This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Amitriptyline hydrochloride
catalog :
A8404
citations: 63
Reference
Ziarrusta H, Ribbenstedt A, Mijangos L, Picart Armada S, Perera Lluna A, Prieto A, et al. Amitriptyline at an Environmentally Relevant Concentration Alters the Profile of Metabolites Beyond Monoamines in Gilt-Head Bream. Environ Toxicol Chem. 2019;38:965-977 pubmed publisher
Beckmann N, Becker K, Walter S, Becker J, Krämer M, Hessler G, et al. Regulation of Arthritis Severity by the Acid Sphingomyelinase. Cell Physiol Biochem. 2017;43:1460-1471 pubmed publisher
Jin G, Guo Z, Xiao Y, Yan J, Dong X, Shen A, et al. Practical method for the definition of chromatographic peak parameters in preparative liquid chromatography. J Sep Sci. 2016;39:3917-3926 pubmed publisher
Lee S, Hutchinson M, Staikopoulos V, Saint D. Amitriptyline pharmacologically preconditions rat hearts against cardiac ischemic-reperfusion injury. Int J Cardiol. 2015;190:353-9 pubmed publisher
Olianas M, Dedoni S, Onali P. Antidepressants activate the lysophosphatidic acid receptor LPA(1) to induce insulin-like growth factor-I receptor transactivation, stimulation of ERK1/2 signaling and cell proliferation in CHO-K1 fibroblasts. Biochem Pharmacol. 2015;95:311-23 pubmed publisher
Curtright A, Rosser M, Goh S, Keown B, Wagner E, Sharifi J, et al. Modeling nociception in zebrafish: a way forward for unbiased analgesic discovery. PLoS ONE. 2015;10:e0116766 pubmed publisher
Gassen N, Hartmann J, Zschocke J, Stepan J, Häfner K, Zellner A, et al. Association of FKBP51 with priming of autophagy pathways and mediation of antidepressant treatment response: evidence in cells, mice, and humans. PLoS Med. 2014;11:e1001755 pubmed publisher
Han F, Wyse B, Smith M. Optimization and pharmacological characterization of a refined cisplatin-induced rat model of peripheral neuropathic pain. Behav Pharmacol. 2014;25:732-40 pubmed publisher
Khanahmadzadeh S, Tarigh A. Ultrasound-assisted combined with nano-sized molecularly imprinted polymer for selective extraction and pre-concentration of amitriptyline in human plasma with gas chromatography-flame detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2014;972:6-13 pubmed publisher
Burke N, Finn D, Roche M. Chronic administration of amitriptyline differentially alters neuropathic pain-related behaviour in the presence and absence of a depressive-like phenotype. Behav Brain Res. 2015;278:193-201 pubmed publisher
Jagla G, Mika J, Makuch W, Obara I, Wordliczek J, Przewlocka B. Analgesic effects of antidepressants alone and after their local co-administration with morphine in a rat model of neuropathic pain. Pharmacol Rep. 2014;66:459-65 pubmed publisher
Xu R, Lee H. Application of electro-enhanced solid phase microextraction combined with gas chromatography-mass spectrometry for the determination of tricyclic antidepressants in environmental water samples. J Chromatogr A. 2014;1350:15-22 pubmed publisher
Mangold A, Cole C, DiCaudo D, Pittelkow M, Sekulic A. Treatment of epidermolysis bullosa pruriginosa using systemic and topical agents. J Am Acad Dermatol. 2014;70:e136-7 pubmed publisher
Alencar F, Viana P, Zamperini C, Becker A. Patient education and self-care for the management of jaw pain upon awakening: a randomized controlled clinical trial comparing the effectiveness of adding pharmacologic treatment with cyclobenzaprine or tizanidine. J Oral Facial Pain Headache. 2014;28:119-27 pubmed publisher
Seip K, Jensen H, Kieu T, Gjelstad A, Pedersen Bjergaard S. Salt effects in electromembrane extraction. J Chromatogr A. 2014;1347:1-7 pubmed publisher
Kovacic K, Miranda A, Chelimsky G, Williams S, Simpson P, Li B. Chronic idiopathic nausea of childhood. J Pediatr. 2014;164:1104-9 pubmed publisher
Soh Y, Elliott S. An investigation of the stability of emerging new psychoactive substances. Drug Test Anal. 2014;6:696-704 pubmed publisher
Gewandter J, Mohile S, Heckler C, Ryan J, Kirshner J, Flynn P, et al. A phase III randomized, placebo-controlled study of topical amitriptyline and ketamine for chemotherapy-induced peripheral neuropathy (CIPN): a University of Rochester CCOP study of 462 cancer survivors. Support Care Cancer. 2014;22:1807-14 pubmed publisher
Slobodin G, Rosner I. Indemonstrable axial spondyloarthritis: does it exist?. Isr Med Assoc J. 2013;15:780-1 pubmed
Yang M, Qiu W, Chen J, Zhan J, Pan C, Lei X, et al. Growth inhibition and coordinated physiological regulation of zebrafish (Danio rerio) embryos upon sublethal exposure to antidepressant amitriptyline. Aquat Toxicol. 2014;151:68-76 pubmed publisher
Powers S, Kashikar Zuck S, Allen J, LeCates S, Slater S, Zafar M, et al. Cognitive behavioral therapy plus amitriptyline for chronic migraine in children and adolescents: a randomized clinical trial. JAMA. 2013;310:2622-30 pubmed publisher
Connelly M. Cognitive behavioral therapy for treatment of pediatric chronic migraine. JAMA. 2013;310:2617-8 pubmed publisher
Herbet M, Gawrońska Grzywacz M, Graca A, Jagiełło Wójtowicz E. Influence of combined therapy with rosuvastatin and amitriptyline on the oxidation-reduction status in rats. Acta Pol Pharm. 2013;70:913-7 pubmed
Narang T, Kumaran M, Dogra S, Saikia U, Kumar B. Red scrotum syndrome: idiopathic neurovascular phenomenon or steroid addiction?. Sex Health. 2013;10:452-5 pubmed publisher
Agius A, Jones N, Muscat R. Serial blood serotonin levels in a randomized controlled trial comparing the efficacy of low-dose amitriptyline, amitriptyline with pindolol and surrogate placebo in patients with chronic tension-type facial pain. Rhinology. 2013;51:236-42 pubmed publisher
Punja M, Neill S, Wong S. Caution with interpreting laboratory results after lipid rescue therapy. Am J Emerg Med. 2013;31:1536.e1-2 pubmed publisher
Tatli O, Karaca Y, Gunaydın M, Yurtsever S, Tuten G. Cerebellitis developing after tricyclic antidepressant poisoning. Am J Emerg Med. 2013;31:1419.e3-5 pubmed publisher
Sokov E, Kornilova L, Artiukov O. [Intraosseous blocks in the treatment of symmetrical distal diabetic polyneuropathy]. Ter Arkh. 2013;85:61-5 pubmed
Picksak G, Stichtenoth D, May M. [Sweating under polypharmacy with tramadol, amitriptyline and duloxetine?]. Med Monatsschr Pharm. 2013;36:195-6 pubmed
Zhang Z, Du X, Zhao C, Cao B, Zhao Y, Mao X. The antidepressant amitriptyline shows potent therapeutic activity against multiple myeloma. Anticancer Drugs. 2013;24:792-8 pubmed publisher
Agius A, Jones N, Muscat R. A Randomized Controlled Trial comparing the efficacy of low-dose amitriptyline, amitriptyline with pindolol and surrogate placebo in the treatment of chronic tension-type facial pain. Rhinology. 2013;51:143-53 pubmed publisher
Heinonen J, Litonius E, Backman J, Neuvonen P, Rosenberg P. Intravenous lipid emulsion entraps amitriptyline into plasma and can lower its brain concentration--an experimental intoxication study in pigs. Basic Clin Pharmacol Toxicol. 2013;113:193-200 pubmed publisher
Ajiboye P, Yusuf A. Monosymptomatic Hypochondriacal Psychosis (somatic delusional disorder): a report of two cases. Afr J Psychiatry (Johannesbg). 2013;16:87, 89 pubmed publisher
Kuczynski A, Crawford S, Bodell L, Dewey D, Barlow K. Characteristics of post-traumatic headaches in children following mild traumatic brain injury and their response to treatment: a prospective cohort. Dev Med Child Neurol. 2013;55:636-41 pubmed publisher
Poterucha T, Weiss W, Warndahl R, Rho R, Sandroni P, Davis M, et al. Topical amitriptyline combined with ketamine for the treatment of erythromelalgia: a retrospective study of 36 patients at Mayo Clinic. J Drugs Dermatol. 2013;12:308-10 pubmed
Perichon D, Turfus S, Gerostamoulos D, Graudins A. An assessment of the in vivo effects of intravenous lipid emulsion on blood drug concentration and haemodynamics following oro-gastric amitriptyline overdose. Clin Toxicol (Phila). 2013;51:208-15 pubmed publisher
Sobennikov V, Prokop eva M. [The combined therapy with valdoxan and amitriptyline of treatment resistant somatized depression]. Zh Nevrol Psikhiatr Im S S Korsakova. 2013;113:20-4 pubmed
Ziobro R, Henry B, Edwards M, Lentsch A, Gulbins E. Ceramide mediates lung fibrosis in cystic fibrosis. Biochem Biophys Res Commun. 2013;434:705-9 pubmed publisher
Janfelt C, Wellner N, Hansen H, Hansen S. Displaced dual-mode imaging with desorption electrospray ionization for simultaneous mass spectrometry imaging in both polarities and with several scan modes. J Mass Spectrom. 2013;48:361-6 pubmed publisher
Stein D, Noordzij J. Amitriptyline for symptomatic treatment of idiopathic chronic laryngeal irritability. Ann Otol Rhinol Laryngol. 2013;122:20-4 pubmed
Hall G, Morant S, Carroll D, Gabriel Z, McQuay H. An observational descriptive study of the epidemiology and treatment of neuropathic pain in a UK general population. BMC Fam Pract. 2013;14:28 pubmed publisher
Birns J, Henderson K, Bhalla A. Recreational amitriptyline toxicity mimicking basilar artery stroke. Eur J Emerg Med. 2013;20:139-40 pubmed publisher
Poterucha T, Murphy S, Davis M, Sandroni P, Rho R, Warndahl R, et al. Topical amitriptyline-ketamine for the treatment of brachioradial pruritus. JAMA Dermatol. 2013;149:148-50 pubmed publisher
Israil A, Ahmed S, Rahman K, Uddin M, Dey S, Battacharjee M, et al. Efficacy of amitriptyline, pizotifen and propranolol in the prevention of migraine. Mymensingh Med J. 2013;22:93-100 pubmed
Chao G, Zhang S. A meta-analysis of the therapeutic effects of amitriptyline for treating irritable bowel syndrome. Intern Med. 2013;52:419-24 pubmed
Wang C, Guo Z, Long Z, Zhang X, Liang X. Overloading study of basic compounds with a positively charged C18 column in liquid chromatography. J Chromatogr A. 2013;1281:60-6 pubmed publisher
Alam M, Kabir Ud Din -, Mandal A. Evaluation of thermodynamic parameters of some amphiphilic drugs in presence of sugars at the cloud point. Colloids Surf B Biointerfaces. 2013;105:236-45 pubmed publisher
Rezazadeh M, Yamini Y, Seidi S, Ebrahimpour B. Electromembrane surrounded solid phase microextraction: a novel approach for efficient extraction from complicated matrices. J Chromatogr A. 2013;1280:16-22 pubmed publisher
Vanelderen P, Rouwette T, Kozicz T, Heylen R, Van Zundert J, Roubos E, et al. Effects of chronic administration of amitriptyline, gabapentin and minocycline on spinal brain-derived neurotrophic factor expression and neuropathic pain behavior in a rat chronic constriction injury model. Reg Anesth Pain Med. 2013;38:124-30 pubmed publisher
Hernandez diaz S, Su Y, Mitchell A, Kelley K, Calafat A, Hauser R. Medications as a potential source of exposure to phthalates among women of childbearing age. Reprod Toxicol. 2013;37:1-5 pubmed publisher
Temesi D, Swales J, KEENE W, Dick S. The stability of amitriptyline N-oxide and clozapine N-oxide on treated and untreated dry blood spot cards. J Pharm Biomed Anal. 2013;76:164-8 pubmed publisher
De Majumdar S, Veleba M, Finn S, Fanning S, Schneiders T. Elucidating the regulon of multidrug resistance regulator RarA in Klebsiella pneumoniae. Antimicrob Agents Chemother. 2013;57:1603-9 pubmed publisher
Nwosu P. Ekboms syndrome (restless legs syndrome): 2 case report and literature review. Niger J Med. 2012;21:252-5 pubmed
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Obianyo O, Ye K. Novel small molecule activators of the Trk family of receptor tyrosine kinases. Biochim Biophys Acta. 2013;1834:2213-8 pubmed publisher
Pascual J. [Chronic migraine: treatment]. Rev Neurol. 2012;54 Suppl 2:S31-8 pubmed
Valente Nabais J, Ledesma B, Laginhas C. Removal of amitriptyline from simulated gastric and intestinal fluids using activated carbons. J Pharm Sci. 2011;100:5096-9 pubmed publisher
Ekins S, Williams A, Xu J. A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug Metab Dispos. 2010;38:2302-8 pubmed publisher
Kabir Ud Din -, Rub M, Naqvi A. Self-association behavior of amitriptyline hydrochloride as a function of temperature and additive (inorganic salts and ureas) concentration. Colloids Surf B Biointerfaces. 2011;82:87-94 pubmed publisher
Greene N, Fisk L, Naven R, Note R, Patel M, Pelletier D. Developing structure-activity relationships for the prediction of hepatotoxicity. Chem Res Toxicol. 2010;23:1215-22 pubmed publisher
Yuan J, Johnson R, Huang R, Wichterman J, Jiang H, Hayton K, et al. Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nat Chem Biol. 2009;5:765-71 pubmed publisher
Diamandis P, Wildenhain J, Clarke I, Sacher A, Graham J, Bellows D, et al. Chemical genetics reveals a complex functional ground state of neural stem cells. Nat Chem Biol. 2007;3:268-73 pubmed
product information
Catalog Number :
A8404
Product Name :
Amitriptyline hydrochloride
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (TLC), powder
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA