This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Aconitine
catalog :
A8001
citations: 51
Reference
Wang Y, Shan Y, Wang Y, Fang Y, Huang T, Wang S, et al. Aconitine inhibits androgen synthesis enzymes by rat immature Leydig cells via down-regulating androgen synthetic enzyme expression in vitro. Chem Biol Interact. 2019;312:108817 pubmed publisher
Povšnar M, Kozelj G, Kreft S, Lumpert M. Rare tradition of the folk medicinal use of Aconitum spp. is kept alive in Sol?avsko, Slovenia. J Ethnobiol Ethnomed. 2017;13:45 pubmed publisher
Liu L, Li H, Guo Z, Ma X, Cao N, Zheng Y, et al. The Combination of Three Natural Compounds Effectively Prevented Lung Carcinogenesis by Optimal Wound Healing. PLoS ONE. 2015;10:e0143438 pubmed publisher
Oliver C, Softley S, Williamson S, Stevenson P, Wright G. Pyrethroids and Nectar Toxins Have Subtle Effects on the Motor Function, Grooming and Wing Fanning Behaviour of Honeybees (Apis mellifera). PLoS ONE. 2015;10:e0133733 pubmed publisher
Xin Y, Liu S. Quantitative Assessment of the Influence of Rhizoma Zingiberis on the Level of Aconitine in Rat Gut Sacs and Qualitative Analysis of the Major Influencing Components of Rhizoma Zingiberis on Aconitine Using UPLC/MS. PLoS ONE. 2015;10:e0124110 pubmed publisher
Koga M, Kanaoka Y, Ohkido Y, Kubo N, Ohishi K, Sugiyama K, et al. Varenicline aggravates plaque formation through α7 nicotinic acetylcholine receptors in ApoE KO mice. Biochem Biophys Res Commun. 2014;455:194-7 pubmed publisher
Jaiswal Y, Liang Z, Ho A, Wong L, Yong P, Chen H, et al. Distribution of toxic alkaloids in tissues from three herbal medicine Aconitum species using laser micro-dissection, UHPLC-QTOF MS and LC-MS/MS techniques. Phytochemistry. 2014;107:155-74 pubmed publisher
Prasad S, Laloo D, Sahu A, Nath G, Hemalatha S. Cryptocoryne spiralis, a substitute of Aconitum heterophyllum in the treatment of diarrhoea. J Pharm Pharmacol. 2014;66:1808-17 pubmed publisher
Paul R, Singh N, Khadeer M, Moaddel R, Sanghvi M, Green C, et al. (R,S)-Ketamine metabolites (R,S)-norketamine and (2S,6S)-hydroxynorketamine increase the mammalian target of rapamycin function. Anesthesiology. 2014;121:149-59 pubmed publisher
Zhou L, Zhu H, Ouyang X, Zhao J, Chen X. A method for analysis of wilfordmine in human plasma by liquid chromatography coupled with ion trap mass spectrometry. J Chromatogr Sci. 2015;53:177-82 pubmed publisher
Sun G, Sun H, Meng X, Hu J, Zhang Q, Liu B, et al. Aconitine-induced Ca2+ overload causes arrhythmia and triggers apoptosis through p38 MAPK signaling pathway in rats. Toxicol Appl Pharmacol. 2014;279:8-22 pubmed publisher
Yang C, Zhang T, Li Z, Xu L, Liu F, Ruan J, et al. P-glycoprotein is responsible for the poor intestinal absorption and low toxicity of oral aconitine: in vitro, in situ, in vivo and in silico studies. Toxicol Appl Pharmacol. 2013;273:561-8 pubmed publisher
Absalom N, Quek G, Lewis T, Qudah T, von Arenstorff I, Ambrus J, et al. Covalent trapping of methyllycaconitine at the α4-α4 interface of the α4β2 nicotinic acetylcholine receptor: antagonist binding site and mode of receptor inhibition revealed. J Biol Chem. 2013;288:26521-32 pubmed publisher
Fujita Y, Tominaga A, Nozawa M, Unei H, Hatano Y, Saito T, et al. [Practical analysis of toxic substances useful for clinical toxicology (2). aconitine alkoloids]. Chudoku Kenkyu. 2013;26:121-6 pubmed
Lin L, Wei X, Wang Y, Jin L, He Z, Du T, et al. [Comparison of content of total alkaloids and aconitine in Aconitum szechenyianum from different producing areas on basis of macroporous adsorption resin purification technology]. Zhongguo Zhong Yao Za Zhi. 2013;38:995-9 pubmed
Vakhitova I, Farafontova E, Khisamutdinova R, Iunusov V, Cypasheva I, Iunusov M. [To the mechanisms of antiarrhythmic action of Allapinine]. Bioorg Khim. 2013;39:105-16 pubmed
Welch K, Pfister J, Gardner D, Green B, Panter K. The role of the α7 subunit of the nicotinic acetylcholine receptor on motor coordination in mice treated with methyllycaconitine and anabasine. J Appl Toxicol. 2013;33:1017-26 pubmed publisher
Krafft P, Caner B, Klebe D, Rolland W, Tang J, Zhang J. PHA-543613 preserves blood-brain barrier integrity after intracerebral hemorrhage in mice. Stroke. 2013;44:1743-7 pubmed publisher
Xu H, Ji G, Wang Q, Li X, Gong Y, Zhang Y, et al. Dose-dependent pharmacokinetics of bulleyaconitine A in rats. Pharmazie. 2013;68:170-2 pubmed
Wang L, Chen Q, Wang F. Conversional synthesis of heteratisine. Nat Prod Commun. 2012;7:1583-6 pubmed
Tong P, Wu C, Wang X, Hu H, Jin H, Li C, et al. Development and assessment of a complete-detoxication strategy for Fuzi (lateral root of Aconitum carmichaeli) and its application in rheumatoid arthritis therapy. J Ethnopharmacol. 2013;146:562-71 pubmed publisher
Griguoli M, Cellot G, Cherubini E. In hippocampal oriens interneurons anti-Hebbian long-term potentiation requires cholinergic signaling via ?7 nicotinic acetylcholine receptors. J Neurosci. 2013;33:1044-9 pubmed publisher
Du J, Lu X, Long Z, Zhang Z, Zhu X, Yang Y, et al. In vitro and in vivo anticancer activity of aconitine on melanoma cell line B16. Molecules. 2013;18:757-67 pubmed publisher
Welch K, Green B, Panter K, Pfister J, Gardner D. The role of the α7 subunit of the nicotinic acetylcholine receptor in the acute toxicosis of methyllycaconitine in mice. J Appl Toxicol. 2013;33:1011-6 pubmed publisher
Zhang J, Huang Z, Qiu X, Yang Y, Zhu D, Xu W. Neutral fragment filtering for rapid identification of new diester-diterpenoid alkaloids in roots of Aconitum carmichaeli by ultra-high-pressure liquid chromatography coupled with linear ion trap-orbitrap mass spectrometry. PLoS ONE. 2012;7:e52352 pubmed publisher
Gao Y, Li P, Ma L, DU K, Wang X, Tang M, et al. Effects of acute administration of ethanol on experimental arrhythmia. Chin J Physiol. 2012;55:307-13 pubmed publisher
Ni F, Lin J, Guo D, Zhou C, Yao X, Ye H, et al. Observation on effects of aconitine via acupoint injection in rabbits. Chin J Integr Med. 2013;19:36-41 pubmed publisher
Yang K, Liang J, Li Q, Kong X, Chen R, Jin Y. Cladosporium cladosporioides XJ-AC03, an aconitine-producing endophytic fungus isolated from Aconitum leucostomum. World J Microbiol Biotechnol. 2013;29:933-8 pubmed publisher
Pubill D, Garcia Ratés S, Camarasa J, Escubedo E. 3,4-Methylenedioxy-methamphetamine induces in vivo regional up-regulation of central nicotinic receptors in rats and potentiates the regulatory effects of nicotine on these receptors. Neurotoxicology. 2013;35:41-9 pubmed publisher
He H, Yan F. Relative quantification of the metabolite of aconitine in rat urine by LC-ESI-MS/MS and its application to pharmacokinetics. Anal Sci. 2012;28:1203-5 pubmed
Welch K, Pfister J, Lima F, Green B, Gardner D. Effect of ?? nicotinic acetylcholine receptor agonists and antagonists on motor function in mice. Toxicol Appl Pharmacol. 2013;266:366-74 pubmed publisher
Kotliarov A, Mosina L, Chibisov S, Dmitrieva O, Kariakina T, Khalabi G. [Antiarrhythmic therapy of paroxysmal tachycardias and extrasystoles in patients with sinus node dysfunction]. Klin Med (Mosk). 2012;90:57-9 pubmed
Ye L, Yang X, Yang Z, Gao S, Yin T, Liu W, et al. The role of efflux transporters on the transport of highly toxic aconitine, mesaconitine, hypaconitine, and their hydrolysates, as determined in cultured Caco-2 and transfected MDCKII cells. Toxicol Lett. 2013;216:86-99 pubmed publisher
Zhu H, Wang C, Qi Y, Song F, Liu Z, Liu S. Fingerprint analysis of Radix Aconiti using ultra-performance liquid chromatography-electrospray ionization/ tandem mass spectrometry (UPLC-ESI/MS n) combined with stoichiometry. Talanta. 2013;103:56-65 pubmed publisher
Ammar E, Said S, El Damarawy S, Suddek G. Cardioprotective effect of grape-seed proanthocyanidins on doxorubicin-induced cardiac toxicity in rats. Pharm Biol. 2013;51:339-44 pubmed publisher
Zyuz kov G, Krapivin A, Nesterova Y, Povetieva T, Zhdanov V, Suslov N, et al. Mechanisms of regeneratory effects of baikal aconite diterpene alkaloids. Bull Exp Biol Med. 2012;153:846-50 pubmed
Zhu H, Wang C, Qi Y, Song F, Liu Z, Liu S. Rapid quality assessment of Radix Aconiti Preparata using direct analysis in real time mass spectrometry. Anal Chim Acta. 2012;752:69-77 pubmed publisher
Garduño J, Galindo Charles L, Jiménez Rodríguez J, Galarraga E, Tapia D, Mihailescu S, et al. Presynaptic ?4?2 nicotinic acetylcholine receptors increase glutamate release and serotonin neuron excitability in the dorsal raphe nucleus. J Neurosci. 2012;32:15148-57 pubmed publisher
Zhu L, Yang X, Zhou J, Tang L, Xia B, Hu M, et al. The exposure of highly toxic aconitine does not significantly impact the activity and expression of cytochrome P450 3A in rats determined by a novel ultra performance liquid chromatography-tandem mass spectrometric method of a specific probe buspiron. Food Chem Toxicol. 2013;51:396-403 pubmed publisher
Yi M, Peng W, Chen X, Wang J, Chen Y. Effect of hypaconitine combined with liquiritin on the expression of calmodulin and connexin43 in rat cardiac muscle in vivo. J Pharm Pharmacol. 2012;64:1654-8 pubmed publisher
Tsuda N. [Evaluation and verification of the effectiveness of analytical apparatus after use by emergency centers]. Chudoku Kenkyu. 2012;25:227-30 pubmed
Zhang H, Shi Y. Preparation of Fe3O4 nanoparticle enclosure hydroxylated multi-walled carbon nanotubes for the determination of aconitines in human serum samples. Anal Chim Acta. 2012;724:54-60 pubmed publisher
Li N, Tsao R, Sui Z, Ma J, Liu Z, Liu Z. Intestinal transport of pure diester-type alkaloids from an aconite extract across the Caco-2 cell monolayer model. Planta Med. 2012;78:692-7 pubmed publisher
Ameri A, Simmet T. Antagonism of the aconitine-induced inexcitability by the structurally related Aconitum alkaloids, lappaconitine and ajacine. Brain Res. 1999;842:332-41 pubmed
Ameri A. The effects of Aconitum alkaloids on the central nervous system. Prog Neurobiol. 1998;56:211-35 pubmed
Seitz U, Ameri A. Different effects on [3H]noradrenaline uptake of the Aconitum alkaloids aconitine, 3-acetylaconitine, lappaconitine, and N-desacetyllappaconitine in rat hippocampus. Biochem Pharmacol. 1998;55:883-8 pubmed
Sawanobori T, Adaniya H, Hirano Y, Hiraoka M. Effects of antiarrhythmic agents and Mg2+ on aconitine-induced arrhythmias. Jpn Heart J. 1996;37:709-18 pubmed
Onur R, Bozdagi O, Ayata C. Effects of aconitine on neurotransmitter release in the rat neuromuscular junction. Neuropharmacology. 1995;34:1139-45 pubmed
Chan T. Aconitine poisoning: a global perspective. Vet Hum Toxicol. 1994;36:326-8 pubmed
Chan T, Tomlinson B, Tse L, Chan J, Chan W, Critchley J. Aconitine poisoning due to Chinese herbal medicines: a review. Vet Hum Toxicol. 1994;36:452-5 pubmed
Tsukada K, Akizuki S, Matsuoka Y, Irimajiri S. [A case of aconitine poisoning accompanied by bidirectional ventricular tachycardia treated with lidocaine]. Kokyu To Junkan. 1992;40:1003-6 pubmed
product information
Catalog Number :
A8001
Product Name :
Aconitine
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥95% (HPLC), crystalline
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA