete response to combined intrathecal and systemic rituximab. Ann Hematol. 2013;92:989-92 pubmed publisher
Olney K, Du J, van t Erve T, Witmer J, Sibenaller Z, Wagner B, et al. Inhibitors of hydroperoxide metabolism enhance ascorbate-induced cytotoxicity. Free Radic Res. 2013;47:154-63 pubmed publisher
Li J, Khot A, Burbury K. Acute kidney injury requiring dialysis following carmustine and etoposide during autologous stem cell transplantation. Chemotherapy. 2012;58:349-51 pubmed publisher
Crabtree M, Brixey R, Batchelor H, Hale A, Channon K. Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling. J Biol Chem. 2013;288:561-9 pubmed publisher
Yuan S, Wang F, Chen G, Zhang H, Feng L, Wang L, et al. Effective elimination of cancer stem cells by a novel drug combination strategy. Stem Cells. 2013;31:23-34 pubmed publisher
Safdar S, Payne C, Tu N, Taite L. Targeted nitric oxide delivery preferentially induces glioma cell chemosensitivity via altered p53 and O(6) -methylguanine-DNA methyltransferase activity. Biotechnol Bioeng. 2013;110:1211-20 pubmed publisher
Raguz S, Adams C, Masrour N, Rasul S, Papoutsoglou P, Hu Y, et al. Loss of O⁶-methylguanine-DNA methyltransferase confers collateral sensitivity to carmustine in topoisomerase II-mediated doxorubicin resistant triple negative breast cancer cells. Biochem Pharmacol. 2013;85:186-96 pubmed publisher
Watts C, Dunn L, Ashkan K, Jenkinson M, Smith P. Establishing the efficacy of Gliadel wafers: progress towards a Phase III trial. Acta Neurochir (Wien). 2013;155:61-2 pubmed publisher
Inverardi F, Chikhladze M, Donzelli A, Moroni R, Regondi M, Pennacchio P, et al. Cytoarchitectural, behavioural and neurophysiological dysfunctions in the BCNU-treated rat model of cortical dysplasia. Eur J Neurosci. 2013;37:150-62 pubmed publisher
Krüger P, Cooney J, Turner J. Iodine-131 rituximab radioimmunotherapy with BEAM conditioning and autologous stem cell transplant salvage therapy for relapsed/refractory aggressive non-Hodgkin lymphoma. Cancer Biother Radiopharm. 2012;27:552-60 pubmed publisher
Bruserud O, Reikvam H, Kittang A, Ahmed A, Tvedt T, Sjo M, et al. High-dose etoposide in allogeneic stem cell transplantation. Cancer Chemother Pharmacol. 2012;70:765-82 pubmed publisher
Maier P, Heckmann D, Spier I, Laufs S, Zucknick M, Allgayer H, et al. F2A sequence linking MGMT(P140K) and MDR1 in a bicistronic lentiviral vector enables efficient chemoprotection of haematopoietic stem cells. Cancer Gene Ther. 2012;19:802-10 pubmed publisher
Antunes I, Haisma H, Elsinga P, Di Gialleonardo V, van Waarde A, Willemsen A, et al. Induction of ?-glucuronidase release by cytostatic agents in small tumors. Mol Pharm. 2012;9:3277-85 pubmed publisher
Chamberlain M. Role for cytotoxic chemotherapy in patients with recurrent glioblastoma progressing on bevacizumab: a retrospective case series. Expert Rev Neurother. 2012;12:929-36 pubmed
Vose J, Bierman P, Loberiza F, Enke C, Hankins J, Bociek R, et al. Phase II trial of 131-Iodine tositumomab with high-dose chemotherapy and autologous stem cell transplantation for relapsed diffuse large B cell lymphoma. Biol Blood Marrow Transplant. 2013;19:123-8 pubmed publisher
He P, Fang L, Su Z. A sequential testing approach to detecting multiple change points in the proportional hazards model. Stat Med. 2013;32:1239-45 pubmed publisher
Preukschas M, Hagel C, Schulte A, Weber K, Lamszus K, Sievert H, et al. Expression of eukaryotic initiation factor 5A and hypusine forming enzymes in glioblastoma patient samples: implications for new targeted therapies. PLoS ONE. 2012;7:e43468 pubmed publisher
Ferreri A, Bruno Ventre M, Donadoni G, Cattaneo C, Fumagalli L, Foppoli M, et al. Safety and activity of a new intensive short-term chemoimmunotherapy in HIV-positive patients with Burkitt lymphoma. Br J Haematol. 2012;159:252-5 pubmed publisher
O Meara A, Halter J, Heim D, Gerull S, Bucher C, Passweg J, et al. Allogeneic stem cell transplantation for relapsed or refractory lymphoma after conditioning with BEAM/fludarabine/TBI. Biol Blood Marrow Transplant. 2013;19:82-6 pubmed publisher
Falahati R, Zhang J, Flebbe Rehwaldt L, Shi Y, Gerson S, Gaensler K. Chemoselection of allogeneic HSC after murine neonatal transplantation without myeloablation or post-transplant immunosuppression. Mol Ther. 2012;20:2180-9 pubmed publisher
Dixit S, Hingorani M, Achawal S, Scott I. The sequential use of carmustine wafers (Gliadel®) and post-operative radiotherapy with concomitant temozolomide followed by adjuvant temozolomide: a clinical review. Br J Neurosurg. 2011;25:459-69 pubmed publisher
Nagaiah G, Almubarak M, Khan M, Altaha R. Cerebrospinal fluid leak during treatment with bevacizumab and irinotecan after carmustine-impregnated wafers placement in patients with grade 2 oligodendroglioma and glioblastoma multiforme: report of two cases and review of literature. Cancer Invest. 2010;28:1048-53 pubmed publisher
Skretas G, Georgiou G. Simple genetic selection protocol for isolation of overexpressed genes that enhance accumulation of membrane-integrated human G protein-coupled receptors in Escherichia coli. Appl Environ Microbiol. 2010;76:5852-9 pubmed publisher
Blazeck J, Alper H. Systems metabolic engineering: genome-scale models and beyond. Biotechnol J. 2010;5:647-59 pubmed publisher
Arredondo S, Chen T, Riggs A, Gilbert H, Georgiou G. Role of dimerization in the catalytic properties of the Escherichia coli disulfide isomerase DsbC. J Biol Chem. 2009;284:23972-9 pubmed publisher
Sabel M, Giese A. Safety profile of carmustine wafers in malignant glioma: a review of controlled trials and a decade of clinical experience. Curr Med Res Opin. 2008;24:3239-57 pubmed
Lin S, Kleinberg L. Carmustine wafers: localized delivery of chemotherapeutic agents in CNS malignancies. Expert Rev Anticancer Ther. 2008;8:343-59 pubmed publisher
Garside R, Pitt M, Anderson R, Rogers G, Dyer M, Mealing S, et al. The effectiveness and cost-effectiveness of carmustine implants and temozolomide for the treatment of newly diagnosed high-grade glioma: a systematic review and economic evaluation. Health Technol Assess. 2007;11:iii-iv, ix-221 pubmed
Zackheim H. Topical carmustine (BCNU) in the treatment of mycosis fungoides. Dermatol Ther. 2003;16:299-302 pubmed
Fleming A, Saltzman W. Pharmacokinetics of the carmustine implant. Clin Pharmacokinet. 2002;41:403-19 pubmed
Becker K, Schirmer R. 1,3-Bis(2-chloroethyl)-1-nitrosourea as thiol-carbamoylating agent in biological systems. Methods Enzymol. 1995;251:173-88 pubmed
Weiss R, Issell B. The nitrosoureas: carmustine (BCNU) and lomustine (CCNU). Cancer Treat Rev. 1982;9:313-30 pubmed
Stahl W, Lenhardt S, Przybylski M, Eisenbrand G. Mechanism of glutathione-mediated DNA damage by the antineoplastic agent 1,3-bis(2-chloroethyl)-N-nitrosourea. Chem Res Toxicol. 1992;5:106-9 pubmed
product information
Catalog Number :
C0400
Product Name :
Carmustine
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98%
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA