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product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
protein
product name :
Resorufin benzyl ether
catalog :
B1532
citations: 25
Reference |
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Pethuan S, Duangkaew P, Sarapusit S, Srisook E, Rongnoparut P. Inhibition against mosquito cytochrome P450 enzymes by rhinacanthin-A, -B, and -C elicits synergism on cypermethrin cytotoxicity in Spodoptera frugiperda cells. J Med Entomol. 2012;49:993-1000 pubmed
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Garmire L, Garmire D, Hunt C. An in silico transwell device for the study of drug transport and drug-drug interactions. Pharm Res. 2007;24:2171-86 pubmed
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Sun L, Chen C, Waxman D, Liu H, Halpert J, Kumar S. Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide. Arch Biochem Biophys. 2007;458:167-74 pubmed
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Kashiwada S, Hinton D, Kullman S. Functional characterization of medaka CYP3A38 and CYP3A40: kinetics and catalysis by expression in a recombinant baculovirus system. Comp Biochem Physiol C Toxicol Pharmacol. 2005;141:338-48 pubmed
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Scott E, Liu H, Qun He Y, Li W, Halpert J. Mutagenesis and molecular dynamics suggest structural and functional roles for residues in the N-terminal portion of the cytochrome P450 2B1 I helix. Arch Biochem Biophys. 2004;423:266-76 pubmed
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Lin Y, Lu P, Tang C, Mei Q, Sandig G, Rodrigues A, et al. Substrate inhibition kinetics for cytochrome P450-catalyzed reactions. Drug Metab Dispos. 2001;29:368-74 pubmed
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Rolph C, Roberts P, Taylor S. Phospholipase-induced modulation of rat liver mixed-function oxidase activity. Biochem Soc Trans. 1999;27:371-4 pubmed
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Renauld A, Melancon M, Sordillo L. Identification of in vitro cytochrome P450 modulators to detect induction by prototype inducers in the mallard duckling (Anas platyrhynchos). Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1999;122:273-81 pubmed
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Beebe L, Roberts E, Fornwald L, Hollenberg P, Alworth W. Mechanism-based inhibition of mouse P4502b-10 by selected arylalkynes. Biochem Pharmacol. 1996;52:1507-13 pubmed
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He Y, Szklarz G, Halpert J. Interconversion of the androstenedione hydroxylase specificities of cytochromes P450 2B4 and 2B5 upon simultaneous site-directed mutagenesis of four key substrate recognition residues. Arch Biochem Biophys. 1996;335:152-60 pubmed
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Klekotka P, Halpert J. Benzyloxyresorufin as a specific substrate for the major phenobarbital-inducible dog liver cytochrome P450 (P4502B11). Drug Metab Dispos. 1995;23:1434-5 pubmed
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Verschoyle R, Dinsdale D, Wolf C. Inhibition and induction of cytochrome P450 isoenzymes in rat lung. J Pharmacol Exp Ther. 1993;265:386-91 pubmed
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Armstrong S, Renton K. Hepatic cytochrome P450 and related drug biotransformation during an outbreak of mouse hepatitis virus in a colony of Swiss BALB/c mice. Can J Physiol Pharmacol. 1993;71:188-90 pubmed
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Nerurkar P, Park S, Thomas P, Nims R, Lubet R. Methoxyresorufin and benzyloxyresorufin: substrates preferentially metabolized by cytochromes P4501A2 and 2B, respectively, in the rat and mouse. Biochem Pharmacol. 1993;46:933-43 pubmed
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Nims R, McClain R, Manchand P, Belica P, Thomas P, Mellini D, et al. Comparative pharmacodynamics of hepatic cytochrome P450 2B induction by 5,5-diphenyl- and 5,5-diethyl-substituted barbiturates and hydantoins in the male F344/NCr rat. J Pharmacol Exp Ther. 1994;270:348-55 pubmed
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Yang H, Lee Q, Rettie A, Juchau M. Functional cytochrome P4503A isoforms in human embryonic tissues: expression during organogenesis. Mol Pharmacol. 1994;46:922-8 pubmed
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Burke M, Thompson S, Elcombe C, Halpert J, Haaparanta T, Mayer R. Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450. Biochem Pharmacol. 1985;34:3337-45 pubmed
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Meehan R, Forrester L, Stevenson K, Hastie N, Buchmann A, Kunz H, et al. Regulation of phenobarbital-inducible cytochrome P-450s in rat and mouse liver following dexamethasone administration and hypophysectomy. Biochem J. 1988;254:789-97 pubmed
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Perrin R, Minn A, Ghersi Egea J, Grassiot M, Siest G. Distribution of cytochrome P450 activities towards alkoxyresorufin derivatives in rat brain regions, subcellular fractions and isolated cerebral microvessels. Biochem Pharmacol. 1990;40:2145-51 pubmed
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product information
Catalog Number :
B1532
Product Name :
Resorufin benzyl ether
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
CYP450 substrate
company information

MilliporeSigma
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