This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
protein
product name :
Amphiregulin human
catalog :
A7080
citations: 50
Reference
Varela Eirin M, Carpintero Fernández P, Sánchez Temprano A, Varela Vazquez A, Paíno C, Casado Diaz A, et al. Senolytic activity of small molecular polyphenols from olive restores chondrocyte redifferentiation and promotes a pro-regenerative environment in osteoarthritis. Aging (Albany NY). 2020;12:15882-15905 pubmed publisher
Callejo G, Pattison L, Greenhalgh J, Chakrabarti S, Andreopoulou E, Hockley J, et al. In silico screening of GMQ-like compounds reveals guanabenz and sephin1 as new allosteric modulators of acid-sensing ion channel 3. Biochem Pharmacol. 2020;174:113834 pubmed publisher
Schuhmacher L, Callejo G, Srivats S, Smith E. Naked mole-rat acid-sensing ion channel 3 forms nonfunctional homomers, but functional heteromers. J Biol Chem. 2018;293:1756-1766 pubmed publisher
Deacon K, Knox A. Human airway smooth muscle cells secrete amphiregulin via bradykinin/COX-2/PGE2, inducing COX-2, CXCL8, and VEGF expression in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2015;309:L237-49 pubmed publisher
Sugimura S, Ritter L, Rose R, Thompson J, Smitz J, Mottershead D, et al. Promotion of EGF receptor signaling improves the quality of low developmental competence oocytes. Dev Biol. 2015;403:139-49 pubmed publisher
Akter S, Lean F, Lu J, Grieco V, Palmieri C. Different Growth Patterns of Canine Prostatic Carcinoma Suggests Different Models of Tumor-Initiating Cells. Vet Pathol. 2015;52:1027-33 pubmed publisher
Barton V, D Amato N, Gordon M, Lind H, Spoelstra N, Babbs B, et al. Multiple molecular subtypes of triple-negative breast cancer critically rely on androgen receptor and respond to enzalutamide in vivo. Mol Cancer Ther. 2015;14:769-78 pubmed publisher
Lee C, Jung H, Oh S, Park C, Tanaka T, Yokozawa T, et al. Kinetic and molecular docking studies of loganin and 7-O-galloyl-D-sedoheptulose from Corni Fructus as therapeutic agents for diabetic complications through inhibition of aldose reductase. Arch Pharm Res. 2015;38:1090-8 pubmed publisher
So W, Fan Q, Lau M, Qiu X, Cheng J, Leung P. Amphiregulin induces human ovarian cancer cell invasion by down-regulating E-cadherin expression. FEBS Lett. 2014;588:3998-4007 pubmed publisher
Chen Y, Hou C, Hou S, Liu J. The effects of amphiregulin induced MMP-13 production in human osteoarthritis synovial fibroblast. Mediators Inflamm. 2014;2014:759028 pubmed publisher
Huang Y, Benaich N, Tape C, Kwok H, Murphy G. Targeting the sheddase activity of ADAM17 by an anti-ADAM17 antibody D1(A12) inhibits head and neck squamous cell carcinoma cell proliferation and motility via blockage of bradykinin induced HERs transactivation. Int J Biol Sci. 2014;10:702-14 pubmed publisher
Evans G, Martinez Conejero J, Phillipson G, Sykes P, Sin I, Lam E, et al. In the secretory endometria of women, luminal epithelia exhibit gene and protein expressions that differ from those of glandular epithelia. Fertil Steril. 2014;102:307-317.e7 pubmed publisher
Liu X, Xie F, Zamah A, Cao B, Conti M. Multiple pathways mediate luteinizing hormone regulation of cGMP signaling in the mouse ovarian follicle. Biol Reprod. 2014;91:9 pubmed publisher
Nagathihalli N, Beesetty Y, Lee W, Washington M, Chen X, Lockhart A, et al. Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-?: impact on gastrointestinal cancers driven by secondary bile acids. Cancer Res. 2014;74:2062-72 pubmed publisher
Subramaniam R, Barnes P, Fletcher K, Boggaram V, Hillberry Z, NEUENSCHWANDER P, et al. Protecting against post-influenza bacterial pneumonia by increasing phagocyte recruitment and ROS production. J Infect Dis. 2014;209:1827-36 pubmed publisher
Burzyn D, Kuswanto W, Kolodin D, Shadrach J, Cerletti M, Jang Y, et al. A special population of regulatory T cells potentiates muscle repair. Cell. 2013;155:1282-95 pubmed publisher
Lahoti T, Hughes J, Kusnadi A, John K, Zhu B, Murray I, et al. Aryl hydrocarbon receptor antagonism attenuates growth factor expression, proliferation, and migration in fibroblast-like synoviocytes from patients with rheumatoid arthritis. J Pharmacol Exp Ther. 2014;348:236-45 pubmed publisher
Chen J, Torcia S, Xie F, Lin C, Cakmak H, Franciosi F, et al. Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes. Nat Cell Biol. 2013;15:1415-23 pubmed publisher
Turner J, Morrison P, Wilhelm C, Wilson M, Ahlfors H, Renauld J, et al. IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation. J Exp Med. 2013;210:2951-65 pubmed publisher
Ma B, Chan S, Ho W, Lau W, Mo F, Hui E, et al. Intermittent versus continuous erlotinib with concomitant modified "XELOX" (q3W) in first-line treatment of metastatic colorectal cancer: correlation with serum amphiregulin and transforming growth factor alpha. Cancer. 2013;119:4145-53 pubmed publisher
Odintsova E, van Niel G, Conjeaud H, Raposo G, Iwamoto R, Mekada E, et al. Metastasis suppressor tetraspanin CD82/KAI1 regulates ubiquitylation of epidermal growth factor receptor. J Biol Chem. 2013;288:26323-34 pubmed publisher
Levi Y, Barshack I, Avivi K, Bar Ilan D, Gutman M, Aderka D, et al. [Correlation between the presence of Kras mutation and the presence of the proteins epiregulin and amphiregulin in colon cancer tissue]. Harefuah. 2013;152:326-9, 369 pubmed
Nickerson N, Mill C, Wu H, Riese D, Foley J. Autocrine-derived epidermal growth factor receptor ligands contribute to recruitment of tumor-associated macrophage and growth of basal breast cancer cells in vivo. Oncol Res. 2013;20:303-17 pubmed
Casimiro M, Wang C, Li Z, Di Sante G, Willmart N, Addya S, et al. Cyclin D1 determines estrogen signaling in the mammary gland in vivo. Mol Endocrinol. 2013;27:1415-28 pubmed publisher
Mahmoud K, Cole L, Newton J, Mohamed S, Al Enazi M, Quirke P, et al. Detection of the epidermal growth factor receptor, amphiregulin and epiregulin in formalin-fixed paraffin-embedded human placenta tissue by matrix-assisted laser desorption/ionization mass spectrometry imaging. Eur J Mass Spectrom (Chichester). 2013;19:17-28 pubmed
Dang M, Armbruster N, Miller M, Cermeno E, Hartmann M, Bell G, et al. Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways. Proc Natl Acad Sci U S A. 2013;110:9776-81 pubmed publisher
McMahan R, Riehle K, Fausto N, Campbell J. A disintegrin and metalloproteinase 17 regulates TNF and TNFR1 levels in inflammation and liver regeneration in mice. Am J Physiol Gastrointest Liver Physiol. 2013;305:G25-34 pubmed publisher
Larmonier C, McFadden R, Hill F, Schreiner R, Ramalingam R, Besselsen D, et al. High vitamin D3 diet administered during active colitis negatively affects bone metabolism in an adoptive T cell transfer model. Am J Physiol Gastrointest Liver Physiol. 2013;305:G35-46 pubmed publisher
Siddiqui S, Novali M, Tsuchiya K, Hirota N, Geller B, McGovern T, et al. The modulation of large airway smooth muscle phenotype and effects of epidermal growth factor receptor inhibition in the repeatedly allergen-challenged rat. Am J Physiol Lung Cell Mol Physiol. 2013;304:L853-62 pubmed publisher
Kobayashi H, Kumagai K, Gotoh A, Eguchi T, Yamada H, Hamada Y, et al. Upregulation of epidermal growth factor receptor 4 in oral leukoplakia. Int J Oral Sci. 2013;5:14-20 pubmed publisher
Nakayama H, Fukuda S, Matsushita N, Nishida Fukuda H, Inoue H, Shirakata Y, et al. Human antigen R-mediated mRNA stabilization is required for ultraviolet B-induced autoinduction of amphiregulin in keratinocytes. J Biol Chem. 2013;288:10338-48 pubmed publisher
Melnick M, Deluca K, Sedghizadeh P, Jaskoll T. Cytomegalovirus-induced salivary gland pathology: AREG, FGF8, TNF-α, and IL-6 signal dysregulation and neoplasia. Exp Mol Pathol. 2013;94:386-97 pubmed publisher
Pentheroudakis G, Kotoula V, De Roock W, Kouvatseas G, Papakostas P, Makatsoris T, et al. Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes. BMC Cancer. 2013;13:49 pubmed publisher
Zaiss D, van Loosdregt J, Gorlani A, Bekker C, Grone A, Sibilia M, et al. Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor. Immunity. 2013;38:275-84 pubmed publisher
Zhu J, Siclari V, Liu F, Spatz J, Chandra A, DIVIETI PAJEVIC P, et al. Amphiregulin-EGFR signaling mediates the migration of bone marrow mesenchymal progenitors toward PTH-stimulated osteoblasts and osteocytes. PLoS ONE. 2012;7:e50099 pubmed publisher
Latasa M, Salis F, Urtasun R, Garcia Irigoyen O, Elizalde M, Uriarte I, et al. Regulation of amphiregulin gene expression by ?-catenin signaling in human hepatocellular carcinoma cells: a novel crosstalk between FGF19 and the EGFR system. PLoS ONE. 2012;7:e52711 pubmed publisher
Franco L, Williams F, Trofimov S, Surdulescu G, Spector T, Livshits G. Contribution of putative genetic factors and candidate gene variants to inter-individual variation of circulating fractalkine (CX3CL1) levels in a large UK twins' sample. Hum Immunol. 2013;74:358-63 pubmed publisher
Song Y, Santen R, Wang J, Yue W. Inhibitory effects of a bazedoxifene/conjugated equine estrogen combination on human breast cancer cells in vitro. Endocrinology. 2013;154:656-65 pubmed publisher
Sayasith K, Lussier J, Doré M, Sirois J. Human chorionic gonadotropin-dependent up-regulation of epiregulin and amphiregulin in equine and bovine follicles during the ovulatory process. Gen Comp Endocrinol. 2013;180:39-47 pubmed publisher
Firth J, Ekuni D, Irie K, Tomofuji T, Morita M, Putnins E. Lipopolysaccharide induces a stromal-epithelial signalling axis in a rat model of chronic periodontitis. J Clin Periodontol. 2013;40:8-17 pubmed publisher
Berasain C, Nicou A, Garcia Irigoyen O, Latasa M, Urtasun R, Elizalde M, et al. Epidermal growth factor receptor signaling in hepatocellular carcinoma: inflammatory activation and a new intracellular regulatory mechanism. Dig Dis. 2012;30:524-31 pubmed publisher
Zhou Y, Lee J, Lee C, Cho W, Kang M, Koff J, et al. Amphiregulin, an epidermal growth factor receptor ligand, plays an essential role in the pathogenesis of transforming growth factor-?-induced pulmonary fibrosis. J Biol Chem. 2012;287:41991-2000 pubmed publisher
Khan J, Bellance C, Guiochon Mantel A, Lombes M, Loosfelt H. Differential regulation of breast cancer-associated genes by progesterone receptor isoforms PRA and PRB in a new bi-inducible breast cancer cell line. PLoS ONE. 2012;7:e45993 pubmed publisher
Benelli R, Vené R, Minghelli S, Carlone S, Gatteschi B, Ferrari N. Celecoxib induces proliferation and Amphiregulin production in colon subepithelial myofibroblasts, activating erk1-2 signaling in synergy with EGFR. Cancer Lett. 2013;328:73-82 pubmed publisher
Tsuji T, Kiyosu C, Akiyama K, Kunieda T. CNP/NPR2 signaling maintains oocyte meiotic arrest in early antral follicles and is suppressed by EGFR-mediated signaling in preovulatory follicles. Mol Reprod Dev. 2012;79:795-802 pubmed publisher
Levano K, Kenny P. Clarification of the C-terminal proteolytic processing site of human Amphiregulin. FEBS Lett. 2012;586:3500-2 pubmed publisher
Mack E, Smith J, Kurz S, Wood J. cAMP-dependent regulation of ovulatory response genes is amplified by IGF1 due to synergistic effects on Akt phosphorylation and NF-?B transcription factors. Reproduction. 2012;144:595-602 pubmed publisher
Adam R, Borer J, Williams J, Eastham J, Loughlin K, Freeman M. Amphiregulin is coordinately expressed with heparin-binding epidermal growth factor-like growth factor in the interstitial smooth muscle of the human prostate. Endocrinology. 1999;140:5866-75 pubmed
Damstrup L, Kuwada S, Dempsey P, Brown C, Hawkey C, Poulsen H, et al. Amphiregulin acts as an autocrine growth factor in two human polarizing colon cancer lines that exhibit domain selective EGF receptor mitogenesis. Br J Cancer. 1999;80:1012-9 pubmed
Wong L, Deb T, Thompson S, Wells A, Johnson G. A differential requirement for the COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling. J Biol Chem. 1999;274:8900-9 pubmed
product information
Catalog Number :
A7080
Product Name :
Amphiregulin human
Product Type :
GROWTH FACTORS
Product Group :
Cell Biology
Product Description :
recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, ≥97% (SDS-PAGE)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA