This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Arg-Gly-Asp
catalog :
A8052
citations: 96
Reference
Kormann R, Kavvadas P, Placier S, Vandermeersch S, Dorison A, Dussaule J, et al. Periostin Promotes Cell Proliferation and Macrophage Polarization to Drive Repair after AKI. J Am Soc Nephrol. 2020;31:85-100 pubmed publisher
Park H, Helfman D. Up-regulated fibronectin in 3D culture facilitates spreading of triple negative breast cancer cells on 2D through integrin β-5 and Src. Sci Rep. 2019;9:19950 pubmed publisher
Woodruff T. Lessons from bioengineering the ovarian follicle: a personal perspective. Reproduction. 2019;158:F113-F126 pubmed publisher
Ngo T, Kim K, Bian Y, Noh H, Lim K, Chung J, et al. Antithrombotic Effects of Paeoniflorin from Paeonia suffruticosa by Selective Inhibition on Shear Stress-Induced Platelet Aggregation. Int J Mol Sci. 2019;20: pubmed publisher
Ahmadpour S, Hosseinimehr S. Recent developments in peptide-based SPECT radiopharmaceuticals for breast tumor targeting. Life Sci. 2019;239:116870 pubmed publisher
Patel D, Lim K. Biomimetic Polymer-Based Engineered Scaffolds for Improved Stem Cell Function. Materials (Basel). 2019;12: pubmed publisher
Guijarro Belmar A, Viskontas M, Wei Y, Bo X, Shewan D, Huang W. Epac2 Elevation Reverses Inhibition by Chondroitin Sulfate Proteoglycans In Vitro and Transforms Postlesion Inhibitory Environment to Promote Axonal Outgrowth in an Ex Vivo Model of Spinal Cord Injury. J Neurosci. 2019;39:8330-8346 pubmed publisher
Dong H, Liu H, Zhou W, Zhang F, Li C, Chen J, et al. GLI1 activation by non-classical pathway integrin αvβ3/ERK1/2 maintains stem cell-like phenotype of multicellular aggregates in gastric cancer peritoneal metastasis. Cell Death Dis. 2019;10:574 pubmed publisher
Hujaya S, Manninen A, Kling K, Wagner J, Vainio S, Liimatainen H. Self-assembled nanofibrils from RGD-functionalized cellulose nanocrystals to improve the performance of PEI/DNA polyplexes. J Colloid Interface Sci. 2019;553:71-82 pubmed publisher
Zhuang P, Ng W, An J, Chua C, Tan L. Layer-by-layer ultraviolet assisted extrusion-based (UAE) bioprinting of hydrogel constructs with high aspect ratio for soft tissue engineering applications. PLoS ONE. 2019;14:e0216776 pubmed publisher
Morales Dalmau J, Vilches C, Sanz V, de Miguel I, Rodríguez Fajardo V, Berto P, et al. Quantification of gold nanoparticle accumulation in tissue by two-photon luminescence microscopy. Nanoscale. 2019;11:11331-11339 pubmed publisher
Gill A, Deol P, Kaur I. An Update on the Use of Alginate in Additive Biofabrication Techniques. Curr Pharm Des. 2019;25:1249-1264 pubmed publisher
MacDonald J, Takai Y, Ishihara O, Seki H, Woods D, Tilly J. Extracellular matrix signaling activates differentiation of adult ovary-derived oogonial stem cells in a species-specific manner. Fertil Steril. 2019;111:794-805 pubmed publisher
Budai Z, Ujlaky Nagy L, Kis G, Antal M, Banko C, Bacso Z, et al. Macrophages engulf apoptotic and primary necrotic thymocytes through similar phosphatidylserine-dependent mechanisms. FEBS Open Bio. 2019;9:446-456 pubmed publisher
Xia P, Gütl D, Zheden V, Heisenberg C. Lateral Inhibition in Cell Specification Mediated by Mechanical Signals Modulating TAZ Activity. Cell. 2019;176:1379-1392.e14 pubmed publisher
D Onofrio P, Shabanzadeh A, Choi B, Bahr M, Koeberle P. MMP Inhibition Preserves Integrin Ligation and FAK Activation to Induce Survival and Regeneration in RGCs Following Optic Nerve Damage. Invest Ophthalmol Vis Sci. 2019;60:634-649 pubmed publisher
Dong B, Du S, Wang C, Fu H, Li Q, Xiao N, et al. Reversible Self-Assembly of Nanoprobes in Live Cells for Dynamic Intracellular pH Imaging. ACS Nano. 2019;13:1421-1432 pubmed publisher
García Gareta E, Levin A, Hook L. Engineering the migration and attachment behaviour of primary dermal fibroblasts. Biotechnol Bioeng. 2019;116:1102-1115 pubmed publisher
Mathew B, Ravindran S, Liu X, Torres L, Chennakesavalu M, Huang C, et al. Mesenchymal stem cell-derived extracellular vesicles and retinal ischemia-reperfusion. Biomaterials. 2019;197:146-160 pubmed publisher
Gutiérrez Sánchez M, Escobar Barrios V, Pozos Guillen A, Escobar García D. RGD-functionalization of PLA/starch scaffolds obtained by electrospinning and evaluated in vitro for potential bone regeneration. Mater Sci Eng C Mater Biol Appl. 2019;96:798-806 pubmed publisher
Tahlawi A, Klontzas M, Allenby M, Morais J, Panoskaltsis N, Mantalaris A. RGD-functionalized polyurethane scaffolds promote umbilical cord blood mesenchymal stem cell expansion and osteogenic differentiation. J Tissue Eng Regen Med. 2019;13:232-243 pubmed publisher
Quan B, Sone E. The effect of polyaspartate chain length on mediating biomimetic remineralization of collagenous tissues. J R Soc Interface. 2018;15: pubmed publisher
Kamsma D, Bochet P, Oswald F, Alblas N, Goyard S, Wuite G, et al. Single-Cell Acoustic Force Spectroscopy: Resolving Kinetics and Strength of T Cell Adhesion to Fibronectin. Cell Rep. 2018;24:3008-3016 pubmed publisher
Scutera S, Salvi V, Lorenzi L, Piersigilli G, Lonardi S, Alotto D, et al. Adaptive Regulation of Osteopontin Production by Dendritic Cells Through the Bidirectional Interaction With Mesenchymal Stromal Cells. Front Immunol. 2018;9:1207 pubmed publisher
Smith M, Eskandari R. A novel technology to model pressure-induced cellular injuries in the brain. J Neurosci Methods. 2018;293:247-253 pubmed publisher
Son S, Moroney G, Butler P. ?1-Integrin-Mediated Adhesion Is Lipid-Bilayer Dependent. Biophys J. 2017;113:1080-1092 pubmed publisher
Xue X, Hong X, Li Z, Deng C, Fu J. Acoustic tweezing cytometry enhances osteogenesis of human mesenchymal stem cells through cytoskeletal contractility and YAP activation. Biomaterials. 2017;134:22-30 pubmed publisher
Riahi N, Liberelle B, Henry O, De Crescenzo G. Impact of RGD amount in dextran-based hydrogels for cell delivery. Carbohydr Polym. 2017;161:219-227 pubmed publisher
Yang C, Chen D, Hong X. Estimation of Viscoelastic Properties of Cells Using Acoustic Tweezing Cytometry. J Ultrasound Med. 2016;35:2537-2542 pubmed
Lee J, Chen J, Shaw J, Chang K. Maintenance of Stem Cell Niche Integrity by a Novel Activator of Integrin Signaling. PLoS Genet. 2016;12:e1006043 pubmed publisher
Suzuki O, Abe M, Hashimoto Y. Sialylation and glycosylation modulate cell adhesion and invasion to extracellular matrix in human malignant lymphoma: Dependency on integrin and the Rho GTPase family. Int J Oncol. 2015;47:2091-9 pubmed publisher
Kang Y, Georgiou A, Macfarlane R, Klontzas M, Heliotis M, Tsiridis E, et al. Fibronectin stimulates the osteogenic differentiation of murine embryonic stem cells. J Tissue Eng Regen Med. 2017;11:1929-1940 pubmed publisher
Roggia M, Ueta T. αvβ5 Integrin/FAK/PGC-1α Pathway Confers Protective Effects on Retinal Pigment Epithelium. PLoS ONE. 2015;10:e0134870 pubmed publisher
Li Q, Wang J, Liu G, Sun H, Bian L, Zhao X, et al. Screening bioactive compounds from Ligusticum chuanxiong by high density immobilized human umbilical vein endothelial cells. Anal Bioanal Chem. 2015;407:5783-92 pubmed publisher
Feng M, Fan Y, Ma X, Li J, Yang X. The gadolinium-based contrast agent Omniscan® promotes in vitro fibroblast survival through in situ precipitation. Metallomics. 2015;7:1103-10 pubmed publisher
Wang S, Ghezzi C, White J, Kaplan D. Coculture of dorsal root ganglion neurons and differentiated human corneal stromal stem cells on silk-based scaffolds. J Biomed Mater Res A. 2015;103:3339-48 pubmed publisher
Sharma A, Orlowski G, Zhu Y, Shore D, Kim S, Divito M, et al. Inducing cells to disperse nickel nanowires via integrin-mediated responses. Nanotechnology. 2015;26:135102 pubmed publisher
Kenny H, Lal Nag M, White E, Shen M, Chiang C, Mitra A, et al. Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy. Nat Commun. 2015;6:6220 pubmed publisher
Jones C, Monge M, Kim J, Matzuk M, Fernandez F. Metabolomic serum profiling detects early-stage high-grade serous ovarian cancer in a mouse model. J Proteome Res. 2015;14:917-27 pubmed publisher
Martí Carvajal A, Knight Madden J, Martinez Zapata M. Interventions for treating leg ulcers in people with sickle cell disease. Cochrane Database Syst Rev. 2014;:CD008394 pubmed publisher
Park J, Lee Y, Ko I, Kim T, Chang Y, Lim S, et al. Improved tumor-targeting MRI contrast agents: Gd(DOTA) conjugates of a cycloalkane-based RGD peptide. Biochem Biophys Res Commun. 2014;455:246-50 pubmed publisher
Bartolomé R, Peláez García A, Gómez I, Torres S, Fernandez Aceñero M, Escudero Paniagua B, et al. An RGD motif present in cadherin 17 induces integrin activation and tumor growth. J Biol Chem. 2014;289:34801-14 pubmed publisher
Mould A, Craig S, Byron S, Humphries M, Jowitt T. Disruption of integrin-fibronectin complexes by allosteric but not ligand-mimetic inhibitors. Biochem J. 2014;464:301-13 pubmed publisher
Broom L, Jenner P, Rose S. Increased neurotrophic factor levels in ventral mesencephalic cultures do not explain the protective effect of osteopontin and the synthetic 15-mer RGD domain against MPP+ toxicity. Exp Neurol. 2015;263:1-7 pubmed publisher
Sumimoto S, Muramatsu R, Fujii S, Yamashita T. Vascular endothelial cells promote cortical neurite outgrowth via an integrin β3-dependent mechanism. Biochem Biophys Res Commun. 2014;450:593-7 pubmed publisher
Neumann C, Garreis F, Paulsen F, Hammer C, Birke M, Scholz M. Osteopontin is induced by TGF-?2 and regulates metabolic cell activity in cultured human optic nerve head astrocytes. PLoS ONE. 2014;9:e92762 pubmed publisher
Welschoff J, Matthey M, Wenzel D. RGD peptides induce relaxation of pulmonary arteries and airways via β3-integrins. FASEB J. 2014;28:2281-92 pubmed publisher
Schwartz M, Rogers R, Singh S, Lee J, Loveland S, Koepsel J, et al. A quantitative comparison of human HT-1080 fibrosarcoma cells and primary human dermal fibroblasts identifies a 3D migration mechanism with properties unique to the transformed phenotype. PLoS ONE. 2013;8:e81689 pubmed publisher
Zanatta A, Zanatta L, Gonçalves R, Zamoner A, Silva F. Rapid responses to reverse T₃ hormone in immature rat Sertoli cells: calcium uptake and exocytosis mediated by integrin. PLoS ONE. 2013;8:e77176 pubmed publisher
Hu B, El Haj A, Dobson J. Receptor-targeted, magneto-mechanical stimulation of osteogenic differentiation of human bone marrow-derived mesenchymal stem cells. Int J Mol Sci. 2013;14:19276-93 pubmed publisher
Winkler J. Oligonucleotide conjugates for therapeutic applications. Ther Deliv. 2013;4:791-809 pubmed publisher
Huang Z, Zhao Y, Luo W, You J, Li S, Yi W, et al. Targeting the vasculature of colorectal carcinoma with a fused protein of (RGD)₃-tTF. ScientificWorldJournal. 2013;2013:637086 pubmed publisher
Fan Z, Sun Y, Di Chen -, Tay D, Chen W, Deng C, et al. Acoustic tweezing cytometry for live-cell subcellular modulation of intracellular cytoskeleton contractility. Sci Rep. 2013;3:2176 pubmed publisher
Bell C, Healey E, van Erp S, Bishop B, Tang C, Gilbert R, et al. Structure of the repulsive guidance molecule (RGM)-neogenin signaling hub. Science. 2013;341:77-80 pubmed publisher
Krause A, Whu W, Qiu J, Wafadari D, Hackett N, Sharma A, et al. RGD capsid modification enhances mucosal protective immunity of a non-human primate adenovirus vector expressing Pseudomonas?aeruginosa OprF. Clin Exp Immunol. 2013;173:230-41 pubmed publisher
Ge H, Tian P, Guan L, Yin X, Liu H, Xiao N, et al. A C-terminal fragment BIGH3 protein with an RGDRGD motif inhibits corneal neovascularization in vitro and in vivo. Exp Eye Res. 2013;112:10-20 pubmed publisher
Wan W, Guo N, Pan D, Yu C, Weng Y, Luo S, et al. First experience of 18F-alfatide in lung cancer patients using a new lyophilized kit for rapid radiofluorination. J Nucl Med. 2013;54:691-8 pubmed publisher
Neirynck P, Brinkmann J, An Q, van der Schaft D, Milroy L, Jonkheijm P, et al. Supramolecular control of cell adhesion via ferrocene-cucurbit[7]uril host-guest binding on gold surfaces. Chem Commun (Camb). 2013;49:3679-81 pubmed publisher
Nam E, Kang J, Sung S, Sa K, Kim K, Seo J, et al. A matrix metalloproteinase 1-cleavable composite peptide derived from transforming growth factor β-inducible gene h3 potently inhibits collagen-induced arthritis. Arthritis Rheum. 2013;65:1753-63 pubmed publisher
Yang Z, Luo X, Zhang X, Liu J, Jiang Q. Targeted delivery of 10-hydroxycamptothecin to human breast cancers by cyclic RGD-modified lipid-polymer hybrid nanoparticles. Biomed Mater. 2013;8:025012 pubmed publisher
Sartori S, Caporale A, Rechichi A, Cufari D, Cristallini C, Barbani N, et al. Biodegradable paclitaxel-loaded microparticles prepared from novel block copolymers: influence of polymer composition on drug encapsulation and release. J Pept Sci. 2013;19:205-13 pubmed publisher
Kong M, Muñoz N, Valdivia A, Alvarez A, Herrera Molina R, Cárdenas A, et al. Thy-1-mediated cell-cell contact induces astrocyte migration through the engagement of αVβ3 integrin and syndecan-4. Biochim Biophys Acta. 2013;1833:1409-20 pubmed publisher
Lu Y, Zhong Y, Wang J, Su Y, Peng F, Zhou Y, et al. Aqueous synthesized near-infrared-emitting quantum dots for RGD-based in vivo active tumour targeting. Nanotechnology. 2013;24:135101 pubmed publisher
Lam J, Segura T. The modulation of MSC integrin expression by RGD presentation. Biomaterials. 2013;34:3938-3947 pubmed publisher
Almodóvar J, Crouzier T, Selimović S, Boudou T, Khademhosseini A, Picart C. Gradients of physical and biochemical cues on polyelectrolyte multilayer films generated via microfluidics. Lab Chip. 2013;13:1562-70 pubmed publisher
Wu H, Downs D, Ghosh K, Ghosh A, Staib P, Monod M, et al. Candida albicans secreted aspartic proteases 4-6 induce apoptosis of epithelial cells by a novel Trojan horse mechanism. FASEB J. 2013;27:2132-44 pubmed publisher
Hou X, Hu Y, He J. Isotopic tracing for calculating the surface density of arginine-glycine-aspartic acid-containing peptide on allogeneic bone. Orthop Surg. 2013;5:51-5 pubmed publisher
Mittal S, Bhadwal M, Chakraborty S, Sarma H, Banerjee S, Pillai M. A novel concept of radiosynthesis of a (99m)Tc-labeled dimeric RGD peptide as a potential radiotracer for tumor imaging. Bioorg Med Chem Lett. 2013;23:1808-12 pubmed publisher
Sheridan E, Austin C, Aitken J, Vogt S, Jolliffe K, Harris H, et al. Synchrotron X-ray fluorescence studies of a bromine-labelled cyclic RGD peptide interacting with individual tumor cells. J Synchrotron Radiat. 2013;20:226-33 pubmed publisher
Wang J, Wang L, Li X, Mao C. Virus activated artificial ECM induces the osteoblastic differentiation of mesenchymal stem cells without osteogenic supplements. Sci Rep. 2013;3:1242 pubmed publisher
Nahrwold M, Weis C, Bogner T, Mertink F, Conradi J, Sammet B, et al. Conjugates of modified cryptophycins and RGD-peptides enter target cells by endocytosis. J Med Chem. 2013;56:1853-64 pubmed publisher
Mokhtarieh A, Kim S, Lee Y, Chung B, Lee M. Novel cell penetrating peptides with multiple motifs composed of RGD and its analogs. Biochem Biophys Res Commun. 2013;432:359-64 pubmed publisher
Silvent J, Sire J, Delgado S. The dentin matrix acidic phosphoprotein 1 (DMP1) in the light of mammalian evolution. J Mol Evol. 2013;76:59-70 pubmed publisher
Cody J, Rivera A, Lyons G, Yang S, Wang M, Ashley J, et al. Expression of osteoprotegerin from a replicating adenovirus inhibits the progression of prostate cancer bone metastases in a murine model. Lab Invest. 2013;93:268-78 pubmed publisher
Wang X, Yan C, Ye K, He Y, Li Z, Ding J. Effect of RGD nanospacing on differentiation of stem cells. Biomaterials. 2013;34:2865-74 pubmed publisher
Ranyuk E, Cauchon N, Klarskov K, Guérin B, van Lier J. Phthalocyanine-peptide conjugates: receptor-targeting bifunctional agents for imaging and photodynamic therapy. J Med Chem. 2013;56:1520-34 pubmed publisher
van Dongen S, Maiuri P, Marie E, Tribet C, Piel M. Triggering cell adhesion, migration or shape change with a dynamic surface coating. Adv Mater. 2013;25:1687-91 pubmed publisher
Jiang L, Lv B, Luo Y. The effects of an RGD-PAMAM dendrimer conjugate in 3D spheroid culture on cell proliferation, expression and aggregation. Biomaterials. 2013;34:2665-73 pubmed publisher
Ke S, Wang W, Qiu X, Zhang F, Yustein J, Cameron A, et al. Multiple target-specific molecular agents for detection and image analysis of breast cancer characteristics in mice. Curr Mol Med. 2013;13:446-58 pubmed
Wang Y, Zhang Z, Xu L, Li X, Chen H. Hydrogels of halogenated Fmoc-short peptides for potential application in tissue engineering. Colloids Surf B Biointerfaces. 2013;104:163-8 pubmed publisher
Zhang H, Li Z, Fu X, Ma J, Ma X. Interactions of bone marrow stromal cells with native and RGD surface modified acellular bone matrix: a biocompatibility study. Arch Med Res. 2013;44:69-74 pubmed publisher
Li Y, Li Z, Wang X, Liu F, Cheng Y, Zhang B, et al. In vivo cancer targeting and imaging-guided surgery with near infrared-emitting quantum dot bioconjugates. Theranostics. 2012;2:769-76 pubmed publisher
Beristain A, Zhu H, Leung P. Regulated expression of ADAMTS-12 in human trophoblastic cells: a role for ADAMTS-12 in epithelial cell invasion?. PLoS ONE. 2011;6:e18473 pubmed publisher
Lv Z, Na D, Liu F, Du Z, Sun Z, Li Z, et al. Induction of gastric cancer cell adhesion through transforming growth factor-beta1-mediated peritoneal fibrosis. J Exp Clin Cancer Res. 2010;29:139 pubmed publisher
Deng H, Bell J, Simmonds A. Vestigial is required during late-stage muscle differentiation in Drosophila melanogaster embryos. Mol Biol Cell. 2010;21:3304-16 pubmed publisher
Takahashi S, Leiss M, Moser M, Ohashi T, Kitao T, Heckmann D, et al. The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. J Cell Biol. 2007;178:167-78 pubmed
Desai B, Rogers M, Chellaiah M. Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells. Mol Cancer. 2007;6:18 pubmed
Bella J, Humphries M. Calpha-H...O = C hydrogen bonds contribute to the specificity of RGD cell-adhesion interactions. BMC Struct Biol. 2005;5:4 pubmed
Hofland L, Capello A, Krenning E, de Jong M, van Hagen M. Induction of apoptosis with hybrids of Arg-Gly-Asp molecules and peptides and antimitotic effects of hybrids of cytostatic drugs and peptides. J Nucl Med. 2005;46 Suppl 1:191S-8S pubmed
Takagi J. Structural basis for ligand recognition by RGD (Arg-Gly-Asp)-dependent integrins. Biochem Soc Trans. 2004;32:403-6 pubmed
Zuo B, Fu Q, Li T, Wan C. [Research progresses of the synthesis and application of oligopeptide containing Arg-Gly-Asp sequence]. Space Med Med Eng (Beijing). 2002;15:152-6 pubmed
Horton M. Arg-gly-Asp (RGD) peptides and peptidomimetics as therapeutics: relevance for renal diseases. Exp Nephrol. 1999;7:178-84 pubmed
Bruck R, Hershkoviz R, Lider O, Shirin H, Aeed H, Halpern Z. The use of synthetic analogues of Arg-Gly-Asp (RGD) and soluble receptor of tumor necrosis factor to prevent acute and chronic experimental liver injury. Yale J Biol Med. 1997;70:391-402 pubmed
Yip K, Marsh D. An Arg-Gly-Asp peptide stimulates constriction in rat afferent arteriole. Am J Physiol. 1997;273:F768-76 pubmed publisher
Udvardy M. [Anti-adhesive and anti-thrombotic effects of integrin-inhibiting tripeptides (Arg-Gly-Asp)]. Orv Hetil. 1995;136:2155-9 pubmed
Reed J, Hull W, Von der Lieth C, Kübler D, Suhai S, Kinzel V. Secondary structure of the Arg-Gly-Asp recognition site in proteins involved in cell-surface adhesion. Evidence for the occurrence of nested beta-bends in the model hexapeptide GRGDSP. Eur J Biochem. 1988;178:141-54 pubmed
product information
Catalog Number :
A8052
Product Name :
Arg-Gly-Asp
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
≥97% (TLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA