This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
protein
product name :
Cathepsin B from human placenta
catalog :
C0150
citations: 55
Reference
Wang D, Zhang M, Bian H, Dong H, Xu W, Xu X, et al. Proteolysis and cathepsin activities in the processing of dry-cured duck. Poult Sci. 2014;93:687-94 pubmed publisher
Langelueddecke C, Lee W, Thevenod F. Differential transcytosis and toxicity of the hNGAL receptor ligands cadmium-metallothionein and cadmium-phytochelatin in colon-like Caco-2 cells: implications for in vivo cadmium toxicity. Toxicol Lett. 2014;226:228-35 pubmed publisher
Ruttayaporn N, Zhou M, Suganuma K, Yamasaki S, Kawazu S, Inoue N. Expression and characterization of cathepsin B from tsetse (Glossina morsitans morsitans). Jpn J Vet Res. 2013;61:137-47 pubmed
Strojnik T, Smigoc T, Lah T. Prognostic value of erythrocyte sedimentation rate and C-reactive protein in the blood of patients with glioma. Anticancer Res. 2014;34:339-47 pubmed
Vidal C, Tjäderhane L, Scaffa P, Tersariol I, Pashley D, Nader H, et al. Abundance of MMPs and cysteine cathepsins in caries-affected dentin. J Dent Res. 2014;93:269-74 pubmed publisher
Cecarini V, Bonfili L, Cuccioloni M, Mozzicafreddo M, Rossi G, Keller J, et al. Wild type and mutant amyloid precursor proteins influence downstream effects of proteasome and autophagy inhibition. Biochim Biophys Acta. 2014;1842:127-34 pubmed publisher
Shin J, Fattah E, Bhattacharya A, Ko S, Eissa N. Inflammasome activation by altered proteostasis. J Biol Chem. 2013;288:35886-95 pubmed publisher
Kubisch R, Frohlich T, Arnold G, Schreiner L, von Schwarzenberg K, Roidl A, et al. V-ATPase inhibition by archazolid leads to lysosomal dysfunction resulting in impaired cathepsin B activation in vivo. Int J Cancer. 2014;134:2478-88 pubmed publisher
Crabtree D, Dodson M, Ouyang X, Boyer Guittaut M, Liang Q, Ballestas M, et al. Over-expression of an inactive mutant cathepsin D increases endogenous alpha-synuclein and cathepsin B activity in SH-SY5Y cells. J Neurochem. 2014;128:950-61 pubmed publisher
Jang B, Choi B, Kim J, Kim M, Sohn M, Suh S. Impairment of autophagic flux promotes glucose reperfusion-induced neuro2A cell death after glucose deprivation. PLoS ONE. 2013;8:e76466 pubmed publisher
Tardif N, Klaude M, Lundell L, Thorell A, Rooyackers O. Autophagic-lysosomal pathway is the main proteolytic system modified in the skeletal muscle of esophageal cancer patients. Am J Clin Nutr. 2013;98:1485-92 pubmed publisher
Guo X, Dong Y, Yin S, Zhao C, Huo Y, Fan L, et al. Patulin induces pro-survival functions via autophagy inhibition and p62 accumulation. Cell Death Dis. 2013;4:e822 pubmed publisher
Heid M, Keyel P, Kamga C, Shiva S, Watkins S, Salter R. Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation. J Immunol. 2013;191:5230-8 pubmed publisher
Ruffell B, Affara N, Cottone L, Junankar S, Johansson M, DeNardo D, et al. Cathepsin C is a tissue-specific regulator of squamous carcinogenesis. Genes Dev. 2013;27:2086-98 pubmed publisher
Li X, Meng X, Kong J, Luo K, Luan S, Cao B, et al. Molecular cloning and characterization of a cathepsin B gene from the Chinese shrimp Fenneropenaeus chinensis. Fish Shellfish Immunol. 2013;35:1604-12 pubmed publisher
Glogowska A, Kunanuvat U, Stetefeld J, Patel T, Thanasupawat T, Krcek J, et al. C1q-tumour necrosis factor-related protein 8 (CTRP8) is a novel interaction partner of relaxin receptor RXFP1 in human brain cancer cells. J Pathol. 2013;231:466-79 pubmed publisher
Burgert T, Schmidt V, Caglayan S, Lin F, Füchtbauer A, Füchtbauer E, et al. SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes. Mol Cell Biol. 2013;33:4308-20 pubmed publisher
Li S, Du L, Zhang L, Hu Y, Xia W, Wu J, et al. Cathepsin B contributes to autophagy-related 7 (Atg7)-induced nod-like receptor 3 (NLRP3)-dependent proinflammatory response and aggravates lipotoxicity in rat insulinoma cell line. J Biol Chem. 2013;288:30094-104 pubmed publisher
Choi S, Lee Kwon W, Lee H, Lee J, Sanada S, Kwon H. Multiple cell death pathways are independently activated by lethal hypertonicity in renal epithelial cells. Am J Physiol Cell Physiol. 2013;305:C1011-20 pubmed publisher
Shankar R, Samykutty A, Riggin C, Kannan S, Wenzel U, Kolhatkar R. Cathepsin B degradable star-shaped peptidic macromolecules for delivery of 2-methoxyestradiol. Mol Pharm. 2013;10:3776-88 pubmed publisher
Morad S, Levin J, Tan S, Fox T, Feith D, Cabot M. Novel off-target effect of tamoxifen--inhibition of acid ceramidase activity in cancer cells. Biochim Biophys Acta. 2013;1831:1657-64 pubmed publisher
Liow K, Chow S. The cathepsin B inhibitor, z-FA-CMK is toxic and readily induced cell death in human T lymphocytes. Toxicol Appl Pharmacol. 2013;272:559-67 pubmed publisher
Balboula A, Yamanaka K, Sakatani M, Kawahara M, Hegab A, Zaabel S, et al. Cathepsin B activity has a crucial role in the developmental competence of bovine cumulus-oocyte complexes exposed to heat shock during in vitro maturation. Reproduction. 2013;146:407-17 pubmed publisher
Zhong Y, Liu S, Firestone R, Hong Y, Li Y. Anticancer effects of Ac‑Phe‑Lys‑PABC‑doxorubicin via mitochondria‑centered apoptosis involving reactive oxidative stress and the ERK1/2 signaling pathway in MGC‑803 cells. Oncol Rep. 2013;30:1681-6 pubmed publisher
Wu Z, Sun L, Hashioka S, Yu S, Schwab C, Okada R, et al. Differential pathways for interleukin-1? production activated by chromogranin A and amyloid ? in microglia. Neurobiol Aging. 2013;34:2715-25 pubmed publisher
Spes A, Sobotič B, Turk V, Turk B. Cysteine cathepsins are not critical for TRAIL- and CD95-induced apoptosis in several human cancer cell lines. Biol Chem. 2012;393:1417-31 pubmed
Mullins S, Sameni M, Blum G, Bogyo M, Sloane B, Moin K. Three-dimensional cultures modeling premalignant progression of human breast epithelial cells: role of cysteine cathepsins. Biol Chem. 2012;393:1405-16 pubmed
Chen H, Mekkaoui C, Cho H, Ngoy S, Marinelli B, Waterman P, et al. Fluorescence tomography of rapamycin-induced autophagy and cardioprotection in vivo. Circ Cardiovasc Imaging. 2013;6:441-7 pubmed publisher
Unciti Broceta J, Maceira J, Morales S, García Pérez A, Muñóz Torres M, Garcia Salcedo J. Nicotinamide inhibits the lysosomal cathepsin b-like protease and kills African trypanosomes. J Biol Chem. 2013;288:10548-57 pubmed publisher
Marques C, Oliveira C, Alves S, Chaves S, Coutinho O, Corte Real M, et al. Acetate-induced apoptosis in colorectal carcinoma cells involves lysosomal membrane permeabilization and cathepsin D release. Cell Death Dis. 2013;4:e507 pubmed publisher
Konovalova S, Savina M, Nikiforov A, Puchkova L. [Mitochondrial and lysosomal pathways of death of hepatocytes of lamprey Lampetra fluviatilis L]. Zh Evol Biokhim Fiziol. 2012;48:557-61 pubmed
Xu F, Li J, Ni W, Shen Y, Zhang X. Peroxisome proliferator-activated receptor-γ agonist 15d-prostaglandin J2 mediates neuronal autophagy after cerebral ischemia-reperfusion injury. PLoS ONE. 2013;8:e55080 pubmed publisher
Tseng T, Cheng C, Hsu S, Shih M, He P, Lyu P. Residue-specific annotation of disorder-to-order transition and cathepsin inhibition of a propeptide-like crammer from D. melanogaster. PLoS ONE. 2013;8:e54187 pubmed publisher
Martinez O, Johnson J, Honko A, Yen B, Shabman R, Hensley L, et al. Ebola virus exploits a monocyte differentiation program to promote its entry. J Virol. 2013;87:3801-14 pubmed publisher
Bao G, Wang H, Shang Y, Fan H, Gu M, Xia R, et al. Quantitative proteomic study identified cathepsin B associated with doxorubicin-induced damage in H9c2 cardiomyocytes. Biosci Trends. 2012;6:283-7 pubmed
Dev A, Byrne S, Verma R, Ashton Rickardt P, Wojchowski D. Erythropoietin-directed erythropoiesis depends on serpin inhibition of erythroblast lysosomal cathepsins. J Exp Med. 2013;210:225-32 pubmed publisher
Kolypetri P, Jiang H, Carayanniotis G. Identification of pathogenic T cell epitopes near cathepsin cleavage sites in thyroglobulin. J Immunol. 2013;190:1466-71 pubmed publisher
Dai C, Fu Y, Chen S, Li B, Yao B, Liu W, et al. Preparation and evaluation of a new releasable PEGylated tumor necrosis factor-α (TNF-α) conjugate for therapeutic application. Sci China Life Sci. 2013;56:51-8 pubmed publisher
Helliwell J. Biochemistry. How to solve protein structures with an X-ray laser. Science. 2013;339:146-7 pubmed publisher
Cantres Rosario Y, Plaud Valentin M, GERENA Y, Skolasky R, Wojna V, Melendez L. Cathepsin B and cystatin B in HIV-seropositive women are associated with infection and HIV-1-associated neurocognitive disorders. AIDS. 2013;27:347-56 pubmed publisher
Sosič I, Mirković B, Arenz K, Stefane B, Kos J, Gobec S. Development of new cathepsin B inhibitors: combining bioisosteric replacements and structure-based design to explore the structure-activity relationships of nitroxoline derivatives. J Med Chem. 2013;56:521-33 pubmed publisher
Dou Z, Coppens I, Carruthers V. Non-canonical maturation of two papain-family proteases in Toxoplasma gondii. J Biol Chem. 2013;288:3523-34 pubmed publisher
Sato C, Rodrigues F, Garcia D, Vidal C, Pashley D, Tjäderhane L, et al. Tooth bleaching increases dentinal protease activity. J Dent Res. 2013;92:187-92 pubmed publisher
Marzi A, Reinheckel T, Feldmann H. Cathepsin B & L are not required for ebola virus replication. PLoS Negl Trop Dis. 2012;6:e1923 pubmed publisher
Gopinath S, Malla R, Alapati K, Gorantla B, Gujrati M, Dinh D, et al. Cathepsin B and uPAR regulate self-renewal of glioma-initiating cells through GLI-regulated Sox2 and Bmi1 expression. Carcinogenesis. 2013;34:550-9 pubmed publisher
Gogineni V, Gupta R, Nalla A, Velpula K, Rao J. uPAR and cathepsin B shRNA impedes TGF-β1-driven proliferation and invasion of meningioma cells in a XIAP-dependent pathway. Cell Death Dis. 2012;3:e439 pubmed publisher
Lee H, Choi K. 4-tert-Octylphenol stimulates the expression of cathepsins in human breast cancer cells and xenografted breast tumors of a mouse model via an estrogen receptor-mediated signaling pathway. Toxicology. 2013;304:13-20 pubmed publisher
Kim Y, Mandadapu S, Groutas W, Chang K. Potent inhibition of feline coronaviruses with peptidyl compounds targeting coronavirus 3C-like protease. Antiviral Res. 2013;97:161-8 pubmed publisher
Hamilton R, Buford M, Xiang C, Wu N, Holian A. NLRP3 inflammasome activation in murine alveolar macrophages and related lung pathology is associated with MWCNT nickel contamination. Inhal Toxicol. 2012;24:995-1008 pubmed publisher
Venkataraman S, Birks D, Balakrishnan I, Alimova I, Harris P, Patel P, et al. MicroRNA 218 acts as a tumor suppressor by targeting multiple cancer phenotype-associated genes in medulloblastoma. J Biol Chem. 2013;288:1918-28 pubmed publisher
Withana N, Blum G, Sameni M, Slaney C, Anbalagan A, Olive M, et al. Cathepsin B inhibition limits bone metastasis in breast cancer. Cancer Res. 2012;72:1199-209 pubmed publisher
Mueller Steiner S, Zhou Y, Arai H, Roberson E, Sun B, Chen J, et al. Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease. Neuron. 2006;51:703-14 pubmed
Bond J, Barrett A. Degradation of fructose-1,6-bisphosphate aldolase by cathepsin B. Biochem J. 1980;189:17-25 pubmed
Kirschke H, Wikstrom P, Shaw E. Active center differences between cathepsins L and B: the S1 binding region. FEBS Lett. 1988;228:128-30 pubmed
Polgar L, Csoma C. Dissociation of ionizing groups in the binding cleft inversely controls the endo- and exopeptidase activities of cathepsin B. J Biol Chem. 1987;262:14448-53 pubmed
product information
Catalog Number :
C0150
Product Name :
Cathepsin B from human placenta
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
lyophilized powder, ?5 units/mg protein
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA