This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Bumetanide
catalog :
B3023
citations: 75
Reference
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Mòdol L, Santos D, Cobianchi S, González Pérez F, López Alvarez V, Navarro X. NKCC1 Activation Is Required for Myelinated Sensory Neurons Regeneration through JNK-Dependent Pathway. J Neurosci. 2015;35:7414-27 pubmed publisher
Tsuchiya Y, Fujita R, Saitou A, Wajima N, Aizawa F, Iinuma A. [6]-gingerol induces electrogenic sodium absorption in the rat colon via the capsaicin receptor TRPV1. J Nutr Sci Vitaminol (Tokyo). 2014;60:403-7 pubmed publisher
Lai C, Wu C, Kuo R, Yang Y, Chen M, Chan K, et al. Clinical outcomes in low risk coronary artery disease patients treated with different limus-based drug-eluting stents--a nationwide retrospective cohort study using insurance claims database. PLoS ONE. 2015;10:e0122860 pubmed publisher
Shrestha S, Park J, Ahn S, Kim Y. PGE2 MEDIATES OENOCYTOID CELL LYSIS VIA A SODIUM-POTASSIUM-CHLORIDE COTRANSPORTER. Arch Insect Biochem Physiol. 2015;89:218-29 pubmed publisher
Titz S, Sammler E, Hormuzdi S. Could tuning of the inhibitory tone involve graded changes in neuronal chloride transport?. Neuropharmacology. 2015;95:321-31 pubmed publisher
Hirst C, Foong J, Stamp L, Fegan E, Dent S, Cooper E, et al. Ion channel expression in the developing enteric nervous system. PLoS ONE. 2015;10:e0123436 pubmed publisher
Tang L, Peng M, Liu L, Chang W, Binder H, Cheng S. Calcium-sensing receptor stimulates Cl(-)- and SCFA-dependent but inhibits cAMP-dependent HCO3(-) secretion in colon. Am J Physiol Gastrointest Liver Physiol. 2015;308:G874-83 pubmed publisher
Wei F, Wei M, Murakami M. Mechanism involved in Danshen-induced fluid secretion in salivary glands. World J Gastroenterol. 2015;21:1444-56 pubmed publisher
Jantzie L, Hu M, Park H, Jackson M, Yu J, Maxwell J, et al. Chloride cotransporter NKCC1 inhibitor bumetanide protects against white matter injury in a rodent model of periventricular leukomalacia. Pediatr Res. 2015;77:554-62 pubmed publisher
Medani M, Collins D, Mohan H, Walsh E, Winter D, Baird A. Prostaglandin D2 regulates human colonic ion transport via the DP1 receptor. Life Sci. 2015;122:87-91 pubmed publisher
Deidda G, Allegra M, Cerri C, Naskar S, Bony G, Zunino G, et al. Early depolarizing GABA controls critical-period plasticity in the rat visual cortex. Nat Neurosci. 2015;18:87-96 pubmed publisher
Nováková L, Rentsch M, Grand Guillaume Perrenoud A, Nicoli R, Saugy M, Veuthey J, et al. Ultra high performance supercritical fluid chromatography coupled with tandem mass spectrometry for screening of doping agents. II: Analysis of biological samples. Anal Chim Acta. 2015;853:647-59 pubmed publisher
Nováková L, Grand Guillaume Perrenoud A, Nicoli R, Saugy M, Veuthey J, Guillarme D. Ultra high performance supercritical fluid chromatography coupled with tandem mass spectrometry for screening of doping agents. I: Investigation of mobile phase and MS conditions. Anal Chim Acta. 2015;853:637-46 pubmed publisher
Hamad M, Krause M, Wahle P. Improving AM ester calcium dye loading efficiency. J Neurosci Methods. 2015;240:48-60 pubmed publisher
Yoon S, Park S, Han J, Kang J, Kim J, Lee J, et al. Caspase-dependent cell death-associated release of nucleosome and damage-associated molecular patterns. Cell Death Dis. 2014;5:e1494 pubmed publisher
Puskarjov M, Ahmad F, Khirug S, Sivakumaran S, Kaila K, Blaesse P. BDNF is required for seizure-induced but not developmental up-regulation of KCC2 in the neonatal hippocampus. Neuropharmacology. 2015;88:103-9 pubmed publisher
Gustafsson J, Linden S, Alwan A, Scholte B, Hansson G, Sjovall H. Carbachol-induced colonic mucus formation requires transport via NKCC1, K⁺ channels and CFTR. Pflugers Arch. 2015;467:1403-1415 pubmed publisher
Sipilä S, Spoljaric A, Virtanen M, Hiironniemi I, Kaila K. Glycine transporter-1 controls nonsynaptic inhibitory actions of glycine receptors in the neonatal rat hippocampus. J Neurosci. 2014;34:10003-9 pubmed publisher
Rouhier M, Hine R, Park S, Raphemot R, Denton J, Piermarini P, et al. Excretion of NaCl and KCl loads in mosquitoes. 2. Effects of the small molecule Kir channel modulator VU573 and its inactive analog VU342. Am J Physiol Regul Integr Comp Physiol. 2014;307:R850-61 pubmed publisher
Hannemann A, Cytlak U, Rees D, Tewari S, Gibson J. Effects of 5-hydroxymethyl-2-furfural on the volume and membrane permeability of red blood cells from patients with sickle cell disease. J Physiol. 2014;592:4039-49 pubmed publisher
Tan S, Xu C, Zhu W, Willis J, Seubert C, Gravenstein N, et al. Endocrine and neurobehavioral abnormalities induced by propofol administered to neonatal rats. Anesthesiology. 2014;121:1010-7 pubmed publisher
Farajnia S, van Westering T, Meijer J, Michel S. Seasonal induction of GABAergic excitation in the central mammalian clock. Proc Natl Acad Sci U S A. 2014;111:9627-32 pubmed publisher
Mòdol L, Cobianchi S, Navarro X. Prevention of NKCC1 phosphorylation avoids downregulation of KCC2 in central sensory pathways and reduces neuropathic pain after peripheral nerve injury. Pain. 2014;155:1577-90 pubmed publisher
Di Rago M, Saar E, Rodda L, Turfus S, Kotsos A, Gerostamoulos D, et al. Fast targeted analysis of 132 acidic and neutral drugs and poisons in whole blood using LC-MS/MS. Forensic Sci Int. 2014;243:35-43 pubmed publisher
Töllner K, Brandt C, Töpfer M, Brunhofer G, Erker T, Gabriel M, et al. A novel prodrug-based strategy to increase effects of bumetanide in epilepsy. Ann Neurol. 2014;75:550-62 pubmed publisher
Tyzio R, Nardou R, Ferrari D, Tsintsadze T, Shahrokhi A, Eftekhari S, et al. Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring. Science. 2014;343:675-9 pubmed publisher
Wu F, Mi W, Cannon S. Beneficial effects of bumetanide in a CaV1.1-R528H mouse model of hypokalaemic periodic paralysis. Brain. 2013;136:3766-74 pubmed publisher
Koyama Y, Andoh T, Kamiya Y, Morita S, Miyazaki T, Uchimoto K, et al. Bumetanide, an inhibitor of cation-chloride cotransporter isoform 1, inhibits γ-aminobutyric acidergic excitatory actions and enhances sedative actions of midazolam in neonatal rats. Anesthesiology. 2013;119:1096-108 pubmed publisher
Pondugula S, Kampalli S, Wu T, De Lisle R, Raveendran N, Harbidge D, et al. cAMP-stimulated Cl- secretion is increased by glucocorticoids and inhibited by bumetanide in semicircular canal duct epithelium. BMC Physiol. 2013;13:6 pubmed publisher
Wu F, Mi W, Cannon S. Bumetanide prevents transient decreases in muscle force in murine hypokalemic periodic paralysis. Neurology. 2013;80:1110-6 pubmed publisher
Nau J. [To dare trying a diuretic in autism treatment]. Rev Med Suisse. 2012;8:2458-9 pubmed
Reid A, Riazi K, Campbell Teskey G, Pittman Q. Increased excitability and molecular changes in adult rats after a febrile seizure. Epilepsia. 2013;54:e45-8 pubmed publisher
Lemonnier E, Degrez C, Phelep M, Tyzio R, Josse F, Grandgeorge M, et al. A randomised controlled trial of bumetanide in the treatment of autism in children. Transl Psychiatry. 2012;2:e202 pubmed publisher
Cooper J, Quinton P, Ballard S. Mucociliary transport in porcine trachea: differential effects of inhibiting chloride and bicarbonate secretion. Am J Physiol Lung Cell Mol Physiol. 2013;304:L184-90 pubmed publisher
Pitcher M, Nieto F, Cervero F. Stimulation of cutaneous low threshold mechanoreceptors in mice after intracolonic capsaicin increases spinal c-Fos labeling in an NKCC1-dependent fashion. J Pain. 2013;14:57-65 pubmed publisher
Shen W, Purpura L, Li B, Nan C, Chang I, Ripps H. Regulation of synaptic transmission at the photoreceptor terminal: a novel role for the cation-chloride co-transporter NKCC1. J Physiol. 2013;591:133-47 pubmed publisher
Eftekhari S, Mehvari Habibabadi J, Najafi Ziarani M, Hashemi Fesharaki S, Gharakhani M, Mostafavi H, et al. Bumetanide reduces seizure frequency in patients with temporal lobe epilepsy. Epilepsia. 2013;54:e9-12 pubmed publisher
Vargas E, Petrou S, Reid C. Genetic and pharmacological modulation of giant depolarizing potentials in the neonatal hippocampus associates with increased seizure susceptibility. J Physiol. 2013;591:57-65 pubmed publisher
Spoida K, Distler C, Trampe A, Hoffmann K. Blocking retinal chloride co-transporters KCC2 and NKCC: impact on direction selective ON and OFF responses in the rat's nucleus of the optic tract. PLoS ONE. 2012;7:e44724 pubmed publisher
Bulkley C, Johnson P, Henry E, Harrison D, Lewis T, Miller J. Bumetanide continuous-infusion dosing in critically ill pediatric patients. Am J Health Syst Pharm. 2012;69:1458, 1460-1 pubmed publisher
Huang J, Shan J, Kim D, Liao J, Evagelidis A, Alper S, et al. Basolateral chloride loading by the anion exchanger type 2: role in fluid secretion by the human airway epithelial cell line Calu-3. J Physiol. 2012;590:5299-316 pubmed publisher
Shan J, Liao J, Huang J, Robert R, Palmer M, Fahrenkrug S, et al. Bicarbonate-dependent chloride transport drives fluid secretion by the human airway epithelial cell line Calu-3. J Physiol. 2012;590:5273-97 pubmed publisher
Algharabil J, Kintner D, Wang Q, Begum G, Clark P, Yang S, et al. Inhibition of Na(+)-K(+)-2Cl(-) cotransporter isoform 1 accelerates temozolomide-mediated apoptosis in glioblastoma cancer cells. Cell Physiol Biochem. 2012;30:33-48 pubmed publisher
Loscher W, Puskarjov M, Kaila K. Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments. Neuropharmacology. 2013;69:62-74 pubmed publisher
Pacifici G. Clinical pharmacology of the loop diuretics furosemide and bumetanide in neonates and infants. Paediatr Drugs. 2012;14:233-46 pubmed publisher
Popović J, Posa M, Popović K, Popović D, Milosevic N, Tepavcević V. Individualization of a pharmacokinetic model by fractional and nonlinear fit improvement. Eur J Drug Metab Pharmacokinet. 2013;38:69-76 pubmed publisher
Hochman D. The extracellular space and epileptic activity in the adult brain: explaining the antiepileptic effects of furosemide and bumetanide. Epilepsia. 2012;53 Suppl 1:18-25 pubmed publisher
Deurwaarder E, Steenbergen E, Hoogeveen E, Wetzels J. Membranous nephropathy with predominance of C1q: another variant of C1q nephropathy?. Clin Nephrol. 2012;77:501-4 pubmed
Garzon Muvdi T, Schiapparelli P, Ap Rhys C, Guerrero Cazares H, Smith C, Kim D, et al. Regulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulation. PLoS Biol. 2012;10:e1001320 pubmed publisher
Shamsuddin A, Quinton P. Surface fluid absorption and secretion in small airways. J Physiol. 2012;590:3561-74 pubmed publisher
COTTON R, Suarez S, Reese J. Unexpected extra-renal effects of loop diuretics in the preterm neonate. Acta Paediatr. 2012;101:835-45 pubmed publisher
Cheng S. Calcium-sensing receptor inhibits secretagogue-induced electrolyte secretion by intestine via the enteric nervous system. Am J Physiol Gastrointest Liver Physiol. 2012;303:G60-70 pubmed publisher
Krystal A, Sutherland J, Hochman D. Loop diuretics have anxiolytic effects in rat models of conditioned anxiety. PLoS ONE. 2012;7:e35417 pubmed publisher
Ben Ari Y. Blocking seizures with the diuretic bumetanide: promises and pitfalls. Epilepsia. 2012;53:394-6 pubmed publisher
Inada H, Watanabe M, Uchida T, Ishibashi H, Wake H, Nemoto T, et al. GABA regulates the multidirectional tangential migration of GABAergic interneurons in living neonatal mice. PLoS ONE. 2011;6:e27048 pubmed publisher
Kahle K, Staley K. The bumetanide-sensitive Na-K-2Cl cotransporter NKCC1 as a potential target of a novel mechanism-based treatment strategy for neonatal seizures. Neurosurg Focus. 2008;25:E22 pubmed publisher
Pierucci Alves F, Schultz B. Bradykinin-stimulated cyclooxygenase activity stimulates vas deferens epithelial anion secretion in vitro in swine and humans. Biol Reprod. 2008;79:501-9 pubmed publisher
Morita H, Fujiki N, Hagiike M, Yamaguchi O, Lee K. Functional evidence for involvement of bumetanide-sensitive Na+K+2CI- cotransport in the hepatoportal Na+ receptor of the Sprague-Dawley rat. Neurosci Lett. 1999;264:65-8 pubmed
Isenring P, Forbush B. Ion and bumetanide binding by the Na-K-Cl cotransporter. Importance of transmembrane domains. J Biol Chem. 1997;272:24556-62 pubmed
Petzinger E, Blumrich M, Brühl B, Eckhardt U, Follmann W, Honscha W, et al. What we have learned about bumetanide and the concept of multispecific bile acid/drug transporters from the liver. J Hepatol. 1996;24 Suppl 1:42-6 pubmed
Chen B. Loop diuretics: comparison of torsemide, furosemide, and bumetanide. Conn Med. 1996;60:343-5 pubmed
Hinchcliff K, Mitten L. Furosemide, bumetanide, and ethacrynic acid. Vet Clin North Am Equine Pract. 1993;9:511-22 pubmed
Flamenbaum W, Friedman R. Pharmacology, therapeutic efficacy, and adverse effects of bumetanide, a new "loop" diuretic. Pharmacotherapy. 1982;2:213-22 pubmed
Ward A, Heel R. Bumetanide. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use. Drugs. 1984;28:426-64 pubmed
Halstenson C, Matzke G. Bumetanide: a new loop diuretic (Bumex, Roche Laboratories). Drug Intell Clin Pharm. 1983;17:786-97 pubmed
Brater D. Disposition and response to bumetanide and furosemide. Am J Cardiol. 1986;57:20A-25A pubmed
Petzinger E. [The loop diuretic bumetanide as a tool in physiology and pharmacology]. Dtsch Tierarztl Wochenschr. 1992;99:412-5 pubmed
product information
Catalog Number :
B3023
Product Name :
Bumetanide
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98%
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA